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Matthew W S Lim School of Cardiovascular & Metabolic Health, University of Glasgow, Glasgow, UK

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Angela K Lucas-Herald School of Cardiovascular & Metabolic Health, University of Glasgow, Glasgow, UK
Department of Paediatric Endocrinology, Royal Hospital for Children, Glasgow, UK

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Avril Mason Department of Paediatric Endocrinology, Royal Hospital for Children, Glasgow, UK

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Christian Delles School of Cardiovascular & Metabolic Health, University of Glasgow, Glasgow, UK

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Paul J Connelly School of Cardiovascular & Metabolic Health, University of Glasgow, Glasgow, UK

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showed that assisted conception with IVF was associated with an increased risk of pre-eclampsia (adjusted odds ratio (OR) 5.3, 95% CI 1.74, 15.89) when compared to those with unassisted pregnancies ( Calhoun et al. 2011 ). The findings agree with a

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-23-0309
Volume/Issue:
Volume 261: Issue 1
Open access
Ioannis Simitsidellis Centre for Inflammation Research, The University of Edinburgh, Queen’s Medical Research Institute, Edinburgh BioQuarter, Edinburgh, UK

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Arantza Esnal-Zuffiaure Centre for Inflammation Research, The University of Edinburgh, Queen’s Medical Research Institute, Edinburgh BioQuarter, Edinburgh, UK

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Olympia Kelepouri Centre for Inflammation Research, The University of Edinburgh, Queen’s Medical Research Institute, Edinburgh BioQuarter, Edinburgh, UK

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Elisabeth O’Flaherty Centre for Inflammation Research, The University of Edinburgh, Queen’s Medical Research Institute, Edinburgh BioQuarter, Edinburgh, UK

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Douglas A Gibson Centre for Inflammation Research, The University of Edinburgh, Queen’s Medical Research Institute, Edinburgh BioQuarter, Edinburgh, UK

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Philippa T K Saunders Centre for Inflammation Research, The University of Edinburgh, Queen’s Medical Research Institute, Edinburgh BioQuarter, Edinburgh, UK

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fundamental role in the establishment of pregnancy in both species ( Filant & Spencer 2013 , Spencer 2014 , Kelleher et al. 2018 ). In response to ovarian hormones endometrial stromal cells differentiate into specialised secretory decidual cells which

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-19-0153
Volume/Issue:
Volume 242: Issue 3
Open access
Scott Haston Developmental Biology and Cancer Research Programme, Birth Defects Research Centre, UCL Great Ormond Street Institute of Child Health, London, UK

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Saba Manshaei Developmental Biology and Cancer Research Programme, Birth Defects Research Centre, UCL Great Ormond Street Institute of Child Health, London, UK

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Juan Pedro Martinez-Barbera Developmental Biology and Cancer Research Programme, Birth Defects Research Centre, UCL Great Ormond Street Institute of Child Health, London, UK

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for plasticity in regulating the number and proportion of secretory cell types in response to physiological changes, such as puberty and pregnancy ( Melmed 2003 , Perez-Castro et al. 2012 ). Recently, it has been demonstrated that the AL contains

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-17-0258
Volume/Issue:
Volume 236: Issue 1
Open access
David E Maridas Maine Medical Center Research Institute, Scarborough, Maine, USA

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Victoria E DeMambro Maine Medical Center Research Institute, Scarborough, Maine, USA

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Phuong T Le Maine Medical Center Research Institute, Scarborough, Maine, USA

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Kenichi Nagano Harvard School of Dental Medicine, Boston, Massachusetts, USA

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Roland Baron Harvard School of Dental Medicine, Boston, Massachusetts, USA

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Subburaman Mohan VA Loma Linda Healthcare System, Loma Linda, California, USA

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Clifford J Rosen Maine Medical Center Research Institute, Scarborough, Maine, USA

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et al . 2013 ). IGFBP-4, which is highly expressed in adipocytes and osteoblasts, is the smallest IGF-binding protein and contains a cleavage site for pregnancy-associated plasma protein A (PAPPA). It also circulates in relatively substantial amounts

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-16-0673
Volume/Issue:
Volume 233: Issue 1
Open access
Ekaterine Tskitishvili Department of Obstetrics and Gynecology/Department of Clinical Sciences, Laboratory of Development Biology and Tumor, GIGA-Cancer, University of Liege, Liege, Belgium

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Christel Pequeux Department of Obstetrics and Gynecology/Department of Clinical Sciences, Laboratory of Development Biology and Tumor, GIGA-Cancer, University of Liege, Liege, Belgium

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Carine Munaut Department of Obstetrics and Gynecology/Department of Clinical Sciences, Laboratory of Development Biology and Tumor, GIGA-Cancer, University of Liege, Liege, Belgium

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Renaud Viellevoye Department of Pediatrics, Neonatal Intensive Care Unit, University of Liege, CHR de la CITADELLE, Liege, Belgium

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Michelle Nisolle Department of Obstetrics and Gynecology, University of Liege, CHR de la CITADELLE, Liege, Belgium

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Agnes Noël Department of Obstetrics and Gynecology/Department of Clinical Sciences, Laboratory of Development Biology and Tumor, GIGA-Cancer, University of Liege, Liege, Belgium

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Jean-Michel Foidart Department of Obstetrics and Gynecology/Department of Clinical Sciences, Laboratory of Development Biology and Tumor, GIGA-Cancer, University of Liege, Liege, Belgium

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to 1 mg/kg/day at term of pregnancy and results of a cooperativity between fetal adrenals, placenta and fetal liver. It is detected in maternal urine from about 9 weeks of gestation, substantially increasing during pregnancy ( Holinka et al . 2008

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-16-0434
Volume/Issue:
Volume 232: Issue 1
Open access
E J Agnew Centre for Cardiovascular Science, The University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh, UK

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A Garcia-Burgos Centre for Cardiovascular Science, The University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh, UK

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R V Richardson Centre for Cardiovascular Science, The University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh, UK

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H Manos Centre for Cardiovascular Science, The University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh, UK

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A J W Thomson Centre for Cardiovascular Science, The University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh, UK

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K Sooy Mass Spectrometry Core, Edinburgh Clinical Research Facility, Centre for Cardiovascular Science, The University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh, UK

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G Just Mass Spectrometry Core, Edinburgh Clinical Research Facility, Centre for Cardiovascular Science, The University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh, UK

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N Z M Homer Mass Spectrometry Core, Edinburgh Clinical Research Facility, Centre for Cardiovascular Science, The University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh, UK

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C M Moran Centre for Cardiovascular Science, The University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh, UK

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P J Brunton Centre for Discovery Brain Sciences, The University of Edinburgh, Hugh Robson Building, George Square, Edinburgh, UK

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G A Gray Centre for Cardiovascular Science, The University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh, UK

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K E Chapman Centre for Cardiovascular Science, The University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh, UK

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inhibition of neuroendocrine stress responses in pregnancy in the rat is induced by the neurosteroid allopregnanolone . Journal of Neuroscience 29 6449 – 6460 . ( https://doi.org/10.1523/JNEUROSCI.0708-09.2009 ) 10.1523/JNEUROSCI.0708-09.2009 Brunton

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-18-0666
Volume/Issue:
Volume 241: Issue 3
Open access
Dawn E W Livingstone Endocrinology, Queen's Medical Research Institute, University and British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK

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Emma M Di Rollo Endocrinology, Queen's Medical Research Institute, University and British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK

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Chenjing Yang Endocrinology, Queen's Medical Research Institute, University and British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK

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Lucy E Codrington Endocrinology, Queen's Medical Research Institute, University and British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK

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John A Mathews Endocrinology, Queen's Medical Research Institute, University and British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK

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Madina Kara Endocrinology, Queen's Medical Research Institute, University and British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK

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Katherine A Hughes Endocrinology, Queen's Medical Research Institute, University and British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK

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Christopher J Kenyon Endocrinology, Queen's Medical Research Institute, University and British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK

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Brian R Walker Endocrinology, Queen's Medical Research Institute, University and British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK

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Ruth Andrew Endocrinology, Queen's Medical Research Institute, University and British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK

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-A receptors to reduce neuronal excitability; this may impinge upon the HPA axis and attenuate stress responses, as is most apparent during late pregnancy ( Russell & Brunton 2006 ). These findings may be relevant to clinical practice. It is notable that in

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-13-0563
Volume/Issue:
Volume 222: Issue 2
Open access
Lesley A Hill Departments of Cellular and Physiological Sciences and Obstetrics and Gynaecology, The University of British Columbia, Vancouver, British Columbia, Canada

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Dimitra A Vassiliadi Endocrine Unit, Second Department of Internal Medicine-Research Institute and Diabetes Center, Attiko University Hospital, Athens, Greece

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Ioanna Dimopoulou Endocrine Unit, Second Department of Internal Medicine-Research Institute and Diabetes Center, Attiko University Hospital, Athens, Greece

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Anna J Anderson BHF Centre for Cardiovascular Science, Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom

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Luke D Boyle BHF Centre for Cardiovascular Science, Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom

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Alixe H M Kilgour BHF Centre for Cardiovascular Science, Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom

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Roland H Stimson BHF Centre for Cardiovascular Science, Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom

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Yoan Machado Department of Biochemistry and Molecular Biology, The University of British Columbia, Vancouver, British Columbia, Canada

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Christopher M Overall Department of Biochemistry and Molecular Biology, The University of British Columbia, Vancouver, British Columbia, Canada

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Brian R Walker BHF Centre for Cardiovascular Science, Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom
Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom

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John G Lewis Canterbury Health Laboratories, Christchurch, New Zealand

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Geoffrey L Hammond Departments of Cellular and Physiological Sciences and Obstetrics and Gynaecology, The University of British Columbia, Vancouver, British Columbia, Canada

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instance during pregnancy or oral contraceptive use ( Nenke et al. 2017 b ), there are no obvious sex differences in the frequency of the discordancy in these ELISA measurements. It is therefore possible that linkage disequilibrium between rs12589136

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-18-0479
Volume/Issue:
Volume 240: Issue 1
Open access
Stuart A Lanham Bone and Joint Research Group, Centre for Human Development, Stem Cells and Regeneration, School of Medicine, University of Southampton, Southampton, UK

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Dominique Blache School of Agriculture and Environment, University of Western Australia, Crawley, Australia

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Richard O C Oreffo Bone and Joint Research Group, Centre for Human Development, Stem Cells and Regeneration, School of Medicine, University of Southampton, Southampton, UK

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Abigail L Fowden Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK

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Alison J Forhead Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK
Department of Biological and Medical Sciences, Oxford Brookes University, Oxford, UK

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gestational ages: 129 and 144 days of gestation, where term is 145 ± 2 days; Table 1 ). In four ewes with a twin pregnancy, the pancreas was removed in one fetus while the other acted as the sham-operated control; in three twin-bearing ewes, only one of the

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-21-0189
Volume/Issue:
Volume 252: Issue 1
Open access
Lianne Abrahams School of Clinical and Experimental Medicine, Institute of Biomedical Research, Centre for Endocrinology, Diabetes and Metabolism, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK

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Nina M Semjonous School of Clinical and Experimental Medicine, Institute of Biomedical Research, Centre for Endocrinology, Diabetes and Metabolism, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK

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Phil Guest School of Clinical and Experimental Medicine, Institute of Biomedical Research, Centre for Endocrinology, Diabetes and Metabolism, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK

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Agnieszka Zielinska School of Clinical and Experimental Medicine, Institute of Biomedical Research, Centre for Endocrinology, Diabetes and Metabolism, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK

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Beverly Hughes School of Clinical and Experimental Medicine, Institute of Biomedical Research, Centre for Endocrinology, Diabetes and Metabolism, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK

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Gareth G Lavery School of Clinical and Experimental Medicine, Institute of Biomedical Research, Centre for Endocrinology, Diabetes and Metabolism, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK

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Paul M Stewart School of Clinical and Experimental Medicine, Institute of Biomedical Research, Centre for Endocrinology, Diabetes and Metabolism, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK

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:10.1210/en.2010-0957 . Shams M Kilby MD Somerset DA Howie AJ Gupta A Wood PJ Afnan M Stewart PM 1998 11-β Hydroxysteroid dehydrogenase type 2 in human pregnancy and reduced expression in intrauterine growth restriction . Human

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-12-0178
Volume/Issue:
Volume 214: Issue 3
Open access
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