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Md Nurul Islam, Yuichiro Mita, Keisuke Maruyama, Ryota Tanida, Weidong Zhang, Hideyuki Sakoda and Masamitsu Nakazato

. Journal of Neuroendocrinology 542 – 554 . ( https://doi.org/10.1111/jne.12168 ) Chuang JC Sakata I Kohno D Perello M Osborne-Lawrence S Repa JJ Zigman JM 2011 Ghrelin directly stimulates glucagon secretion from pancreatic alpha

Open access

Jeffrey Friedman

glucagon. This has raised the possibility that leptin might also be of benefit for patients with type 1 diabetes who often present with weight loss and hyperphagia as a consequence of complete or partial insulin deficiency. In this setting, leptin could

Open access

Dawn E W Livingstone, Sarah L Grassick, Gillian L Currie, Brian R Walker and Ruth Andrew

by glucagon in hepatocytes . Journal of Biological Chemistry 275 11348 – 11354 . Zumoff B Strain GW Miller LK Rosner W Senie R Seres D 1990 Plasma free and nonsex-hormone-binding-globulin-bound testosterone are decreased in obese

Open access

Qinglei Yin, Liyun Shen, Yicheng Qi, Dalong Song, Lei Ye, Ying Peng, Yanqiu Wang, Zhou Jin, Guang Ning, Weiqing Wang, Dongping Lin and Shu Wang

, evolutionary conserved, NF-κB signaling pathway . Science 293 1495 – 1499 . ( https://doi.org/10.1126/science.1062677 ) Son DO Liu W Li X Prud’homme GJ Wang Q 2019 Combined effect of GABA and glucagon-like peptide-1 receptor agonist on

Open access

Manon M Roustit, Joan M Vaughan, Pauline M Jamieson and Mark E Cleasby

W 2003 Urocortin III is expressed in pancreatic β-cells and stimulates insulin and glucagon secretion . Endocrinology 144 3216 – 3224 . ( doi:10.1210/en.2002-0087 ) Li C Chen P Vaughan J Lee KF Vale W 2007 Urocortin 3 regulates

Open access

Lisa L Koorneef, Jan Kroon, Eva M G Viho, Lucas F Wahl, Kim M L Heckmans, Marloes M A R van Dorst, Menno Hoekstra, René Houtman, Hazel Hunt and Onno C Meijer

, given that GC can directly act on β-cells to stimulate insulin and glucagon release ( Delaunay et al. 1997 , Rafacho et al. 2014 ). Although CORT125281 treatment did not alter expression of insulin-dependent target genes in liver, WAT and muscle

Open access

Sian J S Simpson, Lorna I F Smith, Peter M Jones and James E Bowe

insulin secretion from mouse and human islets as well as enhancing proliferation in neonatal rat β-cells ( Huising et al . 2010 ). Similarly, β-cell-derived UCN3 has been implicated in the local regulation of both insulin and glucagon release ( Li et al

Open access

Kunihisa Hamano, Yuko Nakagawa, Yoshiaki Ohtsu, Longfei Li, Johan Medina, Yuji Tanaka, Katsuyoshi Masuda, Mitsuhisa Komatsu and Itaru Kojima

control and amplitude modulation . Diabetologia 52 738 – 751 . ( doi:10.1007/s00125-009-1314-y ) Jang HJ Kokrashvili Z Theodorakis MJ Carloson OD Kim BJ 2010 Gut-expressed gustducin and taste receptors regulate secretion of glucagon

Open access

Noelia Martínez-Sánchez, José M Moreno-Navarrete, Cristina Contreras, Eva Rial-Pensado, Johan Fernø, Rubén Nogueiras, Carlos Diéguez, José-Manuel Fernández-Real and Miguel López

glucagon-like peptide 1 (GLP-1) agonism ( Beiroa et al . 2014 ). To elucidate the contribution of hypothalamic AMPK activity on the browning of WAT by THs, we genetically activated AMPK in the VMH of rats centrally treated with T 3 . Our data showed that

Open access

Pauline Campos, Jamie J Walker and Patrice Mollard

secretion. For example, in rats fed adlibitum , isoflurane increases glycemia, glucagon and GH levels but causes decreases in insulin, ACTH and corticosterone levels ( Saha et al. 2005 ). Similarly, pulsatile LH secretion and LH concentrations are