Search Results

You are looking at 31 - 40 of 132 items for :

  • transcription factor x
  • Refine by access: Open Access content only x
Clear All
Rebecca J Ainslie Institute for Regeneration and Repair, the University of Edinburgh, Edinburgh BioQuarter, Edinburgh, United Kingdom

Search for other papers by Rebecca J Ainslie in
Google Scholar
PubMed
Close
,
Ioannis Simitsidellis Institute for Regeneration and Repair, the University of Edinburgh, Edinburgh BioQuarter, Edinburgh, United Kingdom

Search for other papers by Ioannis Simitsidellis in
Google Scholar
PubMed
Close
,
Phoebe M Kirkwood Institute for Regeneration and Repair, the University of Edinburgh, Edinburgh BioQuarter, Edinburgh, United Kingdom

Search for other papers by Phoebe M Kirkwood in
Google Scholar
PubMed
Close
, and
Douglas A Gibson Institute for Regeneration and Repair, the University of Edinburgh, Edinburgh BioQuarter, Edinburgh, United Kingdom

Search for other papers by Douglas A Gibson in
Google Scholar
PubMed
Close

2016 )). Specifically, regulation of gene expression by AR can be mediated via interaction with general transcription factors (such as SRC-1 and TF II H), components of the chromatin remodelling complex (such as SWI/SNF), histone-modifying enzymes and

Open access
Yaxiong Huang Department of Reproductive Medicine center, Zhongnan Hospital of Wuhan University, Wuhan, Hubei Province, PR China
Hubei Clinical Research Center for Prenatal Diagnosis and Birth Health, Wuhan Hubei Province, PR China
Wuhan Clinical Research Center for Reproductive Science and Birth Health, Wuhan Hubei Province, PR China
Department of Gynaecology and Obstetrics, Sinopharm Dongfeng Hospital, Hubei University of Medicine, Shiyan, Hubei Province, PR China

Search for other papers by Yaxiong Huang in
Google Scholar
PubMed
Close
,
Zihan Wang Department of Reproductive Medicine center, Zhongnan Hospital of Wuhan University, Wuhan, Hubei Province, PR China
Hubei Clinical Research Center for Prenatal Diagnosis and Birth Health, Wuhan Hubei Province, PR China
Wuhan Clinical Research Center for Reproductive Science and Birth Health, Wuhan Hubei Province, PR China

Search for other papers by Zihan Wang in
Google Scholar
PubMed
Close
,
Bin Li Department of Gynaecology and Obstetrics, Sinopharm Dongfeng Hospital, Hubei University of Medicine, Shiyan, Hubei Province, PR China

Search for other papers by Bin Li in
Google Scholar
PubMed
Close
,
Lina Ke Department of Gynaecology and Obstetrics, Sinopharm Dongfeng Hospital, Hubei University of Medicine, Shiyan, Hubei Province, PR China

Search for other papers by Lina Ke in
Google Scholar
PubMed
Close
,
Yao Xiong Department of Reproductive Medicine center, Zhongnan Hospital of Wuhan University, Wuhan, Hubei Province, PR China
Hubei Clinical Research Center for Prenatal Diagnosis and Birth Health, Wuhan Hubei Province, PR China
Wuhan Clinical Research Center for Reproductive Science and Birth Health, Wuhan Hubei Province, PR China

Search for other papers by Yao Xiong in
Google Scholar
PubMed
Close
, and
Yuanzhen Zhang Department of Reproductive Medicine center, Zhongnan Hospital of Wuhan University, Wuhan, Hubei Province, PR China
Hubei Clinical Research Center for Prenatal Diagnosis and Birth Health, Wuhan Hubei Province, PR China
Wuhan Clinical Research Center for Reproductive Science and Birth Health, Wuhan Hubei Province, PR China

Search for other papers by Yuanzhen Zhang in
Google Scholar
PubMed
Close

transcription factors that contain a Cys2/His2 zinc finger domain. These factors bind to specific DNA motifs (CACCC or CGCCC) and are involved in embryogenesis, cell migration, and differentiation ( Garcia-Nino & Zazueta 2021 , Sun et al. 2022 ). Previous

Open access
Ioannis Simitsidellis Centre for Inflammation Research, The University of Edinburgh, Queen’s Medical Research Institute, Edinburgh BioQuarter, Edinburgh, UK

Search for other papers by Ioannis Simitsidellis in
Google Scholar
PubMed
Close
,
Arantza Esnal-Zuffiaure Centre for Inflammation Research, The University of Edinburgh, Queen’s Medical Research Institute, Edinburgh BioQuarter, Edinburgh, UK

Search for other papers by Arantza Esnal-Zuffiaure in
Google Scholar
PubMed
Close
,
Olympia Kelepouri Centre for Inflammation Research, The University of Edinburgh, Queen’s Medical Research Institute, Edinburgh BioQuarter, Edinburgh, UK

Search for other papers by Olympia Kelepouri in
Google Scholar
PubMed
Close
,
Elisabeth O’Flaherty Centre for Inflammation Research, The University of Edinburgh, Queen’s Medical Research Institute, Edinburgh BioQuarter, Edinburgh, UK

Search for other papers by Elisabeth O’Flaherty in
Google Scholar
PubMed
Close
,
Douglas A Gibson Centre for Inflammation Research, The University of Edinburgh, Queen’s Medical Research Institute, Edinburgh BioQuarter, Edinburgh, UK

Search for other papers by Douglas A Gibson in
Google Scholar
PubMed
Close
, and
Philippa T K Saunders Centre for Inflammation Research, The University of Edinburgh, Queen’s Medical Research Institute, Edinburgh BioQuarter, Edinburgh, UK

Search for other papers by Philippa T K Saunders in
Google Scholar
PubMed
Close

as a critical endometrial gland-specific transcription factor and confirmed the importance of gland number in establishment and maintenance of pregnancy ( Kelleher et al. 2018 ). To complement and extend our previous study, in which we detected an

Open access
Geoffrey L Hammond Departments of Cellular & Physiological Sciences and Obstetrics & Gynaecology, University of British Columbia, Vancouver, British Columbia, Canada

Search for other papers by Geoffrey L Hammond in
Google Scholar
PubMed
Close

transcription unit lacks a typical TATA box, but the transcription factor hepatocyte nuclear factor 4α(HNF4α) appears to substitute for the TATA-binding protein in helping to recruit the transcriptional machinery to the promoter ( Jänne & Hammond 1998 ). These

Open access
Lisa Rice Faculty of Medical and Human Sciences, Faculty of Life Sciences, Faculty of Medical and Human Sciences, School of Medicine
Faculty of Medical and Human Sciences, Faculty of Life Sciences, Faculty of Medical and Human Sciences, School of Medicine

Search for other papers by Lisa Rice in
Google Scholar
PubMed
Close
,
Charlotte E Waters Faculty of Medical and Human Sciences, Faculty of Life Sciences, Faculty of Medical and Human Sciences, School of Medicine

Search for other papers by Charlotte E Waters in
Google Scholar
PubMed
Close
,
Jennifer Eccles Faculty of Medical and Human Sciences, Faculty of Life Sciences, Faculty of Medical and Human Sciences, School of Medicine

Search for other papers by Jennifer Eccles in
Google Scholar
PubMed
Close
,
Helen Garside Faculty of Medical and Human Sciences, Faculty of Life Sciences, Faculty of Medical and Human Sciences, School of Medicine

Search for other papers by Helen Garside in
Google Scholar
PubMed
Close
,
Paula Sommer Faculty of Medical and Human Sciences, Faculty of Life Sciences, Faculty of Medical and Human Sciences, School of Medicine

Search for other papers by Paula Sommer in
Google Scholar
PubMed
Close
,
Paul Kay Faculty of Medical and Human Sciences, Faculty of Life Sciences, Faculty of Medical and Human Sciences, School of Medicine

Search for other papers by Paul Kay in
Google Scholar
PubMed
Close
,
Fiona H Blackhall Faculty of Medical and Human Sciences, Faculty of Life Sciences, Faculty of Medical and Human Sciences, School of Medicine

Search for other papers by Fiona H Blackhall in
Google Scholar
PubMed
Close
,
Leo Zeef Faculty of Medical and Human Sciences, Faculty of Life Sciences, Faculty of Medical and Human Sciences, School of Medicine

Search for other papers by Leo Zeef in
Google Scholar
PubMed
Close
,
Brian Telfer Faculty of Medical and Human Sciences, Faculty of Life Sciences, Faculty of Medical and Human Sciences, School of Medicine

Search for other papers by Brian Telfer in
Google Scholar
PubMed
Close
,
Ian Stratford Faculty of Medical and Human Sciences, Faculty of Life Sciences, Faculty of Medical and Human Sciences, School of Medicine

Search for other papers by Ian Stratford in
Google Scholar
PubMed
Close
,
Rob Clarke Faculty of Medical and Human Sciences, Faculty of Life Sciences, Faculty of Medical and Human Sciences, School of Medicine

Search for other papers by Rob Clarke in
Google Scholar
PubMed
Close
,
Dave Singh Faculty of Medical and Human Sciences, Faculty of Life Sciences, Faculty of Medical and Human Sciences, School of Medicine

Search for other papers by Dave Singh in
Google Scholar
PubMed
Close
,
Adam Stevens Faculty of Medical and Human Sciences, Faculty of Life Sciences, Faculty of Medical and Human Sciences, School of Medicine

Search for other papers by Adam Stevens in
Google Scholar
PubMed
Close
,
Anne White Faculty of Medical and Human Sciences, Faculty of Life Sciences, Faculty of Medical and Human Sciences, School of Medicine
Faculty of Medical and Human Sciences, Faculty of Life Sciences, Faculty of Medical and Human Sciences, School of Medicine

Search for other papers by Anne White in
Google Scholar
PubMed
Close
, and
David W Ray Faculty of Medical and Human Sciences, Faculty of Life Sciences, Faculty of Medical and Human Sciences, School of Medicine

Search for other papers by David W Ray in
Google Scholar
PubMed
Close

Introduction Glucocorticoids (GC) act through the GC receptor (GR), a member of the nuclear receptor superfamily of ligand-regulated transcription factors ( Hollenberg et al . 1985 , Weinberger et al . 1985 , 1987 , Perlmann & Evans 1997

Open access
Scott Haston Developmental Biology and Cancer Research Programme, Birth Defects Research Centre, UCL Great Ormond Street Institute of Child Health, London, UK

Search for other papers by Scott Haston in
Google Scholar
PubMed
Close
,
Saba Manshaei Developmental Biology and Cancer Research Programme, Birth Defects Research Centre, UCL Great Ormond Street Institute of Child Health, London, UK

Search for other papers by Saba Manshaei in
Google Scholar
PubMed
Close
, and
Juan Pedro Martinez-Barbera Developmental Biology and Cancer Research Programme, Birth Defects Research Centre, UCL Great Ormond Street Institute of Child Health, London, UK

Search for other papers by Juan Pedro Martinez-Barbera in
Google Scholar
PubMed
Close

) and gonadotropins (FSH and LH), respectively ( Kelberman et al. 2009 ). These secretory cells have been defined by the expression of specific-lineage transcription factors that are important for their induction and maintenance. These lineage

Open access
Mark E Cleasby Department of Comparative Biomedical Sciences, Royal Veterinary College, University of London, London, UK

Search for other papers by Mark E Cleasby in
Google Scholar
PubMed
Close
,
Pauline M Jamieson Centre for Cardiovascular Science, Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, UK

Search for other papers by Pauline M Jamieson in
Google Scholar
PubMed
Close
, and
Philip J Atherton Division of Medical Sciences and Graduate Entry Medicine, University of Nottingham, Medical School, Royal Derby Hospital, Derby, UK

Search for other papers by Philip J Atherton in
Google Scholar
PubMed
Close

with ageing may be in the opposite direction to that in insulin-resistant muscle. Skeletal muscle inflammation is also characterised by activation of the classical signalling pathway to the transcription factor nuclear factor κB (NF-κB). Chronic

Open access
J Fahrenkrug Department of Clinical Biochemistry, Bispebjerg and Frederiksberg Hospital, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark

Search for other papers by J Fahrenkrug in
Google Scholar
PubMed
Close
,
B Georg Department of Clinical Biochemistry, Bispebjerg and Frederiksberg Hospital, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark

Search for other papers by B Georg in
Google Scholar
PubMed
Close
,
J Hannibal Department of Clinical Biochemistry, Bispebjerg and Frederiksberg Hospital, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark

Search for other papers by J Hannibal in
Google Scholar
PubMed
Close
, and
H L Jørgensen Department of Clinical Biochemistry, Bispebjerg and Frederiksberg Hospital, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark

Search for other papers by H L Jørgensen in
Google Scholar
PubMed
Close

cells, the molecular machinery is composed of the same clock genes and their protein products connected by autoregulatory feedback loops. The major loop comprises the PAS domain helix-loop-helix transcriptional activators BMAL1 and CLOCK forming

Open access
Claire L Wood Division of Functional Genetics and Development, Roslin Institute, University of Edinburgh, Edinburgh, UK
Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK

Search for other papers by Claire L Wood in
Google Scholar
PubMed
Close
,
Rob van ‘t Hof Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, UK

Search for other papers by Rob van ‘t Hof in
Google Scholar
PubMed
Close
,
Scott Dillon Division of Functional Genetics and Development, Roslin Institute, University of Edinburgh, Edinburgh, UK

Search for other papers by Scott Dillon in
Google Scholar
PubMed
Close
,
Volker Straub John Walton Muscular Dystrophy Research Centre, Newcastle University and Newcastle Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK

Search for other papers by Volker Straub in
Google Scholar
PubMed
Close
,
Sze C Wong Developmental Endocrinology Research Group, School of Medicine, University of Glasgow, Glasgow, UK

Search for other papers by Sze C Wong in
Google Scholar
PubMed
Close
,
S Faisal Ahmed Developmental Endocrinology Research Group, School of Medicine, University of Glasgow, Glasgow, UK

Search for other papers by S Faisal Ahmed in
Google Scholar
PubMed
Close
, and
Colin Farquharson Division of Functional Genetics and Development, Roslin Institute, University of Edinburgh, Edinburgh, UK

Search for other papers by Colin Farquharson in
Google Scholar
PubMed
Close

in this setting and therefore requires further exploration. Growth hormone (GH) and insulin-like growth factor (IGF-1) are fundamental regulators of longitudinal bone growth and have synergistic effects as well as independent roles in the regulation

Open access
Ashley Patton Department of Specialty Medicine, Heritage College of Osteopathic Medicine, Ohio University, Athens, Ohio, USA
Diabetes Institute, Ohio University, Athens, Ohio, USA
Department of Biological Sciences, Ohio University, Athens, Ohio, USA
Molecular & Cellular Biology Program, College of Arts and Sciences, Ohio University, Athens, Ohio, USA

Search for other papers by Ashley Patton in
Google Scholar
PubMed
Close
,
Tyler Church Department of Specialty Medicine, Heritage College of Osteopathic Medicine, Ohio University, Athens, Ohio, USA
Diabetes Institute, Ohio University, Athens, Ohio, USA

Search for other papers by Tyler Church in
Google Scholar
PubMed
Close
,
Caroline Wilson Department of Chemical and Biomolecular Engineering, Russ College of Engineering and Technology, Ohio University, Athens, Ohio, USA

Search for other papers by Caroline Wilson in
Google Scholar
PubMed
Close
,
Jean Thuma Department of Specialty Medicine, Heritage College of Osteopathic Medicine, Ohio University, Athens, Ohio, USA
Diabetes Institute, Ohio University, Athens, Ohio, USA

Search for other papers by Jean Thuma in
Google Scholar
PubMed
Close
,
Douglas J Goetz Department of Chemical and Biomolecular Engineering, Russ College of Engineering and Technology, Ohio University, Athens, Ohio, USA
Molecular & Cellular Biology Program, College of Arts and Sciences, Ohio University, Athens, Ohio, USA
Biomedical Engineering Program, Ohio University, Athens, Ohio, USA

Search for other papers by Douglas J Goetz in
Google Scholar
PubMed
Close
,
Darlene E Berryman Diabetes Institute, Ohio University, Athens, Ohio, USA
Department of Biomedical Sciences, Ohio University, Athens, Ohio, USA
The Edison Biotechnology Institute, Ohio University, Athens, Ohio, USA

Search for other papers by Darlene E Berryman in
Google Scholar
PubMed
Close
,
Edward O List Department of Specialty Medicine, Heritage College of Osteopathic Medicine, Ohio University, Athens, Ohio, USA
Diabetes Institute, Ohio University, Athens, Ohio, USA
The Edison Biotechnology Institute, Ohio University, Athens, Ohio, USA

Search for other papers by Edward O List in
Google Scholar
PubMed
Close
,
Frank Schwartz Department of Specialty Medicine, Heritage College of Osteopathic Medicine, Ohio University, Athens, Ohio, USA
Diabetes Institute, Ohio University, Athens, Ohio, USA

Search for other papers by Frank Schwartz in
Google Scholar
PubMed
Close
, and
Kelly D McCall Department of Specialty Medicine, Heritage College of Osteopathic Medicine, Ohio University, Athens, Ohio, USA
Diabetes Institute, Ohio University, Athens, Ohio, USA
Department of Biological Sciences, Ohio University, Athens, Ohio, USA
Molecular & Cellular Biology Program, College of Arts and Sciences, Ohio University, Athens, Ohio, USA
Biomedical Engineering Program, Ohio University, Athens, Ohio, USA
Department of Biomedical Sciences, Ohio University, Athens, Ohio, USA

Search for other papers by Kelly D McCall in
Google Scholar
PubMed
Close

Introduction Obesity is the single most important risk factor for the development of nonalcoholic fatty liver disease (NAFLD), which is the most prevalent liver disease in the western hemisphere ( Lazo & Clark 2008 , Bellentani et al . 2010

Open access