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S Schmidt Toxicology, Department of Human Molecular Genetics, Research Group Neurogenetics, Departments of

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A Hommel Toxicology, Department of Human Molecular Genetics, Research Group Neurogenetics, Departments of

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V Gawlik Toxicology, Department of Human Molecular Genetics, Research Group Neurogenetics, Departments of

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R Augustin Toxicology, Department of Human Molecular Genetics, Research Group Neurogenetics, Departments of

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N Junicke Toxicology, Department of Human Molecular Genetics, Research Group Neurogenetics, Departments of

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S Florian Toxicology, Department of Human Molecular Genetics, Research Group Neurogenetics, Departments of

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M Richter Toxicology, Department of Human Molecular Genetics, Research Group Neurogenetics, Departments of

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D J Walther Toxicology, Department of Human Molecular Genetics, Research Group Neurogenetics, Departments of

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D Montag Toxicology, Department of Human Molecular Genetics, Research Group Neurogenetics, Departments of

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H-G Joost Toxicology, Department of Human Molecular Genetics, Research Group Neurogenetics, Departments of

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A Schürmann Toxicology, Department of Human Molecular Genetics, Research Group Neurogenetics, Departments of

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. Developmental Neuroscience 20 369 – 379 . Wang D Pascual JM Yang H Engelstad K Mao X Cheng J Yoo J Noebels JL De Vivo DC 2006 A mouse model for Glut-1 haploinsufficiency . Human Molecular Genetics 15 1169 – 1179 . Wyman A Pinto

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Alyce M Martin College of Medicine and Public Health, Flinders University, Adelaide, South Australia, Australia

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Emily W Sun College of Medicine and Public Health, Flinders University, Adelaide, South Australia, Australia

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Damien J Keating College of Medicine and Public Health, Flinders University, Adelaide, South Australia, Australia
Nutrition and Metabolism, South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia

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.09.055 ) Aponte Y Atasoy D Sternson SM 2011 AGRP neurons are sufficient to orchestrate feeding behavior rapidly and without training . Nature Neuroscience 351 – 355 . ( https://doi.org/10.1038/nn.2739 ) Backhed F Manchester JK Semenkovich CF

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E Meimaridou Centre for Endocrinology, William Harvey Research Institute, John Vane Science Centre, Queen Mary, University of London, London, UK

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M Goldsworthy MRC Harwell Institute, Genetics of Type 2 Diabetes, Mammalian Genetics Unit, Oxfordshire, UK

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V Chortis Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK
Centre for Endocrinology, Diabetes and Metabolism, Birmingham Health Partners, Birmingham, UK

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E Fragouli Centre for Endocrinology, William Harvey Research Institute, John Vane Science Centre, Queen Mary, University of London, London, UK

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P A Foster Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK
Centre for Endocrinology, Diabetes and Metabolism, Birmingham Health Partners, Birmingham, UK

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W Arlt Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK
Centre for Endocrinology, Diabetes and Metabolism, Birmingham Health Partners, Birmingham, UK

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R Cox MRC Harwell Institute, Genetics of Type 2 Diabetes, Mammalian Genetics Unit, Oxfordshire, UK

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L A Metherell Centre for Endocrinology, William Harvey Research Institute, John Vane Science Centre, Queen Mary, University of London, London, UK

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stress induces a heat shock protein response . Journal of Neuroscience Research 78 420 – 429 . ( https://doi.org/10.1002/jnr.20249 ) 15389841 10.1002/jnr.20249 Biagioli M Pinto M Cesselli D Zaninello M Lazarevic D Roncaglia P

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Emma Wilson Centre for Clinical Brain Sciences, The University of Edinburgh, Edinburgh, UK
Simons Initiative for the Developing Brain, The University of Edinburgh, Edinburgh, UK

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Fiona J Ramage Department of Systems Medicine, School of Medicine, University of Dundee, Dundee, UK

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Kimberley E Wever Department of Anesthesiology, Pain and Palliative Care, Radboud University Medical Center, Nijmegen, The Netherlands

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Emily S Sena Centre for Clinical Brain Sciences, The University of Edinburgh, Edinburgh, UK

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Malcolm R Macleod Centre for Clinical Brain Sciences, The University of Edinburgh, Edinburgh, UK

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Gillian L Currie Centre for Clinical Brain Sciences, The University of Edinburgh, Edinburgh, UK

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Neuroscience 11 5. ( https://doi.org/10.1186/1471-2202-11-5 ) Lazic SE Clarke-Williams CJ & Munafò MR 2018 What exactly is ‘N’ in cell culture and animal experiments? PLOS Biology 16 e2005282. ( https://doi.org/10.1371/journal.pbio.2005282

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David O'Regan Endocrinology Unit, Queen's Medical Research Institute, Centre for Cardiovascular Science, 47 Little France Crescent, Edinburgh EH16 4TJ, UK

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Christopher J Kenyon Endocrinology Unit, Queen's Medical Research Institute, Centre for Cardiovascular Science, 47 Little France Crescent, Edinburgh EH16 4TJ, UK

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Jonathan R Seckl Endocrinology Unit, Queen's Medical Research Institute, Centre for Cardiovascular Science, 47 Little France Crescent, Edinburgh EH16 4TJ, UK

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Megan C Holmes Endocrinology Unit, Queen's Medical Research Institute, Centre for Cardiovascular Science, 47 Little France Crescent, Edinburgh EH16 4TJ, UK

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– 950 . Welberg LA Seckl JR Holmes MC 2001 Prenatal glucocorticoid programming of brain corticosteroid receptors and corticotrophin-releasing hormone: possible implications for behaviour . Neuroscience 104 71 – 79

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Karen Piper Hanley
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Tom Hearn Endocrinology and Diabetes Group, Human Genetics Division, Beta-Cell Development and Function Group, Peninsula Medical School, Manchester Academic Health Science Centre, University of Manchester, A V Hill Building, Oxford Road, Manchester M13 9PT, UK

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Andrew Berry
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Melanie J Carvell Endocrinology and Diabetes Group, Human Genetics Division, Beta-Cell Development and Function Group, Peninsula Medical School, Manchester Academic Health Science Centre, University of Manchester, A V Hill Building, Oxford Road, Manchester M13 9PT, UK

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Ann-Marie Patch Endocrinology and Diabetes Group, Human Genetics Division, Beta-Cell Development and Function Group, Peninsula Medical School, Manchester Academic Health Science Centre, University of Manchester, A V Hill Building, Oxford Road, Manchester M13 9PT, UK

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Louise J Williams Endocrinology and Diabetes Group, Human Genetics Division, Beta-Cell Development and Function Group, Peninsula Medical School, Manchester Academic Health Science Centre, University of Manchester, A V Hill Building, Oxford Road, Manchester M13 9PT, UK

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Sarah A Sugden
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David I Wilson Endocrinology and Diabetes Group, Human Genetics Division, Beta-Cell Development and Function Group, Peninsula Medical School, Manchester Academic Health Science Centre, University of Manchester, A V Hill Building, Oxford Road, Manchester M13 9PT, UK

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Sian Ellard Endocrinology and Diabetes Group, Human Genetics Division, Beta-Cell Development and Function Group, Peninsula Medical School, Manchester Academic Health Science Centre, University of Manchester, A V Hill Building, Oxford Road, Manchester M13 9PT, UK

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Neil A Hanley
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. American Journal of Physiology. Cell Physiology 292 C98 – C105 doi:10.1152/ajpcell.00005.2006 . Schluter OM Schmitz F Jahn R Rosenmund C Sudhof TC 2004 A complete genetic analysis of neuronal Rab3 function . Journal of Neuroscience 24

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Sushil K Mahata VA San Diego Healthcare System Metabolic Physiology & Ultrastructural Biology Lab., Department of Medicine, University of California at San Diego, La Jolla, CA, USA

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Hong Zheng Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, NE, USA

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Sumana Mahata Caltech Division of Biology, California Institute of Technology, Pasadena, CA, USA

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Xuefei Liu Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, NE, USA

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Kaushik P Patel Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, NE, USA

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stress transduction at the adrenomedullary synapse? Journal of Molecular Neuroscience 48 403 – 412 . ( doi:10.1007/s12031-012-9749-x ) Stroth N Kuri BA Mustafa T Chan SA Smith CB Eiden LE 2013 PACAP controls

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Sian J S Simpson Department of Diabetes, School of Life Course Sciences, Faculty of Life Science and Medicine, King’s College London, London, UK

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Lorna I F Smith Department of Diabetes, School of Life Course Sciences, Faculty of Life Science and Medicine, King’s College London, London, UK

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Peter M Jones Department of Diabetes, School of Life Course Sciences, Faculty of Life Science and Medicine, King’s College London, London, UK

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James E Bowe Department of Diabetes, School of Life Course Sciences, Faculty of Life Science and Medicine, King’s College London, London, UK

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Smith-Roe S Newman SM Grigoriadis DE Kalin NH 2002 Reduction of stress-induced behavior by antagonism of corticotropin-releasing hormone 2 (CRH2) receptors in lateral septum or CRH1 receptors in amygdala . Journal of Neuroscience 22 2926

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Bernadette M Trojanowski Institute of Physiological Chemistry, Ulm University, Ulm, Germany

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Heba H Salem Faculty of Pharmacy, Cairo University, Cairo, Egypt
Faculty of Pharmacy, King Khalid University, Abha, Saudi Arabia

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Heike Neubauer Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach, Germany

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Eric Simon Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach, Germany

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Martin Wagner Division of Endocrinology, Diabetes and Metabolism, Ulm University Medical Centre, Ulm University, Ulm, Germany

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Rajkumar Dorajoo Genome Institute of Singapore, Agency for Science Technology and Research, Singapore, Singapore

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Bernhard O Boehm Lee Kong Chiang School of Medicine, Nanyang Technological University, Singapore, Singapore
Imperial College London, London, UK

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Leticia Labriola Institute of Physiological Chemistry, Ulm University, Ulm, Germany
Department of Biochemistry, University of São Paulo, São Paulo, Brazil

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Thomas Wirth Institute of Physiological Chemistry, Ulm University, Ulm, Germany

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Bernd Baumann Institute of Physiological Chemistry, Ulm University, Ulm, Germany

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links neuroinflammation to hydrocephalus formation. Journal of Neuroscience 11511 – 11523 . ( https://doi.org/10.1523/JNEUROSCI.0182-12.2012 ) Lee J Ozcan U 2014 Unfolded protein response signaling and metabolic diseases . Journal of

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Louise Grahnemo Departments of Rheumatology and Inflammation Research, Internal Medicine and Clinical Nutrition, Laboratory of Tumor Immunology and Biology, Centre for Bone and Arthritis Research, Institute of Medicine, The Sahlgrenska Academy, University of Gothenburg, Box 480, Gothenburg 405 30, Sweden

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Caroline Jochems Departments of Rheumatology and Inflammation Research, Internal Medicine and Clinical Nutrition, Laboratory of Tumor Immunology and Biology, Centre for Bone and Arthritis Research, Institute of Medicine, The Sahlgrenska Academy, University of Gothenburg, Box 480, Gothenburg 405 30, Sweden
Departments of Rheumatology and Inflammation Research, Internal Medicine and Clinical Nutrition, Laboratory of Tumor Immunology and Biology, Centre for Bone and Arthritis Research, Institute of Medicine, The Sahlgrenska Academy, University of Gothenburg, Box 480, Gothenburg 405 30, Sweden

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Annica Andersson Departments of Rheumatology and Inflammation Research, Internal Medicine and Clinical Nutrition, Laboratory of Tumor Immunology and Biology, Centre for Bone and Arthritis Research, Institute of Medicine, The Sahlgrenska Academy, University of Gothenburg, Box 480, Gothenburg 405 30, Sweden

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Cecilia Engdahl Departments of Rheumatology and Inflammation Research, Internal Medicine and Clinical Nutrition, Laboratory of Tumor Immunology and Biology, Centre for Bone and Arthritis Research, Institute of Medicine, The Sahlgrenska Academy, University of Gothenburg, Box 480, Gothenburg 405 30, Sweden
Departments of Rheumatology and Inflammation Research, Internal Medicine and Clinical Nutrition, Laboratory of Tumor Immunology and Biology, Centre for Bone and Arthritis Research, Institute of Medicine, The Sahlgrenska Academy, University of Gothenburg, Box 480, Gothenburg 405 30, Sweden

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Claes Ohlsson Departments of Rheumatology and Inflammation Research, Internal Medicine and Clinical Nutrition, Laboratory of Tumor Immunology and Biology, Centre for Bone and Arthritis Research, Institute of Medicine, The Sahlgrenska Academy, University of Gothenburg, Box 480, Gothenburg 405 30, Sweden

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Ulrika Islander Departments of Rheumatology and Inflammation Research, Internal Medicine and Clinical Nutrition, Laboratory of Tumor Immunology and Biology, Centre for Bone and Arthritis Research, Institute of Medicine, The Sahlgrenska Academy, University of Gothenburg, Box 480, Gothenburg 405 30, Sweden

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Hans Carlsten Departments of Rheumatology and Inflammation Research, Internal Medicine and Clinical Nutrition, Laboratory of Tumor Immunology and Biology, Centre for Bone and Arthritis Research, Institute of Medicine, The Sahlgrenska Academy, University of Gothenburg, Box 480, Gothenburg 405 30, Sweden

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by increasing hypothalamic insulin sensitivity . Journal of Neuroscience 30 16180 – 16187 . ( doi:10.1523/JNEUROSCI.3202-10.2010 ) Koetz KR Ventz M Diederich S Quinkler M 2012 Bone mineral density is not significantly reduced in adult

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