Search Results

You are looking at 41 - 50 of 90 items for :

  • transcriptional activity x
  • Open access x
Clear All
Open access

Sushil K Mahata, Hong Zheng, Sumana Mahata, Xuefei Liu, and Kaushik P Patel

catecholamines becomes harmful, contributing to the progression of HF. Although most therapeutic pharmaceutical strategies target the peripheral symptoms of the disease, they may not influence the enhanced sympathetic nerve activity. Indeed, various studies have

Open access

T V Novoselova, R Larder, D Rimmington, C Lelliott, E H Wynn, R J Gorrigan, P H Tate, L Guasti, The Sanger Mouse Genetics Project, S O’Rahilly, A J L Clark, D W Logan, A P Coll, and L F Chan

intervals for 48h. Energy expenditure was calculated using indirect calori­metry with the Elia and Livesey constants for respiratory quotie­nt ( Elia & Livesey 1992 ). Activity was assessed by beam breaks (beams 1.25cm apart) and measurements were taken as

Open access

Manon M Roustit, Joan M Vaughan, Pauline M Jamieson, and Mark E Cleasby

). Secondly, pS256–FOXO1 was increased by the manipulation (by 22%, P =0.032; Fig. 3 C/E), implying the inhibition of its transcriptional activity. However, although increased FOXO1 activity would be expected to suppress the expression of pro-atrophic E3

Open access

Yoshihiro Joshua Ono, Yoshito Terai, Akiko Tanabe, Atsushi Hayashi, Masami Hayashi, Yoshiki Yamashita, Satoru Kyo, and Masahide Ohmichi

). Progestins are a class of compounds that mimic the activity of progesterone and are a recommended treatment for the pain associated with endometriosis, but a number of agents in this class are associated with androgenic effects and weight gain at doses that

Open access

Mark E Cleasby, Pauline M Jamieson, and Philip J Atherton

parallel, Akt mediated inhibition of forkhead transcription factor (FOXO) activity reduces expression of the E3 ubiquitin ligases that are principally responsible for mediating atrophy (atrogin-1/muscle atrophy F-box and muscle RING finger 1; Schiaffino

Open access

K E Lines, P J Newey, C J Yates, M Stevenson, R Dyar, G V Walls, M R Bowl, and R V Thakker

. 1997 ). Menin is involved in a diverse range of cellular processes including: transcriptional regulation, genome stability, cell division and proliferation ( Thakker et al. 2012 , Frost et al. 2018 ). However, the mechanisms by which menin loss

Open access

Emma M Roberts, Michael J F Newson, George R Pope, Rainer Landgraf, Stephen J Lolait, and Anne-Marie O'Carroll

pGlu-apelin-13 and apelin-17 bind to APJ and exhibit greater biological activity than the parent peptide on the human ( Habata et al . 1999 , Zou et al . 2000 , Medhurst et al . 2003 ) or rat APJ ( De Mota et al . 2000 ). In recent years cDNA

Open access

Ioannis Simitsidellis, Arantza Esnal-Zuffiaure, Olympia Kelepouri, Elisabeth O’Flaherty, Douglas A Gibson, and Philippa T K Saunders

compare their activities with the potent, natural, non-aromatisable androgen dihydrotestosterone (DHT). The model chosen was one in which we have previously identified changes in gene expression and tissue function in response to DHT ( Simitsidellis et al

Open access

Dawn E W Livingstone, Emma M Di Rollo, Chenjing Yang, Lucy E Codrington, John A Mathews, Madina Kara, Katherine A Hughes, Christopher J Kenyon, Brian R Walker, and Ruth Andrew

-reductase and 5β-reductase activity in liver and Hsd11b2 in kidney ( Boonen et al . 2013 ). We also demonstrated an association between impaired cortisol clearance and a reduced cortisol response to synthetic ACTH. As endogenous ACTH levels were paradoxically

Open access

Peter Kolkhof and Lars Bärfacker

aldosterone activity in animals and humans. At that time, the main role of aldosterone was recognized as the control of renal sodium and potassium excretion, although the far-sighted Hans Selye called the mineralocorticoids ‘prophlogistic’ ( Selye 1955 ). In