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R Prasad Barts and the London School of Medicine and Dentistry, William Harvey Research Institute, Centre for Endocrinology, Queen Mary University of London, John Vane Science Centre, Charterhouse Square, London EC1M 6BQ, UK

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J C Kowalczyk Barts and the London School of Medicine and Dentistry, William Harvey Research Institute, Centre for Endocrinology, Queen Mary University of London, John Vane Science Centre, Charterhouse Square, London EC1M 6BQ, UK

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E Meimaridou Barts and the London School of Medicine and Dentistry, William Harvey Research Institute, Centre for Endocrinology, Queen Mary University of London, John Vane Science Centre, Charterhouse Square, London EC1M 6BQ, UK

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H L Storr Barts and the London School of Medicine and Dentistry, William Harvey Research Institute, Centre for Endocrinology, Queen Mary University of London, John Vane Science Centre, Charterhouse Square, London EC1M 6BQ, UK

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L A Metherell Barts and the London School of Medicine and Dentistry, William Harvey Research Institute, Centre for Endocrinology, Queen Mary University of London, John Vane Science Centre, Charterhouse Square, London EC1M 6BQ, UK

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, differentiation, apoptosis, immune regulation and cellular adaptation to stress ( Ray et al . 2012 , Sena & Chandel 2012 ). A critical balance in redox status needs to be maintained and this is achieved by numerous interacting antioxidant pathways. Oxidative

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-13-0346
Volume/Issue:
Volume 221: Issue 3
Open access
Maayan Vatarescu The Department of Clinical Biochemistry and Pharmacology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel
The National Institute of Biotechnology in the Negev (NIBN), Ben-Gurion University, Beer-Sheva, Israel

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Sapir Bechor The Department of Clinical Biochemistry and Pharmacology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel
The National Institute of Biotechnology in the Negev (NIBN), Ben-Gurion University, Beer-Sheva, Israel

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Yulia Haim The Department of Clinical Biochemistry and Pharmacology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel
The National Institute of Biotechnology in the Negev (NIBN), Ben-Gurion University, Beer-Sheva, Israel

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Tal Pecht The Department of Clinical Biochemistry and Pharmacology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel
The National Institute of Biotechnology in the Negev (NIBN), Ben-Gurion University, Beer-Sheva, Israel

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Tanya Tarnovscki The Department of Clinical Biochemistry and Pharmacology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel

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Noa Slutsky The Department of Clinical Biochemistry and Pharmacology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel

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Ori Nov The Department of Clinical Biochemistry and Pharmacology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel

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Hagit Shapiro The Department of Clinical Biochemistry and Pharmacology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel

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Avishai Shemesh The Shraga Segal Department of Microbiology, Immunology and Genetics, Ben-Gurion University, Beer-Sheva, Israel

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Angel Porgador The Shraga Segal Department of Microbiology, Immunology and Genetics, Ben-Gurion University, Beer-Sheva, Israel

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Nava Bashan The Department of Clinical Biochemistry and Pharmacology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel

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Assaf Rudich The Department of Clinical Biochemistry and Pharmacology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel
The National Institute of Biotechnology in the Negev (NIBN), Ben-Gurion University, Beer-Sheva, Israel

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→NC compared to NC control ( Fig. 3F ). Figure 3 Adipose tissue adaptation to 2 weeks obesity reversal. (A and B) Representative blots and densitometry ( n  = 7–12/group from 2 to 3 independent experiments) of insulin signaling proteins in epididymal

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-17-0007
Volume/Issue:
Volume 233: Issue 3
Open access
Bettina Geidl-Flueck Department of Endocrinology, Diabetology and Clinical Nutrition, University Hospital Zurich (USZ) and University of Zurich (UZH), Switzerland

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Philipp A Gerber Department of Endocrinology, Diabetology and Clinical Nutrition, University Hospital Zurich (USZ) and University of Zurich (UZH), Switzerland

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increase fructose absorption and catabolism in the liver, exacerbating the metabolic effects. Sugar/fructose consumption should be reduced to avoid these unfavorable metabolic adaptations. Declaration of interest The authors declare no conflict of

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-22-0270
Volume/Issue:
Volume 257: Issue 2
Open access
Vicki Chen Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada

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Gia V Shelp Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada

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Jacob L Schwartz Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada

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Niklas D J Aardema Department of Nutrition, Dietetics and Food Sciences, Utah State University, Logan, Utah, United States

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Madison L Bunnell Department of Nutrition, Dietetics and Food Sciences, Utah State University, Logan, Utah, United States

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Clara E Cho Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada

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, weight gain, body composition, and blood glucose measures do not indicate which changes occurred first. We are aware that dynamics of food intake and body weight exist, including a rate of adaptation that may be an important predictor of energy regulation

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-22-0305
Volume/Issue:
Volume 257: Issue 2
Open access
Corinne Caillaud Exercise Health and Performance, Faculty of Health and Medical Sciences, Department of Neuroscience and Pharmacology, School of Medicine and Pharmacology, UMR CNRS 9214, Physiology Department, Department of Endocrinology, Inflammation and Infection Research, Faculty of Health Sciences, and Charles Perkins Centre, The University of Sydney, Sydney, New South Wales, Australia

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Mie Mechta Exercise Health and Performance, Faculty of Health and Medical Sciences, Department of Neuroscience and Pharmacology, School of Medicine and Pharmacology, UMR CNRS 9214, Physiology Department, Department of Endocrinology, Inflammation and Infection Research, Faculty of Health Sciences, and Charles Perkins Centre, The University of Sydney, Sydney, New South Wales, Australia

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Heidi Ainge Exercise Health and Performance, Faculty of Health and Medical Sciences, Department of Neuroscience and Pharmacology, School of Medicine and Pharmacology, UMR CNRS 9214, Physiology Department, Department of Endocrinology, Inflammation and Infection Research, Faculty of Health Sciences, and Charles Perkins Centre, The University of Sydney, Sydney, New South Wales, Australia

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Andreas N Madsen Exercise Health and Performance, Faculty of Health and Medical Sciences, Department of Neuroscience and Pharmacology, School of Medicine and Pharmacology, UMR CNRS 9214, Physiology Department, Department of Endocrinology, Inflammation and Infection Research, Faculty of Health Sciences, and Charles Perkins Centre, The University of Sydney, Sydney, New South Wales, Australia
Exercise Health and Performance, Faculty of Health and Medical Sciences, Department of Neuroscience and Pharmacology, School of Medicine and Pharmacology, UMR CNRS 9214, Physiology Department, Department of Endocrinology, Inflammation and Infection Research, Faculty of Health Sciences, and Charles Perkins Centre, The University of Sydney, Sydney, New South Wales, Australia

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Patricia Ruell Exercise Health and Performance, Faculty of Health and Medical Sciences, Department of Neuroscience and Pharmacology, School of Medicine and Pharmacology, UMR CNRS 9214, Physiology Department, Department of Endocrinology, Inflammation and Infection Research, Faculty of Health Sciences, and Charles Perkins Centre, The University of Sydney, Sydney, New South Wales, Australia

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Emilie Mas Exercise Health and Performance, Faculty of Health and Medical Sciences, Department of Neuroscience and Pharmacology, School of Medicine and Pharmacology, UMR CNRS 9214, Physiology Department, Department of Endocrinology, Inflammation and Infection Research, Faculty of Health Sciences, and Charles Perkins Centre, The University of Sydney, Sydney, New South Wales, Australia

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Catherine Bisbal Exercise Health and Performance, Faculty of Health and Medical Sciences, Department of Neuroscience and Pharmacology, School of Medicine and Pharmacology, UMR CNRS 9214, Physiology Department, Department of Endocrinology, Inflammation and Infection Research, Faculty of Health Sciences, and Charles Perkins Centre, The University of Sydney, Sydney, New South Wales, Australia

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Jacques Mercier Exercise Health and Performance, Faculty of Health and Medical Sciences, Department of Neuroscience and Pharmacology, School of Medicine and Pharmacology, UMR CNRS 9214, Physiology Department, Department of Endocrinology, Inflammation and Infection Research, Faculty of Health Sciences, and Charles Perkins Centre, The University of Sydney, Sydney, New South Wales, Australia
Exercise Health and Performance, Faculty of Health and Medical Sciences, Department of Neuroscience and Pharmacology, School of Medicine and Pharmacology, UMR CNRS 9214, Physiology Department, Department of Endocrinology, Inflammation and Infection Research, Faculty of Health Sciences, and Charles Perkins Centre, The University of Sydney, Sydney, New South Wales, Australia

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Stephen Twigg Exercise Health and Performance, Faculty of Health and Medical Sciences, Department of Neuroscience and Pharmacology, School of Medicine and Pharmacology, UMR CNRS 9214, Physiology Department, Department of Endocrinology, Inflammation and Infection Research, Faculty of Health Sciences, and Charles Perkins Centre, The University of Sydney, Sydney, New South Wales, Australia

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Trevor A Mori Exercise Health and Performance, Faculty of Health and Medical Sciences, Department of Neuroscience and Pharmacology, School of Medicine and Pharmacology, UMR CNRS 9214, Physiology Department, Department of Endocrinology, Inflammation and Infection Research, Faculty of Health Sciences, and Charles Perkins Centre, The University of Sydney, Sydney, New South Wales, Australia

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David Simar Exercise Health and Performance, Faculty of Health and Medical Sciences, Department of Neuroscience and Pharmacology, School of Medicine and Pharmacology, UMR CNRS 9214, Physiology Department, Department of Endocrinology, Inflammation and Infection Research, Faculty of Health Sciences, and Charles Perkins Centre, The University of Sydney, Sydney, New South Wales, Australia

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Romain Barrès Exercise Health and Performance, Faculty of Health and Medical Sciences, Department of Neuroscience and Pharmacology, School of Medicine and Pharmacology, UMR CNRS 9214, Physiology Department, Department of Endocrinology, Inflammation and Infection Research, Faculty of Health Sciences, and Charles Perkins Centre, The University of Sydney, Sydney, New South Wales, Australia

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, Alnaeeli et al . 2014 ). Partial recovery of glucose tolerance was accompanied by recovery of baseline glucose levels in the HFD/EPO group while insulin levels were not yet affected. It is tempting to speculate that we observed early adaptations, and that

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-15-0010
Volume/Issue:
Volume 225: Issue 2
Open access
Rachel V Richardson University/BHF Centre for Cardiovascular Science, University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh, UK

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Emma J Batchen University/BHF Centre for Cardiovascular Science, University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh, UK

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Adrian J W Thomson Edinburgh Preclinical Imaging, University of Edinburgh, Edinburgh, UK

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Rowan Darroch University/BHF Centre for Cardiovascular Science, University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh, UK

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Xinlu Pan University/BHF Centre for Cardiovascular Science, University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh, UK

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Eva A Rog-Zielinska University/BHF Centre for Cardiovascular Science, University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh, UK

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Wiktoria Wyrzykowska University/BHF Centre for Cardiovascular Science, University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh, UK

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Kathleen Scullion University/BHF Centre for Cardiovascular Science, University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh, UK

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Emad A S Al-Dujaili Dietetics, Nutrition, and Biological Sciences Department, Queen Margaret University, Musselburgh, UK

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Mary E Diaz University/BHF Centre for Cardiovascular Science, University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh, UK

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Carmel M Moran University/BHF Centre for Cardiovascular Science, University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh, UK
Edinburgh Preclinical Imaging, University of Edinburgh, Edinburgh, UK

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Christopher J Kenyon University/BHF Centre for Cardiovascular Science, University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh, UK

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Gillian A Gray University/BHF Centre for Cardiovascular Science, University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh, UK

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Karen E Chapman University/BHF Centre for Cardiovascular Science, University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh, UK

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-control study . Heart 90 859 – 865 . ( doi:10.1136/hrt.2003.020180 ) Swynghedauw B 1986 Developmental and functional adaptation of contractile proteins in cardiac and skeletal muscles . Physiological Reviews 66 710 – 771 . Ueda K Fujiki

Article Type:
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DOI:
https://doi.org/10.1530/JOE-16-0458
Volume/Issue:
Volume 232: Issue 3
Open access
Nele Cielen Laboratory of Respiratory Diseases, Department of Clinical and Experimental Medicine, KULeuven, Leuven, Belgium

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Nele Heulens Laboratory of Respiratory Diseases, Department of Clinical and Experimental Medicine, KULeuven, Leuven, Belgium

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Karen Maes Laboratory of Respiratory Diseases, Department of Clinical and Experimental Medicine, KULeuven, Leuven, Belgium

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Geert Carmeliet Laboratory of Clinical and Experimental Endocrinology, Department of Clinical and Experimental Medicine, KULeuven, Leuven, Belgium

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Chantal Mathieu Laboratory of Clinical and Experimental Endocrinology, Department of Clinical and Experimental Medicine, KULeuven, Leuven, Belgium

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Wim Janssens Laboratory of Respiratory Diseases, Department of Clinical and Experimental Medicine, KULeuven, Leuven, Belgium

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Ghislaine Gayan-Ramirez Laboratory of Respiratory Diseases, Department of Clinical and Experimental Medicine, KULeuven, Leuven, Belgium

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particularly relevant for patients with COPD in whom limb muscle adaptation to COPD consists of a fiber shift toward a type II profile. Interestingly, these type II fibers seem to be preferentially affected in our model, as shown by predominant fiber atrophy

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-15-0491
Volume/Issue:
Volume 229: Issue 2
Open access
Jianshu Chen Lanzhou University Second College of Clinical Medicine, Lanzhou, China

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Jing Yu Lanzhou University Second College of Clinical Medicine, Lanzhou, China
Department of Cardiology, Lanzhou University Second Hospital, Lanzhou, China

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Ruowen Yuan Department of Cardiology, Lanzhou University Second Hospital, Lanzhou, China

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Ningyin Li Department of Cardiology, Lanzhou University Second Hospital, Lanzhou, China

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Caie Li Department of Cardiology, Lanzhou University Second Hospital, Lanzhou, China

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Xiaofang Zhang Department of Cardiology, Lanzhou University Second Hospital, Lanzhou, China

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K Sale MJ Howarth KD Hampson M Smith PD Guichard SM Cook SJ 2014 Adaptation to mTOR kinase inhibitors by amplification of eIF4E to maintain cap-dependent translation . Journal of Cell Science 127 788 – 800 . ( https://doi.org/10.1242/jcs

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DOI:
https://doi.org/10.1530/JOE-21-0284
Volume/Issue:
Volume 252: Issue 3
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Neil Tanday Diabetes Research Centre, Ulster University, Coleraine, Londonderry, Northern Ireland

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Aimee Coulter-Parkhill Diabetes Research Centre, Ulster University, Coleraine, Londonderry, Northern Ireland

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R Charlotte Moffett Diabetes Research Centre, Ulster University, Coleraine, Londonderry, Northern Ireland

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Karthick Suruli Diabetes Research Centre, Ulster University, Coleraine, Londonderry, Northern Ireland

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Vaibhav Dubey Diabetes Research Centre, Ulster University, Coleraine, Londonderry, Northern Ireland

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Peter R Flatt Diabetes Research Centre, Ulster University, Coleraine, Londonderry, Northern Ireland

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Nigel Irwin Diabetes Research Centre, Ulster University, Coleraine, Londonderry, Northern Ireland

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composed of more alpha cells than males, with no obvious difference in turnover rates. Thus, our observations of increased alpha-to-beta-cell transdifferentiation in female mice may be related to this phenomenon as an inherent adaptation to increased alpha

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-23-0174
Volume/Issue:
Volume 259: Issue 2
Open access
K L Davies Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge, UK

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J Miles Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge, UK

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E J Camm Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge, UK
The Ritchie Centre, Hudson Institute of Medical Research, Clayton, Australia

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D J Smith Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge, UK

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P Barker MRC Metabolic Diseases Unit, Mouse Biochemistry Laboratory, Cambridge Biomedical Campus, Cambridge, UK

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K Taylor Endocrine Laboratory, Blood Sciences, Cambridge University Hospitals NHS Foundation Trust, Hills Road, Cambridge, UK

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A J Forhead Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge, UK
Department of Biological and Medical Sciences, Oxford Brookes University, Oxford, UK

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A L Fowden Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge, UK

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2017 Prenatal corticosterone exposure programs sex-specific adrenal adaptations in mouse offspring . Journal of Endocrinology 232 37 – 48 . ( https://doi.org/10.1530/JOE-16-0417 ) Davies KL Camm EJ Atkinson EV Lopez T Forhead AJ Murray AJ

Article Type:
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DOI:
https://doi.org/10.1530/JOE-23-0326
Volume/Issue:
Volume 260: Issue 3
Open access