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, inflammation, immune responses, differentiation of fat cells, and sugar metabolism ( Fatima et al . 2014 ), and it plays a key role in metabolic diseases, such as obesity and diabetes ( Goralski et al . 2007 ). Chemerin acts through three receptors
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Introduction Obesity is now a major health problem as it predisposes to insulin resistance, type 2 diabetes and cardiovascular malfunction. Although the pathogenesis of obesity and its associated co-morbidities are multifactorial, growing evidence
Centre for Systems Health and Integrated Metabolic Research, Department of Biosciences, Nottingham Trent University, Birmingham, UK
Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK
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://doi.org/10.7554/eLife.53560 ) Di Dalmazi G Pagotto U Pasquali R & Vicennati V 2012 Glucocorticoids and type 2 diabetes: from physiology to pathology . Journal of Nutrition and Metabolism 2012 525093 . ( https://doi.org/10
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with increased risk of obesity, type 2 diabetes, and cardiovascular disease ( Martin-Gronert & Ozanne 2006 , Taylor & Poston 2007 ), with extensive past research that has emphasized metabolic consequences of gestational caloric or macronutrient intakes
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diabetes mellitus ( Wang et al. 2022 ). There are various indications that GLP-1 may regulate the gonadotrophic axis, possibly at the level of the GnRH neurons. Brainstem-derived neural elements directly contact GnRH neurons in male mice ( Vastagh et
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and technology. This potential conflict has been reviewed and managed by the OHSU Conflict of Interest in Research Committee and the Integrity Program Oversight Council. Funding This work was supported by a National Institute of Diabetes and Digestive
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offspring to metabolic dysfunctions . Diabetes 69 1662 – 1674 . ( https://doi.org/10.2337/db20-0009 ) Davies KL 2018 Developmental regulation of mitochondrial function in ovine fetal skeletal muscle . PhD thesis , University of Cambridge
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. HA is a common endocrinopathy and contributes significantly to increased rates of metabolic syndrome (MetS), including nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes (T2D). NAFLD is characterized by lipid accumulation due to increased
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albuminuria in patients with type 2 diabetes . Clinical Journal of the American Society of Nephrology 1 940 – 951 . ( https://doi.org/10.2215/CJN.00240106 ) Fuller PJ Young MJ 2005 Mechanisms of mineralocorticoid action . Hypertension 46
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treatment for Cushing’s disease . Clinical Diabetes and Endocrinology 2 16 . ( https://doi.org/10.1186/s40842-016-0033-9 ) Dalm S Karssen AM Meijer OC Belanoff JK De Kloet ER 2019 Resetting the stress system with a mifepristone challenge