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Carolina Gaudenzi Neuro-Epigenetics Research Group, Dorothy Hodgkin Building, University of Bristol, Bristol, United Kingdom

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Karen R Mifsud Neuro-Epigenetics Research Group, Dorothy Hodgkin Building, University of Bristol, Bristol, United Kingdom

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Johannes M H M Reul Neuro-Epigenetics Research Group, Dorothy Hodgkin Building, University of Bristol, Bristol, United Kingdom

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(ChIP) on rat hippocampus chromatin, we found that, under baseline early morning (BLAM) conditions, MR binding to GC response elements (GREs) within the well-known GC-target genes Fkbp5 (FK506 binding protein 5), Per1 (Period 1) and Sgk1 (Serum

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-22-0293
Volume/Issue:
Volume 258: Issue 2
Open access
Sebastian R Vanin Departments of Obstetrics and Gynaecology, and Physiology and Pharmacology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada

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Kendrick Lee Departments of Obstetrics and Gynaecology, and Physiology and Pharmacology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada

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Mina Nashed Department of Anatomy and Cell Biology, University of Western Ontario, London, Ontario, Canada

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Brennan Tse Department of Pathology and Laboratory Medicine, Schulich School of Medicine and Dentistry, The Lawson Health Research Institute and Children's Health Research Institute, University of Western Ontario, London, Ontario, Canada

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Mohammed Sarikahya Department of Anatomy and Cell Biology, University of Western Ontario, London, Ontario, Canada

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Sukham Brar Department of Pathology and Laboratory Medicine, Schulich School of Medicine and Dentistry, The Lawson Health Research Institute and Children's Health Research Institute, University of Western Ontario, London, Ontario, Canada

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Gregg Tomy Department of Chemistry, University of Manitoba, Winnipeg, Manitoba, Canada

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Amica-Mariae Lucas Department of Chemistry, University of Manitoba, Winnipeg, Manitoba, Canada

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Thane Tomy Department of Chemistry, University of Manitoba, Winnipeg, Manitoba, Canada

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Steven R Laviolette Department of Anatomy and Cell Biology, University of Western Ontario, London, Ontario, Canada

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Edith J Arany Department of Pathology and Laboratory Medicine, Schulich School of Medicine and Dentistry, The Lawson Health Research Institute and Children's Health Research Institute, University of Western Ontario, London, Ontario, Canada

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Daniel B Hardy Departments of Obstetrics and Gynaecology, and Physiology and Pharmacology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada
The Lawson Health Research Institute and the Children's Health Research Institute, London, Ontario, Canada

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metabolic organs ( Bailey et al. 1987 , Kim et al. 2018 ). Our laboratory recently published that gestational exposure to Δ9-THC alone in rat dams leads to symmetrical fetal growth restriction and female-specific deficits in β-cell mass, glucose

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-23-0173
Volume/Issue:
Volume 260: Issue 1
Open access
Saadia Basharat
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Jennifer A Parker Division of Diabetes, University College London, Brunel University, Endocrinology and Metabolism, Department of Investigative Medicine, Imperial College London, Hammersmith Hospital Campus, 6th Floor, Commonwealth Building, Du Cane Road, London W12 0NN, UK

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Kevin G Murphy
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Stephen R Bloom
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Julia C Buckingham Division of Diabetes, University College London, Brunel University, Endocrinology and Metabolism, Department of Investigative Medicine, Imperial College London, Hammersmith Hospital Campus, 6th Floor, Commonwealth Building, Du Cane Road, London W12 0NN, UK

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Christopher D John
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/corticosterone release from human and rat adrenal cells in vitro ( Gaillard et al . 2000 ). Thus, the possible pathogenic role for leptin in sepsis may be linked to leptin-induced suppression of the HPA axis impairing the protective role of the HPA axis in sepsis. We

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-13-0249
Volume/Issue:
Volume 221: Issue 2
Open access
Helen L Jeanes
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Caroline Tabor
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Darcey Black Centre for Cardiovascular Science, Organon Laboratories Ltd, Department Pharmacology, University of Edinburgh, Queens Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, UK

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Antwan Ederveen Centre for Cardiovascular Science, Organon Laboratories Ltd, Department Pharmacology, University of Edinburgh, Queens Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, UK

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Gillian A Gray
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rat heart ( Grohe et al . 1997 , 1998 , Jankowski et al . 2001 , Yang et al . 2004 ). Experiments using the non-selective ER antagonist ICI 182 780 have demonstrated that the 17βE 2 -induced reduction in infarct size is ER mediated ( Hayashi et

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-08-0071
Volume/Issue:
Volume 197: Issue 3
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David O'Regan Endocrinology Unit, Queen's Medical Research Institute, Centre for Cardiovascular Science, 47 Little France Crescent, Edinburgh EH16 4TJ, UK

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Christopher J Kenyon Endocrinology Unit, Queen's Medical Research Institute, Centre for Cardiovascular Science, 47 Little France Crescent, Edinburgh EH16 4TJ, UK

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Jonathan R Seckl Endocrinology Unit, Queen's Medical Research Institute, Centre for Cardiovascular Science, 47 Little France Crescent, Edinburgh EH16 4TJ, UK

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Megan C Holmes Endocrinology Unit, Queen's Medical Research Institute, Centre for Cardiovascular Science, 47 Little France Crescent, Edinburgh EH16 4TJ, UK

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variation and the role of the SNS in adult BP in animals prenatally treated with excess glucocorticoids, we used the DEX-exposed rat model. Radiotelemetry ( Anderson et al . 1999 ) enabled the remote recording of BP in conscious, unrestrained rats with

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-07-0327
Volume/Issue:
Volume 196: Issue 2
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L A Nolan Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, University of Bristol, Dorothy Hodgkin Building, Whitson Street, Bristol BS1 3NY, UK

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A Levy Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, University of Bristol, Dorothy Hodgkin Building, Whitson Street, Bristol BS1 3NY, UK

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female rat pituitary at oestrous occurs in lactotrophs and requires central brain activity in the preceding pro-oestrous afternoon ( Hashi et al . 1995 ). No statistically significant increase in the proportion of lactotrophs was observed, however

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-08-0474
Volume/Issue:
Volume 200: Issue 3
Open access
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Ryoko Yamamoto Orthodontics and Craniofacial Developmental Biology, Oral Growth and Developmental Biology, Department of Molecular Genetics, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima 734-8553, Japan

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Tomoko Minamizaki Orthodontics and Craniofacial Developmental Biology, Oral Growth and Developmental Biology, Department of Molecular Genetics, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima 734-8553, Japan

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Yuji Yoshiko Orthodontics and Craniofacial Developmental Biology, Oral Growth and Developmental Biology, Department of Molecular Genetics, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima 734-8553, Japan

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Hirotaka Yoshioka Orthodontics and Craniofacial Developmental Biology, Oral Growth and Developmental Biology, Department of Molecular Genetics, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima 734-8553, Japan

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Kazuo Tanne Orthodontics and Craniofacial Developmental Biology, Oral Growth and Developmental Biology, Department of Molecular Genetics, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima 734-8553, Japan

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Jane E Aubin Orthodontics and Craniofacial Developmental Biology, Oral Growth and Developmental Biology, Department of Molecular Genetics, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima 734-8553, Japan

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Norihiko Maeda Orthodontics and Craniofacial Developmental Biology, Oral Growth and Developmental Biology, Department of Molecular Genetics, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima 734-8553, Japan

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D 3 effect on FGF23 mRNA expression is observed in UMR-106 osteosarcoma cells ( Kolek et al . 2005 , Barthel et al . 2007 ) and fetal rat calvarial cells ( Yoshiko et al . 2007 b ). However, Pi (1–4 mM) alone does not change FGF23 promoter

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-10-0058
Volume/Issue:
Volume 206: Issue 3
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Jarrad M Scarlett Department of Pediatrics, Oregon Health and Science University, Mailcode L481, 3181 SW Sam Jackson Park Road, Portland, Oregon 97239, USA

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Darren D Bowe Department of Pediatrics, Oregon Health and Science University, Mailcode L481, 3181 SW Sam Jackson Park Road, Portland, Oregon 97239, USA

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Xinxia Zhu Department of Pediatrics, Oregon Health and Science University, Mailcode L481, 3181 SW Sam Jackson Park Road, Portland, Oregon 97239, USA

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Ayesha K Batra Department of Pediatrics, Oregon Health and Science University, Mailcode L481, 3181 SW Sam Jackson Park Road, Portland, Oregon 97239, USA

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Wilmon F Grant Department of Pediatrics, Oregon Health and Science University, Mailcode L481, 3181 SW Sam Jackson Park Road, Portland, Oregon 97239, USA

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Daniel L Marks Department of Pediatrics, Oregon Health and Science University, Mailcode L481, 3181 SW Sam Jackson Park Road, Portland, Oregon 97239, USA

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potently inhibits central melanocortin signaling by increasing Agrp mRNA expression ( Kamegai et al . 2000 ) and hyperpolarizing POMC neurons ( Cowley et al . 2003 ), has been shown to attenuate the development of cachexia in rat models of CHF ( Nagaya

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-09-0397
Volume/Issue:
Volume 206: Issue 1
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Hiroharu Mifune Institute of Animal Experimentation, Kurume University School of Medicine, Kurume, Japan

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Yuji Tajiri Division of Endocrinology and Metabolism, Kurume University School of Medicine, Kurume, Japan

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Yusuke Sakai Institute of Animal Experimentation, Kurume University School of Medicine, Kurume, Japan

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Yukie Kawahara Department of Pharmacology, Kurume University School of Medicine, Kurume, Japan

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Kento Hara Division of Endocrinology and Metabolism, Kurume University School of Medicine, Kurume, Japan

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Takahiro Sato Molecular Genetics, Life Science Institute, Kurume University, Kurume, Japan

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Yoshihiro Nishi Department of Physiology, Kurume University School of Medicine, Kurume, Japan

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Akinori Nishi Department of Pharmacology, Kurume University School of Medicine, Kurume, Japan

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Ryouichi Mitsuzono Department of Exercise Physiology, Institute of Health and Sports Science, Kurume University, Kurume, Japan

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Tatsuyuki Kakuma Bostatistics Center, Kurume University, Kurume, Japan

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Masayasu Kojima Molecular Genetics, Life Science Institute, Kurume University, Kurume, Japan

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feeding. We previously reported that voluntary exercise contributed to the amelioration of abnormal feeding behavior with a concomitant restoration of the blunted ghrelin production in a rat model of high-fat diet (HFD)-induced obesity ( Mifune et al

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-19-0213
Volume/Issue:
Volume 244: Issue 1
Open access
David Cottet-Dumoulin Cell Isolation and Transplantation Center, Department of Surgery, Geneva University Hospitals and University of Geneva, Geneva, Switzerland
Diabetes Center of the Faculty of Medicine, University of Geneva, Geneva, Switzerland

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Quentin Perrier Cell Isolation and Transplantation Center, Department of Surgery, Geneva University Hospitals and University of Geneva, Geneva, Switzerland
Diabetes Center of the Faculty of Medicine, University of Geneva, Geneva, Switzerland

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Vanessa Lavallard Cell Isolation and Transplantation Center, Department of Surgery, Geneva University Hospitals and University of Geneva, Geneva, Switzerland
Diabetes Center of the Faculty of Medicine, University of Geneva, Geneva, Switzerland

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David Matthey-Doret Cell Isolation and Transplantation Center, Department of Surgery, Geneva University Hospitals and University of Geneva, Geneva, Switzerland
Diabetes Center of the Faculty of Medicine, University of Geneva, Geneva, Switzerland

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Laura Mar Fonseca Cell Isolation and Transplantation Center, Department of Surgery, Geneva University Hospitals and University of Geneva, Geneva, Switzerland
Diabetes Center of the Faculty of Medicine, University of Geneva, Geneva, Switzerland

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Juliette Bignard Cell Isolation and Transplantation Center, Department of Surgery, Geneva University Hospitals and University of Geneva, Geneva, Switzerland
Diabetes Center of the Faculty of Medicine, University of Geneva, Geneva, Switzerland

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Reine Hanna Cell Isolation and Transplantation Center, Department of Surgery, Geneva University Hospitals and University of Geneva, Geneva, Switzerland
Diabetes Center of the Faculty of Medicine, University of Geneva, Geneva, Switzerland

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Géraldine Parnaud Cell Isolation and Transplantation Center, Department of Surgery, Geneva University Hospitals and University of Geneva, Geneva, Switzerland
Diabetes Center of the Faculty of Medicine, University of Geneva, Geneva, Switzerland

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Fanny Lebreton Cell Isolation and Transplantation Center, Department of Surgery, Geneva University Hospitals and University of Geneva, Geneva, Switzerland
Diabetes Center of the Faculty of Medicine, University of Geneva, Geneva, Switzerland

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Kevin Bellofatto Cell Isolation and Transplantation Center, Department of Surgery, Geneva University Hospitals and University of Geneva, Geneva, Switzerland
Diabetes Center of the Faculty of Medicine, University of Geneva, Geneva, Switzerland

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Ekaterine Berishvili Cell Isolation and Transplantation Center, Department of Surgery, Geneva University Hospitals and University of Geneva, Geneva, Switzerland
Diabetes Center of the Faculty of Medicine, University of Geneva, Geneva, Switzerland

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Thierry Berney Cell Isolation and Transplantation Center, Department of Surgery, Geneva University Hospitals and University of Geneva, Geneva, Switzerland
Diabetes Center of the Faculty of Medicine, University of Geneva, Geneva, Switzerland

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Domenico Bosco Cell Isolation and Transplantation Center, Department of Surgery, Geneva University Hospitals and University of Geneva, Geneva, Switzerland
Diabetes Center of the Faculty of Medicine, University of Geneva, Geneva, Switzerland

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unexplored. In this study, we aimed to assess the protein biosynthesis of rat islet cells using the BONCAT strategy that features the incorporation of azidohomoalanine (AHA) in nascent peptides. This method allows the quantification of biosynthetic activity

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-22-0304
Volume/Issue:
Volume 258: Issue 2
Open access