Search Results

You are looking at 51 - 60 of 128 items for :

  • Refine by access: Open Access content only x
Clear All
Thomas Nicholson Institute of Inflammation and Ageing, MRC-ARUK Centre for Musculoskeletal Ageing Research, University of Birmingham, Birmingham, UK

Search for other papers by Thomas Nicholson in
Google Scholar
PubMed
Close
,
Chris Church MedImmune, Cardiovascular and Metabolic Disease (CVMD), Milstein Building, Cambridge, UK

Search for other papers by Chris Church in
Google Scholar
PubMed
Close
,
Kostas Tsintzas MRC-ARUK Centre for Musculoskeletal Ageing Research, School of Life Sciences, Faculty of Medicine & Health Sciences, University of Nottingham, Nottingham, UK

Search for other papers by Kostas Tsintzas in
Google Scholar
PubMed
Close
,
Robert Jones MRC-ARUK Centre for Musculoskeletal Ageing Research, School of Life Sciences, Faculty of Medicine & Health Sciences, University of Nottingham, Nottingham, UK

Search for other papers by Robert Jones in
Google Scholar
PubMed
Close
,
Leigh Breen Institute of Inflammation and Ageing, MRC-ARUK Centre for Musculoskeletal Ageing Research, University of Birmingham, Birmingham, UK

Search for other papers by Leigh Breen in
Google Scholar
PubMed
Close
,
Edward T Davis The Royal Orthopaedic Hospital NHS Foundation Trust, Northfield, Birmingham, UK

Search for other papers by Edward T Davis in
Google Scholar
PubMed
Close
,
David J Baker MedImmune, Cardiovascular and Metabolic Disease (CVMD), Milstein Building, Cambridge, UK

Search for other papers by David J Baker in
Google Scholar
PubMed
Close
, and
Simon W Jones Institute of Inflammation and Ageing, MRC-ARUK Centre for Musculoskeletal Ageing Research, University of Birmingham, Birmingham, UK

Search for other papers by Simon W Jones in
Google Scholar
PubMed
Close

implications for the treatment of metabolic diseases such as type 2 diabetes ( Bluher 2014 , Bluher & Mantzoros 2015 ). It has long been established that the accumulation of abdominal fat (central adiposity) is associated with insulin resistance ( Pratley et

Open access
Mark E Cleasby Department of Comparative Biomedical Sciences, Royal Veterinary College, University of London, London, UK

Search for other papers by Mark E Cleasby in
Google Scholar
PubMed
Close
,
Pauline M Jamieson Centre for Cardiovascular Science, Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, UK

Search for other papers by Pauline M Jamieson in
Google Scholar
PubMed
Close
, and
Philip J Atherton Division of Medical Sciences and Graduate Entry Medicine, University of Nottingham, Medical School, Royal Derby Hospital, Derby, UK

Search for other papers by Philip J Atherton in
Google Scholar
PubMed
Close

Associations between obesity, diabetes and skeletal muscle ageing The International Diabetes Federation has estimated that there were 382 million people living with diabetes in 2013, with this number predicted to rise to 592 million by 2035

Open access
Bettina Geidl-Flueck Department of Endocrinology, Diabetology and Clinical Nutrition, University Hospital Zurich (USZ) and University of Zurich (UZH), Switzerland

Search for other papers by Bettina Geidl-Flueck in
Google Scholar
PubMed
Close
and
Philipp A Gerber Department of Endocrinology, Diabetology and Clinical Nutrition, University Hospital Zurich (USZ) and University of Zurich (UZH), Switzerland

Search for other papers by Philipp A Gerber in
Google Scholar
PubMed
Close

2010 ). HFCS is a cheap sweetener used in the food and beverage industries, and its consumption is linked to the occurrence of type 2 diabetes ( Kmietowicz 2012 ) and other metabolic diseases, as described below. Sugar-sweetened beverage

Open access
Gisela Helfer School of Chemistry and Biosciences, University of Bradford, Bradford, UK

Search for other papers by Gisela Helfer in
Google Scholar
PubMed
Close
and
Qing-Feng Wu State Key Laboratory of Molecular Development Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China

Search for other papers by Qing-Feng Wu in
Google Scholar
PubMed
Close

. Supporting the important roles of chemerin in systemic lipid and glucose metabolism, accumulating clinical data indicate that local and/or circulating chemerin levels are increased in patients with obesity, diabetes and cardiovascular disease ( Perumalsamy

Open access
Samrin Kagdi Department of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada

Search for other papers by Samrin Kagdi in
Google Scholar
PubMed
Close
,
Sulayman A Lyons Department of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada

Search for other papers by Sulayman A Lyons in
Google Scholar
PubMed
Close
, and
Jacqueline L Beaudry Department of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada

Search for other papers by Jacqueline L Beaudry in
Google Scholar
PubMed
Close

attractive pharmacotherapy agent for treating type 2 diabetes mellitus (T2DM) and potentially inducing weight loss in obese patients, like glucagon-like peptide-1 receptor (GLP-1R) agonists ( Finan et al. 2016 , Samms et al. 2020 ). In addition, GIPR

Open access
Michael Rouse Laboratory of Clinical Investigation, Laboratory of Cardiovascular Science, National Institute on Aging, Intramural Research Program, National Institutes of Health, 251 Bayview Blvd, Baltimore, Maryland 21224, USA

Search for other papers by Michael Rouse in
Google Scholar
PubMed
Close
,
Antoine Younès Laboratory of Clinical Investigation, Laboratory of Cardiovascular Science, National Institute on Aging, Intramural Research Program, National Institutes of Health, 251 Bayview Blvd, Baltimore, Maryland 21224, USA

Search for other papers by Antoine Younès in
Google Scholar
PubMed
Close
, and
Josephine M Egan Laboratory of Clinical Investigation, Laboratory of Cardiovascular Science, National Institute on Aging, Intramural Research Program, National Institutes of Health, 251 Bayview Blvd, Baltimore, Maryland 21224, USA

Search for other papers by Josephine M Egan in
Google Scholar
PubMed
Close

Introduction Diabetes mellitus (DM) is a chronic metabolic disease that, in 2013, by global estimates has a worldwide prevalence of 382 million people. The number is expected to increase to 592 million by 2035, most having type 2 DM (T2DM

Open access
Stuart A Morgan Institute of Metabolism & Systems Research, University of Birmingham, Birmingham, UK
Department of Biosciences, Nottingham Trent University, Nottingham, UK

Search for other papers by Stuart A Morgan in
Google Scholar
PubMed
Close
,
Laura L Gathercole Department of Biological & Medical Sciences, Oxford Brooks University, Oxford, UK

Search for other papers by Laura L Gathercole in
Google Scholar
PubMed
Close
,
Zaki K Hassan-Smith Institute of Metabolism & Systems Research, University of Birmingham, Birmingham, UK

Search for other papers by Zaki K Hassan-Smith in
Google Scholar
PubMed
Close
,
Jeremy Tomlinson Radcliffe Department of Medicine, University of Oxford, Oxford, UK

Search for other papers by Jeremy Tomlinson in
Google Scholar
PubMed
Close
,
Paul M Stewart Institute of Metabolism & Systems Research, University of Birmingham, Birmingham, UK
NEXUS, Discovery Way, University of Leeds, Leeds, UK

Search for other papers by Paul M Stewart in
Google Scholar
PubMed
Close
, and
Gareth G Lavery Institute of Metabolism & Systems Research, University of Birmingham, Birmingham, UK
Department of Biosciences, Nottingham Trent University, Nottingham, UK

Search for other papers by Gareth G Lavery in
Google Scholar
PubMed
Close

improve healthspan. Interestingly, the aged phenotype shares several metabolic similarities with that of circulatory glucocorticoid (GC) excess (Cushing’s syndrome), including insulin resistance, type 2 diabetes mellitus, central obesity, hypertension

Open access
Peter Kolkhof Drug Discovery, Cardiology Research, Bayer AG, Wuppertal, Germany

Search for other papers by Peter Kolkhof in
Google Scholar
PubMed
Close
and
Lars Bärfacker Drug Discovery, Medicinal Chemistry, Bayer AG, Wuppertal, Germany

Search for other papers by Lars Bärfacker in
Google Scholar
PubMed
Close

efficacy and safety in hypertensive patients with type 2 diabetes and albuminuria NCT2807987 Dec 2017 Phase 3 50 Japan A study of CS-3150 to evaluate efficacy and safety in combination with ARB or ACE inhibitor in hypertensive patients with

Open access
Manon M Roustit
Search for other papers by Manon M Roustit in
Google Scholar
PubMed
Close
,
Joan M Vaughan Department of Comparative Biomedical Sciences, Laboratory of Neuronal Structure and Function, Queen's Medical Research Institute, Royal Veterinary College, University of London, Royal College Street, London NW1 0TU, UK

Search for other papers by Joan M Vaughan in
Google Scholar
PubMed
Close
,
Pauline M Jamieson Department of Comparative Biomedical Sciences, Laboratory of Neuronal Structure and Function, Queen's Medical Research Institute, Royal Veterinary College, University of London, Royal College Street, London NW1 0TU, UK

Search for other papers by Pauline M Jamieson in
Google Scholar
PubMed
Close
, and
Mark E Cleasby
Search for other papers by Mark E Cleasby in
Google Scholar
PubMed
Close

Introduction Impaired insulin-stimulated glucose disposal into skeletal muscle is a major component of the insulin resistance (IR) that develops in advance of type 2 diabetes (T2D) ( DeFronzo & Tripathy 2009 ). In addition, obesity and IR commonly

Open access
Emma Rose McGlone Department of Surgery and Cancer, Imperial College London, London, UK

Search for other papers by Emma Rose McGlone in
Google Scholar
PubMed
Close
,
Stephen R Bloom Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK

Search for other papers by Stephen R Bloom in
Google Scholar
PubMed
Close
, and
Tricia M-M Tan Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK

Search for other papers by Tricia M-M Tan in
Google Scholar
PubMed
Close

patients with type 2 diabetes ( Petersen & Sullivan 2001 , Guan et al. 2015 , Kelly et al. 2015 ). Lean GCGR −/− mice have lower fasting and fed insulin levels than wild-type littermates ( Conarello et al. 2007 ), although this is not

Open access