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Ya-Li Yang Research Laboratory for Reproductive Health, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China

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Li-Rong Ren Shenzhen Key Laboratory of Birth Defects, Shenzhen Baoan Maternal and Child Health Hospital, Shenzhen, Guangdong, China

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Li-Feng Sun Research Laboratory for Reproductive Health, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China

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Chen Huang Research Laboratory for Reproductive Health, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China
University of Chinese Academy of Sciences, Shenzhen, China

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Tian-Xia Xiao Research Laboratory for Reproductive Health, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China

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Bao-Bei Wang Research Laboratory for Reproductive Health, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China

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Jie Chen Research Laboratory for Reproductive Health, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China

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Brian A Zabel Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of Medicine, Stanford, California, USA, and Center for Molecular Biology and Medicine, Veterans Affairs Palo Alto Health Care System, Palo Alto, California, USA

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Peigen Ren Research Laboratory for Reproductive Health, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China

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Jian V Zhang Research Laboratory for Reproductive Health, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China

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, inflammation, immune responses, differentiation of fat cells, and sugar metabolism ( Fatima et al . 2014 ), and it plays a key role in metabolic diseases, such as obesity and diabetes ( Goralski et al . 2007 ). Chemerin acts through three receptors

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T Mracek
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D Gao
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T Tzanavari
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Y Bao
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X Xiao
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C Stocker Obesity Biology Research Unit, Clore Laboratory, School of Clinical Sciences, University of Liverpool, Duncan Building, Liverpool L69 3GA, UK

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P Trayhurn
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C Bing
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Introduction Obesity is now a major health problem as it predisposes to insulin resistance, type 2 diabetes and cardiovascular malfunction. Although the pathogenesis of obesity and its associated co-morbidities are multifactorial, growing evidence

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Vicki Chen Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada

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Gia V Shelp Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada

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Jacob L Schwartz Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada

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Niklas D J Aardema Department of Nutrition, Dietetics and Food Sciences, Utah State University, Logan, Utah, United States

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Madison L Bunnell Department of Nutrition, Dietetics and Food Sciences, Utah State University, Logan, Utah, United States

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Clara E Cho Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada

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with increased risk of obesity, type 2 diabetes, and cardiovascular disease ( Martin-Gronert & Ozanne 2006 , Taylor & Poston 2007 ), with extensive past research that has emphasized metabolic consequences of gestational caloric or macronutrient intakes

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Elizabeth M Simpson School of Agricultural, Environmental and Veterinary Sciences, Faculty of Science and Health, Charles Sturt University, Wagga Wagga, NSW, Australia
Gulbali Institute, Charles Sturt University, Wagga Wagga, NSW, Australia

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Iain J Clarke School of Agriculture Food and Ecosystem Sciences, Faculty of Science, The University of Melbourne, Parkville, VIC, Australia

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Christopher J Scott School of Dentistry and Medical Science, Faculty of Science and Health, Charles Sturt University, Wagga Wagga, NSW, Australia

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Cyril P Stephen School of Agricultural, Environmental and Veterinary Sciences, Faculty of Science and Health, Charles Sturt University, Wagga Wagga, NSW, Australia
Gulbali Institute, Charles Sturt University, Wagga Wagga, NSW, Australia

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Alexandra Rao School of Agriculture Food and Ecosystem Sciences, Faculty of Science, The University of Melbourne, Parkville, VIC, Australia

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Allan J Gunn School of Agricultural, Environmental and Veterinary Sciences, Faculty of Science and Health, Charles Sturt University, Wagga Wagga, NSW, Australia
Gulbali Institute, Charles Sturt University, Wagga Wagga, NSW, Australia

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diabetes mellitus ( Wang et al. 2022 ). There are various indications that GLP-1 may regulate the gonadotrophic axis, possibly at the level of the GnRH neurons. Brainstem-derived neural elements directly contact GnRH neurons in male mice ( Vastagh et

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Jarrad M Scarlett Department of Pediatrics, Oregon Health and Science University, Mailcode L481, 3181 SW Sam Jackson Park Road, Portland, Oregon 97239, USA

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Darren D Bowe Department of Pediatrics, Oregon Health and Science University, Mailcode L481, 3181 SW Sam Jackson Park Road, Portland, Oregon 97239, USA

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Xinxia Zhu Department of Pediatrics, Oregon Health and Science University, Mailcode L481, 3181 SW Sam Jackson Park Road, Portland, Oregon 97239, USA

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Ayesha K Batra Department of Pediatrics, Oregon Health and Science University, Mailcode L481, 3181 SW Sam Jackson Park Road, Portland, Oregon 97239, USA

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Wilmon F Grant Department of Pediatrics, Oregon Health and Science University, Mailcode L481, 3181 SW Sam Jackson Park Road, Portland, Oregon 97239, USA

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Daniel L Marks Department of Pediatrics, Oregon Health and Science University, Mailcode L481, 3181 SW Sam Jackson Park Road, Portland, Oregon 97239, USA

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and technology. This potential conflict has been reviewed and managed by the OHSU Conflict of Interest in Research Committee and the Integrity Program Oversight Council. Funding This work was supported by a National Institute of Diabetes and Digestive

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K L Davies Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK

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E J Camm Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK
The Ritchie Centre, Hudson Institute of Medical Research, Clayton, Australia

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D J Smith Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK

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O R Vaughan Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK
Institute for Women’s Health, University College London, London, UK

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A J Forhead Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK
Department of Biological and Medical Sciences, Oxford Brookes University, Oxford, UK

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A J Murray Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK

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A L Fowden Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK

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offspring to metabolic dysfunctions . Diabetes 69 1662 – 1674 . ( https://doi.org/10.2337/db20-0009 ) Davies KL 2018 Developmental regulation of mitochondrial function in ovine fetal skeletal muscle . PhD thesis , University of Cambridge

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Tina Seidu Department of Physiology and Biophysics, Howard University College of Medicine, Washington, DC, USA

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Patrick McWhorter Department of Chemistry, Youngstown State University, Youngstown, Ohio, USA

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Jessie Myer Department of Biology, University of Missouri, Columbia, Missouri, USA

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Rabita Alamgir Department of Physiology and Biophysics, Howard University College of Medicine, Washington, DC, USA

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Nicole Eregha Department of Physiology and Biophysics, Howard University College of Medicine, Washington, DC, USA

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Dilip Bogle Department of Physiology and Biophysics, Howard University College of Medicine, Washington, DC, USA

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Taylor Lofton Department of Physiology and Biophysics, Howard University College of Medicine, Washington, DC, USA

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Carolyn Ecelbarger Department of Medicine, Georgetown University Medical Center, Washington, DC, USA

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Stanley Andrisse Department of Physiology and Biophysics, Howard University College of Medicine, Washington, DC, USA
Department of Pediatrics, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA

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. HA is a common endocrinopathy and contributes significantly to increased rates of metabolic syndrome (MetS), including nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes (T2D). NAFLD is characterized by lipid accumulation due to increased

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Amanda E Garza Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA

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Elijah Trefts Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA

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Isis A Katayama Rangel Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA

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Danielle Brooks Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA

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Rene Baudrand Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA
Department of Endocrinology, School of Medicine, Pontificia Universidad Catolica De Chile, Santiago, Chile

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Burhanuddin Moize Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA

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Jose R Romero Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA

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Sanjay Ranjit Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA

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Thitinan Treesaranuwattana Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA

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Tham M Yao Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA

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Gail K Adler Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA

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Luminita H Pojoga Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA

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Gordon H Williams Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA

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albuminuria in patients with type 2 diabetes . Clinical Journal of the American Society of Nephrology 1 940 – 951 . ( https://doi.org/10.2215/CJN.00240106 ) Fuller PJ Young MJ 2005 Mechanisms of mineralocorticoid action . Hypertension 46

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Lisa L Koorneef Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, The Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands

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Jan Kroon Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, The Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands

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Eva M G Viho Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, The Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands

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Lucas F Wahl Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, The Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands

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Kim M L Heckmans Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, The Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands

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Marloes M A R van Dorst Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, The Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands

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Menno Hoekstra Division of BioTherapeutics, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands

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René Houtman Pamgene International, Den Bosch, The Netherlands

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Hazel Hunt Corcept Therapeutics, Menlo Park, California, USA

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Onno C Meijer Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, The Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands

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treatment for Cushing’s disease . Clinical Diabetes and Endocrinology 2 16 . ( https://doi.org/10.1186/s40842-016-0033-9 ) Dalm S Karssen AM Meijer OC Belanoff JK De Kloet ER 2019 Resetting the stress system with a mifepristone challenge

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Jane J Reavey MRC Centre for Reproductive Health, University of Edinburgh, Edinburgh, UK

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Catherine Walker MRC Centre for Reproductive Health, University of Edinburgh, Edinburgh, UK

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Alison A Murray MRC Centre for Reproductive Health, University of Edinburgh, Edinburgh, UK

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Savita Brito-Mutunayagam MRC Centre for Reproductive Health, University of Edinburgh, Edinburgh, UK

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Sheona Sweeney MRC Centre for Reproductive Health, University of Edinburgh, Edinburgh, UK

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Moira Nicol MRC Centre for Reproductive Health, University of Edinburgh, Edinburgh, UK

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Ana Cambursano MRC Centre for Reproductive Health, University of Edinburgh, Edinburgh, UK

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Hilary O D Critchley MRC Centre for Reproductive Health, University of Edinburgh, Edinburgh, UK

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Jacqueline A Maybin MRC Centre for Reproductive Health, University of Edinburgh, Edinburgh, UK

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during PBAC 42 (34.7%) Diabetes 1 (0.82%) *Measurements only in women with fibroids present. Endometrial biopsies ( n   = 28) were collected during the late secretory or menstrual phase with a suction curette (Pipelle

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