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Rebecca J Ainslie Institute for Regeneration and Repair, the University of Edinburgh, Edinburgh BioQuarter, Edinburgh, United Kingdom

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Ioannis Simitsidellis Institute for Regeneration and Repair, the University of Edinburgh, Edinburgh BioQuarter, Edinburgh, United Kingdom

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Phoebe M Kirkwood Institute for Regeneration and Repair, the University of Edinburgh, Edinburgh BioQuarter, Edinburgh, United Kingdom

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Douglas A Gibson Institute for Regeneration and Repair, the University of Edinburgh, Edinburgh BioQuarter, Edinburgh, United Kingdom

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2016 )). Specifically, regulation of gene expression by AR can be mediated via interaction with general transcription factors (such as SRC-1 and TF II H), components of the chromatin remodelling complex (such as SWI/SNF), histone-modifying enzymes and

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-23-0398
Volume/Issue:
Volume 261: Issue 3
Open access
Yaxiong Huang Department of Reproductive Medicine center, Zhongnan Hospital of Wuhan University, Wuhan, Hubei Province, PR China
Hubei Clinical Research Center for Prenatal Diagnosis and Birth Health, Wuhan Hubei Province, PR China
Wuhan Clinical Research Center for Reproductive Science and Birth Health, Wuhan Hubei Province, PR China
Department of Gynaecology and Obstetrics, Sinopharm Dongfeng Hospital, Hubei University of Medicine, Shiyan, Hubei Province, PR China

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Zihan Wang Department of Reproductive Medicine center, Zhongnan Hospital of Wuhan University, Wuhan, Hubei Province, PR China
Hubei Clinical Research Center for Prenatal Diagnosis and Birth Health, Wuhan Hubei Province, PR China
Wuhan Clinical Research Center for Reproductive Science and Birth Health, Wuhan Hubei Province, PR China

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Bin Li Department of Gynaecology and Obstetrics, Sinopharm Dongfeng Hospital, Hubei University of Medicine, Shiyan, Hubei Province, PR China

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Lina Ke Department of Gynaecology and Obstetrics, Sinopharm Dongfeng Hospital, Hubei University of Medicine, Shiyan, Hubei Province, PR China

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Yao Xiong Department of Reproductive Medicine center, Zhongnan Hospital of Wuhan University, Wuhan, Hubei Province, PR China
Hubei Clinical Research Center for Prenatal Diagnosis and Birth Health, Wuhan Hubei Province, PR China
Wuhan Clinical Research Center for Reproductive Science and Birth Health, Wuhan Hubei Province, PR China

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Yuanzhen Zhang Department of Reproductive Medicine center, Zhongnan Hospital of Wuhan University, Wuhan, Hubei Province, PR China
Hubei Clinical Research Center for Prenatal Diagnosis and Birth Health, Wuhan Hubei Province, PR China
Wuhan Clinical Research Center for Reproductive Science and Birth Health, Wuhan Hubei Province, PR China

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transcription factors that contain a Cys2/His2 zinc finger domain. These factors bind to specific DNA motifs (CACCC or CGCCC) and are involved in embryogenesis, cell migration, and differentiation ( Garcia-Nino & Zazueta 2021 , Sun et al. 2022 ). Previous

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-23-0319
Volume/Issue:
Volume 261: Issue 2
Open access
Ioannis Simitsidellis Centre for Inflammation Research, The University of Edinburgh, Queen’s Medical Research Institute, Edinburgh BioQuarter, Edinburgh, UK

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Arantza Esnal-Zuffiaure Centre for Inflammation Research, The University of Edinburgh, Queen’s Medical Research Institute, Edinburgh BioQuarter, Edinburgh, UK

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Olympia Kelepouri Centre for Inflammation Research, The University of Edinburgh, Queen’s Medical Research Institute, Edinburgh BioQuarter, Edinburgh, UK

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Elisabeth O’Flaherty Centre for Inflammation Research, The University of Edinburgh, Queen’s Medical Research Institute, Edinburgh BioQuarter, Edinburgh, UK

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Douglas A Gibson Centre for Inflammation Research, The University of Edinburgh, Queen’s Medical Research Institute, Edinburgh BioQuarter, Edinburgh, UK

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Philippa T K Saunders Centre for Inflammation Research, The University of Edinburgh, Queen’s Medical Research Institute, Edinburgh BioQuarter, Edinburgh, UK

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as a critical endometrial gland-specific transcription factor and confirmed the importance of gland number in establishment and maintenance of pregnancy ( Kelleher et al. 2018 ). To complement and extend our previous study, in which we detected an

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-19-0153
Volume/Issue:
Volume 242: Issue 3
Open access
Geoffrey L Hammond Departments of Cellular & Physiological Sciences and Obstetrics & Gynaecology, University of British Columbia, Vancouver, British Columbia, Canada

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transcription unit lacks a typical TATA box, but the transcription factor hepatocyte nuclear factor 4α(HNF4α) appears to substitute for the TATA-binding protein in helping to recruit the transcriptional machinery to the promoter ( Jänne & Hammond 1998 ). These

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-16-0070
Volume/Issue:
Volume 230: Issue 1
Open access
Lisa Rice Faculty of Medical and Human Sciences, Faculty of Life Sciences, Faculty of Medical and Human Sciences, School of Medicine
Faculty of Medical and Human Sciences, Faculty of Life Sciences, Faculty of Medical and Human Sciences, School of Medicine

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Charlotte E Waters Faculty of Medical and Human Sciences, Faculty of Life Sciences, Faculty of Medical and Human Sciences, School of Medicine

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Jennifer Eccles Faculty of Medical and Human Sciences, Faculty of Life Sciences, Faculty of Medical and Human Sciences, School of Medicine

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Helen Garside Faculty of Medical and Human Sciences, Faculty of Life Sciences, Faculty of Medical and Human Sciences, School of Medicine

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Paula Sommer Faculty of Medical and Human Sciences, Faculty of Life Sciences, Faculty of Medical and Human Sciences, School of Medicine

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Paul Kay Faculty of Medical and Human Sciences, Faculty of Life Sciences, Faculty of Medical and Human Sciences, School of Medicine

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Fiona H Blackhall Faculty of Medical and Human Sciences, Faculty of Life Sciences, Faculty of Medical and Human Sciences, School of Medicine

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Leo Zeef Faculty of Medical and Human Sciences, Faculty of Life Sciences, Faculty of Medical and Human Sciences, School of Medicine

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Brian Telfer Faculty of Medical and Human Sciences, Faculty of Life Sciences, Faculty of Medical and Human Sciences, School of Medicine

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Ian Stratford Faculty of Medical and Human Sciences, Faculty of Life Sciences, Faculty of Medical and Human Sciences, School of Medicine

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Rob Clarke Faculty of Medical and Human Sciences, Faculty of Life Sciences, Faculty of Medical and Human Sciences, School of Medicine

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Dave Singh Faculty of Medical and Human Sciences, Faculty of Life Sciences, Faculty of Medical and Human Sciences, School of Medicine

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Adam Stevens Faculty of Medical and Human Sciences, Faculty of Life Sciences, Faculty of Medical and Human Sciences, School of Medicine

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Anne White Faculty of Medical and Human Sciences, Faculty of Life Sciences, Faculty of Medical and Human Sciences, School of Medicine
Faculty of Medical and Human Sciences, Faculty of Life Sciences, Faculty of Medical and Human Sciences, School of Medicine

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David W Ray Faculty of Medical and Human Sciences, Faculty of Life Sciences, Faculty of Medical and Human Sciences, School of Medicine

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Introduction Glucocorticoids (GC) act through the GC receptor (GR), a member of the nuclear receptor superfamily of ligand-regulated transcription factors ( Hollenberg et al . 1985 , Weinberger et al . 1985 , 1987 , Perlmann & Evans 1997

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-08-0019
Volume/Issue:
Volume 198: Issue 3
Open access
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Scott Haston Developmental Biology and Cancer Research Programme, Birth Defects Research Centre, UCL Great Ormond Street Institute of Child Health, London, UK

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Saba Manshaei Developmental Biology and Cancer Research Programme, Birth Defects Research Centre, UCL Great Ormond Street Institute of Child Health, London, UK

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Juan Pedro Martinez-Barbera Developmental Biology and Cancer Research Programme, Birth Defects Research Centre, UCL Great Ormond Street Institute of Child Health, London, UK

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) and gonadotropins (FSH and LH), respectively ( Kelberman et al. 2009 ). These secretory cells have been defined by the expression of specific-lineage transcription factors that are important for their induction and maintenance. These lineage

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-17-0258
Volume/Issue:
Volume 236: Issue 1
Open access
Mark E Cleasby Department of Comparative Biomedical Sciences, Royal Veterinary College, University of London, London, UK

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Pauline M Jamieson Centre for Cardiovascular Science, Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, UK

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Philip J Atherton Division of Medical Sciences and Graduate Entry Medicine, University of Nottingham, Medical School, Royal Derby Hospital, Derby, UK

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with ageing may be in the opposite direction to that in insulin-resistant muscle. Skeletal muscle inflammation is also characterised by activation of the classical signalling pathway to the transcription factor nuclear factor κB (NF-κB). Chronic

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-15-0533
Volume/Issue:
Volume 229: Issue 2
Open access
J Fahrenkrug Department of Clinical Biochemistry, Bispebjerg and Frederiksberg Hospital, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark

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B Georg Department of Clinical Biochemistry, Bispebjerg and Frederiksberg Hospital, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark

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J Hannibal Department of Clinical Biochemistry, Bispebjerg and Frederiksberg Hospital, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark

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H L Jørgensen Department of Clinical Biochemistry, Bispebjerg and Frederiksberg Hospital, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark

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cells, the molecular machinery is composed of the same clock genes and their protein products connected by autoregulatory feedback loops. The major loop comprises the PAS domain helix-loop-helix transcriptional activators BMAL1 and CLOCK forming

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-17-0111
Volume/Issue:
Volume 233: Issue 3
Open access
Claire L Wood Division of Functional Genetics and Development, Roslin Institute, University of Edinburgh, Edinburgh, UK
Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK

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Rob van ‘t Hof Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, UK

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Scott Dillon Division of Functional Genetics and Development, Roslin Institute, University of Edinburgh, Edinburgh, UK

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Volker Straub John Walton Muscular Dystrophy Research Centre, Newcastle University and Newcastle Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK

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Sze C Wong Developmental Endocrinology Research Group, School of Medicine, University of Glasgow, Glasgow, UK

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S Faisal Ahmed Developmental Endocrinology Research Group, School of Medicine, University of Glasgow, Glasgow, UK

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Colin Farquharson Division of Functional Genetics and Development, Roslin Institute, University of Edinburgh, Edinburgh, UK

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in this setting and therefore requires further exploration. Growth hormone (GH) and insulin-like growth factor (IGF-1) are fundamental regulators of longitudinal bone growth and have synergistic effects as well as independent roles in the regulation

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-21-0388
Volume/Issue:
Volume 253: Issue 2
Open access
Ashley Patton Department of Specialty Medicine, Heritage College of Osteopathic Medicine, Ohio University, Athens, Ohio, USA
Diabetes Institute, Ohio University, Athens, Ohio, USA
Department of Biological Sciences, Ohio University, Athens, Ohio, USA
Molecular & Cellular Biology Program, College of Arts and Sciences, Ohio University, Athens, Ohio, USA

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Tyler Church Department of Specialty Medicine, Heritage College of Osteopathic Medicine, Ohio University, Athens, Ohio, USA
Diabetes Institute, Ohio University, Athens, Ohio, USA

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Caroline Wilson Department of Chemical and Biomolecular Engineering, Russ College of Engineering and Technology, Ohio University, Athens, Ohio, USA

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Jean Thuma Department of Specialty Medicine, Heritage College of Osteopathic Medicine, Ohio University, Athens, Ohio, USA
Diabetes Institute, Ohio University, Athens, Ohio, USA

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Douglas J Goetz Department of Chemical and Biomolecular Engineering, Russ College of Engineering and Technology, Ohio University, Athens, Ohio, USA
Molecular & Cellular Biology Program, College of Arts and Sciences, Ohio University, Athens, Ohio, USA
Biomedical Engineering Program, Ohio University, Athens, Ohio, USA

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Darlene E Berryman Diabetes Institute, Ohio University, Athens, Ohio, USA
Department of Biomedical Sciences, Ohio University, Athens, Ohio, USA
The Edison Biotechnology Institute, Ohio University, Athens, Ohio, USA

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Edward O List Department of Specialty Medicine, Heritage College of Osteopathic Medicine, Ohio University, Athens, Ohio, USA
Diabetes Institute, Ohio University, Athens, Ohio, USA
The Edison Biotechnology Institute, Ohio University, Athens, Ohio, USA

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Frank Schwartz Department of Specialty Medicine, Heritage College of Osteopathic Medicine, Ohio University, Athens, Ohio, USA
Diabetes Institute, Ohio University, Athens, Ohio, USA

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Kelly D McCall Department of Specialty Medicine, Heritage College of Osteopathic Medicine, Ohio University, Athens, Ohio, USA
Diabetes Institute, Ohio University, Athens, Ohio, USA
Department of Biological Sciences, Ohio University, Athens, Ohio, USA
Molecular & Cellular Biology Program, College of Arts and Sciences, Ohio University, Athens, Ohio, USA
Biomedical Engineering Program, Ohio University, Athens, Ohio, USA
Department of Biomedical Sciences, Ohio University, Athens, Ohio, USA

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Introduction Obesity is the single most important risk factor for the development of nonalcoholic fatty liver disease (NAFLD), which is the most prevalent liver disease in the western hemisphere ( Lazo & Clark 2008 , Bellentani et al . 2010

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-18-0078
Volume/Issue:
Volume 237: Issue 3
Open access