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Dipartimento Pediatrico Universitario Ospedaliero ‘Bambino Gesù’ Children’s Hospital – Tor Vergata University, Rome, Italy
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function and testis size Several genes selected for their functional role in SCs were dysregulated in response to UPI; at 5 d pp , Sox9 expression was decreased in IUGR rats compared to shams . Sox9 is a transcription factor of the SOX (SRY
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growth hormone-induced gene expression in bone: T-box3, a novel transcription factor, regulates osteoblast proliferation . American Journal of Physiology. Endocrinology and Metabolism 291 E128 – E136 . ( doi:10.1152/ajpendo.00592.2005 ) Govoni KE
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Department of Physiology, University of Toronto, Department of Medicine, Mount Sinai Hospital, Toronto General Research Institute and Banting and Best Diabetes Centre, University Health Network, Muscle Health Research Center and Physical Activity and Chronic Disease Unit, Faculty of Health, School of Kinesiology and Health Science, York University, Department of Internal Medicine, University of Manitoba, Medical Sciences Building, 1 King's College Circle, Toronto, Ontario, Canada M5S 1A8
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Department of Physiology, University of Toronto, Department of Medicine, Mount Sinai Hospital, Toronto General Research Institute and Banting and Best Diabetes Centre, University Health Network, Muscle Health Research Center and Physical Activity and Chronic Disease Unit, Faculty of Health, School of Kinesiology and Health Science, York University, Department of Internal Medicine, University of Manitoba, Medical Sciences Building, 1 King's College Circle, Toronto, Ontario, Canada M5S 1A8
Department of Physiology, University of Toronto, Department of Medicine, Mount Sinai Hospital, Toronto General Research Institute and Banting and Best Diabetes Centre, University Health Network, Muscle Health Research Center and Physical Activity and Chronic Disease Unit, Faculty of Health, School of Kinesiology and Health Science, York University, Department of Internal Medicine, University of Manitoba, Medical Sciences Building, 1 King's College Circle, Toronto, Ontario, Canada M5S 1A8
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( Aguirre et al . 2000 ), and ii) activation of the transcription factor nuclear factor kB (NF-kB), which upregulates the expression of various cytokines ( Barnes & Karin 1997 ). NF-kB is inhibited when bound to IkBa in the cytoplasm, but upon
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, the Netherlands
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Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, the Netherlands
Corcept Therapeutics, Menlo Park, CA, USA
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Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, the Netherlands
Corcept Therapeutics, Menlo Park, CA, USA
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exclusively secrete corticosterone. The GR is a ligand-dependent transcription factor that is expressed in a wide variety of tissues and cell types ( Weikum et al. 2017 ) and is activated during the circadian GC peak, upon stress, or due to hypercortisolism
Department of Internal Medicine IV, Division of Diabetology, Endocrinology and Nephrology, Eberhard-Karls University of Tübingen, Tübingen, Germany
Institute for Diabetes Research and Metabolic Diseases, Helmholtz Center Munich, Eberhard-Karls University of Tübingen, Tübingen, Germany
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Department of Internal Medicine IV, Division of Diabetology, Endocrinology and Nephrology, Eberhard-Karls University of Tübingen, Tübingen, Germany
Institute for Diabetes Research and Metabolic Diseases, Helmholtz Center Munich, Eberhard-Karls University of Tübingen, Tübingen, Germany
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transcription factors, glycogen synthase kinase 3 (GSK3), and mTORC1/SREBP1 to regulate glycogen, glucose, and lipid synthesis, respectively. Several studies have investigated the signaling pathways involved in the regulation of liver metabolism by insulin and
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). β-catenin is a transcriptional regulator that interacts with T-cell factor (TCF/lymphoid enhancer factor (LEF)) and converts the TCF/LEF repressor complex into a transcriptional activator ( Daniels & Weis 2005 , Willert & Jones 2006 ). Progesterone
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). It is well-established that in rodents that the lactogenic hormones acting on the β-cell Prlr and downstream activation of transcription factor Stat5, trigger an increase in β-cell proliferation in vitro and in vivo via the upregulation of the
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, de Ronde et al . 2003 ). E 2 effects are typically mediated through two structurally related oestrogen receptors, the α and β (ERα and ERβ) subtypes that function as ligand-activated transcription factors. On activation ERs can either bind directly
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flow was quantified during the administration of acetylcholine to offspring delivered from untreated and estrogen-deprived baboons. The factors that mediate the impact of estrogen on fetal microvascular development are unknown. Vascular endothelial
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280 ratio of 1.85 or greater. Following RNA extraction, 1 μg of each sample was reverse transcribed to cDNA in a 20 μl reaction using QuantiTect Reverse transcription kit (Qiagen). This kit contains a mix of random and oligo-dT primers thereby