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Open access

Rachel V Richardson, Emma J Batchen, Adrian J W Thomson, Rowan Darroch, Xinlu Pan, Eva A Rog-Zielinska, Wiktoria Wyrzykowska, Kathleen Scullion, Emad A S Al-Dujaili, Mary E Diaz, Carmel M Moran, Christopher J Kenyon, Gillian A Gray, and Karen E Chapman

(VSM) MR knockout is protective against age-related hypertension and cardiac hypertrophy, it has negligible effect on blood pressure and heart size in young mice (<7 months of age) ( McCurley et al . 2012 ). The physiological role of GR in the

Open access

Jarrad M Scarlett, Darren D Bowe, Xinxia Zhu, Ayesha K Batra, Wilmon F Grant, and Daniel L Marks

WT-Sham 0.16±0.01 g, P <0.001; Table 1 ). The HW-to-BW ratio (HW:BW), a well-established index of cardiac hypertrophy, was significantly greater for WT-MI mice compared to WT-Sham mice (WT-MI 13.7±0.54 g versus WT-Sham 6.39±0.17 g, P <0.001; Table

Open access

Katie J Mylonas, Neil A Turner, Sumia A Bageghni, Christopher J Kenyon, Christopher I White, Kieran McGregor, Robert A Kimmitt, Richard Sulston, Valerie Kelly, Brian R Walker, Karen E Porter, Karen E Chapman, and Gillian A Gray

muscle ( Hatakeyama et al . 2001 ), mast cells ( Coutinho et al . 2013 ) and resident macrophages ( Gilmour et al . 2006 ) and fibroblasts ( Sun & Myatt 2003 ). In a recent study ( White et al . 2016 ), we reported that 11β-HSD1 deletion in cardiac

Open access

Manon M Roustit, Joan M Vaughan, Pauline M Jamieson, and Mark E Cleasby

treatments available. However, recent work has demonstrated that generalised overexpression of urocortin 3 (UCN3) in mice results in both hypertrophy and increased glucose disposal into muscle ( Jamieson et al . 2011 ), making this an interesting candidate

Open access

Amanda E Garza, Elijah Trefts, Isis A Katayama Rangel, Danielle Brooks, Rene Baudrand, Burhanuddin Moize, Jose R Romero, Sanjay Ranjit, Thitinan Treesaranuwattana, Tham M Yao, Gail K Adler, Luminita H Pojoga, and Gordon H Williams

significantly reduced in the L-NAME/AngII treated WT mice compared to WT control mice. Striatin deficiency did not modify L-NAME/AngII induced cardiac injury As an assessment of cardiac hypertrophy, we measured the heart to body weight (BW) ratio. L

Open access

Peter Kolkhof and Lars Bärfacker

1942, he reported that desoxycorticosterone (as the acetate, DOCA), a precursor of aldosterone that was crystallized a decade later, induces nephrosclerosis accompanied by cardiac hypertrophy in animals ( Selye 1942 ). Later, Selye found that

Open access

Sushil K Mahata, Hong Zheng, Sumana Mahata, Xuefei Liu, and Kaushik P Patel

A Hein L Gilsbach R 2011 Chronic cardiac pressure overload induces adrenal medulla hypertrophy and increased catecholamine synthesis . Basic Research in Cardiology 106 591 – 602 . ( doi:10.1007/s00395-011-0166-z ) Sengupta D

Open access

Nele Cielen, Nele Heulens, Karen Maes, Geert Carmeliet, Chantal Mathieu, Wim Janssens, and Ghislaine Gayan-Ramirez

& Metabolism 11 47 . ( doi:10.1186/1743-7075-11-47 ) Doucet M Russell AP Leger B Debigare R Joanisse DR Caron MA LeBlanc P Maltais F 2007 Muscle atrophy and hypertrophy signaling in patients with chronic obstructive

Open access

David M Golding, Daniel J Rees, Jennifer R Davies, Dinko Relkovic, Hannah V Furby, Irina A Guschina, Anna L Hopkins, Jeffrey S Davies, James L Resnick, Anthony R Isles, and Timothy Wells

cervical dislocation after 24 h of total food removal or ad libitum feeding (with water available to both groups ad libitum ). After thoracotomy, blood samples were obtained by cardiac puncture using BD Microtainers (SST Amber Tubes, BD Biosciences, UK

Open access

R Dobie, V E MacRae, C Huesa, R van't Hof, S F Ahmed, and C Farquharson

weighed each day before the first GH injection. Three hours after final GH-injection, the mice were killed. Blood was immediately extracted by cardiac puncture. The left femurs and livers were dissected, and the femurs had their epiphysis and marrow