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Ping Ye
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Christopher J Kenyon MRC Blood Pressure Group, The Queen's Medical Research Institute, Division of Cardiovascular and Medical Sciences, BHF Glasgow Cardiovascular Research Centre, 126 University Place, Glasgow G12 8TA, UK

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Scott M MacKenzie
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Katherine Nichol MRC Blood Pressure Group, The Queen's Medical Research Institute, Division of Cardiovascular and Medical Sciences, BHF Glasgow Cardiovascular Research Centre, 126 University Place, Glasgow G12 8TA, UK

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Jonathan R Seckl MRC Blood Pressure Group, The Queen's Medical Research Institute, Division of Cardiovascular and Medical Sciences, BHF Glasgow Cardiovascular Research Centre, 126 University Place, Glasgow G12 8TA, UK

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Robert Fraser
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John M C Connell
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Eleanor Davies
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Introduction Corticosteroid hormones such as aldosterone and corticosterone are synthesized by specific enzymes in the adrenal cortex but now there is strong evidence that these enzymes are also present in other tissues ( Davies & MacKenzie

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-07-0439
Volume/Issue:
Volume 196: Issue 2
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Toyoshi Endo Third Department of Internal Medicine, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Chuo City, Yamanashi 409-3898, Japan

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Tetsuro Kobayashi Third Department of Internal Medicine, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Chuo City, Yamanashi 409-3898, Japan

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autoantibody stimulates hormone synthesis, secretion, and cell growth, and induces thyrotoxicosis and goiter in the disease ( Kohn & Shifrin 1982 ). However, the precise mechanisms in which TSHR peptides are presented as antigens still remain unclear. Shimojo

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-09-0089
Volume/Issue:
Volume 202: Issue 2
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Eun Young Lee
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Shuji Kaneko Department of Medical Physiology, Department of Molecular Pharmacology, Department of Pharmacology and Toxicology, Division of Molecular and Metabolic Medicine, Drug Development Center, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan

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Promsuk Jutabha Department of Medical Physiology, Department of Molecular Pharmacology, Department of Pharmacology and Toxicology, Division of Molecular and Metabolic Medicine, Drug Development Center, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan

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Xilin Zhang
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Susumu Seino Department of Medical Physiology, Department of Molecular Pharmacology, Department of Pharmacology and Toxicology, Division of Molecular and Metabolic Medicine, Drug Development Center, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan

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Takahito Jomori Department of Medical Physiology, Department of Molecular Pharmacology, Department of Pharmacology and Toxicology, Division of Molecular and Metabolic Medicine, Drug Development Center, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan

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Naohiko Anzai Department of Medical Physiology, Department of Molecular Pharmacology, Department of Pharmacology and Toxicology, Division of Molecular and Metabolic Medicine, Drug Development Center, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan

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Takashi Miki
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Introduction Oral ingestion of nutrients triggers the secretion of gut hormones from various enteroendocrine cells ( Ezcurra et al . 2013 , Cho et al . 2014 ). Among these, glucagon-like peptide 1 (GLP1) and glucose-dependent insulinotropic

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-14-0555
Volume/Issue:
Volume 224: Issue 3
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Dawn E W Livingstone Endocrinology Unit, Queen's Medical Research Institute, Centre for Cardiovascular Science, University of Edinburgh, 47, Little France Crescent, Edinburgh EH16 4TJ, UK

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Sarah L Grassick Endocrinology Unit, Queen's Medical Research Institute, Centre for Cardiovascular Science, University of Edinburgh, 47, Little France Crescent, Edinburgh EH16 4TJ, UK

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Gillian L Currie Endocrinology Unit, Queen's Medical Research Institute, Centre for Cardiovascular Science, University of Edinburgh, 47, Little France Crescent, Edinburgh EH16 4TJ, UK

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Brian R Walker Endocrinology Unit, Queen's Medical Research Institute, Centre for Cardiovascular Science, University of Edinburgh, 47, Little France Crescent, Edinburgh EH16 4TJ, UK

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Ruth Andrew Endocrinology Unit, Queen's Medical Research Institute, Centre for Cardiovascular Science, University of Edinburgh, 47, Little France Crescent, Edinburgh EH16 4TJ, UK

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: effect of physicochemical and hormonal manipulations . Endocrinology 136 4754 – 4761 . Jang C Obeyesekere VR Dilley RJ Alford FP Inder WJ 2006 11β-Hydroxysteroid dehydrogenase type 1 is expressed and is biologically active in human

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-09-0003
Volume/Issue:
Volume 201: Issue 2
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Neerav Mullur The University of Ottawa, Faculty of Medicine, Ottawa, Ontario, Canada

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Arianne Morissette The University of Ottawa Heart Institute, Ottawa, Ontario, Canada

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Nadya M Morrow The University of Ottawa Heart Institute, Ottawa, Ontario, Canada
Department of Biochemistry, Microbiology and Immunology, The University of Ottawa, Faculty of Medicine, Ottawa, Ontario, Canada

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Erin E Mulvihill The University of Ottawa Heart Institute, Ottawa, Ontario, Canada
Department of Biochemistry, Microbiology and Immunology, The University of Ottawa, Faculty of Medicine, Ottawa, Ontario, Canada

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administration ( McIntyre et al. 1965 ). The incretin hormones, glucose-dependent insulinotropic polypeptide (GIP), and glucagon-like peptide-1 (GLP-1) potentiate meal-stimulated insulin secretion through direct and indirect actions on islet β-cells. The first

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-24-0046
Volume/Issue:
Volume 263: Issue 1
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David M Golding School of Biosciences, Cardiff University, Cardiff, UK

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Daniel J Rees Institute of Life Sciences, College of Medicine, Swansea University, Swansea, UK

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Jennifer R Davies Behavioural Genetics Group, MRC Centre for Neuropsychiatric Genetics and Genomics, Neuroscience and Mental Health Research Institute, Schools of Medicine & Psychology, Cardiff University, Cardiff, UK

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Dinko Relkovic Behavioural Genetics Group, MRC Centre for Neuropsychiatric Genetics and Genomics, Neuroscience and Mental Health Research Institute, Schools of Medicine & Psychology, Cardiff University, Cardiff, UK

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Hannah V Furby Behavioural Genetics Group, MRC Centre for Neuropsychiatric Genetics and Genomics, Neuroscience and Mental Health Research Institute, Schools of Medicine & Psychology, Cardiff University, Cardiff, UK

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Irina A Guschina School of Biosciences, Cardiff University, Cardiff, UK

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Anna L Hopkins School of Biosciences, Cardiff University, Cardiff, UK

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Jeffrey S Davies Institute of Life Sciences, College of Medicine, Swansea University, Swansea, UK

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James L Resnick Center for Mammalian Genetics, University of Florida, College of Medicine, Gainesville, Florida, USA

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Anthony R Isles Behavioural Genetics Group, MRC Centre for Neuropsychiatric Genetics and Genomics, Neuroscience and Mental Health Research Institute, Schools of Medicine & Psychology, Cardiff University, Cardiff, UK

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Timothy Wells School of Biosciences, Cardiff University, Cardiff, UK

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reduced circulating IGF-1 and elevated GH-releasing hormone mRNA reported in Snord116del mice ( Qi et al . 2016 ) indicate that loss of Snord116 expression causes a pituitary-specific deficiency in the GH axis. Despite growth retardation, PWS-IC del

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-16-0367
Volume/Issue:
Volume 232: Issue 1
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Sushil K Mahata VA San Diego Healthcare System Metabolic Physiology & Ultrastructural Biology Lab., Department of Medicine, University of California at San Diego, La Jolla, CA, USA

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Hong Zheng Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, NE, USA

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Sumana Mahata Caltech Division of Biology, California Institute of Technology, Pasadena, CA, USA

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Xuefei Liu Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, NE, USA

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Kaushik P Patel Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, NE, USA

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& Lee Wong 2015 ). Although plasma DA concentration is similar to those of EPI, circulating DA does not act as a hormone because of its much lower potency. Plasma concentrations of NE and EPI increase dramatically in response to physical, psychological

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-16-0146
Volume/Issue:
Volume 230: Issue 3
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Emma M Roberts
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Michael J F Newson
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George R Pope
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Rainer Landgraf Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, Max Planck Institute of Psychiatry, University of Bristol, Bristol BS1 3NY, UK

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Stephen J Lolait
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Anne-Marie O'Carroll
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homeostasis is the hypothalamic PVN. Arginine vasopressin (AVP), a major neurohypophysial hormone within the HNS, is synthesised in magnocellular neurones of the hypothalamic PVN and SON ( Burbach et al . 2001 ) that project through the median eminence to the

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-09-0134
Volume/Issue:
Volume 202: Issue 3
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Shun-Neng Hsu The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, Midlothian, UK
Division of Nephrology, Department of Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan

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Louise A Stephen The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, Midlothian, UK

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Scott Dillon The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, Midlothian, UK

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Elspeth Milne The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, Midlothian, UK

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Behzad Javaheri Comparative Biomedical Sciences, The Royal Veterinary College, London, UK

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Andrew A Pitsillides Comparative Biomedical Sciences, The Royal Veterinary College, London, UK

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Amanda Novak The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, Midlothian, UK

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Jose Luis Millán Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California, USA

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Vicky E MacRae The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, Midlothian, UK

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Katherine A Staines Centre for Stress and Age-Related Disease, University of Brighton, Brighton, UK

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Colin Farquharson The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, Midlothian, UK

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systemic levels of calcium (Ca), inorganic phosphate (Pi), parathyroid hormone (PTH), and fibroblastic growth factor-23 (FGF23) ( Moe et al. 2006 ). Hyperphosphatemia, hyperparathyroidism, and elevated FGF-23 are the primary indicators for the diagnosis

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-22-0097
Volume/Issue:
Volume 254: Issue 3
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Taira Wada Laboratory of Health Science, School of Pharmacy, Nihon University, Funabshi, Chiba, Japan

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Yukiko Yamamoto Laboratory of Health Science, School of Pharmacy, Nihon University, Funabshi, Chiba, Japan

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Yukiko Takasugi Laboratory of Health Science, School of Pharmacy, Nihon University, Funabshi, Chiba, Japan

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Hirotake Ishii Laboratory of Health Science, School of Pharmacy, Nihon University, Funabshi, Chiba, Japan

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Taketo Uchiyama Laboratory of Organic Chemistry, School of Pharmacy, Nihon University, Funabshi, Chiba, Japan

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Kaori Saitoh Department of Psychiatry, Nihon University School of Medicine, Itabashi-ku, Tokyo, Japan

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Masahiro Suzuki Department of Psychiatry, Nihon University School of Medicine, Itabashi-ku, Tokyo, Japan

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Makoto Uchiyama Department of Psychiatry, Nihon University School of Medicine, Itabashi-ku, Tokyo, Japan
Tokyo Adachi Hospital, Adachi, Tokyo, Japan

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Hikari Yoshitane Department of Biological Sciences, School of Science, The University of Tokyo, Bunkyo-ku, Tokyo, Japan

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Yoshitaka Fukada Department of Biological Sciences, School of Science, The University of Tokyo, Bunkyo-ku, Tokyo, Japan

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Shigeki Shimba Laboratory of Health Science, School of Pharmacy, Nihon University, Funabshi, Chiba, Japan

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). The SCN clock and the peripheral clocks are synchronized by neural and hormonal stimuli ( Kaneko et al. 1980 , Ueyama et al. 1999 , Oster et al. 2006 , Kalsbeek et al. 2010 ). The activity of the peripheral clocks is also influenced by the

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-22-0006
Volume/Issue:
Volume 254: Issue 2
Open access