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TRIzol reagent (Life Technologies) followed by the RNeasy Mini Kit (Qiagen). The RNA was reverse transcribed into cDNA using High-Capacity cDNA Reverse Transcription Kit (#4368814, Applied Biosystems), and real-time PCR analysis was performed using
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Department of Physiology, Institute of Neuroscience and Physiology, Metabolic Research Unit, University of Gothenburg, Göteborg, Sweden
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CNC - Center for Neuroscience and Cell Biology, CIBB - Centre for Innovative Biomedicine and Biotechnology, University of Coimbra, Coimbra, Portugal
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may become defective in diabetes. A brief history of α-cells Although glucagon has not received as much attention as insulin, its history is almost as long ( Fig. 1 , a simplified timeline). The first description of a pancreatic factor that
Department of Neurosurgery, Graduate School of Medicine, Nippon Medical School, Bunkyo-ku, Tokyo, Japan
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correction. There was a significant interaction between the two factors (group and week) in i.v. and i.p. groups. Values with different letters and asterisks show significant BW differences at each week and vs BW just before STZ injection, respectively ( P
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and tumour necrosis factor-α ( Konsman et al . 2002 ), and has been shown to potentially activate the HPA axis by a variety of mechanisms. While these mechanisms have been outlined elsewhere (e.g. see Lolait et al . (2007) ), the consensus view is
Division of Nephrology, Department of Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan
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altering the expression of mineralization-associated genes and transcription factors ( Beck et al. 2000 , Foster et al. 2006 ). The regulation of biomineralization by Pi may be related to its ability to stimulate MV release and/or the accumulation of
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impacting adipocyte function including insulin responsiveness and its secretory capacity. Mechanistically, CD44 does so possibly through suppressing adipogenic transcription factor Pparg expression and cell cycle-related pathways. CD44 has previously
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Preemptive Medicine and Lifestyle Related Disease Research Center, Kyoto University Hospital, Kyoto, Japan
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513 974 – 982 . ( https://doi.org/10.1016/j.bbrc.2019.04.036 ) Ikeguchi E Harada N Kanemaru Y Sankoda A Yamane S Iwasaki K Imajo M Murata Y Suzuki K Joo E , et al . 2018 Transcriptional factor Pdx1 is involved in age
The Roslin Institute, University of Edinburgh, Easter Bush Campus, Midlothian, UK
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The Roslin Institute, University of Edinburgh, Easter Bush Campus, Midlothian, UK
Zhejiang University-University of Edinburgh Institute, International Campus, Haining, Zhejiang, P.R. China
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control and stressed maternal groups ( Figs. 1 and 2 ). Two-way ANOVA (with stress and sex as main factors) were used for comparisons in the placenta and fetuses, with Fisher's least significance difference test as the post-hoc test ( Figs. 3 - 5 ). P
Department of Veterinary Basic Sciences, Diabetes and Obesity Research Program, Faculty of Medicine, Department of Medicine, Faculty of Medicine, Royal Veterinary College, University of London, Royal College Street, London NW1 0TU, UK
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Department of Veterinary Basic Sciences, Diabetes and Obesity Research Program, Faculty of Medicine, Department of Medicine, Faculty of Medicine, Royal Veterinary College, University of London, Royal College Street, London NW1 0TU, UK
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Department of Veterinary Basic Sciences, Diabetes and Obesity Research Program, Faculty of Medicine, Department of Medicine, Faculty of Medicine, Royal Veterinary College, University of London, Royal College Street, London NW1 0TU, UK
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Department of Veterinary Basic Sciences, Diabetes and Obesity Research Program, Faculty of Medicine, Department of Medicine, Faculty of Medicine, Royal Veterinary College, University of London, Royal College Street, London NW1 0TU, UK
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of APPL1, perhaps exerted by regulation of transcription factors, analogous to the effects of APPL1 OE recently observed on β-catenin/TCF ( Rashid et al . 2009 ) or in the case of IRS1, and is likely to be the result of altered proteasomal
The National Institute of Biotechnology in the Negev (NIBN), Ben-Gurion University, Beer-Sheva, Israel
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The National Institute of Biotechnology in the Negev (NIBN), Ben-Gurion University, Beer-Sheva, Israel
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The National Institute of Biotechnology in the Negev (NIBN), Ben-Gurion University, Beer-Sheva, Israel
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The National Institute of Biotechnology in the Negev (NIBN), Ben-Gurion University, Beer-Sheva, Israel
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The National Institute of Biotechnology in the Negev (NIBN), Ben-Gurion University, Beer-Sheva, Israel
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transcription factor PPARγ ( Pparg ), increased in HFF mice compared to those of NC ( Fig. 2E ). The effect of HFF on Pparg expression was completely abrogated in the HFF→NC group. Figure 2 Early hepatic response to obesity reversal. Representative images