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Xiaofeng Wang Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Alberta, Canada T6G 2R3

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Catherine B Chan Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Alberta, Canada T6G 2R3

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Introduction It is well-known that n-3 polyunsaturated fatty acids (PUFAs), especially eicosapentanoic acid (EPA, 20:5, n-3) and docosahexanoic acid (DHA, 22:6, n-3), have positive effects in a wide range of health and disease conditions. For

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-14-0581
Volume/Issue:
Volume 224: Issue 3
Free access
Cristina Velasco Laboratorio de Fisioloxía Animal, Departamento de Fisiología de Peces y Biotecnología, Departamento de Bioloxía Funcional e Ciencias da Saúde, Facultade de Bioloxía, Universidade de Vigo, 36310 Vigo, Spain

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Marta Librán-Pérez Laboratorio de Fisioloxía Animal, Departamento de Fisiología de Peces y Biotecnología, Departamento de Bioloxía Funcional e Ciencias da Saúde, Facultade de Bioloxía, Universidade de Vigo, 36310 Vigo, Spain

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Cristina Otero-Rodiño Laboratorio de Fisioloxía Animal, Departamento de Fisiología de Peces y Biotecnología, Departamento de Bioloxía Funcional e Ciencias da Saúde, Facultade de Bioloxía, Universidade de Vigo, 36310 Vigo, Spain

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Marcos A López-Patiño Laboratorio de Fisioloxía Animal, Departamento de Fisiología de Peces y Biotecnología, Departamento de Bioloxía Funcional e Ciencias da Saúde, Facultade de Bioloxía, Universidade de Vigo, 36310 Vigo, Spain

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Jesús M Míguez Laboratorio de Fisioloxía Animal, Departamento de Fisiología de Peces y Biotecnología, Departamento de Bioloxía Funcional e Ciencias da Saúde, Facultade de Bioloxía, Universidade de Vigo, 36310 Vigo, Spain

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José Miguel Cerdá-Reverter Laboratorio de Fisioloxía Animal, Departamento de Fisiología de Peces y Biotecnología, Departamento de Bioloxía Funcional e Ciencias da Saúde, Facultade de Bioloxía, Universidade de Vigo, 36310 Vigo, Spain

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José L Soengas Laboratorio de Fisioloxía Animal, Departamento de Fisiología de Peces y Biotecnología, Departamento de Bioloxía Funcional e Ciencias da Saúde, Facultade de Bioloxía, Universidade de Vigo, 36310 Vigo, Spain

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amphetamine-related transcript (CART), ultimately leading to changes in food intake ( Blouet & Schwartz 2010 ). These neurons integrate information of peripheral signals, such as i) changes in the levels of nutrients/metabolites like glucose, fatty acids and

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-15-0391
Volume/Issue:
Volume 228: Issue 1
Free access
Oliver C Watkins Department of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore

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Mohammed Omedul Islam Department of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore

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Preben Selvam Department of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore

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Reshma Appukuttan Pillai Department of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore

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Amaury Cazenave-Gassiot Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
Singapore Lipidomics Incubator, Life Sciences Institute, National University of Singapore, Singapore, Singapore

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Anne K Bendt Singapore Lipidomics Incubator, Life Sciences Institute, National University of Singapore, Singapore, Singapore

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Neerja Karnani Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research, Singapore, Singapore

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Keith M Godfrey MRC Lifecourse Epidemiology Unit and NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, UK

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Rohan M Lewis MRC Lifecourse Epidemiology Unit and NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, UK

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Markus R Wenk Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
Singapore Lipidomics Incubator, Life Sciences Institute, National University of Singapore, Singapore, Singapore

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Shiao-Yng Chan Department of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research, Singapore, Singapore

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-inositol states could impact placental lipid metabolism with consequences for fetal development. In this study we sought to address the specific hypothesis that myo-inositol treatment alters the processing of fatty acids in normal human term placenta. We

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-19-0267
Volume/Issue:
Volume 243: Issue 1
Free access
R Ganga Grupo de Investigación en Acuicultura, Instituto Canario de Ciencias Marinas, PO Box 56, 35200-Telde, Las Palmas, Canary Islands, Spain
Department of Cell Biology, Physiology and Immunology, Universitat Autonòma de Barcelona, Bellaterra 08193, Spain

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L Tort Grupo de Investigación en Acuicultura, Instituto Canario de Ciencias Marinas, PO Box 56, 35200-Telde, Las Palmas, Canary Islands, Spain
Department of Cell Biology, Physiology and Immunology, Universitat Autonòma de Barcelona, Bellaterra 08193, Spain

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L Acerete Grupo de Investigación en Acuicultura, Instituto Canario de Ciencias Marinas, PO Box 56, 35200-Telde, Las Palmas, Canary Islands, Spain
Department of Cell Biology, Physiology and Immunology, Universitat Autonòma de Barcelona, Bellaterra 08193, Spain

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D Montero Grupo de Investigación en Acuicultura, Instituto Canario de Ciencias Marinas, PO Box 56, 35200-Telde, Las Palmas, Canary Islands, Spain
Department of Cell Biology, Physiology and Immunology, Universitat Autonòma de Barcelona, Bellaterra 08193, Spain

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M S Izquierdo Grupo de Investigación en Acuicultura, Instituto Canario de Ciencias Marinas, PO Box 56, 35200-Telde, Las Palmas, Canary Islands, Spain
Department of Cell Biology, Physiology and Immunology, Universitat Autonòma de Barcelona, Bellaterra 08193, Spain

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Introduction Highly unsaturated fatty acids with 20 or more carbon atoms and three or more double bonds (HUFA) are essential components of cellular membranes and can modulate physiological processes, including membrane transport

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.1.06770
Volume/Issue:
Volume 190: Issue 1
Free access
Nigel Turner Department of Pharmacology, School of Medical Sciences, Diabetes and Obesity Division, St Vincent's Clinical School, Department of Physiology, University of New South Wales, Sydney, New South Wales, Australia
Department of Pharmacology, School of Medical Sciences, Diabetes and Obesity Division, St Vincent's Clinical School, Department of Physiology, University of New South Wales, Sydney, New South Wales, Australia

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Gregory J Cooney Department of Pharmacology, School of Medical Sciences, Diabetes and Obesity Division, St Vincent's Clinical School, Department of Physiology, University of New South Wales, Sydney, New South Wales, Australia
Department of Pharmacology, School of Medical Sciences, Diabetes and Obesity Division, St Vincent's Clinical School, Department of Physiology, University of New South Wales, Sydney, New South Wales, Australia

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Edward W Kraegen Department of Pharmacology, School of Medical Sciences, Diabetes and Obesity Division, St Vincent's Clinical School, Department of Physiology, University of New South Wales, Sydney, New South Wales, Australia
Department of Pharmacology, School of Medical Sciences, Diabetes and Obesity Division, St Vincent's Clinical School, Department of Physiology, University of New South Wales, Sydney, New South Wales, Australia

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Clinton R Bruce Department of Pharmacology, School of Medical Sciences, Diabetes and Obesity Division, St Vincent's Clinical School, Department of Physiology, University of New South Wales, Sydney, New South Wales, Australia

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Overview Fatty acids (FAs) are organic acids largely defined by the length and saturation of the aliphatic side chain attached to a carboxylic acid. In animals, these side chains normally contain an even number of carbon atoms and FAs are grouped

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-13-0397
Volume/Issue:
Volume 220: Issue 2
Free access
Miao Hou Departments of, Child Health Care, General Surgery, Institute of Pediatric Research, Department of Public Health and Clinical Medicine, Nanjing Children's Hospital, Nanjing Medical University, 72 Guangzhou Road, Nanjing 210008, People's Republic of China

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Chenlin Ji Departments of, Child Health Care, General Surgery, Institute of Pediatric Research, Department of Public Health and Clinical Medicine, Nanjing Children's Hospital, Nanjing Medical University, 72 Guangzhou Road, Nanjing 210008, People's Republic of China

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Jing Wang Departments of, Child Health Care, General Surgery, Institute of Pediatric Research, Department of Public Health and Clinical Medicine, Nanjing Children's Hospital, Nanjing Medical University, 72 Guangzhou Road, Nanjing 210008, People's Republic of China

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Yanhua Liu Departments of, Child Health Care, General Surgery, Institute of Pediatric Research, Department of Public Health and Clinical Medicine, Nanjing Children's Hospital, Nanjing Medical University, 72 Guangzhou Road, Nanjing 210008, People's Republic of China

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Bin Sun Departments of, Child Health Care, General Surgery, Institute of Pediatric Research, Department of Public Health and Clinical Medicine, Nanjing Children's Hospital, Nanjing Medical University, 72 Guangzhou Road, Nanjing 210008, People's Republic of China

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Mei Guo Departments of, Child Health Care, General Surgery, Institute of Pediatric Research, Department of Public Health and Clinical Medicine, Nanjing Children's Hospital, Nanjing Medical University, 72 Guangzhou Road, Nanjing 210008, People's Republic of China

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Jonas Burén Departments of, Child Health Care, General Surgery, Institute of Pediatric Research, Department of Public Health and Clinical Medicine, Nanjing Children's Hospital, Nanjing Medical University, 72 Guangzhou Road, Nanjing 210008, People's Republic of China

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Xiaonan Li Departments of, Child Health Care, General Surgery, Institute of Pediatric Research, Department of Public Health and Clinical Medicine, Nanjing Children's Hospital, Nanjing Medical University, 72 Guangzhou Road, Nanjing 210008, People's Republic of China
Departments of, Child Health Care, General Surgery, Institute of Pediatric Research, Department of Public Health and Clinical Medicine, Nanjing Children's Hospital, Nanjing Medical University, 72 Guangzhou Road, Nanjing 210008, People's Republic of China

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neuroendocrine system occurs mainly during the postnatal period, in contrast to primates, in which it occurs during the third trimester ( Matthews 2002 ). Dietary fatty acids are important regulators of gene expression, acting as intracellular messengers or

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-12-0191
Volume/Issue:
Volume 215: Issue 1
Free access
Eleftheria Diakogiannaki Peninsula Medical School, Institute of Biomedical and Clinical Sciences, John Bull Building, Plymouth, Devon PL6 8BU, UK
School of Medicine, Institute of Human Nutrition, University of Southampton, Southampton SO16 7PX, UK

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Shalinee Dhayal Peninsula Medical School, Institute of Biomedical and Clinical Sciences, John Bull Building, Plymouth, Devon PL6 8BU, UK
School of Medicine, Institute of Human Nutrition, University of Southampton, Southampton SO16 7PX, UK

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Caroline E Childs Peninsula Medical School, Institute of Biomedical and Clinical Sciences, John Bull Building, Plymouth, Devon PL6 8BU, UK
School of Medicine, Institute of Human Nutrition, University of Southampton, Southampton SO16 7PX, UK

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Philip C Calder Peninsula Medical School, Institute of Biomedical and Clinical Sciences, John Bull Building, Plymouth, Devon PL6 8BU, UK
School of Medicine, Institute of Human Nutrition, University of Southampton, Southampton SO16 7PX, UK

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Hannah J Welters Peninsula Medical School, Institute of Biomedical and Clinical Sciences, John Bull Building, Plymouth, Devon PL6 8BU, UK
School of Medicine, Institute of Human Nutrition, University of Southampton, Southampton SO16 7PX, UK

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Noel G Morgan Peninsula Medical School, Institute of Biomedical and Clinical Sciences, John Bull Building, Plymouth, Devon PL6 8BU, UK
School of Medicine, Institute of Human Nutrition, University of Southampton, Southampton SO16 7PX, UK

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fatty acids (FFA) in vitro leads to enhanced rates of insulin secretion ( Sako & Grill 1990 , Newsholme et al. 2007 ), whereas more prolonged treatment can be associated with toxicity ( Lupi et al. 2002 , El-Assaad et al. 2003

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-07-0082
Volume/Issue:
Volume 194: Issue 2
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David P Macfarlane Endocrinology Unit, Queen's Medical Research Institute, Centre for Cardiovascular Science, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, Scotland, UK

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Shareen Forbes Endocrinology Unit, Queen's Medical Research Institute, Centre for Cardiovascular Science, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, Scotland, UK

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Brian R Walker Endocrinology Unit, Queen's Medical Research Institute, Centre for Cardiovascular Science, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, Scotland, UK

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availability of substrates for mitochondrial oxidation (from glucose, amino acids and fatty acids). The consequences of failure of these adaptive responses are clearly demonstrated in the syndrome of adrenal insufficiency (in Addison's disease or

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-08-0054
Volume/Issue:
Volume 197: Issue 2
Free access
Fausto Bogazzi
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Francesco Raggi
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Federica Ultimieri
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Dania Russo
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Aldo D'Alessio Department of Endocrinology and Metabolism, Department of Chemistry and Industrial Chemistry, University of Pisa, Ospedale Cisanello, Via Paradisa 2, 56124 Pisa, Italy

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Antonella Manariti Department of Endocrinology and Metabolism, Department of Chemistry and Industrial Chemistry, University of Pisa, Ospedale Cisanello, Via Paradisa 2, 56124 Pisa, Italy

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Sandra Brogioni
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Luca Manetti
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Enio Martino
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different energy requirements. Energy metabolism in normal hearts depends on ATP production from mitochondrial oxidation of glucose and fatty acids (FA; Taegtmeyer 1994 , Stanley & Chandler 2002 ). FA oxidation is the main cardiac energy source accounting

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-08-0194
Volume/Issue:
Volume 201: Issue 3
Free access
Keld Fosgerau In vivoPharmacology, Rheoscience, Ledøje Bygade 23B, DK-2765 Ledøje-Smørum, Denmark
Novo Nordisk Discovery and Development, Novo Nordisk A/S, Novo Nordisk Park, DK-2760 Maaloev, Denmark
Garvan Institute of Medical Research, 384 Victoria Street, Sydney NSW 2010, Australia

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Christian Fledelius In vivoPharmacology, Rheoscience, Ledøje Bygade 23B, DK-2765 Ledøje-Smørum, Denmark
Novo Nordisk Discovery and Development, Novo Nordisk A/S, Novo Nordisk Park, DK-2760 Maaloev, Denmark
Garvan Institute of Medical Research, 384 Victoria Street, Sydney NSW 2010, Australia

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Kent E Pedersen In vivoPharmacology, Rheoscience, Ledøje Bygade 23B, DK-2765 Ledøje-Smørum, Denmark
Novo Nordisk Discovery and Development, Novo Nordisk A/S, Novo Nordisk Park, DK-2760 Maaloev, Denmark
Garvan Institute of Medical Research, 384 Victoria Street, Sydney NSW 2010, Australia

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Jesper B Kristensen In vivoPharmacology, Rheoscience, Ledøje Bygade 23B, DK-2765 Ledøje-Smørum, Denmark
Novo Nordisk Discovery and Development, Novo Nordisk A/S, Novo Nordisk Park, DK-2760 Maaloev, Denmark
Garvan Institute of Medical Research, 384 Victoria Street, Sydney NSW 2010, Australia

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Jens R Daugaard In vivoPharmacology, Rheoscience, Ledøje Bygade 23B, DK-2765 Ledøje-Smørum, Denmark
Novo Nordisk Discovery and Development, Novo Nordisk A/S, Novo Nordisk Park, DK-2760 Maaloev, Denmark
Garvan Institute of Medical Research, 384 Victoria Street, Sydney NSW 2010, Australia

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Miguel A Iglesias In vivoPharmacology, Rheoscience, Ledøje Bygade 23B, DK-2765 Ledøje-Smørum, Denmark
Novo Nordisk Discovery and Development, Novo Nordisk A/S, Novo Nordisk Park, DK-2760 Maaloev, Denmark
Garvan Institute of Medical Research, 384 Victoria Street, Sydney NSW 2010, Australia

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Edward W Kraegen In vivoPharmacology, Rheoscience, Ledøje Bygade 23B, DK-2765 Ledøje-Smørum, Denmark
Novo Nordisk Discovery and Development, Novo Nordisk A/S, Novo Nordisk Park, DK-2760 Maaloev, Denmark
Garvan Institute of Medical Research, 384 Victoria Street, Sydney NSW 2010, Australia

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Stuart M Furler In vivoPharmacology, Rheoscience, Ledøje Bygade 23B, DK-2765 Ledøje-Smørum, Denmark
Novo Nordisk Discovery and Development, Novo Nordisk A/S, Novo Nordisk Park, DK-2760 Maaloev, Denmark
Garvan Institute of Medical Research, 384 Victoria Street, Sydney NSW 2010, Australia

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fatty acids and their derivatives have been shown to interfere with glucose metabolism via a number of mechanisms, including substrate competition, inhibition of insulin signaling pathways, and modulation of gene transcription processes ( Hegarty et al

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.1.06809
Volume/Issue:
Volume 190: Issue 3
Free access