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Emma Rose McGlone Department of Surgery and Cancer, Imperial College London, London, UK

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Stephen R Bloom Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK

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Tricia M-M Tan Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK

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transcription of the preproglucagon gene, which in turn leads to increases in circulating glucagon and glucagon-like peptide 1 (GLP-1). There are increased levels of hepatic and plasma fibroblast growth factor 21 (FGF-21). Reduced hepatic glucagon receptor

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-23-0365
Volume/Issue:
Volume 261: Issue 3
Open access
Amanda E Garza Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA

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Elijah Trefts Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA

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Isis A Katayama Rangel Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA

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Danielle Brooks Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA

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Rene Baudrand Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA
Department of Endocrinology, School of Medicine, Pontificia Universidad Catolica De Chile, Santiago, Chile

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Burhanuddin Moize Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA

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Jose R Romero Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA

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Sanjay Ranjit Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA

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Thitinan Treesaranuwattana Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA

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Tham M Yao Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA

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Gail K Adler Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA

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Luminita H Pojoga Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA

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Gordon H Williams Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA

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a nuclear transcription factor, and the rapidly activated, non-genomic pathway ( Fuller & Young 2005 , Baudrand et al. 2014 ). Activation of the non-genomic pathway is associated with increased phosphorylation of several proteins, including those

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-19-0562
Volume/Issue:
Volume 245: Issue 3
Open access
Huali Yu Key Laboratory of Molecular Epigenetics, Ministry of Education and Institute of Cytology and Genetics, Northeast Normal University, Changchun, China

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Ye Guo Key Laboratory of Molecular Epigenetics, Ministry of Education and Institute of Cytology and Genetics, Northeast Normal University, Changchun, China

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Yang Zhao Key Laboratory of Molecular Epigenetics, Ministry of Education and Institute of Cytology and Genetics, Northeast Normal University, Changchun, China

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Feng Zhou Key Laboratory of Molecular Epigenetics, Ministry of Education and Institute of Cytology and Genetics, Northeast Normal University, Changchun, China

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Kehan Zhao Key Laboratory of Molecular Epigenetics, Ministry of Education and Institute of Cytology and Genetics, Northeast Normal University, Changchun, China

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Mayuqing Li Key Laboratory of Molecular Epigenetics, Ministry of Education and Institute of Cytology and Genetics, Northeast Normal University, Changchun, China

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Junxiong Wen Key Laboratory of Molecular Epigenetics, Ministry of Education and Institute of Cytology and Genetics, Northeast Normal University, Changchun, China

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Zixuan He Key Laboratory of Molecular Epigenetics, Ministry of Education and Institute of Cytology and Genetics, Northeast Normal University, Changchun, China

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Xiaojuan Zhu Key Laboratory of Molecular Epigenetics, Ministry of Education and Institute of Cytology and Genetics, Northeast Normal University, Changchun, China

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Xiaoxiao He Key Laboratory of Molecular Epigenetics, Ministry of Education and Institute of Cytology and Genetics, Northeast Normal University, Changchun, China

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translocate to the nucleus and regulate gene expression through either direct interaction with specific promoter sequences or protein–protein interactions with other transcription factors ( Mitre-Aguilar et al. 2015 ). Although GC/GR signaling-mediated gene

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-19-0207
Volume/Issue:
Volume 242: Issue 2
Open access
Saadia Basharat
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Jennifer A Parker Division of Diabetes, University College London, Brunel University, Endocrinology and Metabolism, Department of Investigative Medicine, Imperial College London, Hammersmith Hospital Campus, 6th Floor, Commonwealth Building, Du Cane Road, London W12 0NN, UK

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Kevin G Murphy
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Stephen R Bloom
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Julia C Buckingham Division of Diabetes, University College London, Brunel University, Endocrinology and Metabolism, Department of Investigative Medicine, Imperial College London, Hammersmith Hospital Campus, 6th Floor, Commonwealth Building, Du Cane Road, London W12 0NN, UK

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Christopher D John
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. Obesity is a risk factor for sepsis morbidity and mortality. Morbid obesity increases the risk of death by sepsis following major surgery by 50% ( Prabhakar et al . 2002 ). It is thought that the pro-inflammatory phenotype that accompanies obesity creates

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-13-0249
Volume/Issue:
Volume 221: Issue 2
Open access
Ekaterine Tskitishvili Department of Obstetrics and Gynecology/Department of Clinical Sciences, Laboratory of Development Biology and Tumor, GIGA-Cancer, University of Liege, Liege, Belgium

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Christel Pequeux Department of Obstetrics and Gynecology/Department of Clinical Sciences, Laboratory of Development Biology and Tumor, GIGA-Cancer, University of Liege, Liege, Belgium

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Carine Munaut Department of Obstetrics and Gynecology/Department of Clinical Sciences, Laboratory of Development Biology and Tumor, GIGA-Cancer, University of Liege, Liege, Belgium

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Renaud Viellevoye Department of Pediatrics, Neonatal Intensive Care Unit, University of Liege, CHR de la CITADELLE, Liege, Belgium

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Michelle Nisolle Department of Obstetrics and Gynecology, University of Liege, CHR de la CITADELLE, Liege, Belgium

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Agnes Noël Department of Obstetrics and Gynecology/Department of Clinical Sciences, Laboratory of Development Biology and Tumor, GIGA-Cancer, University of Liege, Liege, Belgium

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Jean-Michel Foidart Department of Obstetrics and Gynecology/Department of Clinical Sciences, Laboratory of Development Biology and Tumor, GIGA-Cancer, University of Liege, Liege, Belgium

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. 2005 , Shankaran et al . 2005 ). As a recent study suggests, neonatal HIE might start antenatally, implying the importance of different factors (i.e. genetic and/or infectious, and placental factors), but parturition might have importance for the

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-16-0434
Volume/Issue:
Volume 232: Issue 1
Open access
J N Zamarbide Losada Imperial Centre for Translational and Experimental Medicine, Department of Surgery & Cancer, Imperial College London, Hammersmith Hospital, London, UK

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E Sulpice Université Grenoble Alpes, CEA, INSERM, BIG, BGE, Grenoble, France

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S Combe Université Grenoble Alpes, CEA, INSERM, BIG, BGE, Grenoble, France

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G S Almeida Imperial Centre for Translational and Experimental Medicine, Department of Surgery & Cancer, Imperial College London, Hammersmith Hospital, London, UK

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D A Leach Imperial Centre for Translational and Experimental Medicine, Department of Surgery & Cancer, Imperial College London, Hammersmith Hospital, London, UK

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J Choo Imperial Centre for Translational and Experimental Medicine, Department of Surgery & Cancer, Imperial College London, Hammersmith Hospital, London, UK

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L Protopapa Imperial Centre for Translational and Experimental Medicine, Department of Surgery & Cancer, Imperial College London, Hammersmith Hospital, London, UK

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M P Hamilton Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA

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S McGuire Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA

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X Gidrol Université Grenoble Alpes, CEA, INSERM, BIG, BGE, Grenoble, France

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C L Bevan Imperial Centre for Translational and Experimental Medicine, Department of Surgery & Cancer, Imperial College London, Hammersmith Hospital, London, UK

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C E Fletcher Imperial Centre for Translational and Experimental Medicine, Department of Surgery & Cancer, Imperial College London, Hammersmith Hospital, London, UK

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. 2000 ). ERα is a ligand-activated nuclear receptor transcription factor that, upon estrogen binding, translocates to the nucleus, where it associates with estrogen response elements in promoter and enhancer regions of target genes to activate

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-22-0229
Volume/Issue:
Volume 256: Issue 3
Open access
J Cantley School of Medicine, University of Dundee, Dundee, United Kingdom of Great Britain and Northern Ireland

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D L Eizirik ULB Center for Diabetes Research, Université Libre de Bruxelles Faculté de Médecine, Bruxelles, Belgium

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E Latres JDRF International, New York, NY, USA

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C M Dayan Cardiff University School of Medicine, Cardiff, United Kingdom of Great Britain and Northern Ireland

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the JDRF-DiabetesUK-INNODIA-nPOD Stockholm Symposium 2022
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the JDRF-DiabetesUK-INNODIA-nPOD Stockholm Symposium 2022

-enriched transcription factors (TFs) ( Brissova et al. 2018 , Wang et al. 2019 , Camunas-Soler et al. 2020 ). Recent work using islets from non-diabetic adult single GAD autoantibody-positive individuals led to a surprising discovery that alpha cells appear to

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-23-0082
Volume/Issue:
Volume 259: Issue 1
Open access
Dominik Simon Botermann Institute of Human Genetics, Molecular Developmental Genetics and Tumor Genetics Group, University Medical Center, Göttingen, Germany

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Nadine Brandes Institute of Human Genetics, Molecular Developmental Genetics and Tumor Genetics Group, University Medical Center, Göttingen, Germany

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Anke Frommhold Institute of Human Genetics, Molecular Developmental Genetics and Tumor Genetics Group, University Medical Center, Göttingen, Germany

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Ina Heß Institute of Human Genetics, Molecular Developmental Genetics and Tumor Genetics Group, University Medical Center, Göttingen, Germany

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Alexander Wolff Institute of Human Genetics, Molecular Developmental Genetics and Tumor Genetics Group, University Medical Center, Göttingen, Germany

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Arne Zibat Institute of Human Genetics, Molecular Developmental Genetics and Tumor Genetics Group, University Medical Center, Göttingen, Germany

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Heidi Hahn Institute of Human Genetics, Molecular Developmental Genetics and Tumor Genetics Group, University Medical Center, Göttingen, Germany

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Rolf Buslei Institute of Pathology, Sozialstiftung Bamberg, Klinikum am Bruderwald, Bamberg, Germany

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Anja Uhmann Institute of Human Genetics, Molecular Developmental Genetics and Tumor Genetics Group, University Medical Center, Göttingen, Germany

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transcription factors of the Gli family to induce target gene expression (e.g. Gli1, Gli2 or Ptch ) (reviewed in Bangs & Anderson 2017 ). Inactivation or overactivation of the pathway during pituitary organogenesis can lead to agenesis of the gland

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-20-0388
Volume/Issue:
Volume 248: Issue 3
Open access
K A Staines
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A S Pollard
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I M McGonnell
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C Farquharson Comparative Biomedical Sciences, Roslin Institute and R(D)SVS, The Royal Veterinary College, Royal College Street, London NW1 0TU, UK

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A A Pitsillides
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not undergo a sequence of proliferation, maturation, hypertrophy, apoptosis and ossification ( Pacifici et al . 2005 , 2006 ). It has been suggested that the expression of the transcription factor ETS-related gene (ERG) is necessary early in joint

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-13-0276
Volume/Issue:
Volume 219: Issue 1
Open access
T V Novoselova Centre for Endocrinology, Queen Mary University of London, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Charterhouse Square, London, UK

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R Larder University of Cambridge Metabolic Research Laboratories, MRC Metabolic Disease Unit, Wellcome Trust-MRC Institute of Metabolic Science and NIHR Cambridge Biomedical Research Centre, Addenbrooke’s Hospital, Cambridge, UK

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D Rimmington University of Cambridge Metabolic Research Laboratories, MRC Metabolic Disease Unit, Wellcome Trust-MRC Institute of Metabolic Science and NIHR Cambridge Biomedical Research Centre, Addenbrooke’s Hospital, Cambridge, UK

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C Lelliott Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK

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E H Wynn Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK

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R J Gorrigan Centre for Endocrinology, Queen Mary University of London, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Charterhouse Square, London, UK

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P H Tate Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK

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L Guasti Centre for Endocrinology, Queen Mary University of London, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Charterhouse Square, London, UK

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The Sanger Mouse Genetics Project Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK

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S O’Rahilly University of Cambridge Metabolic Research Laboratories, MRC Metabolic Disease Unit, Wellcome Trust-MRC Institute of Metabolic Science and NIHR Cambridge Biomedical Research Centre, Addenbrooke’s Hospital, Cambridge, UK

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A J L Clark Centre for Endocrinology, Queen Mary University of London, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Charterhouse Square, London, UK

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D W Logan Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK

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A P Coll University of Cambridge Metabolic Research Laboratories, MRC Metabolic Disease Unit, Wellcome Trust-MRC Institute of Metabolic Science and NIHR Cambridge Biomedical Research Centre, Addenbrooke’s Hospital, Cambridge, UK

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L F Chan Centre for Endocrinology, Queen Mary University of London, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Charterhouse Square, London, UK

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expression of the HDL scavenger receptor Scarb1 , LDL receptor ( Ldlr ) and the key transcription factor of cholesterol biosynthesis Srebp2 ( Shimomura et al . 1998 ) in the livers of 129/Sv Mrap2 tm1a/tm1a mice. Interestingly, Srebp2 mRNA levels were

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-16-0057
Volume/Issue:
Volume 230: Issue 1
Open access