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Thomas Nicholson Institute of Inflammation and Ageing, MRC-ARUK Centre for Musculoskeletal Ageing Research, University of Birmingham, Birmingham, UK

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Chris Church MedImmune, Cardiovascular and Metabolic Disease (CVMD), Milstein Building, Cambridge, UK

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Kostas Tsintzas MRC-ARUK Centre for Musculoskeletal Ageing Research, School of Life Sciences, Faculty of Medicine & Health Sciences, University of Nottingham, Nottingham, UK

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Robert Jones MRC-ARUK Centre for Musculoskeletal Ageing Research, School of Life Sciences, Faculty of Medicine & Health Sciences, University of Nottingham, Nottingham, UK

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Leigh Breen Institute of Inflammation and Ageing, MRC-ARUK Centre for Musculoskeletal Ageing Research, University of Birmingham, Birmingham, UK

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Edward T Davis The Royal Orthopaedic Hospital NHS Foundation Trust, Northfield, Birmingham, UK

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David J Baker MedImmune, Cardiovascular and Metabolic Disease (CVMD), Milstein Building, Cambridge, UK

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Simon W Jones Institute of Inflammation and Ageing, MRC-ARUK Centre for Musculoskeletal Ageing Research, University of Birmingham, Birmingham, UK

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implications for the treatment of metabolic diseases such as type 2 diabetes ( Bluher 2014 , Bluher & Mantzoros 2015 ). It has long been established that the accumulation of abdominal fat (central adiposity) is associated with insulin resistance ( Pratley et

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-18-0528
Volume/Issue:
Volume 241: Issue 1
Open access
Mark E Cleasby Department of Comparative Biomedical Sciences, Royal Veterinary College, University of London, London, UK

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Pauline M Jamieson Centre for Cardiovascular Science, Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, UK

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Philip J Atherton Division of Medical Sciences and Graduate Entry Medicine, University of Nottingham, Medical School, Royal Derby Hospital, Derby, UK

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Associations between obesity, diabetes and skeletal muscle ageing The International Diabetes Federation has estimated that there were 382 million people living with diabetes in 2013, with this number predicted to rise to 592 million by 2035

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-15-0533
Volume/Issue:
Volume 229: Issue 2
Open access
Bettina Geidl-Flueck Department of Endocrinology, Diabetology and Clinical Nutrition, University Hospital Zurich (USZ) and University of Zurich (UZH), Switzerland

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Philipp A Gerber Department of Endocrinology, Diabetology and Clinical Nutrition, University Hospital Zurich (USZ) and University of Zurich (UZH), Switzerland

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2010 ). HFCS is a cheap sweetener used in the food and beverage industries, and its consumption is linked to the occurrence of type 2 diabetes ( Kmietowicz 2012 ) and other metabolic diseases, as described below. Sugar-sweetened beverage

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https://doi.org/10.1530/JOE-22-0270
Volume/Issue:
Volume 257: Issue 2
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Gisela Helfer School of Chemistry and Biosciences, University of Bradford, Bradford, UK

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Qing-Feng Wu State Key Laboratory of Molecular Development Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China

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. Supporting the important roles of chemerin in systemic lipid and glucose metabolism, accumulating clinical data indicate that local and/or circulating chemerin levels are increased in patients with obesity, diabetes and cardiovascular disease ( Perumalsamy

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-18-0174
Volume/Issue:
Volume 238: Issue 2
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Samrin Kagdi Department of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada

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Sulayman A Lyons Department of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada

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Jacqueline L Beaudry Department of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada

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attractive pharmacotherapy agent for treating type 2 diabetes mellitus (T2DM) and potentially inducing weight loss in obese patients, like glucagon-like peptide-1 receptor (GLP-1R) agonists ( Finan et al. 2016 , Samms et al. 2020 ). In addition, GIPR

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-23-0361
Volume/Issue:
Volume 261: Issue 3
Open access
Michael Rouse Laboratory of Clinical Investigation, Laboratory of Cardiovascular Science, National Institute on Aging, Intramural Research Program, National Institutes of Health, 251 Bayview Blvd, Baltimore, Maryland 21224, USA

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Antoine Younès Laboratory of Clinical Investigation, Laboratory of Cardiovascular Science, National Institute on Aging, Intramural Research Program, National Institutes of Health, 251 Bayview Blvd, Baltimore, Maryland 21224, USA

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Josephine M Egan Laboratory of Clinical Investigation, Laboratory of Cardiovascular Science, National Institute on Aging, Intramural Research Program, National Institutes of Health, 251 Bayview Blvd, Baltimore, Maryland 21224, USA

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Introduction Diabetes mellitus (DM) is a chronic metabolic disease that, in 2013, by global estimates has a worldwide prevalence of 382 million people. The number is expected to increase to 592 million by 2035, most having type 2 DM (T2DM

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-14-0335
Volume/Issue:
Volume 223: Issue 2
Open access
Stuart A Morgan Institute of Metabolism & Systems Research, University of Birmingham, Birmingham, UK
Department of Biosciences, Nottingham Trent University, Nottingham, UK

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Laura L Gathercole Department of Biological & Medical Sciences, Oxford Brooks University, Oxford, UK

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Zaki K Hassan-Smith Institute of Metabolism & Systems Research, University of Birmingham, Birmingham, UK

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Jeremy Tomlinson Radcliffe Department of Medicine, University of Oxford, Oxford, UK

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Paul M Stewart Institute of Metabolism & Systems Research, University of Birmingham, Birmingham, UK
NEXUS, Discovery Way, University of Leeds, Leeds, UK

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Gareth G Lavery Institute of Metabolism & Systems Research, University of Birmingham, Birmingham, UK
Department of Biosciences, Nottingham Trent University, Nottingham, UK

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improve healthspan. Interestingly, the aged phenotype shares several metabolic similarities with that of circulatory glucocorticoid (GC) excess (Cushing’s syndrome), including insulin resistance, type 2 diabetes mellitus, central obesity, hypertension

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-22-0169
Volume/Issue:
Volume 255: Issue 3
Open access
Peter Kolkhof Drug Discovery, Cardiology Research, Bayer AG, Wuppertal, Germany

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Lars Bärfacker Drug Discovery, Medicinal Chemistry, Bayer AG, Wuppertal, Germany

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efficacy and safety in hypertensive patients with type 2 diabetes and albuminuria NCT2807987 Dec 2017 Phase 3 50 Japan A study of CS-3150 to evaluate efficacy and safety in combination with ARB or ACE inhibitor in hypertensive patients with

Article Type:
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DOI:
https://doi.org/10.1530/JOE-16-0600
Volume/Issue:
Volume 234: Issue 1
Open access
Manon M Roustit
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Joan M Vaughan Department of Comparative Biomedical Sciences, Laboratory of Neuronal Structure and Function, Queen's Medical Research Institute, Royal Veterinary College, University of London, Royal College Street, London NW1 0TU, UK

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Pauline M Jamieson Department of Comparative Biomedical Sciences, Laboratory of Neuronal Structure and Function, Queen's Medical Research Institute, Royal Veterinary College, University of London, Royal College Street, London NW1 0TU, UK

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Mark E Cleasby
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Introduction Impaired insulin-stimulated glucose disposal into skeletal muscle is a major component of the insulin resistance (IR) that develops in advance of type 2 diabetes (T2D) ( DeFronzo & Tripathy 2009 ). In addition, obesity and IR commonly

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-14-0181
Volume/Issue:
Volume 223: Issue 2
Open access
Emma Rose McGlone Department of Surgery and Cancer, Imperial College London, London, UK

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Stephen R Bloom Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK

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Tricia M-M Tan Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK

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patients with type 2 diabetes ( Petersen & Sullivan 2001 , Guan et al. 2015 , Kelly et al. 2015 ). Lean GCGR −/− mice have lower fasting and fed insulin levels than wild-type littermates ( Conarello et al. 2007 ), although this is not

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-23-0365
Volume/Issue:
Volume 261: Issue 3
Open access