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Kenichiro Watanabe Departments of Obstetrics and Gynecology, Physiology, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8602, Japan
Departments of Obstetrics and Gynecology, Physiology, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8602, Japan

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Takahiro Nemoto Departments of Obstetrics and Gynecology, Physiology, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8602, Japan

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Shigeo Akira Departments of Obstetrics and Gynecology, Physiology, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8602, Japan

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Toshiyuki Takeshita Departments of Obstetrics and Gynecology, Physiology, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8602, Japan

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Tamotsu Shibasaki Departments of Obstetrics and Gynecology, Physiology, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8602, Japan

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, adrenal, uterus, ovary, and testis ( Hsu & Hsueh 2001 , Yamauchi et al . 2005 , Lee et al . 2011 ). It has been reported that expression of Ucn2 mRNA in various tissues is controlled by stress, inflammation, and hypoxia ( Tanaka et al . 2003 , Tao

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Soyoung Choi
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Hyejin Shin
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Haengseok Song Department of Biomedical Science and Technology, Department of Biomedical Science, Institute of Biomedical Science and Technology, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul 143-701, Korea

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Hyunjung Jade Lim
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Introduction The uterus is an important hormone-responsive reproductive organ in mammals. Histologically, the uterus is composed of three major cell types: epithelial cells, stromal cells, and myometrial cells. Epithelial and stromal cells together

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Ioannis Simitsidellis Centre for Inflammation Research, The University of Edinburgh, Queen’s Medical Research Institute, Edinburgh BioQuarter, Edinburgh, UK

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Arantza Esnal-Zuffiaure Centre for Inflammation Research, The University of Edinburgh, Queen’s Medical Research Institute, Edinburgh BioQuarter, Edinburgh, UK

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Olympia Kelepouri Centre for Inflammation Research, The University of Edinburgh, Queen’s Medical Research Institute, Edinburgh BioQuarter, Edinburgh, UK

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Elisabeth O’Flaherty Centre for Inflammation Research, The University of Edinburgh, Queen’s Medical Research Institute, Edinburgh BioQuarter, Edinburgh, UK

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Douglas A Gibson Centre for Inflammation Research, The University of Edinburgh, Queen’s Medical Research Institute, Edinburgh BioQuarter, Edinburgh, UK

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Philippa T K Saunders Centre for Inflammation Research, The University of Edinburgh, Queen’s Medical Research Institute, Edinburgh BioQuarter, Edinburgh, UK

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Introduction Androgens are pleiotropic hormones which bind with high affinity and specificity to androgen receptors (ARs) to regulate both reproductive and other tissues. In the uterus, androgen-target cells include stromal fibroblasts and

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Jie Liu College of Veterinary Medicine, South China Agricultural University, Guangzhou, China
Department of Biology, Shantou University, Shantou, China

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Fei Gao Department of Biology, Shantou University, Shantou, China

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Yue-Fang Liu College of Veterinary Medicine, South China Agricultural University, Guangzhou, China

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Hai-Ting Dou College of Veterinary Medicine, South China Agricultural University, Guangzhou, China

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Jia-Qi Yan College of Veterinary Medicine, South China Agricultural University, Guangzhou, China

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Zong-Min Fan College of Veterinary Medicine, South China Agricultural University, Guangzhou, China

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Zeng-Ming Yang College of Veterinary Medicine, South China Agricultural University, Guangzhou, China

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et al . 2013 ). Based on our preliminary microarray analysis on mouse uterus, Prss56 mRNA level at implantation site is significantly higher than that at inter-implantation site. Prss56 (protease, serine, 56, also called MCOP6 or Rik1700027L120) is

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Virginia Rider Department of Biology, Pittsburg State University, Pittsburg, Kansas, USA

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Alex Talbott Department of Biology, Pittsburg State University, Pittsburg, Kansas, USA

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Anuradha Bhusri Department of Biology, Pittsburg State University, Pittsburg, Kansas, USA

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Zach Krumsick Department of Biology, Pittsburg State University, Pittsburg, Kansas, USA

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Sierra Foster Department of Biology, Pittsburg State University, Pittsburg, Kansas, USA

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Joshua Wormington Department of Biology, Pittsburg State University, Pittsburg, Kansas, USA

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Bruce F Kimler Department of Radiation Oncology, The University of Kansas Medical Center, Kansas City, Kansas, USA

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Introduction In adult female mammals, the uterus undergoes remodeling with a regular cyclicity under the control of the sex hormones, progesterone and estradiol ( Bell 1983 , Pawar et al . 2014 ). In the rodent uterus, estradiol stimulates

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Marlise Guerrero Schimpf Instituto de Salud y Ambiente del Litoral (ISAL, UNL-CONICET), Facultad de Bioquímica y Ciencias Biológicas, Universidad Nacional del Litoral, Santa Fe, Argentina
Cátedra de Fisiología Humana, Facultad de Bioquímica y Ciencias Biológicas, Universidad Nacional del Litoral, Santa Fe, Argentina

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María M Milesi Instituto de Salud y Ambiente del Litoral (ISAL, UNL-CONICET), Facultad de Bioquímica y Ciencias Biológicas, Universidad Nacional del Litoral, Santa Fe, Argentina
Cátedra de Fisiología Humana, Facultad de Bioquímica y Ciencias Biológicas, Universidad Nacional del Litoral, Santa Fe, Argentina

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Enrique H Luque Instituto de Salud y Ambiente del Litoral (ISAL, UNL-CONICET), Facultad de Bioquímica y Ciencias Biológicas, Universidad Nacional del Litoral, Santa Fe, Argentina
Cátedra de Fisiología Humana, Facultad de Bioquímica y Ciencias Biológicas, Universidad Nacional del Litoral, Santa Fe, Argentina

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Jorgelina Varayoud Instituto de Salud y Ambiente del Litoral (ISAL, UNL-CONICET), Facultad de Bioquímica y Ciencias Biológicas, Universidad Nacional del Litoral, Santa Fe, Argentina
Cátedra de Fisiología Humana, Facultad de Bioquímica y Ciencias Biológicas, Universidad Nacional del Litoral, Santa Fe, Argentina

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and dioxin-like compounds (polychlorinated biphenyls and furans) showed increased incidence of cystic endometrial hyperplasia, luminal squamous metaplasia and carcinoma in the uterus. Other authors demonstrated that developmental exposure to

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Yiran Zhou Department of Anatomy, School of Biomedical Sciences, University of Otago, Dunedin, New Zealand

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Christine Neyt Department of Anatomy, School of Biomedical Sciences, University of Otago, Dunedin, New Zealand

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Nicola J Batchelor Department of Anatomy, School of Biomedical Sciences, University of Otago, Dunedin, New Zealand

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Rebecca L Kelley School of Biosciences, University of Melbourne, Melbourne, Australia

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Karmilla Jaafar Amsak Department of Anatomy, School of Biomedical Sciences, University of Otago, Dunedin, New Zealand

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Greg M Anderson Department of Anatomy, School of Biomedical Sciences, University of Otago, Dunedin, New Zealand
Centre for Neuroendocrinology, University of Otago, Dunedin, New Zealand

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Dorothy E Oorschot Department of Anatomy, School of Biomedical Sciences, University of Otago, Dunedin, New Zealand
Brain Health Research Centre, University of Otago, Dunedin, New Zealand

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Christine L Jasoni Department of Anatomy, School of Biomedical Sciences, University of Otago, Dunedin, New Zealand
Centre for Neuroendocrinology, University of Otago, Dunedin, New Zealand

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Jane E Girling Department of Anatomy, School of Biomedical Sciences, University of Otago, Dunedin, New Zealand

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Michael W Pankhurst Department of Anatomy, School of Biomedical Sciences, University of Otago, Dunedin, New Zealand

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-releasing hormone neurons in the hypothalamus ( Cimino et al. 2016 ), pituitary gonadotrope cells ( Garrel et al. 2019 ) and in uterus and placenta ( Renaud et al. 2005 , Wang et al. 2009 , Novembri et al. 2015 ). These findings may not only indicate

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Dang-Dang Li College of Veterinary Medicine, Jilin University, Changchun 130062, People's Republic of China

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Ying-Jie Gao College of Veterinary Medicine, Jilin University, Changchun 130062, People's Republic of China

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Xue-Chao Tian College of Veterinary Medicine, Jilin University, Changchun 130062, People's Republic of China

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Zhan-Qing Yang College of Veterinary Medicine, Jilin University, Changchun 130062, People's Republic of China

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Hang Cao College of Veterinary Medicine, Jilin University, Changchun 130062, People's Republic of China

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Qiao-Ling Zhang College of Veterinary Medicine, Jilin University, Changchun 130062, People's Republic of China

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Bin Guo College of Veterinary Medicine, Jilin University, Changchun 130062, People's Republic of China

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Zhan-Peng Yue College of Veterinary Medicine, Jilin University, Changchun 130062, People's Republic of China

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, T do 2 was strongly expressed by day 8 decidua and deciduoma under artificial decidualization compared with the untreated uterine horn. However, the expression and regulation of T do 2 in mouse uterus during decidualization have not been defined

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Denys deCatanzaro Department of Psychology, Neuroscience & Behaviour, McMaster University, Hamilton, Ontario, Canada

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Tyler Pollock Department of Psychology, Neuroscience & Behaviour, McMaster University, Hamilton, Ontario, Canada

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a few days subsequently showed radioactivity in the uterus, ovaries, brain and other tissues ( Guzzo et al . 2012 , 2013 ). [ 3 H]P 4 can also transfer between individuals, although less readily than does [ 3 H]E 2 ( Guzzo et al . 2013 ). Male

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Karin L Gustafsson Sahlgrenska Osteoporosis Centre, Centre for Bone and Arthritis Research at Institute of Medicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden

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Sofia Movérare-Skrtic Sahlgrenska Osteoporosis Centre, Centre for Bone and Arthritis Research at Institute of Medicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden

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Helen H Farman Sahlgrenska Osteoporosis Centre, Centre for Bone and Arthritis Research at Institute of Medicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden

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Cecilia Engdahl Sahlgrenska Osteoporosis Centre, Centre for Bone and Arthritis Research at Institute of Medicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden

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Petra Henning Sahlgrenska Osteoporosis Centre, Centre for Bone and Arthritis Research at Institute of Medicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden

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Karin H Nilsson Sahlgrenska Osteoporosis Centre, Centre for Bone and Arthritis Research at Institute of Medicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden

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Julia M Scheffler Sahlgrenska Osteoporosis Centre, Centre for Bone and Arthritis Research at Institute of Medicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden

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Edina Sehic Sahlgrenska Osteoporosis Centre, Centre for Bone and Arthritis Research at Institute of Medicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden

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Ulrika Islander Sahlgrenska Osteoporosis Centre, Centre for Bone and Arthritis Research at Institute of Medicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden

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Ellis Levin Division of Endocrinology, Department of Medicine, University of California, Irvine, Irvine, California, USA
Department of Veterans Affairs Medical Center, Long Beach, Long Beach, California, USA

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Claes Ohlsson Sahlgrenska Osteoporosis Centre, Centre for Bone and Arthritis Research at Institute of Medicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
Department of Drug Treatment, Sahlgrenska University Hospital, Region Västra Götaland, Gothenburg, Sweden

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Marie K Lagerquist Sahlgrenska Osteoporosis Centre, Centre for Bone and Arthritis Research at Institute of Medicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden

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), demonstrating antagonistic effects of these SERMs in the uterus in the presence of estrogen, and Las and Bza treatment in postmenopausal women does not result in adverse uterine effects ( Ronkin et al. 2005 , Cummings et al. 2010 , De Villiers et al. 2011

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