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fatty acids, which subsequently activate a specialised thermogenic protein known as uncoupling protein 1 (UCP1) ( Cannon & Nedergaard 2004 ). UCP1 is located on the inner mitochondrial membrane and generates heat by uncoupling oxidative phosphorylation
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precise mechanism of hepatic lipid accumulation remains incompletely understood, abnormal regulation of lipid disposal through fatty acid (FA) oxidation and processes affecting lipid availability, such as circulating free FA (FFA) uptake, have been
Department of Veterinary Basic Sciences, Diabetes and Obesity Research Program, Faculty of Medicine, Department of Medicine, Faculty of Medicine, Royal Veterinary College, University of London, Royal College Street, London NW1 0TU, UK
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Department of Veterinary Basic Sciences, Diabetes and Obesity Research Program, Faculty of Medicine, Department of Medicine, Faculty of Medicine, Royal Veterinary College, University of London, Royal College Street, London NW1 0TU, UK
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Department of Veterinary Basic Sciences, Diabetes and Obesity Research Program, Faculty of Medicine, Department of Medicine, Faculty of Medicine, Royal Veterinary College, University of London, Royal College Street, London NW1 0TU, UK
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Department of Veterinary Basic Sciences, Diabetes and Obesity Research Program, Faculty of Medicine, Department of Medicine, Faculty of Medicine, Royal Veterinary College, University of London, Royal College Street, London NW1 0TU, UK
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adiponectin to increase both fatty acid oxidation and glucose disposal into skeletal muscle ( Yamauchi et al . 2002 , Yoon et al . 2006 ) and additionally to improve insulin sensitivity ( Yamauchi et al . 2001 ) has been proposed, effects that have been
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Morgan SA Rose AJ Herzig S Lavery GG Odermatt A 2014 11β-Hydroxysteroid dehydrogenase-1 is involved in bile acid homeostasis by modulating fatty acid transport protein-5 in the liver of mice . Molecular Metabolism 3 554 – 564
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abundance of THRA , NRF1 , DIO1 and PPARGC1A was greater than in HS cows, a regulation which might help to switch hepatic metabolism toward fatty acid oxidation during times of energy deficiency at thermoneutrality. A switch of metabolic rate and a
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Department of Biological and Medical Sciences, Oxford Brookes University, Oxford, UK
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NIHR Birmingham Biomedical Research Centre, University Hospitals Birmingham NHS Foundation Trust and University of Birmingham, Birmingham, UK
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Department of Biological and Medical Sciences, Oxford Brookes University, Oxford, UK
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well as increasing functional de novo lipogenesis, as measured by deuterated water incorporation into fatty acids ( Nikolaou et al. 2019 b ). The data from our study now provide additional evidence of the adverse impact of AKR1D1 down
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mediator of ribosomal protein synthesis, in rodent muscle and a saturated fatty acid (SFA)/ceramide-induced increase in elongation factor 2α activation in cultured muscle cells ( Tardif et al. 2014 ). However, the nature of the lipids is important because
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Department of Physiology, Institute of Neuroscience and Physiology, Metabolic Research Unit, University of Gothenburg, Göteborg, Sweden
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CNC - Center for Neuroscience and Cell Biology, CIBB - Centre for Innovative Biomedicine and Biotechnology, University of Coimbra, Coimbra, Portugal
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can transfer phosphate to ADP to produce ATP, as it does in β-cells ( Krippeit-Drews et al. 2003 ). Moreover, it was proposed that α-cells can generate ATP via fatty acid oxidation ( Briant et al. 2018 ). In mice with α-cells lacking CPT1, an
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all three adipose-specific marker genes, PPAR γ 2 ( PPARG ; Fig. 3 A), fatty acid binding protein 4 ( FABP4 ; Fig. 3 B) and adiponectin/ ADIPOQ ( Fig. 3 C), were induced in a 1,25(OH) 2 D 3 concentration and time-dependent manner ( P <0.001 for
Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, ON, Canada
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Department of Medicine, University of Toronto, Toronto, ON, Canada
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Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, ON, Canada
Department of Obstetrics, Gynecology and Pediatrics, McMaster University, Hamilton, ON, Canada
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. 2 ), including the fermentation of non-digestible carbohydrates into short-chain fatty acids (SCFA), the processing of bile acids (BA) into secondary BAs, and the unique processing of amino acids such as tryptophan into indole compounds. The most