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Open access

M J F Newson, G R Pope, E M Roberts, S J Lolait, and A-M O'Carroll

adrenalectomy ( O'Carroll et al . 2003 ), the direct effect of a targeted disruption of APJ on HPA axis activity has not been investigated. To test the hypothesis that activation of the apelin/APJ system is important in the HPA axis response to acute stress, we

Open access

Georgina G J Hazell, Song T Yao, James A Roper, Eric R Prossnitz, Anne-Marie O'Carroll, and Stephen J Lolait

, de Ronde et al . 2003 ). E 2 effects are typically mediated through two structurally related oestrogen receptors, the α and β (ERα and ERβ) subtypes that function as ligand-activated transcription factors. On activation ERs can either bind directly

Open access

David E Maridas, Victoria E DeMambro, Phuong T Le, Kenichi Nagano, Roland Baron, Subburaman Mohan, and Clifford J Rosen

. RNA concentrations were estimated using NanoDrop2000 (Thermo Fisher Scientific), and 500 ng RNA was used as template for the reverse transcription reaction into cDNA using High-Capacity cDNA Reverse Transcription Kit (Thermo Fisher Scientific). The

Open access

Sandra Pereira, Wen Qin Yu, María E Frigolet, Jacqueline L Beaudry, Yaniv Shpilberg, Edward Park, Cristina Dirlea, B L Grégoire Nyomba, Michael C Riddell, I George Fantus, and Adria Giacca

( Aguirre et al . 2000 ), and ii) activation of the transcription factor nuclear factor kB (NF-kB), which upregulates the expression of various cytokines ( Barnes & Karin 1997 ). NF-kB is inhibited when bound to IkBa in the cytoplasm, but upon

Open access

Ashley Patton, Tyler Church, Caroline Wilson, Jean Thuma, Douglas J Goetz, Darlene E Berryman, Edward O List, Frank Schwartz, and Kelly D McCall

TLR3 and TLR4 signaling in both immune and non-immune cells by blocking homodimerization of IRF3 and thus blocking its nuclear translocation and transcriptional activation activity ( Courreges et al . 2012 ). Thus, we hypothesized that C10 will

Open access

Katie J Mylonas, Neil A Turner, Sumia A Bageghni, Christopher J Kenyon, Christopher I White, Kieran McGregor, Robert A Kimmitt, Richard Sulston, Valerie Kelly, Brian R Walker, Karen E Porter, Karen E Chapman, and Gillian A Gray

chemoattractant signals from injured tissue, as well as adhesion to endothelial cells and migration into the tissue. Previous studies have focused on the latter, showing that neutrophil 11β-HSD1 activity is increased during inflammation and that this activity

Open access

M E Cleasby, Q Lau, E Polkinghorne, S A Patel, S J Leslie, N Turner, G J Cooney, A Xu, and E W Kraegen

, recently published data implicate a ceramidase activity of the receptors in the improvement of insulin sensitivity through a reduction in intracellular ceramide accumulation ( Holland et al . 2010 ). Adaptor protein containing pleckstrin homology domain

Open access

Huali Yu, Ye Guo, Yang Zhao, Feng Zhou, Kehan Zhao, Mayuqing Li, Junxiong Wen, Zixuan He, Xiaojuan Zhu, and Xiaoxiao He

exert anti-inflammatory and immunosuppressive effects and thus are used as therapeutic agents ( Coutinho & Chapman 2011 ). The major actions of GC are mediated by the glucocorticoid receptor (GR), which is a transcriptional regulator that is ubiquitously

Open access

David M Golding, Daniel J Rees, Jennifer R Davies, Dinko Relkovic, Hannah V Furby, Irina A Guschina, Anna L Hopkins, Jeffrey S Davies, James L Resnick, Anthony R Isles, and Timothy Wells

aspects of PWS in this model, including reduced locomotor activity and deficits in cognitive function, such as attention and impulse control ( Doe et al . 2009 , Relkovic et al . 2010 ). However, although we have shown that hyperphagia in PWS-IC del

Open access

Scott Haston, Saba Manshaei, and Juan Pedro Martinez-Barbera

) and gonadotropins (FSH and LH), respectively ( Kelberman et al. 2009 ). These secretory cells have been defined by the expression of specific-lineage transcription factors that are important for their induction and maintenance. These lineage