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The alternate pathway of androgen metabolism and window of sensitivity

Marilyn B Renfree

Marilyn B Renfree School of BioSciences, The University of Melbourne, Melbourne, Victoria, Australia

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Geoff Shaw

Geoff Shaw School of BioSciences, The University of Melbourne, Melbourne, Victoria, Australia

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syndrome (PCOS) since PCOS ovaries have enhanced expression of genes and proteins of the alternate pathway ( Marti et al. 2017 ). The aldo-keto reductases ( AKR1C1 /AKR1C4), 5α-reductases ( SRD5A1/2 ) and retinol dehydrogenase ( RoDH ) are all expressed