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signalling; therefore, there is great interest in defining mechanisms underlying how local tissue Gc sensitivity is being regulated ( Yang et al . 2012 ). Amongst the best-characterised alterations in local Gc sensitivity is the acquired resistance that
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C Tanaka T Noguchi M Tomita T Fujikura J Yamamoto Y 2010 Glucocorticoid reamplification within cells intensifies NF-κB and MAPK signaling and reinforces inflammation in activated preadipocytes . American Journal of Physiology
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activation of the ERK MAPK signalling pathway by macrophage migration inhibitory factor (MIF) and dependence on JAB1/CSN5 and Src kinase activity . Cell Signalling 18 688 – 703 . ( doi:10.1016/j.cellsig.2005.06.013 ) McGarry JD Brown NF 1997 The
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in pregnancy are summarised. In obese women, impaired insulin signalling and/or pancreatic ß-cell dysfunction predispose to the development of GDM. Even before diagnosis of GDM, higher insulin levels can be detected early in pregnancy (week 16
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of perfusion and administration of CP-H spin trap was repeated. Finally, to determine the contribution of superoxide radicals to the oxidant signal generated by the heart 500 U superoxide dismutase (SOD) was perfused through the entire heart along
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responsible for this hyperoxidation of PRDX3. Inactivation of PRDX3 results in accumulation of H 2 O 2 which can diffuse into the cytosol, activating p38 MAPK signalling pathways with subsequent suppression of STAR protein synthesis and inhibition of
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Department of Endocrinology, School of Medicine, Pontificia Universidad Catolica De Chile, Santiago, Chile
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in the mitogen-activated protein kinase (MAPK) pathway and with intracellular calcium regulation ( Funder 2017 ). It is well known that activation of the aldosterone/MR pathway, in the presence of a liberal sodium (1.6% Na + ), diet, is a risk
University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Cambridge, UK
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Cambridge University Nanjing Centre of Technology and Innovation, Nanjing, P. R. China
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secretion, which suggests they might be initial signals communicating the need for increased insulin secretion to blunt lipolysis. These observations highlight the dual role of FAs in regulating β-cell function and the necessity to maintain appropriate lipid
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Department of Metabolic Physiology, Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden
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( Supplementary Fig. 4 ). To assess mitochondrial activity, we measured the signal for MitoTracker Red, a fluorescent dye that specifically accumulates within respiring mitochondria. Surprisingly, we found that the relative area staining for MitoTracker Red was 6
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period of time, and then slowly expires the animal to residual volume ( De Vleeschauwer et al. 2011 , Rinaldi et al. 2012 ). Lung compliance is calculated from the pressure–volume curve, and an average of three signals was used for subsequent