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Open access

A Edlund, M Barghouth, M Hühn, M Abels, J S E Esguerra, I G Mollet, E Svedin, A Wendt, E Renström, E Zhang, N Wierup, B J Scholte, M Flodström-Tullberg, and L Eliasson

a FVB background has reduced beta cell mass and increased insulin sensitivity at young age, but developed glucose intolerance with increased age ( Fontes et al. 2015 ). Here, we have investigated intrinsic effects of CFTR in pancreatic islet

Open access

Lei Zhang, Carol Paddon, Mark D Lewis, Fiona Grennan-Jones, and Marian Ludgate

Quon MJ Karnieli E 2006 FOXO1 represses peroxisome proliferator activator receptor gamma 1 and gamma 2 gene promoters in primary adipocytes – a novel paradigm to increase insulin sensitivity . Journal of Biological Chemistry 28 19881

Open access

Farhana Naznin, Koji Toshinai, T M Zaved Waise, Cherl NamKoong, Abu Saleh Md Moin, Hideyuki Sakoda, and Masamitsu Nakazato

intake and energy expenditure . Brain Research 1350 18 – 34 . ( doi:10.1016/j.brainres.2010.03.059 ) Schenk S Saberi M Olefsky JM 2008 Insulin sensitivity: modulation by nutrients and inflammation . Journal of Clinical Investigation 118

Open access

A Tsuchiya, T Kanno, and T Nishizaki

induces rapid hypertrophy . Molecular and Cellular Biology 24 9295 – 9304 . ( doi:10.1128/MCB.24.21.9295-9304.2004 ) Maarbjerg SJ Sylow L Richter EA 2011 Current understanding of increased insulin sensitivity after exercise

Open access

Eun Young Lee, Shuji Kaneko, Promsuk Jutabha, Xilin Zhang, Susumu Seino, Takahito Jomori, Naohiko Anzai, and Takashi Miki

independent of insulin sensitivity and β-cell function . Diabetes Care 35 1119 – 1125 . ( doi:10.2337/dc11-2050 ) Matschinsky FM Magnuson MA Zelent D Jetton TL Doliba N Han Y Taub R Grimsby J 2006 The network of glucokinase

Open access

Dawn E W Livingstone, Emma M Di Rollo, Chenjing Yang, Lucy E Codrington, John A Mathews, Madina Kara, Katherine A Hughes, Christopher J Kenyon, Brian R Walker, and Ruth Andrew

Hughes KA Livingstone DEW Gray CD Minns FC MacFarlane DP Marshall I Stewart LH Walker BR Andrew R 5α-Reductase type 1 modulates insulin sensitivity in men Journal of Clinical Endocrinology and Metabolism 2014 [in press] doi:10

Open access

Gisela Helfer and Qing-Feng Wu

, the precise mechanisms are still not clear. Targeting insulin resistance Chemerin has also been reported to regulate insulin sensitivity and glucose uptake ( Table 1 ). It is conflicting that in vitro studies using 3T3-L1 adipocytes provide

Open access

Louise Grahnemo, Caroline Jochems, Annica Andersson, Cecilia Engdahl, Claes Ohlsson, Ulrika Islander, and Hans Carlsten

by increasing hypothalamic insulin sensitivity . Journal of Neuroscience 30 16180 – 16187 . ( doi:10.1523/JNEUROSCI.3202-10.2010 ) Koetz KR Ventz M Diederich S Quinkler M 2012 Bone mineral density is not significantly reduced in adult

Open access

Valentina Pampanini, Daniela Germani, Antonella Puglianiello, Jan-Bernd Stukenborg, Ahmed Reda, Iuliia Savchuk, Kristín Rós Kjartansdóttir, Stefano Cianfarani, and Olle Söder

Duivenvoorden HJ Hofman PL Cutfield WS Hokken-Koelega AC 2005 Reduced insulin sensitivity and the presence of cardiovascular risk factors in short prepubertal children born small for gestational age (SGA) . Clinical Endocrinology 62 44

Open access

Sara Della Torre, Gianpaolo Rando, Clara Meda, Paolo Ciana, Luisa Ottobrini, and Adriana Maggi

in the regulation of glucose homeostasis in mice: insulin sensitivity in the liver . Diabetologia 49 588 – 597 . ( ) 10.1007/s00125-005-0105-3 16463047 Campbell-Thompson M Reyher KK Wilkinson LB 2001