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K L Davies Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK

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E J Camm Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK
The Ritchie Centre, Hudson Institute of Medical Research, Clayton, Australia

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D J Smith Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK

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O R Vaughan Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK
Institute for Women’s Health, University College London, London, UK

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A J Forhead Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK
Department of Biological and Medical Sciences, Oxford Brookes University, Oxford, UK

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A J Murray Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK

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A L Fowden Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK

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Introduction In adults, glucocorticoids are stress hormones with metabolic actions on a wide range of tissues that maintain functions critical to survival in adverse environmental conditions and during normal physiological challenges to

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-21-0171
Volume/Issue:
Volume 251: Issue 1
Open access
R Dobie
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V E MacRae
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C Huesa
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R van't Hof Division of Developmental Biology, Institute of Ageing and Chronic Disease, Developmental Endocrinology Research Group, The Roslin Institute and R(D)SVS, The University of Edinburgh, Easter Bush, Midlothian, Edinburgh EH25 9RG, Scotland, UK

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S F Ahmed Division of Developmental Biology, Institute of Ageing and Chronic Disease, Developmental Endocrinology Research Group, The Roslin Institute and R(D)SVS, The University of Edinburgh, Easter Bush, Midlothian, Edinburgh EH25 9RG, Scotland, UK

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C Farquharson
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Introduction Growth hormone (GH) is a key regulator of postnatal skeletal development; however, its mode of action remains unclear ( Slootweg 1993 , Ohlsson et al . 1998 ). It is likely to involve both endocrine (systemic) actions via hepatic

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-14-0292
Volume/Issue:
Volume 223: Issue 1
Open access
Dawn E W Livingstone Endocrinology, Queen's Medical Research Institute, University and British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK

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Emma M Di Rollo Endocrinology, Queen's Medical Research Institute, University and British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK

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Chenjing Yang Endocrinology, Queen's Medical Research Institute, University and British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK

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Lucy E Codrington Endocrinology, Queen's Medical Research Institute, University and British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK

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John A Mathews Endocrinology, Queen's Medical Research Institute, University and British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK

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Madina Kara Endocrinology, Queen's Medical Research Institute, University and British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK

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Katherine A Hughes Endocrinology, Queen's Medical Research Institute, University and British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK

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Christopher J Kenyon Endocrinology, Queen's Medical Research Institute, University and British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK

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Brian R Walker Endocrinology, Queen's Medical Research Institute, University and British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK

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Ruth Andrew Endocrinology, Queen's Medical Research Institute, University and British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK

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Introduction Activation of the hypothalamic–pituitary–adrenal (HPA) axis is a vital component of the stress response, driving production of glucocorticoid hormones (cortisol in humans, corticosterone in rodents) that mediate essential adaptations of

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-13-0563
Volume/Issue:
Volume 222: Issue 2
Open access
Jin Yu Department of Gynecology of Traditional Chinese Medicine, Changhai Hospital, Naval Medical University, Shanghai, China

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Yuhuan Liu Department of Gynecology and Obstetrics, Changhai Hospital, Naval Medical University, Shanghai, China

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Danying Zhang Department of Gynecology of Traditional Chinese Medicine, Changhai Hospital, Naval Medical University, Shanghai, China

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Dongxia Zhai Department of Gynecology of Traditional Chinese Medicine, Changhai Hospital, Naval Medical University, Shanghai, China

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Linyi Song Department of Gynecology of Traditional Chinese Medicine, Changhai Hospital, Naval Medical University, Shanghai, China

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Zailong Cai Department of Biochemistry and Molecular Biology, Naval Medical University, Shanghai, China

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Chaoqin Yu Department of Gynecology of Traditional Chinese Medicine, Changhai Hospital, Naval Medical University, Shanghai, China

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cells and hormonal profiles of the orbital venous blood. Besides, six rats were randomly selected and confirmed by ovarian morphology. The successfully established model rats, with a disordered estrous cycle and hormonal profile, were selected and

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-18-0678
Volume/Issue:
Volume 240: Issue 3
Open access
Jianshu Chen Lanzhou University Second College of Clinical Medicine, Lanzhou, China

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Jing Yu Lanzhou University Second College of Clinical Medicine, Lanzhou, China
Department of Cardiology, Lanzhou University Second Hospital, Lanzhou, China

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Ruowen Yuan Department of Cardiology, Lanzhou University Second Hospital, Lanzhou, China

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Ningyin Li Department of Cardiology, Lanzhou University Second Hospital, Lanzhou, China

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Caie Li Department of Cardiology, Lanzhou University Second Hospital, Lanzhou, China

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Xiaofang Zhang Department of Cardiology, Lanzhou University Second Hospital, Lanzhou, China

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postmenopausal hypertension patients is closely associated with the changes of sex hormone axis in postmenopausal women ( Gohar et al. 2020 , Shawky et al. 2020 ). Experimental studies have confirmed that dynamic changes in estrogen levels are significantly

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-21-0284
Volume/Issue:
Volume 252: Issue 3
Open access
Emma Castrique Henry Wellcome Labs for Integrative Neuroscience and Endocrinology, Division of Molecular Neuroendocrinology, Department of Cellular and Molecular Medicine, University of Bristol, Dorothy Hodgkin Building, Whitson Street, Bristol BS1 3NY, UK

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Marta Fernandez-Fuente Henry Wellcome Labs for Integrative Neuroscience and Endocrinology, Division of Molecular Neuroendocrinology, Department of Cellular and Molecular Medicine, University of Bristol, Dorothy Hodgkin Building, Whitson Street, Bristol BS1 3NY, UK

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Paul Le Tissier Henry Wellcome Labs for Integrative Neuroscience and Endocrinology, Division of Molecular Neuroendocrinology, Department of Cellular and Molecular Medicine, University of Bristol, Dorothy Hodgkin Building, Whitson Street, Bristol BS1 3NY, UK

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Andy Herman Henry Wellcome Labs for Integrative Neuroscience and Endocrinology, Division of Molecular Neuroendocrinology, Department of Cellular and Molecular Medicine, University of Bristol, Dorothy Hodgkin Building, Whitson Street, Bristol BS1 3NY, UK

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Andy Levy Henry Wellcome Labs for Integrative Neuroscience and Endocrinology, Division of Molecular Neuroendocrinology, Department of Cellular and Molecular Medicine, University of Bristol, Dorothy Hodgkin Building, Whitson Street, Bristol BS1 3NY, UK

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potential of failing to identify lactotrophs which have secreted a large proportion of their hormone. To exploit the principal power of the Cre recombinase model, which is specificity rather than sensitivity, the present study was designed particularly to

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-09-0414
Volume/Issue:
Volume 205: Issue 1
Open access
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Kristen R Lednovich Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA

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Sophie Gough Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA

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Medha Priyadarshini Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA

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Nupur Pandya Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA

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Chioma Nnyamah Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA

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Kai Xu Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA

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Barton Wicksteed Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA

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Sidharth Mishra USF Center for Microbiome Research, University of South Florida Morsani College of Medicine, Tampa, Florida, USA

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Shalini Jain USF Center for Microbiome Research, University of South Florida Morsani College of Medicine, Tampa, Florida, USA

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Joseph L Zapater Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA
Jesse Brown Veterans Affairs Medical Center, Chicago, Illinois, USA

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Jose Cordoba-Chacon Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA

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Hariom Yadav USF Center for Microbiome Research, University of South Florida Morsani College of Medicine, Tampa, Florida, USA

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Brian T Layden Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA
Jesse Brown Veterans Affairs Medical Center, Chicago, Illinois, USA

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2 specifically within enteroendocrine cells (EECs) and intestinal epithelial cells (IECs) ( Karaki et al. 2006 , Andersen et al. 2018 ). Within EECs, FFA2 has been suggested to mediate the release of multiple postprandial peptide hormones

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-23-0184
Volume/Issue:
Volume 260: Issue 2
Open access
Valentina Pampanini Department of Women’s and Children’s Health, Pediatric Endocrinology Unit, Q2:08, Karolinska Institutet and University Hospital, Stockholm, Sweden

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Daniela Germani Department of Systems Medicine, Tor Vergata University, Rome, Italy

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Antonella Puglianiello Department of Systems Medicine, Tor Vergata University, Rome, Italy

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Jan-Bernd Stukenborg Department of Women’s and Children’s Health, Pediatric Endocrinology Unit, Q2:08, Karolinska Institutet and University Hospital, Stockholm, Sweden

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Ahmed Reda Department of Women’s and Children’s Health, Pediatric Endocrinology Unit, Q2:08, Karolinska Institutet and University Hospital, Stockholm, Sweden

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Iuliia Savchuk Department of Women’s and Children’s Health, Pediatric Endocrinology Unit, Q2:08, Karolinska Institutet and University Hospital, Stockholm, Sweden

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Kristín Rós Kjartansdóttir Department of Women’s and Children’s Health, Pediatric Endocrinology Unit, Q2:08, Karolinska Institutet and University Hospital, Stockholm, Sweden

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Stefano Cianfarani Department of Women’s and Children’s Health, Pediatric Endocrinology Unit, Q2:08, Karolinska Institutet and University Hospital, Stockholm, Sweden
Dipartimento Pediatrico Universitario Ospedaliero ‘Bambino Gesù’ Children’s Hospital – Tor Vergata University, Rome, Italy

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Olle Söder Department of Women’s and Children’s Health, Pediatric Endocrinology Unit, Q2:08, Karolinska Institutet and University Hospital, Stockholm, Sweden

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cryptorchidism, hypospadias and testicular cancer, grouped under the definition of testicular dysgenesis syndrome (TDS) ( Skakkebaek et al . 2001 , Main et al . 2006 ). Previous studies reported alterations of puberty and hormonal levels in boys, but the

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-16-0418
Volume/Issue:
Volume 232: Issue 2
Open access
Miroslav Adzic
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Jelena Djordjevic
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Ana Djordjevic
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Ana Niciforovic
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Constantinos Demonacos Laboratory of Molecular Biology and Endocrinology, School of Pharmacy, Faculty of Life Sciences, VINCA Institute of Nuclear Sciences, PO Box-522-MBE090, 11001 Belgrade, Serbia

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Marija Radojcic
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Marija Krstic-Demonacos Laboratory of Molecular Biology and Endocrinology, School of Pharmacy, Faculty of Life Sciences, VINCA Institute of Nuclear Sciences, PO Box-522-MBE090, 11001 Belgrade, Serbia

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Introduction Response to neuroendocrine stress begins with the activation of the hypothalamic–pituitary–adrenal (HPA) axis leading to the increase in stress hormones glucocorticoids (GCs). These hormones mediate adaptation to stress and also

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-08-0509
Volume/Issue:
Volume 202: Issue 1
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Denys deCatanzaro Department of Psychology, Neuroscience & Behaviour, McMaster University, Hamilton, Ontario, Canada

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Tyler Pollock Department of Psychology, Neuroscience & Behaviour, McMaster University, Hamilton, Ontario, Canada

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gonadotropins. During the follicular phase of the cycle, E 2 stimulates uterine endometrial growth ( Garcia et al . 1988 ) and triggers a mid-cycle surge of luteinizing hormone (LH), which in turn induces ovulation and release of P 4 during the luteal phase

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-16-0247
Volume/Issue:
Volume 231: Issue 3
Open access