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Open access

Young Hoon Son, Seok-Jin Lee, Ki-Baek Lee, Jin-Haeng Lee, Eui Man Jeong, Sun Gun Chung, Sang-Chul Park, and In-Gyu Kim

region upstream of the transcriptional start site of Cav1 . The deletion constructs were fused with a luciferase reporter and transfected into the C2C12 myotubes. The reporter assay revealed that DEX caused a 50% reduction in luciferase activity in

Open access

Ekaterine Tskitishvili, Christel Pequeux, Carine Munaut, Renaud Viellevoye, Michelle Nisolle, Agnes Noël, and Jean-Michel Foidart

activities distinct from E2, depending on the tissues and cells and the selective binding to the nuclear/membrane form of ERα ( Abot et al . 2014 ). In general, palmitoylation regulates 17β-estradiol-induced ERα degradation and transcriptional activity ( La

Open access

Alvaro Souto Padron, Ruy Andrade Louzada Neto, Thiago Urgal Pantaleão, Maria Carolina de Souza dos Santos, Renata Lopes Araujo, Bruno Moulin de Andrade, Monique da Silva Leandro, João Pedro Saar Werneck de Castro, Andrea Claudia Freitas Ferreira, and Denise Pires de Carvalho

regulated at the transcriptional level. In accordance with our data, Baur et al . (1997) showed that 3,5-T2 stimulates D1 activity in rat anterior pituitaries in vivo . By contrast, in the thyroid gland, D1 activity is under the positive control of TSH

Open access

Jin-Ran Chen, Oxana P Lazarenko, Haijun Zhao, Alexander W Alund, and Kartik Shankar

lifestyle, such as the amount of physical activity. Intrauterine programming of bone development leading to increased risk of osteoporosis in adulthood has been recently suggested ( Dennison et al . 2013 ). Although there are no convincing data on

Open access

Ping Ye, Christopher J Kenyon, Scott M MacKenzie, Katherine Nichol, Jonathan R Seckl, Robert Fraser, John M C Connell, and Eleanor Davies

detection limit of 100 copies/μg total RNA permitted the detection of both CYP11B1 and CYP11B2 transcription throughout the rat brain and revealed that local CYP11B2 transcription increases in response to dietary sodium restriction ( Ye et al . 2003

Open access

Nadia Schoenmakers, Kyriaki S Alatzoglou, V Krishna Chatterjee, and Mehul T Dattani

. 2010 ) Trans -repression, where liganded TR's interact with and inhibit the activity of other transcription factors, has also been implicated, eg GATA2 during TR-mediated repression of TSHB ( Matsushita et al . 2007 , Santos et al . 2011

Open access

Karen Piper Hanley, Tom Hearn, Andrew Berry, Melanie J Carvell, Ann-Marie Patch, Louise J Williams, Sarah A Sugden, David I Wilson, Sian Ellard, and Neil A Hanley

give rise to the adult cell lineages, including β-cells ( Murtaugh 2007 ). Experiments manipulating genes in mice have discovered a multitude of transcription factors that regulate this transition ( Wilson et al . 2003 ). Within a subset of progenitors

Open access

I J Bujalska, L L Gathercole, J W Tomlinson, C Darimont, J Ermolieff, A N Fanjul, P A Rejto, and P M Stewart

, specifically in omental depots, can be generated from inactive circulating cortisone (in humans) or 11-dehydrocorticosterone (in rodents) through the oxo-reductase activity of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1; Bujalska et al . 1997 b

Open access

Nan Yang, Giorgio Caratti, Louise M Ince, Toryn M Poolman, Peter J Trebble, Cathy M Holt, David W Ray, and Laura C Matthews

synthetic Gc molecules modulate the activity of the near ubiquitously expressed glucocorticoid receptor (GR). The GR is a member of the nuclear hormone receptor superfamily and acts as a ligand-inducible transcription factor by interacting with chromatin to

Open access

Kevin J P Ryan, Zoe C T R Daniel, Lucinda J L Craggs, Tim Parr, and John M Brameld

the active 1,25(OH) 2 D ( Takeyama & Kato 2011 ). Activation then enables 1,25(OH) 2 D 3 to bind to the vitamin D receptor (VDR), a type of nuclear receptor, and thereby regulates transcription of a number of VitD target genes, which is thought to be