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Bernard Freudenthal Molecular Endocrinology Laboratory, Department of Medicine, Imperial College London, London, UK

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John Logan Molecular Endocrinology Laboratory, Department of Medicine, Imperial College London, London, UK

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Sanger Institute Mouse Pipelines Mouse Pipelines, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK

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Peter I Croucher Garvan Institute of Medical Research, Sydney, New South Wales, Australia

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Graham R Williams Molecular Endocrinology Laboratory, Department of Medicine, Imperial College London, London, UK

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J H Duncan Bassett Molecular Endocrinology Laboratory, Department of Medicine, Imperial College London, London, UK

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regulated by gene regulation networks and epigenetic control, are also of great importance. Consequently, study of variations in levels of RNA transcripts has also been applied to identify new molecular mechanisms and signalling pathways involved in

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Sara Della Torre Center of Excellence on Neurodegenerative Diseases, University of Milan, Milan, Italy
Department of Pharmacological and Biomolecular Sciences, University of Milan, Milan, Italy

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Gianpaolo Rando Center of Excellence on Neurodegenerative Diseases, University of Milan, Milan, Italy
Department of Pharmacological and Biomolecular Sciences, University of Milan, Milan, Italy

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Clara Meda Center of Excellence on Neurodegenerative Diseases, University of Milan, Milan, Italy
Department of Pharmacological and Biomolecular Sciences, University of Milan, Milan, Italy

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Paolo Ciana Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy

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Luisa Ottobrini Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy

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Adriana Maggi Center of Excellence on Neurodegenerative Diseases, University of Milan, Milan, Italy
Department of Pharmacological and Biomolecular Sciences, University of Milan, Milan, Italy

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activity) and that results in a male and female differential endocrine susceptibility and gene regulation, particularly in sex steroid-responsive genes. The relevance of oestrogen programming mechanisms within the mammalian foetus and perinatal time period

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R Prasad Barts and the London School of Medicine and Dentistry, William Harvey Research Institute, Centre for Endocrinology, Queen Mary University of London, John Vane Science Centre, Charterhouse Square, London EC1M 6BQ, UK

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J C Kowalczyk Barts and the London School of Medicine and Dentistry, William Harvey Research Institute, Centre for Endocrinology, Queen Mary University of London, John Vane Science Centre, Charterhouse Square, London EC1M 6BQ, UK

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E Meimaridou Barts and the London School of Medicine and Dentistry, William Harvey Research Institute, Centre for Endocrinology, Queen Mary University of London, John Vane Science Centre, Charterhouse Square, London EC1M 6BQ, UK

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H L Storr Barts and the London School of Medicine and Dentistry, William Harvey Research Institute, Centre for Endocrinology, Queen Mary University of London, John Vane Science Centre, Charterhouse Square, London EC1M 6BQ, UK

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L A Metherell Barts and the London School of Medicine and Dentistry, William Harvey Research Institute, Centre for Endocrinology, Queen Mary University of London, John Vane Science Centre, Charterhouse Square, London EC1M 6BQ, UK

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organization and gene regulation . European Journal of Biochemistry 157 27 – 31 . ( doi:10.1111/j.1432-1033.1986.tb09633.x ) Hayashi H Oohashi M 1995 Incorporation of acetyl-CoA generated from peroxisomal β-oxidation into ethanolamine plasmalogen

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Gulizar Issa Ameen Department of Cellular and Molecular Physiology, Institute of Translational Medicine, University of Liverpool, Liverpool, UK

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Silvia Mora Department of Cellular and Molecular Physiology, Institute of Translational Medicine, University of Liverpool, Liverpool, UK

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gene (data not shown). This suggested that oestrogens may contribute to RBP4 gene regulation. To determine whether 17β-estradiol regulates Rbp4 expression in adipocytes, we treated differentiated 3T3L1 adipocytes with increasing concentrations (0, 1

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Karen Piper Hanley
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Tom Hearn Endocrinology and Diabetes Group, Human Genetics Division, Beta-Cell Development and Function Group, Peninsula Medical School, Manchester Academic Health Science Centre, University of Manchester, A V Hill Building, Oxford Road, Manchester M13 9PT, UK

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Andrew Berry
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Melanie J Carvell Endocrinology and Diabetes Group, Human Genetics Division, Beta-Cell Development and Function Group, Peninsula Medical School, Manchester Academic Health Science Centre, University of Manchester, A V Hill Building, Oxford Road, Manchester M13 9PT, UK

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Ann-Marie Patch Endocrinology and Diabetes Group, Human Genetics Division, Beta-Cell Development and Function Group, Peninsula Medical School, Manchester Academic Health Science Centre, University of Manchester, A V Hill Building, Oxford Road, Manchester M13 9PT, UK

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Louise J Williams Endocrinology and Diabetes Group, Human Genetics Division, Beta-Cell Development and Function Group, Peninsula Medical School, Manchester Academic Health Science Centre, University of Manchester, A V Hill Building, Oxford Road, Manchester M13 9PT, UK

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Sarah A Sugden
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David I Wilson Endocrinology and Diabetes Group, Human Genetics Division, Beta-Cell Development and Function Group, Peninsula Medical School, Manchester Academic Health Science Centre, University of Manchester, A V Hill Building, Oxford Road, Manchester M13 9PT, UK

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Sian Ellard Endocrinology and Diabetes Group, Human Genetics Division, Beta-Cell Development and Function Group, Peninsula Medical School, Manchester Academic Health Science Centre, University of Manchester, A V Hill Building, Oxford Road, Manchester M13 9PT, UK

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Neil A Hanley
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fetal adrenal gland: potential interactions in gene regulation . Molecular Endocrinology 15 57 – 68 doi:10.1210/me.15.1.57 . Hay CW Docherty K 2006 Comparative analysis of insulin gene promoters: implications for diabetes research

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Emma M Roberts
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Michael J F Newson
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George R Pope
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Rainer Landgraf Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, Max Planck Institute of Psychiatry, University of Bristol, Bristol BS1 3NY, UK

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Stephen J Lolait
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Anne-Marie O'Carroll
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2002 Apelin-immunoreactivity in the rat hypothalamus and pituitary . Neuroscience Letters 327 193 – 197 . Burbach JPH Luckman SM Murphy D Gainer H 2001 Gene-regulation in the magnocellular hypothalamo-neurohypophsial system

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E Meimaridou Centre for Endocrinology, William Harvey Research Institute, John Vane Science Centre, Queen Mary, University of London, London, UK

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M Goldsworthy MRC Harwell Institute, Genetics of Type 2 Diabetes, Mammalian Genetics Unit, Oxfordshire, UK

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V Chortis Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK
Centre for Endocrinology, Diabetes and Metabolism, Birmingham Health Partners, Birmingham, UK

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E Fragouli Centre for Endocrinology, William Harvey Research Institute, John Vane Science Centre, Queen Mary, University of London, London, UK

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P A Foster Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK
Centre for Endocrinology, Diabetes and Metabolism, Birmingham Health Partners, Birmingham, UK

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W Arlt Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK
Centre for Endocrinology, Diabetes and Metabolism, Birmingham Health Partners, Birmingham, UK

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R Cox MRC Harwell Institute, Genetics of Type 2 Diabetes, Mammalian Genetics Unit, Oxfordshire, UK

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L A Metherell Centre for Endocrinology, William Harvey Research Institute, John Vane Science Centre, Queen Mary, University of London, London, UK

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Sauvageau M Goff L Rinn JL Pachter L 2013 Differential analysis of gene regulation at transcript resolution with RNA-seq . Nature Biotechnology 31 46 – 53 . ( https://doi.org/10.1038/nbt.2450 ) 10.1038/nbt.2450 23222703 Vinogradov

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Andrea Lovdel University/BHF Centre for Cardiovascular Science, The University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh BioQuarter, Edinburgh, UK

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Karla J Suchacki University/BHF Centre for Cardiovascular Science, The University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh BioQuarter, Edinburgh, UK

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Fiona Roberts University/BHF Centre for Cardiovascular Science, The University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh BioQuarter, Edinburgh, UK

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Richard J Sulston University/BHF Centre for Cardiovascular Science, The University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh BioQuarter, Edinburgh, UK

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Robert J Wallace Department of Orthopaedics, The University of Edinburgh, Edinburgh, UK

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Benjamin J Thomas University/BHF Centre for Cardiovascular Science, The University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh BioQuarter, Edinburgh, UK

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Rachel M B Bell University/BHF Centre for Cardiovascular Science, The University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh BioQuarter, Edinburgh, UK

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Iris Pruñonosa Cervera University/BHF Centre for Cardiovascular Science, The University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh BioQuarter, Edinburgh, UK

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Gavin J Macpherson Department of Orthopaedic Surgery, Royal Infirmary of Edinburgh, Edinburgh, UK

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Nicholas M Morton University/BHF Centre for Cardiovascular Science, The University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh BioQuarter, Edinburgh, UK
Centre for Systems Health and Integrated Metabolic Research, Department of Biosciences, School of Science and Technology, Nottingham Trent University, Nottingham, UK

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Natalie Z M Homer University/BHF Centre for Cardiovascular Science, The University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh BioQuarter, Edinburgh, UK

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Karen E Chapman University/BHF Centre for Cardiovascular Science, The University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh BioQuarter, Edinburgh, UK

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William P Cawthorn University/BHF Centre for Cardiovascular Science, The University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh BioQuarter, Edinburgh, UK

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of mouse skin tumor promotion by adrenalectomy . Carcinogenesis 13 1925 – 1928 . ( https://doi.org/10.1093/carcin/13.10.1925 ) Pecci A Ogara MF Sanz RT & Vicent GP 2022 Choosing the right partner in hormone-dependent gene regulation

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