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Eva M G Viho
Eva M G Viho
Department of Medicine, Division of Endocrinology, Leiden University Medical Center, Leiden, the Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, the Netherlands
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Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, the Netherlands
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Jan Kroon
Jan Kroon
Department of Medicine, Division of Endocrinology, Leiden University Medical Center, Leiden, the Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, the Netherlands
Corcept Therapeutics, Menlo Park, CA, USA
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Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, the Netherlands
Corcept Therapeutics, Menlo Park, CA, USA
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Richard A Feelders
Richard A Feelders
Department of Internal Medicine, Division of Endocrinology, Erasmus Medical Center, Rotterdam, the Netherlands
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René Houtman
René Houtman
Precision Medicine Lab, Oss, the Netherlands
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Elisabeth S R van den Dungen
Elisabeth S R van den Dungen
Department of Internal Medicine, Division of Endocrinology, Erasmus Medical Center, Rotterdam, the Netherlands
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Alberto M Pereira
Alberto M Pereira
Department of Endocrinology and Metabolism, Amsterdam University Medical Center, Amsterdam, the Netherlands
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Hazel J Hunt
Hazel J Hunt
Corcept Therapeutics, Menlo Park, CA, USA
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Leo J Hofland
Leo J Hofland
Department of Internal Medicine, Division of Endocrinology, Erasmus Medical Center, Rotterdam, the Netherlands
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Onno C Meijer
Onno C Meijer
Department of Medicine, Division of Endocrinology, Leiden University Medical Center, Leiden, the Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, the Netherlands
Corcept Therapeutics, Menlo Park, CA, USA
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Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, the Netherlands
Corcept Therapeutics, Menlo Park, CA, USA
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treated with mifepristone: consensus recommendations . Clinical Diabetes and Endocrinology 6 18. ( https://doi.org/10.1186/s40842-020-00105-4 ) Creemers SG Feelders RA de Jong FH Franssen GJH de Rijke YB van Koetsveld PM Hofland LJ 2021
Jin-Ran Chen
Jin-Ran Chen
Arkansas Children’s Nutrition Center, Little Rock, Arkansas, USA
Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
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Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
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Oxana P Lazarenko
Oxana P Lazarenko
Arkansas Children’s Nutrition Center, Little Rock, Arkansas, USA
Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
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Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
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Haijun Zhao
Haijun Zhao
Arkansas Children’s Nutrition Center, Little Rock, Arkansas, USA
Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
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Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
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Alexander W Alund
Alexander W Alund
Interdisciplinary Biomedical Sciences , University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
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Kartik Shankar
Kartik Shankar
Arkansas Children’s Nutrition Center, Little Rock, Arkansas, USA
Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
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Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
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The maternal environment, in particular, the nutritional status and obesity during pregnancy, has been shown to be important in the developmental trajectory of the fetus and to influence risk for chronic diseases such as diabetes, cardiovascular
Bernard Freudenthal
Bernard Freudenthal
Molecular Endocrinology Laboratory, Department of Medicine, Imperial College London, London, UK
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John Logan
John Logan
Molecular Endocrinology Laboratory, Department of Medicine, Imperial College London, London, UK
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Sanger Institute Mouse Pipelines
Sanger Institute Mouse Pipelines
Mouse Pipelines, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK
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Peter I Croucher
Peter I Croucher
Garvan Institute of Medical Research, Sydney, New South Wales, Australia
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Graham R Williams
Graham R Williams
Molecular Endocrinology Laboratory, Department of Medicine, Imperial College London, London, UK
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J H Duncan Bassett
J H Duncan Bassett
Molecular Endocrinology Laboratory, Department of Medicine, Imperial College London, London, UK
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Introduction A novel strategy for osteoporosis gene discovery Studies of human monogenic extreme phenotype disorders have been instrumental in discovering genetic and molecular mechanisms of common diseases including obesity and diabetes
Andrea Lovdel
Andrea Lovdel
University/BHF Centre for Cardiovascular Science, The University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh BioQuarter, Edinburgh, UK
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Karla J Suchacki
Karla J Suchacki
University/BHF Centre for Cardiovascular Science, The University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh BioQuarter, Edinburgh, UK
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Fiona Roberts
Fiona Roberts
University/BHF Centre for Cardiovascular Science, The University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh BioQuarter, Edinburgh, UK
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Richard J Sulston
Richard J Sulston
University/BHF Centre for Cardiovascular Science, The University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh BioQuarter, Edinburgh, UK
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Robert J Wallace
Robert J Wallace
Department of Orthopaedics, The University of Edinburgh, Edinburgh, UK
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Benjamin J Thomas
Benjamin J Thomas
University/BHF Centre for Cardiovascular Science, The University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh BioQuarter, Edinburgh, UK
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Rachel M B Bell
Rachel M B Bell
University/BHF Centre for Cardiovascular Science, The University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh BioQuarter, Edinburgh, UK
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Iris Pruñonosa Cervera
Iris Pruñonosa Cervera
University/BHF Centre for Cardiovascular Science, The University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh BioQuarter, Edinburgh, UK
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Gavin J Macpherson
Gavin J Macpherson
Department of Orthopaedic Surgery, Royal Infirmary of Edinburgh, Edinburgh, UK
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Nicholas M Morton
Nicholas M Morton
University/BHF Centre for Cardiovascular Science, The University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh BioQuarter, Edinburgh, UK
Centre for Systems Health and Integrated Metabolic Research, Department of Biosciences, School of Science and Technology, Nottingham Trent University, Nottingham, UK
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Centre for Systems Health and Integrated Metabolic Research, Department of Biosciences, School of Science and Technology, Nottingham Trent University, Nottingham, UK
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Natalie Z M Homer
Natalie Z M Homer
University/BHF Centre for Cardiovascular Science, The University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh BioQuarter, Edinburgh, UK
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Karen E Chapman
Karen E Chapman
University/BHF Centre for Cardiovascular Science, The University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh BioQuarter, Edinburgh, UK
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William P Cawthorn
William P Cawthorn
University/BHF Centre for Cardiovascular Science, The University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh BioQuarter, Edinburgh, UK
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) ( Bravenboer et al. 2020 , Cawthorn 2020 ). Bone marrow adipocytes further accumulate in diverse conditions, including ageing, obesity, type 2 diabetes, osteoporosis, chronic kidney disease, and in iatrogenic contexts such as chronic glucocorticoid treatment
A Tsuchiya
A Tsuchiya
Division of Bioinformation, Department of Physiology, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya 663-8501, Japan
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T Kanno
T Kanno
Division of Bioinformation, Department of Physiology, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya 663-8501, Japan
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T Nishizaki
T Nishizaki
Division of Bioinformation, Department of Physiology, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya 663-8501, Japan
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2003 Severe diabetes, age-dependent loss of adipose tissue, and mild growth deficiency in mice lacking Akt2/PKBβ . Journal of Clinical Investigation 112 197 – 208 . Gonzalez E McGraw TE 2009 Insulin-modulated Akt subcellular localization
M A Hyatt
M A Hyatt
Early Life Nutrition Research Unit, Respiratory Biomedical Research Unit, Department of Animal Sciences, Division of Human Development, Academic Child Health
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D H Keisler
D H Keisler
Early Life Nutrition Research Unit, Respiratory Biomedical Research Unit, Department of Animal Sciences, Division of Human Development, Academic Child Health
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H Budge
H Budge
Early Life Nutrition Research Unit, Respiratory Biomedical Research Unit, Department of Animal Sciences, Division of Human Development, Academic Child Health
Early Life Nutrition Research Unit, Respiratory Biomedical Research Unit, Department of Animal Sciences, Division of Human Development, Academic Child Health
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Early Life Nutrition Research Unit, Respiratory Biomedical Research Unit, Department of Animal Sciences, Division of Human Development, Academic Child Health
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M E Symonds
M E Symonds
Early Life Nutrition Research Unit, Respiratory Biomedical Research Unit, Department of Animal Sciences, Division of Human Development, Academic Child Health
Early Life Nutrition Research Unit, Respiratory Biomedical Research Unit, Department of Animal Sciences, Division of Human Development, Academic Child Health
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Early Life Nutrition Research Unit, Respiratory Biomedical Research Unit, Department of Animal Sciences, Division of Human Development, Academic Child Health
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Cao JX-C 2005 Reduction of hepatic and adipose tissue glucocorticoid receptor expression with antisense oligonucleotides improves hyperglycemia and hyperlipidemia in diabetic rodents without causing systemic glucocorticoid antagonism . Diabetes
Lina Lawenius
Lina Lawenius
Sahlgrenska Osteoporosis Centre and Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden
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Hannah Colldén
Hannah Colldén
Sahlgrenska Osteoporosis Centre and Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden
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Karin Horkeby
Karin Horkeby
Sahlgrenska Osteoporosis Centre and Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden
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Jianyao Wu
Jianyao Wu
Sahlgrenska Osteoporosis Centre and Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden
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Louise Grahnemo
Louise Grahnemo
Sahlgrenska Osteoporosis Centre and Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden
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Liesbeth Vandenput
Liesbeth Vandenput
Sahlgrenska Osteoporosis Centre and Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden
Mary MacKillop Institute for Health Research, Australian Catholic University, Melbourne, Australia
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Mary MacKillop Institute for Health Research, Australian Catholic University, Melbourne, Australia
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Claes Ohlsson
Claes Ohlsson
Sahlgrenska Osteoporosis Centre and Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden
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Klara Sjögren
Klara Sjögren
Sahlgrenska Osteoporosis Centre and Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden
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( McCabe et al. 2013 , Collins et al. 2019 ). L. reuteri also has beneficial effects on bone in male mice with low bone mass due to glucocorticoid treatment, diabetes type 1 or long-term antibiotic treatment ( Zhang et al. 2015 , Schepper et al
L A Nolan
L A Nolan
Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, University of Bristol, Dorothy Hodgkin Building, Whitson Street, Bristol BS1 3NY, UK
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A Levy
A Levy
Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, University of Bristol, Dorothy Hodgkin Building, Whitson Street, Bristol BS1 3NY, UK
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. Sandoval DA Ertl AC Richardson MA Tate DB Davis SN 2003 Estrogen blunts neuroendocrine and metabolic responses to hypoglycemia . Diabetes 52 1749 – 1755 . Schaller B 2005 Gender-related differences in prolactinomas. A
S Schmidt
S Schmidt
Toxicology, Department of Human Molecular Genetics, Research Group Neurogenetics, Departments of
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A Hommel
A Hommel
Toxicology, Department of Human Molecular Genetics, Research Group Neurogenetics, Departments of
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V Gawlik
V Gawlik
Toxicology, Department of Human Molecular Genetics, Research Group Neurogenetics, Departments of
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R Augustin
R Augustin
Toxicology, Department of Human Molecular Genetics, Research Group Neurogenetics, Departments of
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N Junicke
N Junicke
Toxicology, Department of Human Molecular Genetics, Research Group Neurogenetics, Departments of
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S Florian
S Florian
Toxicology, Department of Human Molecular Genetics, Research Group Neurogenetics, Departments of
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M Richter
M Richter
Toxicology, Department of Human Molecular Genetics, Research Group Neurogenetics, Departments of
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D J Walther
D J Walther
Toxicology, Department of Human Molecular Genetics, Research Group Neurogenetics, Departments of
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D Montag
D Montag
Toxicology, Department of Human Molecular Genetics, Research Group Neurogenetics, Departments of
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H-G Joost
H-G Joost
Toxicology, Department of Human Molecular Genetics, Research Group Neurogenetics, Departments of
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A Schürmann
A Schürmann
Toxicology, Department of Human Molecular Genetics, Research Group Neurogenetics, Departments of
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of the high-affinity transporter GLUT3 correlates with the switch to a metabolic preference for glucose versus pyruvate ( Pantaleon et al . 1997 ). Similar defects in embryo development were observed in mice in which diabetes mellitus was induced by
Sara Della Torre
Sara Della Torre
Center of Excellence on Neurodegenerative Diseases, University of Milan, Milan, Italy
Department of Pharmacological and Biomolecular Sciences, University of Milan, Milan, Italy
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Department of Pharmacological and Biomolecular Sciences, University of Milan, Milan, Italy
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Gianpaolo Rando
Gianpaolo Rando
Center of Excellence on Neurodegenerative Diseases, University of Milan, Milan, Italy
Department of Pharmacological and Biomolecular Sciences, University of Milan, Milan, Italy
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Department of Pharmacological and Biomolecular Sciences, University of Milan, Milan, Italy
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Clara Meda
Clara Meda
Center of Excellence on Neurodegenerative Diseases, University of Milan, Milan, Italy
Department of Pharmacological and Biomolecular Sciences, University of Milan, Milan, Italy
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Department of Pharmacological and Biomolecular Sciences, University of Milan, Milan, Italy
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Paolo Ciana
Paolo Ciana
Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy
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Luisa Ottobrini
Luisa Ottobrini
Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy
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Adriana Maggi
Adriana Maggi
Center of Excellence on Neurodegenerative Diseases, University of Milan, Milan, Italy
Department of Pharmacological and Biomolecular Sciences, University of Milan, Milan, Italy
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Department of Pharmacological and Biomolecular Sciences, University of Milan, Milan, Italy
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.1159/000191104 ) 10.1159/000191104) Yuchi Y Cai Y Legein B De Groef S Leuckx G Coppens V Van Overmeire E Staels W De Leu N Martens G , et al . 2015 Estrogen receptor alpha regulates beta-cell formation during pancreas development and following injury . Diabetes
