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S Khan Centre for Cardiovascular Science, Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, UK

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D E W Livingstone Centre for Cardiovascular Science, Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, UK
Centre for Discovery Brain Science, University of Edinburgh, Hugh Robson Building, Edinburgh, UK

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A Zielinska College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK

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C L Doig Department of Biosciences, School of Science & Technology, Nottingham Trent University, Nottingham, UK

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D F Cobice Centre for Cardiovascular Science, Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, UK

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C L Esteves Centre for Cardiovascular Science, Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, UK

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J T Y Man Centre for Cardiovascular Science, Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, UK

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N Z M Homer Mass Spectrometry Core Laboratory, Edinburgh Clinical Research Facility, Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, UK

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J R Seckl Centre for Cardiovascular Science, Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, UK

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C L MacKay SIRCAMS, School of Chemistry, University of Edinburgh, Joseph Black Building, King's Buildings, Edinburgh, UK

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S P Webster Centre for Cardiovascular Science, Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, UK

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G G Lavery Department of Biosciences, School of Science & Technology, Nottingham Trent University, Nottingham, UK

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K E Chapman Centre for Cardiovascular Science, Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, UK

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B R Walker Centre for Cardiovascular Science, Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, UK
Clinical & Translational Research Institute, Newcastle University, International Centre for Life, Central Parkway, Newcastle upon Tyne, UK

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R Andrew Centre for Cardiovascular Science, Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, UK
Mass Spectrometry Core Laboratory, Edinburgh Clinical Research Facility, Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, UK

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both sexes are required, particularly given the differences in the distribution of adipose tissue between sexes, as well as sexual dimorphism in enzyme activity ( Jamieson et al. 2000 ) and other regulatory factors such as binding globulins ( Toews

Article Type:
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DOI:
https://doi.org/10.1530/JOE-23-0034
Volume/Issue:
Volume 258: Issue 3
Open access
Ryun S Ahn
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Jee H Choi Graduate School of Integrative Medicine, Hormone Research Center, Department of Obstetrics and Gynecology, Department of Family Medicine, Department of Life sciences, Research Institute of Integrative Medicine, CHA Medical University, Yuksam‐dong 605, Kangnamgu, Seoul 135-907, Republic of Korea

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Bum C Choi Graduate School of Integrative Medicine, Hormone Research Center, Department of Obstetrics and Gynecology, Department of Family Medicine, Department of Life sciences, Research Institute of Integrative Medicine, CHA Medical University, Yuksam‐dong 605, Kangnamgu, Seoul 135-907, Republic of Korea

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Jung H Kim Graduate School of Integrative Medicine, Hormone Research Center, Department of Obstetrics and Gynecology, Department of Family Medicine, Department of Life sciences, Research Institute of Integrative Medicine, CHA Medical University, Yuksam‐dong 605, Kangnamgu, Seoul 135-907, Republic of Korea

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Sung H Lee Graduate School of Integrative Medicine, Hormone Research Center, Department of Obstetrics and Gynecology, Department of Family Medicine, Department of Life sciences, Research Institute of Integrative Medicine, CHA Medical University, Yuksam‐dong 605, Kangnamgu, Seoul 135-907, Republic of Korea

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Simon S Sung Graduate School of Integrative Medicine, Hormone Research Center, Department of Obstetrics and Gynecology, Department of Family Medicine, Department of Life sciences, Research Institute of Integrative Medicine, CHA Medical University, Yuksam‐dong 605, Kangnamgu, Seoul 135-907, Republic of Korea

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: sexual dimorphism and changes across the estrous cycle . Endocrinology 138 3842 – 3848 . doi:10.1210/en.138.9.3842 . Bao AM Liu RY van Someren EJ Hofman MA Cao YX Zhou JN 2003 Diurnal rhythm of free estradiol during the menstrual

Article Type:
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DOI:
https://doi.org/10.1530/JOE-11-0247
Volume/Issue:
Volume 211: Issue 3
Open access
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Laura L Gathercole Oxford Centre for Diabetes, Endocrinology and Metabolism, NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford, UK
Department of Biological and Medical Sciences, Oxford Brookes University, Oxford, UK

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Nikolaos Nikolaou Oxford Centre for Diabetes, Endocrinology and Metabolism, NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford, UK

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Shelley E Harris Oxford Centre for Diabetes, Endocrinology and Metabolism, NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford, UK

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Anastasia Arvaniti Oxford Centre for Diabetes, Endocrinology and Metabolism, NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford, UK
Department of Biological and Medical Sciences, Oxford Brookes University, Oxford, UK

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Toryn M Poolman Oxford Centre for Diabetes, Endocrinology and Metabolism, NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford, UK

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Jonathan M Hazlehurst Oxford Centre for Diabetes, Endocrinology and Metabolism, NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford, UK
Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK

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Denise V Kratschmar Swiss Centre for Applied Human Toxicology and Division of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland

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Marijana Todorčević Oxford Centre for Diabetes, Endocrinology and Metabolism, NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford, UK

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Ahmad Moolla Oxford Centre for Diabetes, Endocrinology and Metabolism, NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford, UK

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Niall Dempster Oxford Centre for Diabetes, Endocrinology and Metabolism, NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford, UK

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Ryan C Pink Department of Biological and Medical Sciences, Oxford Brookes University, Oxford, UK

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Michael F Saikali Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada

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Liz Bentley Mammalian Genetics Unit, Medical Research Council Harwell, Oxford, UK

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Trevor M Penning Center of Excellence in Environmental Toxicology, Department of Systems Pharmacology & Translational Therapeutics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA

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Claes Ohlsson Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

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Carolyn L Cummins Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada

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Matti Poutanen Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
Institute of Biomedicine, Research Centre for Integrative Physiology and Pharmacology, University of Turku, Turku, Finland

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Alex Odermatt Swiss Centre for Applied Human Toxicology and Division of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland

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Roger D Cox Mammalian Genetics Unit, Medical Research Council Harwell, Oxford, UK

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Jeremy W Tomlinson Oxford Centre for Diabetes, Endocrinology and Metabolism, NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford, UK

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phenotype, the effect on females was mild despite a similar decrease in total bile acid levels. The mechanism that underpins the sexual dimorphism is unclear, but differences in the composition of the bile acid pool may be involved. The expression and

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-21-0280
Volume/Issue:
Volume 253: Issue 3
Open access
F Wahab Stem Cell Biology Unit, Laboratory of Reproductive Neuroendocrinology, Leibniz Institute for Primate Research, German Primate Center, Kellnerweg 4, D-37077 Göttingen, Germany

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M Shahab Stem Cell Biology Unit, Laboratory of Reproductive Neuroendocrinology, Leibniz Institute for Primate Research, German Primate Center, Kellnerweg 4, D-37077 Göttingen, Germany

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R Behr Stem Cell Biology Unit, Laboratory of Reproductive Neuroendocrinology, Leibniz Institute for Primate Research, German Primate Center, Kellnerweg 4, D-37077 Göttingen, Germany

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.1159/000332822 ) Clarkson J Herbison AE 2006 Postnatal development of kisspeptin neurons in mouse hypothalamus; sexual dimorphism and projections to gonadotropin-releasing hormone neurons . Endocrinology 147 5817 – 5825 . ( doi:10.1210/en.2006-0787 ) Cleary

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DOI:
https://doi.org/10.1530/JOE-14-0688
Volume/Issue:
Volume 225: Issue 2
Open access
David O'Regan Endocrinology Unit, Queen's Medical Research Institute, Centre for Cardiovascular Science, 47 Little France Crescent, Edinburgh EH16 4TJ, UK

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Christopher J Kenyon Endocrinology Unit, Queen's Medical Research Institute, Centre for Cardiovascular Science, 47 Little France Crescent, Edinburgh EH16 4TJ, UK

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Jonathan R Seckl Endocrinology Unit, Queen's Medical Research Institute, Centre for Cardiovascular Science, 47 Little France Crescent, Edinburgh EH16 4TJ, UK

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Megan C Holmes Endocrinology Unit, Queen's Medical Research Institute, Centre for Cardiovascular Science, 47 Little France Crescent, Edinburgh EH16 4TJ, UK

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: MacGraw Hill . Fulton CT Stallone JN 2002 Sexual dimorphism in prostanoid-potentiated vascular contraction: roles of endothelium and ovarian steroids . American Journal of Physiology 283 H2062 – H2073 . Garcia

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DOI:
https://doi.org/10.1677/JOE-07-0327
Volume/Issue:
Volume 196: Issue 2
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Seokwon Jo Department of Integrative Biology & Physiology, University of Minnesota Medical School, Minneapolis, Minnesota, USA

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Emilyn U Alejandro Department of Integrative Biology & Physiology, University of Minnesota Medical School, Minneapolis, Minnesota, USA

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glucose transporter by insulin-like growth factor I (IGF-I) . PLoS One 9 e106037 . ( https://doi.org/10.1371/journal.pone.0106037 ) Beetch M & Alejandro EU 2021 Placental mTOR signaling and sexual dimorphism in metabolic health across the lifespan

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DOI:
https://doi.org/10.1530/JOE-23-0069
Volume/Issue:
Volume 259: Issue 3
Open access
Ismael González-García Department of Physiology, CiMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, Spain
CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela, Spain

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Pablo B Martínez de Morentin Department of Physiology, CiMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, Spain
CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela, Spain

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Ánxela Estévez-Salguero Department of Physiology, CiMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, Spain
CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela, Spain

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Cristina Contreras Department of Physiology, CiMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, Spain
CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela, Spain

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Amparo Romero-Picó Department of Physiology, CiMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, Spain
CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela, Spain

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Johan Fernø Hormone Laboratory, Haukeland University Hospital, Bergen, Norway
KG Jebsen Center for Diabetes Research, Department of Clinical Science, University of Bergen, Bergen, Norway

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Rubén Nogueiras Department of Physiology, CiMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, Spain
CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela, Spain

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Carlos Diéguez Department of Physiology, CiMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, Spain
CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela, Spain

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Manuel Tena-Sempere Department of Cell Biology, Physiology and Immunology, University of Córdoba, Córdoba, Spain
Instituto Maimónides de Investigación Biomédica (IMIBIC)/Hospital Reina Sofía, Córdoba, Spain
FiDiPro Program, University of Turku, Turku, Finland

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Sulay Tovar Department of Physiology, CiMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, Spain
CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela, Spain

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Miguel López Department of Physiology, CiMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, Spain
CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela, Spain

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. ( https://doi.org/10.1016/S0169-328X(97)00351-3 ) 9526077 10.1016/S0169-328X(97)00351-3 Palmer BF Clegg DJ 2015 The sexual dimorphism of obesity . Molecular and Cellular Endocrinology 402 113 – 119 . ( https://doi.org/10.1016/j.mce.2014

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DOI:
https://doi.org/10.1530/JOE-18-0190
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Volume 238: Issue 3
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Emma Wilson Centre for Clinical Brain Sciences, The University of Edinburgh, Edinburgh, UK
Simons Initiative for the Developing Brain, The University of Edinburgh, Edinburgh, UK

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Fiona J Ramage Department of Systems Medicine, School of Medicine, University of Dundee, Dundee, UK

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Kimberley E Wever Department of Anesthesiology, Pain and Palliative Care, Radboud University Medical Center, Nijmegen, The Netherlands

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Emily S Sena Centre for Clinical Brain Sciences, The University of Edinburgh, Edinburgh, UK

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Malcolm R Macleod Centre for Clinical Brain Sciences, The University of Edinburgh, Edinburgh, UK

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Gillian L Currie Centre for Clinical Brain Sciences, The University of Edinburgh, Edinburgh, UK

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, Flenniken AM , 2017 Prevalence of sexual dimorphism in mammalian phenotypic traits . Nature Communications 8 15475. ( https://doi.org/10.1038/ncomms15475 ) Kerr NL 1998 HARKing: hypothesizing after the results are known . Personality and Social

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https://doi.org/10.1530/JOE-22-0330
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Volume 258: Issue 1
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Rachel V Richardson University/BHF Centre for Cardiovascular Science, University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh, UK

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Emma J Batchen University/BHF Centre for Cardiovascular Science, University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh, UK

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Adrian J W Thomson Edinburgh Preclinical Imaging, University of Edinburgh, Edinburgh, UK

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Rowan Darroch University/BHF Centre for Cardiovascular Science, University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh, UK

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Xinlu Pan University/BHF Centre for Cardiovascular Science, University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh, UK

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Eva A Rog-Zielinska University/BHF Centre for Cardiovascular Science, University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh, UK

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Wiktoria Wyrzykowska University/BHF Centre for Cardiovascular Science, University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh, UK

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Kathleen Scullion University/BHF Centre for Cardiovascular Science, University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh, UK

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Emad A S Al-Dujaili Dietetics, Nutrition, and Biological Sciences Department, Queen Margaret University, Musselburgh, UK

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Mary E Diaz University/BHF Centre for Cardiovascular Science, University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh, UK

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Carmel M Moran University/BHF Centre for Cardiovascular Science, University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh, UK
Edinburgh Preclinical Imaging, University of Edinburgh, Edinburgh, UK

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Christopher J Kenyon University/BHF Centre for Cardiovascular Science, University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh, UK

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Gillian A Gray University/BHF Centre for Cardiovascular Science, University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh, UK

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Karen E Chapman University/BHF Centre for Cardiovascular Science, University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh, UK

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1982 Testosterone-mediated sexual dimorphism of the rodent heart. Ventricular lysosomes, mitochondria, and cell growth are modulated by androgens . Circulation Research 50 782 – 787 . ( doi:10.1161/01.RES.50.6.782 ) Kuster GM Kotlyar E

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DOI:
https://doi.org/10.1530/JOE-16-0458
Volume/Issue:
Volume 232: Issue 3
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Neil Tanday Diabetes Research Centre, Ulster University, Coleraine, Londonderry, Northern Ireland

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Aimee Coulter-Parkhill Diabetes Research Centre, Ulster University, Coleraine, Londonderry, Northern Ireland

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R Charlotte Moffett Diabetes Research Centre, Ulster University, Coleraine, Londonderry, Northern Ireland

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Karthick Suruli Diabetes Research Centre, Ulster University, Coleraine, Londonderry, Northern Ireland

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Vaibhav Dubey Diabetes Research Centre, Ulster University, Coleraine, Londonderry, Northern Ireland

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Peter R Flatt Diabetes Research Centre, Ulster University, Coleraine, Londonderry, Northern Ireland

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Nigel Irwin Diabetes Research Centre, Ulster University, Coleraine, Londonderry, Northern Ireland

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of pharmacological interventions and drug metabolism ( Kautzky-Willer et al. 2023 ). This sexual dimorphism is poorly understood for various reasons. First, preclinical assessment of novel antidiabetic compounds generally tends to be conducted in

Article Type:
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DOI:
https://doi.org/10.1530/JOE-23-0174
Volume/Issue:
Volume 259: Issue 2
Open access