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WAT mass with larger adipocytes and increased lipogenic gene expression (e.g. Cidec, Fasn, Fabp1, Mogat2 ) ( Kang et al . 2013 ), indicative of enhanced adipogenesis and lipogenesis, which support our findings. Moreover, we provided additional
University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Cambridge, UK
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Cambridge University Nanjing Centre of Technology and Innovation, Nanjing, P. R. China
Centro de Investigacion Principe Felipe, Valencia, Spain
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results from an imbalance between lipid synthesis, uptake and disposal. While de novo lipogenesis does not substantially contribute to pancreatic islets’ fatty acid content, at least in non-stimulated states, circulating FFAs represent the primary source
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Systems Life Sciences Laboratory, Department of Medical Life Systems, Faculty of Life and Medical Sciences, Doshisha University, Kyoto, Japan
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Department of Sports and Fitness, Faculty of Wellness, Shigakkan University, Aichi, Japan
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2016 Acylated and desacyl ghrelin are associated with hepatic lipogenesis, β-oxidation and autophagy: role in NAFLD amelioration after sleeve gastrectomy in obese rats . Scientific Reports 39942 . ( https://doi.org/10.1038/srep39942 ) Friedman
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enhanced lipogenesis. Given the role of ZAG as an LMF, the fall of ZAG synthesis in the liver of obese mice may contribute to the hepatic accumulation of triglycerides. In addition to alterations in lipid metabolism, there are significant disturbances in
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Nutrition and Metabolism, South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia
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, together with GIP, ghrelin increases the storage of lipids by upregulating lipogenesis ( Getty-Kaushik et al . 2006 , Theander-Carrillo et al . 2006 ). On the other hand, gut hormones that increase thermogenic capacity of adipocytes can prevent the
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), or through de novo lipogenesis from glucose ( Held et al. 2018 , Jung et al. 2021 ). Further studies and techniques are required to determine the contribution of these processes to triglyceride replenishment in human BAT. MRI can also be
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Department of Metabolic Physiology, Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden
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mitochondrial fatty acid oxidation on the other side (output) – or a combination of these mechanisms. We found that the pancreatic mRNA expression of the two key enzymes in de novo lipogenesis – acetyl-CoA carboxylase 1 ( Acaca, also known as Acc1 ) and fatty
The National Institute of Biotechnology in the Negev (NIBN), Ben-Gurion University, Beer-Sheva, Israel
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histologically, a marked reversal of hepatic steatosis was observed. mRNA levels of either the rate-limiting enzyme of de-novo lipogenesis (acetyl CoA carboxylase, Acaca ) or of cholesterol biosynthesis (HMG-CoA reductase, Hmgcr ) and the lipogenic
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Foltz W Lu H Fantus IG Jin T 2012 Curcumin prevents high fat diet induced insulin resistance and obesity via attenuating lipogenesis in liver and inflammatory pathway in adipocytes . PLoS ONE 7 e28784 . ( doi:10.1371/journal.pone.0028784
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cycling between de novo lipogenesis and lipid oxidation . Endocrinology 147 31 – 38 . ( doi:10.1210/en.2005-1033 ) Stenholm S Harris TB Rantanen T Visser M Kritchevsky SB Ferrucci L 2008 Sarcopenic obesity: definition, cause and