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Nele Cielen Laboratory of Respiratory Diseases, Department of Clinical and Experimental Medicine, KULeuven, Leuven, Belgium

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Nele Heulens Laboratory of Respiratory Diseases, Department of Clinical and Experimental Medicine, KULeuven, Leuven, Belgium

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Karen Maes Laboratory of Respiratory Diseases, Department of Clinical and Experimental Medicine, KULeuven, Leuven, Belgium

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Geert Carmeliet Laboratory of Clinical and Experimental Endocrinology, Department of Clinical and Experimental Medicine, KULeuven, Leuven, Belgium

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Chantal Mathieu Laboratory of Clinical and Experimental Endocrinology, Department of Clinical and Experimental Medicine, KULeuven, Leuven, Belgium

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Wim Janssens Laboratory of Respiratory Diseases, Department of Clinical and Experimental Medicine, KULeuven, Leuven, Belgium

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Ghislaine Gayan-Ramirez Laboratory of Respiratory Diseases, Department of Clinical and Experimental Medicine, KULeuven, Leuven, Belgium

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of myoregulatory transcription factors. Endocrinology 144 5138 – 5144 . Engelen MP Schols AM Does JD Wouters EF 2000 Skeletal muscle weakness is associated with wasting of extremity fat-free mass but not with airflow

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-15-0491
Volume/Issue:
Volume 229: Issue 2
Open access
Maria Karsai Department of Endocrinology, Diabetology and Clinical Nutrition, University Hospital Zurich (USZ) and University of Zurich (UZH), Zurich, Switzerland

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Richard A Zuellig Department of Endocrinology, Diabetology and Clinical Nutrition, University Hospital Zurich (USZ) and University of Zurich (UZH), Zurich, Switzerland

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Roger Lehmann Department of Endocrinology, Diabetology and Clinical Nutrition, University Hospital Zurich (USZ) and University of Zurich (UZH), Zurich, Switzerland

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Federica Cuozzo Institute of Metabolism and Systems Research (IMSR) and Centre of Membrane Proteins and Receptors (COMPARE), University of Birmingham, Birmingham, UK
Centre for Endocrinology, Diabetes and Metabolism, Birmingham Health Partners, Birmingham, UK

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Daniela Nasteska Institute of Metabolism and Systems Research (IMSR) and Centre of Membrane Proteins and Receptors (COMPARE), University of Birmingham, Birmingham, UK
Centre for Endocrinology, Diabetes and Metabolism, Birmingham Health Partners, Birmingham, UK

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Edlira Luca Department of Endocrinology, Diabetology and Clinical Nutrition, University Hospital Zurich (USZ) and University of Zurich (UZH), Zurich, Switzerland

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Constanze Hantel Department of Endocrinology, Diabetology and Clinical Nutrition, University Hospital Zurich (USZ) and University of Zurich (UZH), Zurich, Switzerland
Medizinische Klinik und Poliklinik III, University Hospital Carl Gustav Carus Dresden, Dresden, Germany

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David J Hodson Institute of Metabolism and Systems Research (IMSR) and Centre of Membrane Proteins and Receptors (COMPARE), University of Birmingham, Birmingham, UK
Centre for Endocrinology, Diabetes and Metabolism, Birmingham Health Partners, Birmingham, UK

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Giatgen A Spinas Department of Endocrinology, Diabetology and Clinical Nutrition, University Hospital Zurich (USZ) and University of Zurich (UZH), Zurich, Switzerland

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Guy A Rutter Section of Cell Biology and Functional Genomics, Division of Diabetes, Endocrinology and Metabolism, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK
CR-CHUM, University of Montreal, Montreal, QC, Canada
Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore

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Philipp A Gerber Department of Endocrinology, Diabetology and Clinical Nutrition, University Hospital Zurich (USZ) and University of Zurich (UZH), Zurich, Switzerland

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performed using a mixture of cytokines: 1000 U/mL Tumour necrosis factor-α (TNF-α; ThermoFischer), 1000 U/mL Interferon-γ (IFN-γ; ThermoFischer) and 50 U/mL interleukin-1β (IL-1β; ThermoFischer) ( Jain et al. 2015 ). All treatments were conducted for 24 h

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-21-0271
Volume/Issue:
Volume 253: Issue 1
Open access
Zhenguang Zhang University/BHF Centre for Cardiovascular Science, The Queen’s Medical Research Institute, The University of Edinburgh, Edinburgh, UK

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Agnes E Coutinho University/BHF Centre for Cardiovascular Science, The Queen’s Medical Research Institute, The University of Edinburgh, Edinburgh, UK

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Tak Yung Man University/BHF Centre for Cardiovascular Science, The Queen’s Medical Research Institute, The University of Edinburgh, Edinburgh, UK

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Tiina M J Kipari Centre for Genomic and Experimental Medicine, MRC Institute of Genetic and Molecular Medicine, The University of Edinburgh, Western General Hospital, Edinburgh, UK

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Patrick W F Hadoke University/BHF Centre for Cardiovascular Science, The Queen’s Medical Research Institute, The University of Edinburgh, Edinburgh, UK

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Donald M Salter Centre for Genomic and Experimental Medicine, MRC Institute of Genetic and Molecular Medicine, The University of Edinburgh, Western General Hospital, Edinburgh, UK

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Jonathan R Seckl University/BHF Centre for Cardiovascular Science, The Queen’s Medical Research Institute, The University of Edinburgh, Edinburgh, UK

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Karen E Chapman University/BHF Centre for Cardiovascular Science, The Queen’s Medical Research Institute, The University of Edinburgh, Edinburgh, UK

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CM Henkel GW Murphy KM Ostrowski MC McKercher SR Maki RA Hume DA 1999 Differentiation of the mononuclear phagocyte system during mouse embryogenesis: the role of transcription factor PU.1 . Blood 94 127 – 138

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-17-0223
Volume/Issue:
Volume 234: Issue 3
Open access
Andrea Mafficini ARC-Net Centre for Applied Research on Cancer, University and Hospital Trust of Verona, Verona, Italy
Department of Diagnostics and Public Health, Section of Pathology, University and Hospital Trust of Verona, Verona, Italy

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Aldo Scarpa ARC-Net Centre for Applied Research on Cancer, University and Hospital Trust of Verona, Verona, Italy
Department of Diagnostics and Public Health, Section of Pathology, University and Hospital Trust of Verona, Verona, Italy

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2015 PI3K/AKT signaling modulates transcriptional expression of EWS/FLI1 through specificity protein 1 . Oncotarget 6 28895 – 28910 . ( https://doi.org/10.18632/oncotarget.5000 ) 26336820 Heaphy CM de Wilde RF Jiao Y Klein AP Edil BH Shi C

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-17-0560
Volume/Issue:
Volume 236: Issue 3
Open access
E Meimaridou Centre for Endocrinology, William Harvey Research Institute, John Vane Science Centre, Queen Mary, University of London, London, UK

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M Goldsworthy MRC Harwell Institute, Genetics of Type 2 Diabetes, Mammalian Genetics Unit, Oxfordshire, UK

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V Chortis Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK
Centre for Endocrinology, Diabetes and Metabolism, Birmingham Health Partners, Birmingham, UK

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E Fragouli Centre for Endocrinology, William Harvey Research Institute, John Vane Science Centre, Queen Mary, University of London, London, UK

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P A Foster Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK
Centre for Endocrinology, Diabetes and Metabolism, Birmingham Health Partners, Birmingham, UK

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W Arlt Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK
Centre for Endocrinology, Diabetes and Metabolism, Birmingham Health Partners, Birmingham, UK

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R Cox MRC Harwell Institute, Genetics of Type 2 Diabetes, Mammalian Genetics Unit, Oxfordshire, UK

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L A Metherell Centre for Endocrinology, William Harvey Research Institute, John Vane Science Centre, Queen Mary, University of London, London, UK

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Endocrinology and Metabolism 94 936 – 939 . ( https://doi.org/10.1210/jc.2008-1118 ) 10.1210/jc.2008-1118 Saha D Koli S Reddy KVR 2017 Transcriptional regulation of Hb-α and Hb-β through nuclear factor E2-related factor-2 (Nrf2) activation

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-16-0638
Volume/Issue:
Volume 236: Issue 1
Open access
Nikolaos Nikolaou Oxford Centre for Diabetes, Endocrinology and Metabolism, NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford, UK

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Anastasia Arvaniti Oxford Centre for Diabetes, Endocrinology and Metabolism, NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford, UK
Department of Biological and Medical Sciences, Oxford Brookes University, Oxford, UK

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Nathan Appanna Oxford Centre for Diabetes, Endocrinology and Metabolism, NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford, UK

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Anna Sharp Oxford Centre for Diabetes, Endocrinology and Metabolism, NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford, UK

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Beverly A Hughes Institute of Metabolism and Systems Research, University of Birmingham, Edgbaston, Birmingham, UK

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Dena Digweed Diurnal Ltd, Cardiff, UK

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Martin J Whitaker Diurnal Ltd, Cardiff, UK

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Richard Ross Department of Oncology and Metabolism, Faculty of Medicine, Dentistry and Health, University of Sheffield, Sheffield, UK

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Wiebke Arlt Institute of Metabolism and Systems Research, University of Birmingham, Edgbaston, Birmingham, UK
NIHR Birmingham Biomedical Research Centre, University Hospitals Birmingham NHS Foundation Trust and University of Birmingham, Birmingham, UK

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Trevor M Penning Department of Systems Pharmacology & Translational Therapeutics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA

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Karen Morris Biochemistry Department, Manchester University NHS Trust, Manchester, UK

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Sherly George Biochemistry Department, Manchester University NHS Trust, Manchester, UK

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Brian G Keevil Biochemistry Department, Manchester University NHS Trust, Manchester, UK

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Leanne Hodson Oxford Centre for Diabetes, Endocrinology and Metabolism, NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford, UK

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Laura L Gathercole Oxford Centre for Diabetes, Endocrinology and Metabolism, NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford, UK
Department of Biological and Medical Sciences, Oxford Brookes University, Oxford, UK

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Jeremy W Tomlinson Oxford Centre for Diabetes, Endocrinology and Metabolism, NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford, UK

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-regulation, here to drive gluconeogenesis, with the potential to fuel hepatic glucose output. The down-regulation of AKR1D1 by synthetic steroids may therefore be an important contributing factor to the adverse metabolic features associated with their use

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-19-0473
Volume/Issue:
Volume 245: Issue 2
Open access
D Pugazhendhi School of Biological Sciences, Structural Biology Unit, School of Chemistry, The University of Reading, Reading RG6 6AJ, UK

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K A Watson School of Biological Sciences, Structural Biology Unit, School of Chemistry, The University of Reading, Reading RG6 6AJ, UK
School of Biological Sciences, Structural Biology Unit, School of Chemistry, The University of Reading, Reading RG6 6AJ, UK

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S Mills School of Biological Sciences, Structural Biology Unit, School of Chemistry, The University of Reading, Reading RG6 6AJ, UK

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N Botting School of Biological Sciences, Structural Biology Unit, School of Chemistry, The University of Reading, Reading RG6 6AJ, UK

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G S Pope School of Biological Sciences, Structural Biology Unit, School of Chemistry, The University of Reading, Reading RG6 6AJ, UK

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P D Darbre School of Biological Sciences, Structural Biology Unit, School of Chemistry, The University of Reading, Reading RG6 6AJ, UK

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ligand-activated functions of these transcription factors on patterns of gene expression ( Woods 2003 ). Of the many phytoestrogens, the isoflavones genistein and daidzein can be consumed in relatively large amounts in soya bean-rich diets such as those

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-07-0384
Volume/Issue:
Volume 197: Issue 3
Open access
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David Cottet-Dumoulin Cell Isolation and Transplantation Center, Department of Surgery, Geneva University Hospitals and University of Geneva, Geneva, Switzerland
Diabetes Center of the Faculty of Medicine, University of Geneva, Geneva, Switzerland

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Quentin Perrier Cell Isolation and Transplantation Center, Department of Surgery, Geneva University Hospitals and University of Geneva, Geneva, Switzerland
Diabetes Center of the Faculty of Medicine, University of Geneva, Geneva, Switzerland

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Vanessa Lavallard Cell Isolation and Transplantation Center, Department of Surgery, Geneva University Hospitals and University of Geneva, Geneva, Switzerland
Diabetes Center of the Faculty of Medicine, University of Geneva, Geneva, Switzerland

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David Matthey-Doret Cell Isolation and Transplantation Center, Department of Surgery, Geneva University Hospitals and University of Geneva, Geneva, Switzerland
Diabetes Center of the Faculty of Medicine, University of Geneva, Geneva, Switzerland

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Laura Mar Fonseca Cell Isolation and Transplantation Center, Department of Surgery, Geneva University Hospitals and University of Geneva, Geneva, Switzerland
Diabetes Center of the Faculty of Medicine, University of Geneva, Geneva, Switzerland

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Juliette Bignard Cell Isolation and Transplantation Center, Department of Surgery, Geneva University Hospitals and University of Geneva, Geneva, Switzerland
Diabetes Center of the Faculty of Medicine, University of Geneva, Geneva, Switzerland

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Reine Hanna Cell Isolation and Transplantation Center, Department of Surgery, Geneva University Hospitals and University of Geneva, Geneva, Switzerland
Diabetes Center of the Faculty of Medicine, University of Geneva, Geneva, Switzerland

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Géraldine Parnaud Cell Isolation and Transplantation Center, Department of Surgery, Geneva University Hospitals and University of Geneva, Geneva, Switzerland
Diabetes Center of the Faculty of Medicine, University of Geneva, Geneva, Switzerland

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Fanny Lebreton Cell Isolation and Transplantation Center, Department of Surgery, Geneva University Hospitals and University of Geneva, Geneva, Switzerland
Diabetes Center of the Faculty of Medicine, University of Geneva, Geneva, Switzerland

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Kevin Bellofatto Cell Isolation and Transplantation Center, Department of Surgery, Geneva University Hospitals and University of Geneva, Geneva, Switzerland
Diabetes Center of the Faculty of Medicine, University of Geneva, Geneva, Switzerland

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Ekaterine Berishvili Cell Isolation and Transplantation Center, Department of Surgery, Geneva University Hospitals and University of Geneva, Geneva, Switzerland
Diabetes Center of the Faculty of Medicine, University of Geneva, Geneva, Switzerland

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Thierry Berney Cell Isolation and Transplantation Center, Department of Surgery, Geneva University Hospitals and University of Geneva, Geneva, Switzerland
Diabetes Center of the Faculty of Medicine, University of Geneva, Geneva, Switzerland

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Domenico Bosco Cell Isolation and Transplantation Center, Department of Surgery, Geneva University Hospitals and University of Geneva, Geneva, Switzerland
Diabetes Center of the Faculty of Medicine, University of Geneva, Geneva, Switzerland

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cells by stimulating insulin gene transcription, by stabilizing insulin messenger ribonucleic acid and by enhancing the speed of beta cell protein translation ( Poitout et al. 2006 , Vander Mierde et al. 2007 ). On the other hand, we showed that

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-22-0304
Volume/Issue:
Volume 258: Issue 2
Open access
Alessandro Pocai Diabetes and Endocrinology, Merck Research Laboratories, Merck Sharp and Dohme Corp., 126 East Lincoln Avenue, Rahway, New Jersey 07065, USA

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Introduction As the prevalence of type 2 diabetes increases, there is a medical need for additional antihyperglycemic agents that offer improved efficacy in glycemic control and tolerability. Obesity is an important risk factor for a number of

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-12-0368
Volume/Issue:
Volume 215: Issue 3
Open access
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Michael Rouse Laboratory of Clinical Investigation, Laboratory of Cardiovascular Science, National Institute on Aging, Intramural Research Program, National Institutes of Health, 251 Bayview Blvd, Baltimore, Maryland 21224, USA

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Antoine Younès Laboratory of Clinical Investigation, Laboratory of Cardiovascular Science, National Institute on Aging, Intramural Research Program, National Institutes of Health, 251 Bayview Blvd, Baltimore, Maryland 21224, USA

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Josephine M Egan Laboratory of Clinical Investigation, Laboratory of Cardiovascular Science, National Institute on Aging, Intramural Research Program, National Institutes of Health, 251 Bayview Blvd, Baltimore, Maryland 21224, USA

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essential β-cell transcription factors forkhead box protein O1 ( FOXO1 ), NKX6-1 , NKX2-2 , and PDX1 in rhesus monkeys given a high-fat high-sugar diet. In addition, we observed a similar type of protection upon RES treatment in human islets cultured

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-14-0335
Volume/Issue:
Volume 223: Issue 2
Open access