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Se-Min Kim The Mount Sinai Bone Program, Departments of Pharmacological Sciences and Medicine, and Center for Translational Medicine and Pharmacology, Icahn School of Medicine, Mount Sinai, New York, USA

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Farhath Sultana The Mount Sinai Bone Program, Departments of Pharmacological Sciences and Medicine, and Center for Translational Medicine and Pharmacology, Icahn School of Medicine, Mount Sinai, New York, USA

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Steven Sims The Mount Sinai Bone Program, Departments of Pharmacological Sciences and Medicine, and Center for Translational Medicine and Pharmacology, Icahn School of Medicine, Mount Sinai, New York, USA

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Judit Gimenez-Roig The Mount Sinai Bone Program, Departments of Pharmacological Sciences and Medicine, and Center for Translational Medicine and Pharmacology, Icahn School of Medicine, Mount Sinai, New York, USA

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Victoria Laurencin The Mount Sinai Bone Program, Departments of Pharmacological Sciences and Medicine, and Center for Translational Medicine and Pharmacology, Icahn School of Medicine, Mount Sinai, New York, USA

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Anusha Pallapati The Mount Sinai Bone Program, Departments of Pharmacological Sciences and Medicine, and Center for Translational Medicine and Pharmacology, Icahn School of Medicine, Mount Sinai, New York, USA

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Satish Rojekar The Mount Sinai Bone Program, Departments of Pharmacological Sciences and Medicine, and Center for Translational Medicine and Pharmacology, Icahn School of Medicine, Mount Sinai, New York, USA

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Tal Frolinger The Mount Sinai Bone Program, Departments of Pharmacological Sciences and Medicine, and Center for Translational Medicine and Pharmacology, Icahn School of Medicine, Mount Sinai, New York, USA

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Weibin Zhou The Mount Sinai Bone Program, Departments of Pharmacological Sciences and Medicine, and Center for Translational Medicine and Pharmacology, Icahn School of Medicine, Mount Sinai, New York, USA

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Anisa Gumerova The Mount Sinai Bone Program, Departments of Pharmacological Sciences and Medicine, and Center for Translational Medicine and Pharmacology, Icahn School of Medicine, Mount Sinai, New York, USA

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Anne Macdonald The Mount Sinai Bone Program, Departments of Pharmacological Sciences and Medicine, and Center for Translational Medicine and Pharmacology, Icahn School of Medicine, Mount Sinai, New York, USA

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Vitaly Ryu The Mount Sinai Bone Program, Departments of Pharmacological Sciences and Medicine, and Center for Translational Medicine and Pharmacology, Icahn School of Medicine, Mount Sinai, New York, USA

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Daria Lizneva The Mount Sinai Bone Program, Departments of Pharmacological Sciences and Medicine, and Center for Translational Medicine and Pharmacology, Icahn School of Medicine, Mount Sinai, New York, USA

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Funda Korkmaz The Mount Sinai Bone Program, Departments of Pharmacological Sciences and Medicine, and Center for Translational Medicine and Pharmacology, Icahn School of Medicine, Mount Sinai, New York, USA

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Tony Yuen The Mount Sinai Bone Program, Departments of Pharmacological Sciences and Medicine, and Center for Translational Medicine and Pharmacology, Icahn School of Medicine, Mount Sinai, New York, USA

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Mone Zaidi The Mount Sinai Bone Program, Departments of Pharmacological Sciences and Medicine, and Center for Translational Medicine and Pharmacology, Icahn School of Medicine, Mount Sinai, New York, USA

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mammals. FSHR has been identified in nongonadal reproductive tracts, blood vessels, endothelial cells, the liver, skeletal tissue, bone cells, adipose tissue, and the brain ( Table 1 ). These discoveries have raised the question of whether FSH exerts

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-23-0377
Volume/Issue:
Volume 262: Issue 1
Restricted access
Hannah M Eggink Department of Endocrinology and Metabolism, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
Hypothalamic Integration Mechanisms, Netherlands Institute for Neuroscience, Amsterdam, The Netherlands

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Lauren L Tambyrajah Division of Endocrinology, Department of Medicine, Leiden University Medical Centre, Leiden, The Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Centre, Leiden, The Netherlands

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Rosa van den Berg Division of Endocrinology, Department of Medicine, Leiden University Medical Centre, Leiden, The Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Centre, Leiden, The Netherlands

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Isabel M Mol Division of Endocrinology, Department of Medicine, Leiden University Medical Centre, Leiden, The Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Centre, Leiden, The Netherlands

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Jose K van den Heuvel Division of Endocrinology, Department of Medicine, Leiden University Medical Centre, Leiden, The Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Centre, Leiden, The Netherlands

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Martijn Koehorst Department of Pediatrics and Laboratory Medicine, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands

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Albert K Groen Department of Pediatrics and Laboratory Medicine, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands
Department of Vascular Medicine, Amsterdam Diabetes Centre, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands

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Anita Boelen Department of Endocrinology and Metabolism, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands

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Andries Kalsbeek Department of Endocrinology and Metabolism, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
Hypothalamic Integration Mechanisms, Netherlands Institute for Neuroscience, Amsterdam, The Netherlands

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Johannes A Romijn Department of Medicine, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands

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Patrick C N Rensen Division of Endocrinology, Department of Medicine, Leiden University Medical Centre, Leiden, The Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Centre, Leiden, The Netherlands

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Sander Kooijman Division of Endocrinology, Department of Medicine, Leiden University Medical Centre, Leiden, The Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Centre, Leiden, The Netherlands

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Maarten R Soeters Department of Endocrinology and Metabolism, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands

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using immunohistochemistry ( Keitel et al . 2010 ) and FXR was present and active in mouse brain ( Huang et al . 2016 ). The presence of these receptors and their agonists suggest a functional role for BAs in the brain. Considering the well

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-17-0503
Volume/Issue:
Volume 236: Issue 2
Free access
Leonie Cabot Synaptic Transmission in Energy Homeostasis Group, Max Planck Institute for Metabolism Research, Gleueler Straße, Cologne, Germany
Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases (CECAD), University of Cologne, Joseph-Stelzmann-Straße, Cologne, Germany

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Juliet Erlenbeck-Dinkelmann Synaptic Transmission in Energy Homeostasis Group, Max Planck Institute for Metabolism Research, Gleueler Straße, Cologne, Germany

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Henning Fenselau Synaptic Transmission in Energy Homeostasis Group, Max Planck Institute for Metabolism Research, Gleueler Straße, Cologne, Germany
Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases (CECAD), University of Cologne, Joseph-Stelzmann-Straße, Cologne, Germany
Center for Endocrinology, Diabetes and Preventive Medicine (CEDP), University Hospital Cologne, Kerpener Straße, Cologne, Germany

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Introduction The brain plays an essential role in coordinating feeding behavior and systemic glucose metabolism. For example, the brain determines the timing, composition, and quantity of nutrients that are consumed. On the other hand, it

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-22-0320
Volume/Issue:
Volume 258: Issue 3
Free access
Marian Joëls Department of Translational Neuroscience, Brain Center Rudolf Magnus, University Medical Center, Utrecht, The Netherlands
University of Groningen, University Medical Center, Groningen, The Netherlands

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E Ronald de Kloet Division of Endocrinology, Department of Internal Medicine, Leiden University Medical Center, Leiden, The Netherlands

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, evidence was mounting that there had to be an MR-like receptor co-existing with the classical glucocorticoid receptors (GRs) in the brain. This was discovered in seminal binding studies using 3 H-corticosterone in the absence or presence of the unlabeled

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-16-0660
Volume/Issue:
Volume 234: Issue 1
Free access
S Khan Centre for Cardiovascular Science, Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, UK

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D E W Livingstone Centre for Cardiovascular Science, Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, UK
Centre for Discovery Brain Science, University of Edinburgh, Hugh Robson Building, Edinburgh, UK

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A Zielinska College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK

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C L Doig Department of Biosciences, School of Science & Technology, Nottingham Trent University, Nottingham, UK

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D F Cobice Centre for Cardiovascular Science, Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, UK

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C L Esteves Centre for Cardiovascular Science, Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, UK

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J T Y Man Centre for Cardiovascular Science, Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, UK

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N Z M Homer Mass Spectrometry Core Laboratory, Edinburgh Clinical Research Facility, Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, UK

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J R Seckl Centre for Cardiovascular Science, Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, UK

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C L MacKay SIRCAMS, School of Chemistry, University of Edinburgh, Joseph Black Building, King's Buildings, Edinburgh, UK

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S P Webster Centre for Cardiovascular Science, Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, UK

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G G Lavery Department of Biosciences, School of Science & Technology, Nottingham Trent University, Nottingham, UK

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K E Chapman Centre for Cardiovascular Science, Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, UK

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B R Walker Centre for Cardiovascular Science, Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, UK
Clinical & Translational Research Institute, Newcastle University, International Centre for Life, Central Parkway, Newcastle upon Tyne, UK

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R Andrew Centre for Cardiovascular Science, Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, UK
Mass Spectrometry Core Laboratory, Edinburgh Clinical Research Facility, Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, UK

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concept but did not achieve better endpoints than current therapies ( Rosenstock et al. 2010 , Feig et al. 2011 , Shah et al. 2011 , Heise et al. 2014 ). Brain penetrant 11βHSD1 inhibitors have been evaluated as potential therapies for Alzheimer

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-23-0034
Volume/Issue:
Volume 258: Issue 3
Open access
Brittney L Marshall Bond Life Sciences Center, University of Missouri, Columbia, Missouri, USA
Biomedical Sciences, University of Missouri, Columbia, Missouri, USA

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Yang Liu Bond Life Sciences Center, University of Missouri, Columbia, Missouri, USA
Informatics Institute, University of Missouri, Columbia, Missouri, USA

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Michelle J Farrington Bond Life Sciences Center, University of Missouri, Columbia, Missouri, USA
Biomedical Sciences, University of Missouri, Columbia, Missouri, USA

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Jiude Mao Bond Life Sciences Center, University of Missouri, Columbia, Missouri, USA
Biomedical Sciences, University of Missouri, Columbia, Missouri, USA

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William G Helferich Food Science and Human Nutrition, University of Illinois, Urbana, Illinois, USA

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A Katrin Schenk Physics, Randolph College, Lynchburg, Virginia, USA

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Nathan J Bivens DNA Core Facility, University of Missouri, Columbia, Missouri, USA

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Saurav J Sarma Bond Life Sciences Center, University of Missouri, Columbia, Missouri, USA
MU Metabolomics Center, University of Missouri, Columbia, Missouri, USA

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Zhentian Lei Bond Life Sciences Center, University of Missouri, Columbia, Missouri, USA
MU Metabolomics Center, University of Missouri, Columbia, Missouri, USA
Department of Biochemistry, University of Missouri, Columbia, Missouri, USA

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Lloyd W Sumner Bond Life Sciences Center, University of Missouri, Columbia, Missouri, USA
MU Metabolomics Center, University of Missouri, Columbia, Missouri, USA
Department of Biochemistry, University of Missouri, Columbia, Missouri, USA

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Trupti Joshi Bond Life Sciences Center, University of Missouri, Columbia, Missouri, USA
Informatics Institute, University of Missouri, Columbia, Missouri, USA
Department of Health Management and Informatics, School of Medicine, University of Missouri, Columbia, Missouri, USA

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Cheryl S Rosenfeld Bond Life Sciences Center, University of Missouri, Columbia, Missouri, USA
Biomedical Sciences, University of Missouri, Columbia, Missouri, USA
Informatics Institute, University of Missouri, Columbia, Missouri, USA
Thompson Center for Autism and Neurobehavioral Disorders, University of Missouri, Columbia, Missouri, USA
Genetics Area Program, University of Missouri, Columbia, Missouri, USA

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chemicals can act similarly to estradiol (E2) and presumably disrupt normal developmental processes, including gonad and brain sexual differentiation. Thus, animal model and human epidemiological studies have been initiated to examine how this chemical

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-19-0214
Volume/Issue:
Volume 242: Issue 2
Free access
Bruce S McEwen Laboratory of Neuroendocrinology, The Rockefeller University, 1230 York Avenue, New York, New York 10065, USA

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Jason D Gray Laboratory of Neuroendocrinology, The Rockefeller University, 1230 York Avenue, New York, New York 10065, USA

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Carla Nasca Laboratory of Neuroendocrinology, The Rockefeller University, 1230 York Avenue, New York, New York 10065, USA

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Introduction The fundamental discovery of the communication between hypothalamus and pituitary, by Geoffrey Harris, established the basis for understanding brain–body communication via the neuroendocrine system ( Harris 1970 ). As originally

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-15-0121
Volume/Issue:
Volume 226: Issue 2
Free access
Stijn L J Van Herck
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Stijn Geysens
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Edward Bald Laboratory of Comparative Endocrinology, Department of Environmental Chemistry, Animal Sciences Unit, Department of Biology, KU Leuven, Naamsestraat 61, PB 2464, B-3000 Leuven, Belgium

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Grazyna Chwatko Laboratory of Comparative Endocrinology, Department of Environmental Chemistry, Animal Sciences Unit, Department of Biology, KU Leuven, Naamsestraat 61, PB 2464, B-3000 Leuven, Belgium

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Evelyne Delezie Laboratory of Comparative Endocrinology, Department of Environmental Chemistry, Animal Sciences Unit, Department of Biology, KU Leuven, Naamsestraat 61, PB 2464, B-3000 Leuven, Belgium

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Elham Dianati
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R G Ahmed
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Veerle M Darras
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embryo/foetus. Maternally derived MMI can block the developing thyroid gland as shown repeatedly in rats ( Comer & Norton 1985 , Ruiz de Ona et al . 1988 , Calvo et al . 1990 ). However, the early vertebrate brain is highly dependent on adequate 3

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-13-0089
Volume/Issue:
Volume 218: Issue 1
Free access
N David Åberg Center of Brain Research and Rehabilitation, Laboratory of Experimental Endocrinology, Institute of Physiology and Neuroscience, University of Gothenburg, Gothenburg, Sweden
Center of Brain Research and Rehabilitation, Laboratory of Experimental Endocrinology, Institute of Physiology and Neuroscience, University of Gothenburg, Gothenburg, Sweden

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Inger Johansson Center of Brain Research and Rehabilitation, Laboratory of Experimental Endocrinology, Institute of Physiology and Neuroscience, University of Gothenburg, Gothenburg, Sweden

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Maria A I Åberg Center of Brain Research and Rehabilitation, Laboratory of Experimental Endocrinology, Institute of Physiology and Neuroscience, University of Gothenburg, Gothenburg, Sweden

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Johan Lind Center of Brain Research and Rehabilitation, Laboratory of Experimental Endocrinology, Institute of Physiology and Neuroscience, University of Gothenburg, Gothenburg, Sweden

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Ulf E Johansson Center of Brain Research and Rehabilitation, Laboratory of Experimental Endocrinology, Institute of Physiology and Neuroscience, University of Gothenburg, Gothenburg, Sweden

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Christiana M Cooper-Kuhn Center of Brain Research and Rehabilitation, Laboratory of Experimental Endocrinology, Institute of Physiology and Neuroscience, University of Gothenburg, Gothenburg, Sweden

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H Georg Kuhn Center of Brain Research and Rehabilitation, Laboratory of Experimental Endocrinology, Institute of Physiology and Neuroscience, University of Gothenburg, Gothenburg, Sweden

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Jörgen Isgaard Center of Brain Research and Rehabilitation, Laboratory of Experimental Endocrinology, Institute of Physiology and Neuroscience, University of Gothenburg, Gothenburg, Sweden

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studying the mechanistic effects of GH therapy in patients. Subcutaneous GH administered to hypopituitary humans or animals reaches the brain via blood circulation. In principle, GH might affect the brain by directly passing through the blood–brain barrier

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-08-0495
Volume/Issue:
Volume 201: Issue 1
Free access
Ferran Jardí Clinical and Experimental Endocrinology, Department of Chronic Diseases, Metabolism and Ageing (CHROMETA), KU Leuven, Leuven, Belgium

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Michaël R Laurent Molecular Endocrinology Laboratory, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium
Gerontology and Geriatrics, Department of Chronic Diseases, Metabolism and Ageing (CHROMETA), KU Leuven, Leuven, Belgium

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Vanessa Dubois Molecular Endocrinology Laboratory, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium

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Nari Kim Clinical and Experimental Endocrinology, Department of Chronic Diseases, Metabolism and Ageing (CHROMETA), KU Leuven, Leuven, Belgium

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Rougin Khalil Clinical and Experimental Endocrinology, Department of Chronic Diseases, Metabolism and Ageing (CHROMETA), KU Leuven, Leuven, Belgium

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Brigitte Decallonne Clinical and Experimental Endocrinology, Department of Chronic Diseases, Metabolism and Ageing (CHROMETA), KU Leuven, Leuven, Belgium

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Dirk Vanderschueren Clinical and Experimental Endocrinology, Department of Chronic Diseases, Metabolism and Ageing (CHROMETA), KU Leuven, Leuven, Belgium

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Frank Claessens Molecular Endocrinology Laboratory, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium

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non-reproductive tissues, including brain, muscle, adipose tissue and bone. Testosterone, the principal circulating androgen, may stimulate the androgen receptor (AR) either directly, or indirectly following 5 alpha-reduction to dihydrotestosterone

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-18-0125
Volume/Issue:
Volume 238: Issue 1
Free access