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Open access

Georgina G J Hazell, Song T Yao, James A Roper, Eric R Prossnitz, Anne-Marie O'Carroll, and Stephen J Lolait

. 2009 , Otto et al . 2008 ). In addition, GPR30 is expressed in oxytocin (OXT) neurones of the rat hypothalamic paraventricular nucleus (PVH) and supraoptic nucleus (SON), implicating a role for GPR30 in the fast, non-genomic actions of E 2 on OXT

Open access

David M Golding, Daniel J Rees, Jennifer R Davies, Dinko Relkovic, Hannah V Furby, Irina A Guschina, Anna L Hopkins, Jeffrey S Davies, James L Resnick, Anthony R Isles, and Timothy Wells

possible that proportionate hyperphagia may arise from impairment of the anorexic oxytocin circuitry. Although we have yet to quantify oxytocin expression in PWS-IC del mice, a reduction in the population of parvocellular oxytocin neurons has previously

Open access

David R Grattan

levels in the blood at all times that prolactin secretion is high. The same is probably true for a large number of factors that have been investigated as putative ‘prolactin releasing hormones’, including thyrotropin-releasing hormone, oxytocin, galanin

Open access

Emma M Roberts, Michael J F Newson, George R Pope, Rainer Landgraf, Stephen J Lolait, and Anne-Marie O'Carroll

neurohypophysis and form the hypothalamo-neurohypophysial tract ( Antunes-Rodrigues et al . 2004 ). The HNS is the primary source of AVP and the related peptide oxytocin (OT) that are secreted into the systemic circulation from neurones terminating in the

Open access

T V Novoselova, R Larder, D Rimmington, C Lelliott, E H Wynn, R J Gorrigan, P H Tate, L Guasti, The Sanger Mouse Genetics Project, S O’Rahilly, A J L Clark, D W Logan, A P Coll, and L F Chan

found that Sim1 mRNA level in the PVN of Mrap2 tm1a/tm1a mice was less than 50% of that observed in wild-type littermates ( Fig. 5C ). Sim1 is responsible for the late stages of the differentiation of oxytocin (Oxt), arginine vasopressin (Avp

Open access

Michael J F Newson, Emma M Roberts, George R Pope, Stephen J Lolait, and Anne-Marie O'Carroll

). Additionally, in the same study, we have shown basal levels of AVP, oxytocin and CRF gene expression in the hypothalamic PVN, and pro-opiomelanocortin (the precursor for ACTH) gene expression in the anterior pituitary to be similar in V1bR KO and WT mice

Open access

Anne-Marie O'Carroll, Gillian M Howell, Emma M Roberts, and Stephen J Lolait

AVP (and the related nonapeptide oxytocin) was found in the rat and human pancreas, suggesting that like CRH, AVP may play a local regulatory role in pancreatic function ( Amico et al . 1988 ). More recently pharmacological and gene knockout studies

Open access

F Wahab, M Shahab, and R Behr

an hypothesis about the possible involvement of GnIH in the post-ejaculatory refractory period after orgasm. It would be worthwhile to test this hypothesis in experimental models. Many studies have described the involvement of oxytocin and prolactin

Open access

Helen L Jeanes, Caroline Tabor, Darcey Black, Antwan Ederveen, and Gillian A Gray

oxytocin promoter (RO) with firefly luciferase reporter gene (LUC) hERα-RO-LUC or human ERβ-RO-LUC was cultured in medium with 5% charcoal-treated supplemented-defined bovine calf serum. For the assay, 5×10 4  cells/well were seeded into a 96-well plate and

Open access

Dawn E W Livingstone, Emma M Di Rollo, Chenjing Yang, Lucy E Codrington, John A Mathews, Madina Kara, Katherine A Hughes, Christopher J Kenyon, Brian R Walker, and Ruth Andrew

finasteride on adrenal steroidogenesis in men . Journal of Andrology 15 298 – 301 . ( doi:10.1002/j.1939-4640.1994.tb00453.x ) Russell JA Brunton PJ 2006 Neuroactive steroids attenuate oxytocin stress responses in late pregnancy . Neuroscience