Search Results

You are looking at 31 - 40 of 90 items for :

  • transcriptional activity x
  • Open access x
Clear All
Open access

Lei Zhang, Carol Paddon, Mark D Lewis, Fiona Grennan-Jones, and Marian Ludgate

, there was no further increase in either the non-modified or L629F cell number, but the gsp* population continued to proliferate, in keeping with the absence of differentiation. The transcriptional activity of PPARγ is reduced when it is phosphorylated

Open access

L Nicol, M-O Faure, J R McNeilly, J Fontaine, C Taragnat, and A S McNeilly

/ml) were able to stimulate basal FSH secretion and FSHβ promoter activity ( Huang et al . 2001 , Otsuka & Shimasaki 2002 , Lee et al . 2007 ). This difference of BMP effect between the mouse and the sheep could reflect a dissimilar pattern of BMP

Open access

Md Nurul Islam, Yuichiro Mita, Keisuke Maruyama, Ryota Tanida, Weidong Zhang, Hideyuki Sakoda, and Masamitsu Nakazato

finding in Hepa 1-6 cells. Phosphorylated AMPK suppresses the activity of sterol regulatory element-binding protein 1 (SREBP1), a key transcription factor involved in the regulation of lipid metabolism ( Li et al. 2011 ). The binding consensus sequence

Open access

Yoshinori Kanemaru, Norio Harada, Satoko Shimazu-Kuwahara, Shunsuke Yamane, Eri Ikeguchi, Yuki Murata, Sakura Kiyobayashi, Tomonobu Hatoko, and Nobuya Inagaki

decline of activities of daily living (ADL) in elderly people and is also related to the high prevalence of medical disorders such as diabetes, hyperlipidemia, and hypertension ( Cheng et al . 2013 , Chang et al . 2017 ). It is therefore important for

Open access

Judith E Cartwright and Paula Juliet Williams

by post-translational cleavage of Kp-154. All kisspeptins share an Arg-Phe-NH 2 motif at the C-terminus, which is required for biological activity ( Roa et al . 2008 ). The activity of KISS1 is regulated via the expression of the KISS1 receptor

Open access

K S Wilson, C S Tucker, E A S Al-Dujaili, M C Holmes, P W F Hadoke, C J Kenyon, and M A Denvir

with an antisense GR morpholino (GR Mo); (ii) increasing GC activity by adding dexamethasone, a synthetic GC hormone, to the water; and (iii) using a hypoxic environment to evoke a stress response mimicking stagnant water conditions that might occur in

Open access

Ryoko Yamamoto, Tomoko Minamizaki, Yuji Yoshiko, Hirotaka Yoshioka, Kazuo Tanne, Jane E Aubin, and Norihiko Maeda

-linked hypophosphatemia with loss-of-function mutations in phosphate-regulating gene with endopeptidase activity on the X chromosome ( Phex )) background ( Sitara et al . 2006 ) and Dmp1 −/− mice ( Feng et al . 2006 ) indicated that osteocytes are the major sources of

Open access

Hyo Youl Moon, Parkyong Song, Cheol Soo Choi, Sung Ho Ryu, and Pann-Ghill Suh

28 339 – 350 . ( doi:10.1055/s-0028-1091978 ) Lee M Hwang JT Lee HJ Jung SN Kang I Chi SG Kim SS Ha J 2003 AMP-activated protein kinase activity is critical for hypoxia-inducible factor-1 transcriptional activity and its target

Open access

Farhana Naznin, Koji Toshinai, T M Zaved Waise, Cherl NamKoong, Abu Saleh Md Moin, Hideyuki Sakoda, and Masamitsu Nakazato

secretagogue receptor (GHSR), also known as the ghrelin receptor, is synthesized in vagal afferent neurons and transported to the stomach by axonal transport ( Date et al . 2002 ). Ghrelin binds to this receptor and suppresses the electrical activity of the

Open access

Bernadette M Trojanowski, Heba H Salem, Heike Neubauer, Eric Simon, Martin Wagner, Rajkumar Dorajoo, Bernhard O Boehm, Leticia Labriola, Thomas Wirth, and Bernd Baumann

secretion associated with MODY4 in mice is related to the mitochondrial transcription factor TFAM, whose expression is depending on Pdx1 levels in β-cells ( Gauthier et al. 2009 ). Thus, reduced Pdx1 activity may define a prediabetic state that is prone