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transcription of the preproglucagon gene, which in turn leads to increases in circulating glucagon and glucagon-like peptide 1 (GLP-1). There are increased levels of hepatic and plasma fibroblast growth factor 21 (FGF-21). Reduced hepatic glucagon receptor
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Department of Endocrinology, School of Medicine, Pontificia Universidad Catolica De Chile, Santiago, Chile
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a nuclear transcription factor, and the rapidly activated, non-genomic pathway ( Fuller & Young 2005 , Baudrand et al. 2014 ). Activation of the non-genomic pathway is associated with increased phosphorylation of several proteins, including those
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translocate to the nucleus and regulate gene expression through either direct interaction with specific promoter sequences or protein–protein interactions with other transcription factors ( Mitre-Aguilar et al. 2015 ). Although GC/GR signaling-mediated gene
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. Obesity is a risk factor for sepsis morbidity and mortality. Morbid obesity increases the risk of death by sepsis following major surgery by 50% ( Prabhakar et al . 2002 ). It is thought that the pro-inflammatory phenotype that accompanies obesity creates
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. 2005 , Shankaran et al . 2005 ). As a recent study suggests, neonatal HIE might start antenatally, implying the importance of different factors (i.e. genetic and/or infectious, and placental factors), but parturition might have importance for the
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. 2000 ). ERα is a ligand-activated nuclear receptor transcription factor that, upon estrogen binding, translocates to the nucleus, where it associates with estrogen response elements in promoter and enhancer regions of target genes to activate
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-enriched transcription factors (TFs) ( Brissova et al. 2018 , Wang et al. 2019 , Camunas-Soler et al. 2020 ). Recent work using islets from non-diabetic adult single GAD autoantibody-positive individuals led to a surprising discovery that alpha cells appear to
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transcription factors of the Gli family to induce target gene expression (e.g. Gli1, Gli2 or Ptch ) (reviewed in Bangs & Anderson 2017 ). Inactivation or overactivation of the pathway during pituitary organogenesis can lead to agenesis of the gland
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not undergo a sequence of proliferation, maturation, hypertrophy, apoptosis and ossification ( Pacifici et al . 2005 , 2006 ). It has been suggested that the expression of the transcription factor ETS-related gene (ERG) is necessary early in joint
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expression of the HDL scavenger receptor Scarb1 , LDL receptor ( Ldlr ) and the key transcription factor of cholesterol biosynthesis Srebp2 ( Shimomura et al . 1998 ) in the livers of 129/Sv Mrap2 tm1a/tm1a mice. Interestingly, Srebp2 mRNA levels were