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Saeed Alshahrani Department of Pharmacology and Toxicology, Pacific Northwest Diabetes Research Institute, Boonshoft School of Medicine, Wright State University, 3640 Colonel Glenn Highway, 216 HSB, Dayton, Ohio 45435, USA

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Mohammed Mashari Almutairi Department of Pharmacology and Toxicology, Pacific Northwest Diabetes Research Institute, Boonshoft School of Medicine, Wright State University, 3640 Colonel Glenn Highway, 216 HSB, Dayton, Ohio 45435, USA

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Shams Kursan Department of Pharmacology and Toxicology, Pacific Northwest Diabetes Research Institute, Boonshoft School of Medicine, Wright State University, 3640 Colonel Glenn Highway, 216 HSB, Dayton, Ohio 45435, USA

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Eduardo Dias-Junior Department of Pharmacology and Toxicology, Pacific Northwest Diabetes Research Institute, Boonshoft School of Medicine, Wright State University, 3640 Colonel Glenn Highway, 216 HSB, Dayton, Ohio 45435, USA

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Mohamed Mahmoud Almiahuob Department of Pharmacology and Toxicology, Pacific Northwest Diabetes Research Institute, Boonshoft School of Medicine, Wright State University, 3640 Colonel Glenn Highway, 216 HSB, Dayton, Ohio 45435, USA

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Lydia Aguilar-Bryan Department of Pharmacology and Toxicology, Pacific Northwest Diabetes Research Institute, Boonshoft School of Medicine, Wright State University, 3640 Colonel Glenn Highway, 216 HSB, Dayton, Ohio 45435, USA

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Mauricio Di Fulvio Department of Pharmacology and Toxicology, Pacific Northwest Diabetes Research Institute, Boonshoft School of Medicine, Wright State University, 3640 Colonel Glenn Highway, 216 HSB, Dayton, Ohio 45435, USA

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neuron-restrictive silencing factor/repressor element silencing transcription factor, a neuron-restrictive silencer . Journal of Biological Chemistry 272 1929 – 1934 . ( doi:10.1074/jbc.272.3.1929 ) Ayala JE Samuel VT Morton GJ Obici S

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-15-0327
Volume/Issue:
Volume 227: Issue 3
Open access
Emma M Roberts
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Michael J F Newson
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George R Pope
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Rainer Landgraf Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, Max Planck Institute of Psychiatry, University of Bristol, Bristol BS1 3NY, UK

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Stephen J Lolait
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Anne-Marie O'Carroll
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: linearised with EcoRI and generated with T7 polymerase; sense: linearised with HindIII and generated with SP6 polymerase) with 35 S-UTP (Perkin Elmer) and the MAXIscript in vitro transcription kit (Ambion, Austin, TX, USA). The integrity of each probe was

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-09-0134
Volume/Issue:
Volume 202: Issue 3
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Maria L Price Institute of Metabolism and Systems Research and Centre for Endocrinology, Diabetes and Metabolism, University of Birmingham, Birmingham, UK
Centre of Membrane Proteins and Receptors (COMPARE), Universities of Birmingham and Nottingham, Birmingham, UK

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Cameron D Ley Institute of Metabolism and Systems Research and Centre for Endocrinology, Diabetes and Metabolism, University of Birmingham, Birmingham, UK
Centre of Membrane Proteins and Receptors (COMPARE), Universities of Birmingham and Nottingham, Birmingham, UK

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Caroline M Gorvin Institute of Metabolism and Systems Research and Centre for Endocrinology, Diabetes and Metabolism, University of Birmingham, Birmingham, UK
Centre of Membrane Proteins and Receptors (COMPARE), Universities of Birmingham and Nottingham, Birmingham, UK

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mobilisation when in dimers by coupling to Gq-PLC. GHSR1a-DRD1 signalling increases: - phosphorylation of CaMKII, AMPAR, and activates synaptic plasticity;- exocytosis of glutamate receptors in hippocampal neurons- gene transcription to initiate neuronal

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-21-0206
Volume/Issue:
Volume 252: Issue 1
Open access
Peter Kolkhof Drug Discovery, Cardiology Research, Bayer AG, Wuppertal, Germany

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Lars Bärfacker Drug Discovery, Medicinal Chemistry, Bayer AG, Wuppertal, Germany

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moderate renal impairment NCT2848170 Dec 2017 Phase 3 40 Japan Phase 3 study to examine the relation between antihypertensive effect and baseline factors exploratively, compared to olmesartan medoxomil in patients with essential hypertension

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Review Article
DOI:
https://doi.org/10.1530/JOE-16-0600
Volume/Issue:
Volume 234: Issue 1
Open access
Alyce M Martin College of Medicine and Public Health, Flinders University, Adelaide, South Australia, Australia

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Emily W Sun College of Medicine and Public Health, Flinders University, Adelaide, South Australia, Australia

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Damien J Keating College of Medicine and Public Health, Flinders University, Adelaide, South Australia, Australia
Nutrition and Metabolism, South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia

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receptors expressed by target tissues. Endocrine pancreas Dysregulated secretion of insulin and glucagon, the two primary islet hormones, is a major contributing factor of the development of diabetes mellitus. Although a number of gut-derived hormones

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-19-0399
Volume/Issue:
Volume 244: Issue 1
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Pauline Campos College of Engineering, Mathematics and Physical Sciences, University of Exeter, Exeter, UK

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Jamie J Walker College of Engineering, Mathematics and Physical Sciences, University of Exeter, Exeter, UK
EPSRC Centre for Predictive Modelling in Healthcare, University of Exeter, Exeter, UK
Bristol Medical School, Translational Health Sciences, University of Bristol, Bristol, UK

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Patrice Mollard IGF, University of Montpellier, CNRS, INSERM, Montpellier, France

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gene transcription and synaptic transmission, and changes in these oscillations are observed in a variety of (patho)physiological states ( Le Tissier et al. 2017 ). Although it has long been postulated that neuroendocrine neurons have the ability to

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-20-0028
Volume/Issue:
Volume 246: Issue 2
Open access
Lesley A Hill Departments of Cellular and Physiological Sciences and Obstetrics and Gynaecology, The University of British Columbia, Vancouver, British Columbia, Canada

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Dimitra A Vassiliadi Endocrine Unit, Second Department of Internal Medicine-Research Institute and Diabetes Center, Attiko University Hospital, Athens, Greece

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Ioanna Dimopoulou Endocrine Unit, Second Department of Internal Medicine-Research Institute and Diabetes Center, Attiko University Hospital, Athens, Greece

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Anna J Anderson BHF Centre for Cardiovascular Science, Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom

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Luke D Boyle BHF Centre for Cardiovascular Science, Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom

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Alixe H M Kilgour BHF Centre for Cardiovascular Science, Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom

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Roland H Stimson BHF Centre for Cardiovascular Science, Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom

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Yoan Machado Department of Biochemistry and Molecular Biology, The University of British Columbia, Vancouver, British Columbia, Canada

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Christopher M Overall Department of Biochemistry and Molecular Biology, The University of British Columbia, Vancouver, British Columbia, Canada

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Brian R Walker BHF Centre for Cardiovascular Science, Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom
Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom

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John G Lewis Canterbury Health Laboratories, Christchurch, New Zealand

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Geoffrey L Hammond Departments of Cellular and Physiological Sciences and Obstetrics and Gynaecology, The University of British Columbia, Vancouver, British Columbia, Canada

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transcription start site close to a consensus estrogen response element ( Bolton et al. 2014 ). Although it has been suggested that estrogen dependent increases in CBG production might account for differences in 9G12 monoclonal antibody recognition, for

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-18-0479
Volume/Issue:
Volume 240: Issue 1
Open access
Alvaro Souto Padron Laboratório de Fisiologia Endócrina Doris Rosenthal, Laboratório de Biologia do Exercício, Instituto de Biofísica Carlos Chagas Filho and Instituto de Pesquisa Translacional em Saúde e Ambiente na Região Amazônica (INPeTAM), CCS-Bloco G- Cidade Universitria, Ilha do Fundo, Rio de Janeiro 21949-900, Brazil

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Ruy Andrade Louzada Neto Laboratório de Fisiologia Endócrina Doris Rosenthal, Laboratório de Biologia do Exercício, Instituto de Biofísica Carlos Chagas Filho and Instituto de Pesquisa Translacional em Saúde e Ambiente na Região Amazônica (INPeTAM), CCS-Bloco G- Cidade Universitria, Ilha do Fundo, Rio de Janeiro 21949-900, Brazil
Laboratório de Fisiologia Endócrina Doris Rosenthal, Laboratório de Biologia do Exercício, Instituto de Biofísica Carlos Chagas Filho and Instituto de Pesquisa Translacional em Saúde e Ambiente na Região Amazônica (INPeTAM), CCS-Bloco G- Cidade Universitria, Ilha do Fundo, Rio de Janeiro 21949-900, Brazil

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Thiago Urgal Pantaleão Laboratório de Fisiologia Endócrina Doris Rosenthal, Laboratório de Biologia do Exercício, Instituto de Biofísica Carlos Chagas Filho and Instituto de Pesquisa Translacional em Saúde e Ambiente na Região Amazônica (INPeTAM), CCS-Bloco G- Cidade Universitria, Ilha do Fundo, Rio de Janeiro 21949-900, Brazil

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Maria Carolina de Souza dos Santos Laboratório de Fisiologia Endócrina Doris Rosenthal, Laboratório de Biologia do Exercício, Instituto de Biofísica Carlos Chagas Filho and Instituto de Pesquisa Translacional em Saúde e Ambiente na Região Amazônica (INPeTAM), CCS-Bloco G- Cidade Universitria, Ilha do Fundo, Rio de Janeiro 21949-900, Brazil

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Renata Lopes Araujo Laboratório de Fisiologia Endócrina Doris Rosenthal, Laboratório de Biologia do Exercício, Instituto de Biofísica Carlos Chagas Filho and Instituto de Pesquisa Translacional em Saúde e Ambiente na Região Amazônica (INPeTAM), CCS-Bloco G- Cidade Universitria, Ilha do Fundo, Rio de Janeiro 21949-900, Brazil

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Bruno Moulin de Andrade Laboratório de Fisiologia Endócrina Doris Rosenthal, Laboratório de Biologia do Exercício, Instituto de Biofísica Carlos Chagas Filho and Instituto de Pesquisa Translacional em Saúde e Ambiente na Região Amazônica (INPeTAM), CCS-Bloco G- Cidade Universitria, Ilha do Fundo, Rio de Janeiro 21949-900, Brazil

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Monique da Silva Leandro Laboratório de Fisiologia Endócrina Doris Rosenthal, Laboratório de Biologia do Exercício, Instituto de Biofísica Carlos Chagas Filho and Instituto de Pesquisa Translacional em Saúde e Ambiente na Região Amazônica (INPeTAM), CCS-Bloco G- Cidade Universitria, Ilha do Fundo, Rio de Janeiro 21949-900, Brazil

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João Pedro Saar Werneck de Castro Laboratório de Fisiologia Endócrina Doris Rosenthal, Laboratório de Biologia do Exercício, Instituto de Biofísica Carlos Chagas Filho and Instituto de Pesquisa Translacional em Saúde e Ambiente na Região Amazônica (INPeTAM), CCS-Bloco G- Cidade Universitria, Ilha do Fundo, Rio de Janeiro 21949-900, Brazil

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Andrea Claudia Freitas Ferreira Laboratório de Fisiologia Endócrina Doris Rosenthal, Laboratório de Biologia do Exercício, Instituto de Biofísica Carlos Chagas Filho and Instituto de Pesquisa Translacional em Saúde e Ambiente na Região Amazônica (INPeTAM), CCS-Bloco G- Cidade Universitria, Ilha do Fundo, Rio de Janeiro 21949-900, Brazil

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Denise Pires de Carvalho Laboratório de Fisiologia Endócrina Doris Rosenthal, Laboratório de Biologia do Exercício, Instituto de Biofísica Carlos Chagas Filho and Instituto de Pesquisa Translacional em Saúde e Ambiente na Região Amazônica (INPeTAM), CCS-Bloco G- Cidade Universitria, Ilha do Fundo, Rio de Janeiro 21949-900, Brazil

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regulated at the transcriptional level. In accordance with our data, Baur et al . (1997) showed that 3,5-T2 stimulates D1 activity in rat anterior pituitaries in vivo . By contrast, in the thyroid gland, D1 activity is under the positive control of TSH

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-13-0502
Volume/Issue:
Volume 221: Issue 3
Open access
Noelia Martínez-Sánchez Department of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, Spain
CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela, Spain

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José M Moreno-Navarrete CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela, Spain
Department of Diabetes, Endocrinology and Nutrition, Hospital de Girona ‘Dr Josep Trueta’, Institut D’investigació Biomèdica de Girona (IdIBGi) and University of Girona, Girona, Spain

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Cristina Contreras Department of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, Spain
CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela, Spain

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Eva Rial-Pensado Department of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, Spain
CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela, Spain

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Johan Fernø Department of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, Spain
Department of Clinical Science, KG Jebsen Center for Diabetes Research, University of Bergen, Bergen, Norway

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Rubén Nogueiras Department of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, Spain
CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela, Spain

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Carlos Diéguez Department of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, Spain
CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela, Spain

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José-Manuel Fernández-Real CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela, Spain
Department of Diabetes, Endocrinology and Nutrition, Hospital de Girona ‘Dr Josep Trueta’, Institut D’investigació Biomèdica de Girona (IdIBGi) and University of Girona, Girona, Spain

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Miguel López Department of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, Spain
CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela, Spain

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, which has been described as a key factor regulating the actions of THs at the central level ( Lopez et al . 2010 , 2016 , Alvarez-Crespo et al . 2016 ). It has been known for more than a century that THs increase the basal metabolic rate ( Magnus

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-16-0425
Volume/Issue:
Volume 232: Issue 2
Open access
David M Golding School of Biosciences, Cardiff University, Cardiff, UK

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Daniel J Rees Institute of Life Sciences, College of Medicine, Swansea University, Swansea, UK

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Jennifer R Davies Behavioural Genetics Group, MRC Centre for Neuropsychiatric Genetics and Genomics, Neuroscience and Mental Health Research Institute, Schools of Medicine & Psychology, Cardiff University, Cardiff, UK

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Dinko Relkovic Behavioural Genetics Group, MRC Centre for Neuropsychiatric Genetics and Genomics, Neuroscience and Mental Health Research Institute, Schools of Medicine & Psychology, Cardiff University, Cardiff, UK

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Hannah V Furby Behavioural Genetics Group, MRC Centre for Neuropsychiatric Genetics and Genomics, Neuroscience and Mental Health Research Institute, Schools of Medicine & Psychology, Cardiff University, Cardiff, UK

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Irina A Guschina School of Biosciences, Cardiff University, Cardiff, UK

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Anna L Hopkins School of Biosciences, Cardiff University, Cardiff, UK

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Jeffrey S Davies Institute of Life Sciences, College of Medicine, Swansea University, Swansea, UK

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James L Resnick Center for Mammalian Genetics, University of Florida, College of Medicine, Gainesville, Florida, USA

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Anthony R Isles Behavioural Genetics Group, MRC Centre for Neuropsychiatric Genetics and Genomics, Neuroscience and Mental Health Research Institute, Schools of Medicine & Psychology, Cardiff University, Cardiff, UK

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Timothy Wells School of Biosciences, Cardiff University, Cardiff, UK

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Qiagen RNeasy Mini extraction kit before quantification and assessment of RNA purity. RNA was subsequently reverse transcribed using the Precision nanoScript Reverse Transcription kit (Primerdesign, Southampton, UK), 1 µg RNA being reverse transcribed in

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-16-0367
Volume/Issue:
Volume 232: Issue 1
Open access