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David M Golding School of Biosciences, Cardiff University, Cardiff, UK

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Daniel J Rees Institute of Life Sciences, College of Medicine, Swansea University, Swansea, UK

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Jennifer R Davies Behavioural Genetics Group, MRC Centre for Neuropsychiatric Genetics and Genomics, Neuroscience and Mental Health Research Institute, Schools of Medicine & Psychology, Cardiff University, Cardiff, UK

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Dinko Relkovic Behavioural Genetics Group, MRC Centre for Neuropsychiatric Genetics and Genomics, Neuroscience and Mental Health Research Institute, Schools of Medicine & Psychology, Cardiff University, Cardiff, UK

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Hannah V Furby Behavioural Genetics Group, MRC Centre for Neuropsychiatric Genetics and Genomics, Neuroscience and Mental Health Research Institute, Schools of Medicine & Psychology, Cardiff University, Cardiff, UK

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Irina A Guschina School of Biosciences, Cardiff University, Cardiff, UK

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Anna L Hopkins School of Biosciences, Cardiff University, Cardiff, UK

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Jeffrey S Davies Institute of Life Sciences, College of Medicine, Swansea University, Swansea, UK

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James L Resnick Center for Mammalian Genetics, University of Florida, College of Medicine, Gainesville, Florida, USA

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Anthony R Isles Behavioural Genetics Group, MRC Centre for Neuropsychiatric Genetics and Genomics, Neuroscience and Mental Health Research Institute, Schools of Medicine & Psychology, Cardiff University, Cardiff, UK

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Timothy Wells School of Biosciences, Cardiff University, Cardiff, UK

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supply/uptake, de novo lipogenesis and/or decreased lipolysis or lipid export, resulting in hypertrophy ( Wells 2009 ). We did not quantify intra-abdominal adipogenesis directly, but the reduced adiposity in the tibial marrow of PWS-IC del mice was

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-16-0367
Volume/Issue:
Volume 232: Issue 1
Open access
Sian J S Simpson Department of Diabetes, School of Life Course Sciences, Faculty of Life Science and Medicine, King’s College London, London, UK

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Lorna I F Smith Department of Diabetes, School of Life Course Sciences, Faculty of Life Science and Medicine, King’s College London, London, UK

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Peter M Jones Department of Diabetes, School of Life Course Sciences, Faculty of Life Science and Medicine, King’s College London, London, UK

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James E Bowe Department of Diabetes, School of Life Course Sciences, Faculty of Life Science and Medicine, King’s College London, London, UK

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-0050 ) Zouboulis CC Seltmann H Hiroi N Chen W Young M Oeff M Scherbaum WA Orfanos CE McCann SM Bornstein SR 2002 Corticotropin-releasing hormone: an autocrine hormone that promotes lipogenesis in human sebocytes . PNAS 99 7148 – 7153

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-19-0568
Volume/Issue:
Volume 245: Issue 2
Open access
Thomas Nicholson Institute of Inflammation and Ageing, MRC-ARUK Centre for Musculoskeletal Ageing Research, University of Birmingham, Birmingham, UK

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Chris Church MedImmune, Cardiovascular and Metabolic Disease (CVMD), Milstein Building, Cambridge, UK

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Kostas Tsintzas MRC-ARUK Centre for Musculoskeletal Ageing Research, School of Life Sciences, Faculty of Medicine & Health Sciences, University of Nottingham, Nottingham, UK

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Robert Jones MRC-ARUK Centre for Musculoskeletal Ageing Research, School of Life Sciences, Faculty of Medicine & Health Sciences, University of Nottingham, Nottingham, UK

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Leigh Breen Institute of Inflammation and Ageing, MRC-ARUK Centre for Musculoskeletal Ageing Research, University of Birmingham, Birmingham, UK

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Edward T Davis The Royal Orthopaedic Hospital NHS Foundation Trust, Northfield, Birmingham, UK

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David J Baker MedImmune, Cardiovascular and Metabolic Disease (CVMD), Milstein Building, Cambridge, UK

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Simon W Jones Institute of Inflammation and Ageing, MRC-ARUK Centre for Musculoskeletal Ageing Research, University of Birmingham, Birmingham, UK

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hyperglycaemia promotes lipogenesis and triacylglycerol accumulation in human skeletal muscle cells . Diabetologia 47 1452 – 1461 . ( https://doi.org/10.1007/s00125-004-1465-9 ) 15309295 Al-Khalili L Chibalin AV Kannisto K Zhang BB Permert J Holman GD

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-18-0528
Volume/Issue:
Volume 241: Issue 1
Open access
Neerav Mullur The University of Ottawa, Faculty of Medicine, Ottawa, Ontario, Canada

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Arianne Morissette The University of Ottawa Heart Institute, Ottawa, Ontario, Canada

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Nadya M Morrow The University of Ottawa Heart Institute, Ottawa, Ontario, Canada
Department of Biochemistry, Microbiology and Immunology, The University of Ottawa, Faculty of Medicine, Ottawa, Ontario, Canada

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Erin E Mulvihill The University of Ottawa Heart Institute, Ottawa, Ontario, Canada
Department of Biochemistry, Microbiology and Immunology, The University of Ottawa, Faculty of Medicine, Ottawa, Ontario, Canada

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activation in achieving weight loss in preclinical studies ( Finan et al. 2015 ). GLP-1R/GCGR agonism with cotadutide was also shown to indirectly improve experimental components of steatohepatitis through direct actions to reduce hepatic lipogenesis and

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-24-0046
Volume/Issue:
Volume 263: Issue 1
Open access
Rui Gao Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford, UK

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Samuel Acreman Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford, UK
Department of Physiology, Institute of Neuroscience and Physiology, Metabolic Research Unit, University of Gothenburg, Göteborg, Sweden

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Jinfang Ma Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford, UK

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Fernando Abdulkader Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil

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Anna Wendt Department of Clinical Sciences Malmö, Islet Cell Exocytosis, Lund University Diabetes Centre, Lund University, Malmö, Sweden

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Quan Zhang Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford, UK
CNC - Center for Neuroscience and Cell Biology, CIBB - Centre for Innovative Biomedicine and Biotechnology, University of Coimbra, Coimbra, Portugal

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enzyme that shuttles fatty acids into the mitochondria, fasting blood glucose and glucagon are reduced ( Briant et al. 2018 ). This echoes the observation that reducing lipogenesis in α-cells by knocking out acetyl-CoA-carboxylase 1 dampens glucose

Article Type:
Review Article
Collections:
100 years of glucagon: Anniversary collection
DOI:
https://doi.org/10.1530/JOE-22-0295
Volume/Issue:
Volume 258: Issue 2
Open access
Geoffrey L Hammond Departments of Cellular & Physiological Sciences and Obstetrics & Gynaecology, University of British Columbia, Vancouver, British Columbia, Canada

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-induced lipogenesis regulates the human hepatic sex hormone-binding globulin gene . Journal of Clinical Investigation 117 3979 – 3987 . Seralini GE Berube D Gagne R Hammond GL 1990 The human corticosteroid binding globulin gene is located on

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-16-0070
Volume/Issue:
Volume 230: Issue 1
Open access
Erica Yeo Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON, Canada
Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, ON, Canada

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Patricia L Brubaker Department of Physiology, University of Toronto, Toronto, ON, Canada
Department of Medicine, University of Toronto, Toronto, ON, Canada

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Deborah M Sloboda Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON, Canada
Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, ON, Canada
Department of Obstetrics, Gynecology and Pediatrics, McMaster University, Hamilton, ON, Canada

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well studied are bacterial SCFAs; SCFAs can be used directly by the host for energy, act as substrates for gluconeogenesis and lipogenesis, and bind receptors present in numerous organ systems ( Tan et al. 2014 ). Activation of SCFA receptors (GPR42

Article Type:
Review Article
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Gut microbiome special collection
DOI:
https://doi.org/10.1530/JOE-21-0354
Volume/Issue:
Volume 253: Issue 1
Open access
Antonia Hufnagel University of Cambridge Metabolic Research Laboratories and MRC Metabolic Diseases Unit, Wellcome Trust-MRC Institute of Metabolic Science, Level 4, Addenbrooke’s Hospital, Cambridge, Cambridgeshire, UK

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Laura Dearden University of Cambridge Metabolic Research Laboratories and MRC Metabolic Diseases Unit, Wellcome Trust-MRC Institute of Metabolic Science, Level 4, Addenbrooke’s Hospital, Cambridge, Cambridgeshire, UK

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Denise S Fernandez-Twinn University of Cambridge Metabolic Research Laboratories and MRC Metabolic Diseases Unit, Wellcome Trust-MRC Institute of Metabolic Science, Level 4, Addenbrooke’s Hospital, Cambridge, Cambridgeshire, UK

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Susan E Ozanne University of Cambridge Metabolic Research Laboratories and MRC Metabolic Diseases Unit, Wellcome Trust-MRC Institute of Metabolic Science, Level 4, Addenbrooke’s Hospital, Cambridge, Cambridgeshire, UK

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hyperinsulinaemia Metabolic adaptations Drastic changes in maternal physiology are necessary during pregnancy to support fetal growth and development. In early pregnancy, metabolism adapts to increase maternal energy stores by increasing lipogenesis and

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-21-0332
Volume/Issue:
Volume 253: Issue 2
Open access
Affiong Ika Oqua Section of Cell Biology and Functional Genomics, Division of Diabetes, Endocrinology and Metabolism, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK

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Yusman Manchanda Section of Cell Biology and Functional Genomics, Division of Diabetes, Endocrinology and Metabolism, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK

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Emma Rose McGlone Department of Surgery and Cancer, Imperial College London, London, UK

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Ben Jones Section of Investigative Medicine, Division of Diabetes, Endocrinology and Metabolism, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK

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Sarah Rouse Department of Life Sciences, Imperial College, London, UK

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Alejandra Tomas Section of Cell Biology and Functional Genomics, Division of Diabetes, Endocrinology and Metabolism, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK

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gluconeogenesis, as well as hepatic amino acid uptake and ureagenesis ( Marroqui et al . 2014 ), while reducing hepatic fat accumulation by increasing fatty acid oxidation and decreasing de novo lipogenesis ( Longuet et al . 2008 ). GLP-2R is expressed mainly

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-23-0335
Volume/Issue:
Volume 261: Issue 3
Open access
Samrin Kagdi Department of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada

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Sulayman A Lyons Department of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada

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Jacqueline L Beaudry Department of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada

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-activated protein kinase (AMPK), causing LPL activation and TG accumulation in differentiated 3T3-L1 cells (Kim et al. 2007). The primary role of AMPK is to stimulate the pathway which increases lipid oxidation and suppresses lipogenesis and lipolysis, while LKB1

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-23-0361
Volume/Issue:
Volume 261: Issue 3
Open access