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effects of circRNAs on reproductive hormones in rats is limited. In this study, we systematically investigated the circRNA content in the immature (D15) and mature (D120) rat anterior pituitary using the Illumina platform. Our findings will provide a
The Third Xiangya Hospital of Central South University, Changsha, Hunan, China
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Animal Core Facility, Nanjing Medical University, Nanjing, Jiangsu, China
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females, suggesting that BAT dysfunction might be an important cause of PCOS and that BAT supply might help to cure PCOS. In fact, rat-to-rat BAT transplantation was recently tested in a rat PCOS model. The strategy significantly improved the endocrine
Cátedra de Fisiología Humana, Facultad de Bioquímica y Ciencias Biológicas, Universidad Nacional del Litoral, Santa Fe, Argentina
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Cátedra de Fisiología Humana, Facultad de Bioquímica y Ciencias Biológicas, Universidad Nacional del Litoral, Santa Fe, Argentina
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Cátedra de Fisiología Humana, Facultad de Bioquímica y Ciencias Biológicas, Universidad Nacional del Litoral, Santa Fe, Argentina
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Cátedra de Fisiología Humana, Facultad de Bioquímica y Ciencias Biológicas, Universidad Nacional del Litoral, Santa Fe, Argentina
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low dose (2 mg/kg of body weight (bw)/day) of a GBH during the first postnatal days (PND) alters the development of the rat uterus by affecting uterine morphology and the expression of proteins that regulate uterine organogenetic differentiation during
Department of Pediatrics, Department of Medicine, Department of Pediatric Endocrinology, Endocrinology and Metabolism, Developmental Biology and Cancer Programme, Department of Pharmacology and Therapeutics, Center for Reproductive Medicine, Leiden University Medical Center, Leiden, The Netherlands
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Department of Pediatrics, Department of Medicine, Department of Pediatric Endocrinology, Endocrinology and Metabolism, Developmental Biology and Cancer Programme, Department of Pharmacology and Therapeutics, Center for Reproductive Medicine, Leiden University Medical Center, Leiden, The Netherlands
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temporal patterns of IGSF1 protein and mRNA expression in the rat. Materials and methods Animals The research protocol was approved by the Institutional Animal Care and Use Committees of the Leiden University Medical Center and the Academic Medical Center
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Department of Analytical Chemistry, University of Chemistry and Technology, Prague, Czech Republic
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Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
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Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
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standard diet. In addition to the DIO rat model, the Zucker diabetic rat model, which is a model with impaired leptin receptor signaling ( Fellmann et al . 2013 ), is frequently used for studying the potential of anti-obesity and anti-diabetic peptidic
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Department of Endocrinology and Metabolism, Hypothalamic Integration Mechanisms, Laboratory of Endocrinology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
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TH metabolism in the rat liver. Besides an enhanced metabolism of TH in peripheral tissues via altered deiodinases, sequestration of TH in tissues is also suggested to play a role in the decreased serum TH concentrations. In order to enter the
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according to a split litter design. In some groups, more than one rat of the same sex and the same litter was included and this was taken into consideration for statistical analyses (litter effect). Four to six animals per group were killed by decapitation
INRA, Laboratory of Nutrition and Integrative Neurobiology, INSERM, Nutrition and Integrative Neurobiology, UMR1286, Université de Bordeaux 2, 146, rue Léo Saignat, 33076 Bordeaux Cedex, France
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INRA, Laboratory of Nutrition and Integrative Neurobiology, INSERM, Nutrition and Integrative Neurobiology, UMR1286, Université de Bordeaux 2, 146, rue Léo Saignat, 33076 Bordeaux Cedex, France
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INRA, Laboratory of Nutrition and Integrative Neurobiology, INSERM, Nutrition and Integrative Neurobiology, UMR1286, Université de Bordeaux 2, 146, rue Léo Saignat, 33076 Bordeaux Cedex, France
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INRA, Laboratory of Nutrition and Integrative Neurobiology, INSERM, Nutrition and Integrative Neurobiology, UMR1286, Université de Bordeaux 2, 146, rue Léo Saignat, 33076 Bordeaux Cedex, France
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from cholesterol by vitamin A deficiency in rat adrenals ( Juneja et al . 1966 ). Furthermore, RA treatment was shown to inhibit corticosterone (CORT) production in experimental Cushing's syndrome ( Paez-Pereda et al . 2001 ). The inhibitory effect of
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would also like to discuss some information about epigenetic inheritance, which should partially explain the gene–environment interaction. Rat models of obesity and hypertension Animal models are essential to understand the pathophysiology of human
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Sabra rat model. This model consists of two strains: the Sabra hypertension-prone (SBH/y) rats that remain normotensive when fed regular diet but become hypertensive when salt loaded, and the Sabra hypertension-resistant (SBN/y) rats that remain