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2016 )). Specifically, regulation of gene expression by AR can be mediated via interaction with general transcription factors (such as SRC-1 and TF II H), components of the chromatin remodelling complex (such as SWI/SNF), histone-modifying enzymes and
Hubei Clinical Research Center for Prenatal Diagnosis and Birth Health, Wuhan Hubei Province, PR China
Wuhan Clinical Research Center for Reproductive Science and Birth Health, Wuhan Hubei Province, PR China
Department of Gynaecology and Obstetrics, Sinopharm Dongfeng Hospital, Hubei University of Medicine, Shiyan, Hubei Province, PR China
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Hubei Clinical Research Center for Prenatal Diagnosis and Birth Health, Wuhan Hubei Province, PR China
Wuhan Clinical Research Center for Reproductive Science and Birth Health, Wuhan Hubei Province, PR China
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Hubei Clinical Research Center for Prenatal Diagnosis and Birth Health, Wuhan Hubei Province, PR China
Wuhan Clinical Research Center for Reproductive Science and Birth Health, Wuhan Hubei Province, PR China
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Hubei Clinical Research Center for Prenatal Diagnosis and Birth Health, Wuhan Hubei Province, PR China
Wuhan Clinical Research Center for Reproductive Science and Birth Health, Wuhan Hubei Province, PR China
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transcription factors that contain a Cys2/His2 zinc finger domain. These factors bind to specific DNA motifs (CACCC or CGCCC) and are involved in embryogenesis, cell migration, and differentiation ( Garcia-Nino & Zazueta 2021 , Sun et al. 2022 ). Previous
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as a critical endometrial gland-specific transcription factor and confirmed the importance of gland number in establishment and maintenance of pregnancy ( Kelleher et al. 2018 ). To complement and extend our previous study, in which we detected an
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transcription unit lacks a typical TATA box, but the transcription factor hepatocyte nuclear factor 4α(HNF4α) appears to substitute for the TATA-binding protein in helping to recruit the transcriptional machinery to the promoter ( Jänne & Hammond 1998 ). These
Faculty of Medical and Human Sciences, Faculty of Life Sciences, Faculty of Medical and Human Sciences, School of Medicine
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Faculty of Medical and Human Sciences, Faculty of Life Sciences, Faculty of Medical and Human Sciences, School of Medicine
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Introduction Glucocorticoids (GC) act through the GC receptor (GR), a member of the nuclear receptor superfamily of ligand-regulated transcription factors ( Hollenberg et al . 1985 , Weinberger et al . 1985 , 1987 , Perlmann & Evans 1997
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) and gonadotropins (FSH and LH), respectively ( Kelberman et al. 2009 ). These secretory cells have been defined by the expression of specific-lineage transcription factors that are important for their induction and maintenance. These lineage
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with ageing may be in the opposite direction to that in insulin-resistant muscle. Skeletal muscle inflammation is also characterised by activation of the classical signalling pathway to the transcription factor nuclear factor κB (NF-κB). Chronic
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cells, the molecular machinery is composed of the same clock genes and their protein products connected by autoregulatory feedback loops. The major loop comprises the PAS domain helix-loop-helix transcriptional activators BMAL1 and CLOCK forming
Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK
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in this setting and therefore requires further exploration. Growth hormone (GH) and insulin-like growth factor (IGF-1) are fundamental regulators of longitudinal bone growth and have synergistic effects as well as independent roles in the regulation
Diabetes Institute, Ohio University, Athens, Ohio, USA
Department of Biological Sciences, Ohio University, Athens, Ohio, USA
Molecular & Cellular Biology Program, College of Arts and Sciences, Ohio University, Athens, Ohio, USA
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Diabetes Institute, Ohio University, Athens, Ohio, USA
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Diabetes Institute, Ohio University, Athens, Ohio, USA
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Molecular & Cellular Biology Program, College of Arts and Sciences, Ohio University, Athens, Ohio, USA
Biomedical Engineering Program, Ohio University, Athens, Ohio, USA
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Department of Biomedical Sciences, Ohio University, Athens, Ohio, USA
The Edison Biotechnology Institute, Ohio University, Athens, Ohio, USA
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Diabetes Institute, Ohio University, Athens, Ohio, USA
The Edison Biotechnology Institute, Ohio University, Athens, Ohio, USA
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Diabetes Institute, Ohio University, Athens, Ohio, USA
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Diabetes Institute, Ohio University, Athens, Ohio, USA
Department of Biological Sciences, Ohio University, Athens, Ohio, USA
Molecular & Cellular Biology Program, College of Arts and Sciences, Ohio University, Athens, Ohio, USA
Biomedical Engineering Program, Ohio University, Athens, Ohio, USA
Department of Biomedical Sciences, Ohio University, Athens, Ohio, USA
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Introduction Obesity is the single most important risk factor for the development of nonalcoholic fatty liver disease (NAFLD), which is the most prevalent liver disease in the western hemisphere ( Lazo & Clark 2008 , Bellentani et al . 2010