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Intestinal FFA2 promotes obesity by altering food intake in Western diet-fed mice

Kristen R Lednovich

Kristen R Lednovich Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA

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Sophie Gough

Sophie Gough Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA

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Medha Priyadarshini

Medha Priyadarshini Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA

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Nupur Pandya

Nupur Pandya Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA

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Chioma Nnyamah

Chioma Nnyamah Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA

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Kai Xu

Kai Xu Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA

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Barton Wicksteed

Barton Wicksteed Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA

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Sidharth Mishra

Sidharth Mishra USF Center for Microbiome Research, University of South Florida Morsani College of Medicine, Tampa, Florida, USA

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Shalini Jain

Shalini Jain USF Center for Microbiome Research, University of South Florida Morsani College of Medicine, Tampa, Florida, USA

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Joseph L Zapater

Joseph L Zapater Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA
Jesse Brown Veterans Affairs Medical Center, Chicago, Illinois, USA

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Jose Cordoba-Chacon

Jose Cordoba-Chacon Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA

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Hariom Yadav

Hariom Yadav USF Center for Microbiome Research, University of South Florida Morsani College of Medicine, Tampa, Florida, USA

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Brian T Layden

Brian T Layden Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA
Jesse Brown Veterans Affairs Medical Center, Chicago, Illinois, USA

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purification with the RNeasy Mini Kit (Qiagen), and treatment with RNase-Free DNase (Qiagen). DNA-free RNA (1 µg) was reverse transcribed using iScript Reverse transcription (Bio-Rad Laboratories) and gene expression was measured by qPCR using SYBR Green

Article Type:: Research Article

DOI:: https://doi.org/10.1530/JOE-23-0184

Volume/Issue:: Volume 260: Issue 2

Open access

Does glucose-dependent insulinotropic polypeptide receptor blockade as well as agonism have a role to play in management of obesity and diabetes?

Ryan A Lafferty

Ryan A Lafferty Diabetes Research Centre, Schools of Biomedical Sciences and Pharmacy & Pharmaceutical Sciences, Ulster University, Coleraine, Northern Ireland, UK

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Peter R Flatt

Peter R Flatt Diabetes Research Centre, Schools of Biomedical Sciences and Pharmacy & Pharmaceutical Sciences, Ulster University, Coleraine, Northern Ireland, UK

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Victor A Gault

Victor A Gault Diabetes Research Centre, Schools of Biomedical Sciences and Pharmacy & Pharmaceutical Sciences, Ulster University, Coleraine, Northern Ireland, UK

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Nigel Irwin

Nigel Irwin Diabetes Research Centre, Schools of Biomedical Sciences and Pharmacy & Pharmaceutical Sciences, Ulster University, Coleraine, Northern Ireland, UK

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omental preadipocytes highlighting proliferative actions alongside a reduction in pro-apoptotic transcription factors such as Bcl-2-associated death promoter (BAD) ( Chen et al. 2021 ). Importantly, a GIPR antagonist was reported to annul these