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Helen L Jeanes
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Caroline Tabor
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Darcey Black Centre for Cardiovascular Science, Organon Laboratories Ltd, Department Pharmacology, University of Edinburgh, Queens Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, UK

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Antwan Ederveen Centre for Cardiovascular Science, Organon Laboratories Ltd, Department Pharmacology, University of Edinburgh, Queens Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, UK

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Gillian A Gray
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–reperfusion injury in ovariectomised rats ( Squadrito et al . 1997 , Jeanes et al . 2007 ). There are two known oestrogen receptors (ERs), ERα and ERβ. The receptors are members of the steroid hormone receptor family with distinct tissue distribution and

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-08-0071
Volume/Issue:
Volume 197: Issue 3
Open access
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Rebecca J Ainslie Institute for Regeneration and Repair, the University of Edinburgh, Edinburgh BioQuarter, Edinburgh, United Kingdom

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Ioannis Simitsidellis Institute for Regeneration and Repair, the University of Edinburgh, Edinburgh BioQuarter, Edinburgh, United Kingdom

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Phoebe M Kirkwood Institute for Regeneration and Repair, the University of Edinburgh, Edinburgh BioQuarter, Edinburgh, United Kingdom

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Douglas A Gibson Institute for Regeneration and Repair, the University of Edinburgh, Edinburgh BioQuarter, Edinburgh, United Kingdom

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Invited Author’s profile Dr Douglas Gibson is a principal investigator and Sir Henry Dale Fellow in the Institute for Regeneration and Repair at the University of Edinburgh. His research focusses on understanding how hormones, particularly

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-23-0398
Volume/Issue:
Volume 261: Issue 3
Open access
Sara Della Torre Center of Excellence on Neurodegenerative Diseases, University of Milan, Milan, Italy
Department of Pharmacological and Biomolecular Sciences, University of Milan, Milan, Italy

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Gianpaolo Rando Center of Excellence on Neurodegenerative Diseases, University of Milan, Milan, Italy
Department of Pharmacological and Biomolecular Sciences, University of Milan, Milan, Italy

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Clara Meda Center of Excellence on Neurodegenerative Diseases, University of Milan, Milan, Italy
Department of Pharmacological and Biomolecular Sciences, University of Milan, Milan, Italy

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Paolo Ciana Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy

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Luisa Ottobrini Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy

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Adriana Maggi Center of Excellence on Neurodegenerative Diseases, University of Milan, Milan, Italy
Department of Pharmacological and Biomolecular Sciences, University of Milan, Milan, Italy

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Introduction Oestrogens have been long known as cell proliferation and differentiation factors ( Tsai & O’Malley 1994 ), and several lines of evidence suggest that, in the course of foetal programming, these hormones are relevant for the

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-18-0003
Volume/Issue:
Volume 238: Issue 3
Open access
Dawn E W Livingstone University/British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, Queen’s Medical Research Institute, Edinburgh, UK
Centre for Integrative Physiology, University of Edinburgh, Edinburgh, UK

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Emma M Di Rollo University/British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, Queen’s Medical Research Institute, Edinburgh, UK

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Tracy C-S Mak University/British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, Queen’s Medical Research Institute, Edinburgh, UK

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Karen Sooy University/British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, Queen’s Medical Research Institute, Edinburgh, UK

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Brian R Walker University/British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, Queen’s Medical Research Institute, Edinburgh, UK

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Ruth Andrew University/British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, Queen’s Medical Research Institute, Edinburgh, UK

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consequences of inhibition of 5αRs on metabolic health. This has implications for men receiving 5αR inhibitors for chronic treatment of prostatic disease or women receiving these drugs for hirsutism. Furthermore, 5α-reduction of steroid hormones is increased in

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-16-0125
Volume/Issue:
Volume 232: Issue 1
Open access
Xuefeng Yang Department of Nutrition, Department of Nutrition and Food Hygiene, Department of Preventive Medicine, Department of Nutrition and Food Hygiene, Department of Medicine, Department of Medicine (Endocrinology), Department of Medicine (Endocrinology and Metabolism), Gillings School of Global Public Health, Nutrition Research Institute (NRI) at Kannapolis, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27559, USA
Department of Nutrition, Department of Nutrition and Food Hygiene, Department of Preventive Medicine, Department of Nutrition and Food Hygiene, Department of Medicine, Department of Medicine (Endocrinology), Department of Medicine (Endocrinology and Metabolism), Gillings School of Global Public Health, Nutrition Research Institute (NRI) at Kannapolis, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27559, USA

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Shuang Mei Department of Nutrition, Department of Nutrition and Food Hygiene, Department of Preventive Medicine, Department of Nutrition and Food Hygiene, Department of Medicine, Department of Medicine (Endocrinology), Department of Medicine (Endocrinology and Metabolism), Gillings School of Global Public Health, Nutrition Research Institute (NRI) at Kannapolis, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27559, USA

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Haihua Gu Department of Nutrition, Department of Nutrition and Food Hygiene, Department of Preventive Medicine, Department of Nutrition and Food Hygiene, Department of Medicine, Department of Medicine (Endocrinology), Department of Medicine (Endocrinology and Metabolism), Gillings School of Global Public Health, Nutrition Research Institute (NRI) at Kannapolis, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27559, USA

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Huailan Guo Department of Nutrition, Department of Nutrition and Food Hygiene, Department of Preventive Medicine, Department of Nutrition and Food Hygiene, Department of Medicine, Department of Medicine (Endocrinology), Department of Medicine (Endocrinology and Metabolism), Gillings School of Global Public Health, Nutrition Research Institute (NRI) at Kannapolis, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27559, USA
Department of Nutrition, Department of Nutrition and Food Hygiene, Department of Preventive Medicine, Department of Nutrition and Food Hygiene, Department of Medicine, Department of Medicine (Endocrinology), Department of Medicine (Endocrinology and Metabolism), Gillings School of Global Public Health, Nutrition Research Institute (NRI) at Kannapolis, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27559, USA

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Longying Zha Department of Nutrition, Department of Nutrition and Food Hygiene, Department of Preventive Medicine, Department of Nutrition and Food Hygiene, Department of Medicine, Department of Medicine (Endocrinology), Department of Medicine (Endocrinology and Metabolism), Gillings School of Global Public Health, Nutrition Research Institute (NRI) at Kannapolis, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27559, USA
Department of Nutrition, Department of Nutrition and Food Hygiene, Department of Preventive Medicine, Department of Nutrition and Food Hygiene, Department of Medicine, Department of Medicine (Endocrinology), Department of Medicine (Endocrinology and Metabolism), Gillings School of Global Public Health, Nutrition Research Institute (NRI) at Kannapolis, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27559, USA

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Junwei Cai Department of Nutrition, Department of Nutrition and Food Hygiene, Department of Preventive Medicine, Department of Nutrition and Food Hygiene, Department of Medicine, Department of Medicine (Endocrinology), Department of Medicine (Endocrinology and Metabolism), Gillings School of Global Public Health, Nutrition Research Institute (NRI) at Kannapolis, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27559, USA
Department of Nutrition, Department of Nutrition and Food Hygiene, Department of Preventive Medicine, Department of Nutrition and Food Hygiene, Department of Medicine, Department of Medicine (Endocrinology), Department of Medicine (Endocrinology and Metabolism), Gillings School of Global Public Health, Nutrition Research Institute (NRI) at Kannapolis, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27559, USA

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Xuefeng Li Department of Nutrition, Department of Nutrition and Food Hygiene, Department of Preventive Medicine, Department of Nutrition and Food Hygiene, Department of Medicine, Department of Medicine (Endocrinology), Department of Medicine (Endocrinology and Metabolism), Gillings School of Global Public Health, Nutrition Research Institute (NRI) at Kannapolis, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27559, USA

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Zhenqi Liu Department of Nutrition, Department of Nutrition and Food Hygiene, Department of Preventive Medicine, Department of Nutrition and Food Hygiene, Department of Medicine, Department of Medicine (Endocrinology), Department of Medicine (Endocrinology and Metabolism), Gillings School of Global Public Health, Nutrition Research Institute (NRI) at Kannapolis, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27559, USA

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Wenhong Cao Department of Nutrition, Department of Nutrition and Food Hygiene, Department of Preventive Medicine, Department of Nutrition and Food Hygiene, Department of Medicine, Department of Medicine (Endocrinology), Department of Medicine (Endocrinology and Metabolism), Gillings School of Global Public Health, Nutrition Research Institute (NRI) at Kannapolis, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27559, USA
Department of Nutrition, Department of Nutrition and Food Hygiene, Department of Preventive Medicine, Department of Nutrition and Food Hygiene, Department of Medicine, Department of Medicine (Endocrinology), Department of Medicine (Endocrinology and Metabolism), Gillings School of Global Public Health, Nutrition Research Institute (NRI) at Kannapolis, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27559, USA
Department of Nutrition, Department of Nutrition and Food Hygiene, Department of Preventive Medicine, Department of Nutrition and Food Hygiene, Department of Medicine, Department of Medicine (Endocrinology), Department of Medicine (Endocrinology and Metabolism), Gillings School of Global Public Health, Nutrition Research Institute (NRI) at Kannapolis, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27559, USA

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plate and pre-incubated for 24 h before any experimentation. Measurements of serum cytokines, hormones, and lipids Serum triglyceride (TG) and FFA were measured with kits purchased from Cayman Chemical (Ann Arbor, MI, USA) (Cat No: 10010303 and 700310

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-14-0117
Volume/Issue:
Volume 221: Issue 3
Open access
L A Nolan Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, University of Bristol, Dorothy Hodgkin Building, Whitson Street, Bristol BS1 3NY, UK

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A Levy Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, University of Bristol, Dorothy Hodgkin Building, Whitson Street, Bristol BS1 3NY, UK

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hormone and thyroid hormone levels ( Nolan et al . 1998 , 1999 , 2004 ). Several studies have also been sensitive enough to suggest a diurnal variation in mitotic activity in the pituitary, although there is some disagreement about the exact number and

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-08-0474
Volume/Issue:
Volume 200: Issue 3
Open access
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Virginia Rider Department of Biology, Pittsburg State University, Pittsburg, Kansas, USA

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Alex Talbott Department of Biology, Pittsburg State University, Pittsburg, Kansas, USA

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Anuradha Bhusri Department of Biology, Pittsburg State University, Pittsburg, Kansas, USA

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Zach Krumsick Department of Biology, Pittsburg State University, Pittsburg, Kansas, USA

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Sierra Foster Department of Biology, Pittsburg State University, Pittsburg, Kansas, USA

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Joshua Wormington Department of Biology, Pittsburg State University, Pittsburg, Kansas, USA

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Bruce F Kimler Department of Radiation Oncology, The University of Kansas Medical Center, Kansas City, Kansas, USA

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Introduction In adult female mammals, the uterus undergoes remodeling with a regular cyclicity under the control of the sex hormones, progesterone and estradiol ( Bell 1983 , Pawar et al . 2014 ). In the rodent uterus, estradiol stimulates

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-15-0523
Volume/Issue:
Volume 229: Issue 2
Open access
Andrea Lovdel University/BHF Centre for Cardiovascular Science, The University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh BioQuarter, Edinburgh, UK

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Karla J Suchacki University/BHF Centre for Cardiovascular Science, The University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh BioQuarter, Edinburgh, UK

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Fiona Roberts University/BHF Centre for Cardiovascular Science, The University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh BioQuarter, Edinburgh, UK

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Richard J Sulston University/BHF Centre for Cardiovascular Science, The University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh BioQuarter, Edinburgh, UK

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Robert J Wallace Department of Orthopaedics, The University of Edinburgh, Edinburgh, UK

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Benjamin J Thomas University/BHF Centre for Cardiovascular Science, The University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh BioQuarter, Edinburgh, UK

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Rachel M B Bell University/BHF Centre for Cardiovascular Science, The University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh BioQuarter, Edinburgh, UK

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Iris Pruñonosa Cervera University/BHF Centre for Cardiovascular Science, The University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh BioQuarter, Edinburgh, UK

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Gavin J Macpherson Department of Orthopaedic Surgery, Royal Infirmary of Edinburgh, Edinburgh, UK

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Nicholas M Morton University/BHF Centre for Cardiovascular Science, The University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh BioQuarter, Edinburgh, UK
Centre for Systems Health and Integrated Metabolic Research, Department of Biosciences, School of Science and Technology, Nottingham Trent University, Nottingham, UK

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Natalie Z M Homer University/BHF Centre for Cardiovascular Science, The University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh BioQuarter, Edinburgh, UK

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Karen E Chapman University/BHF Centre for Cardiovascular Science, The University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh BioQuarter, Edinburgh, UK

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William P Cawthorn University/BHF Centre for Cardiovascular Science, The University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh BioQuarter, Edinburgh, UK

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hormones 11-dehydrocorticosterone (11-DHC), corticosterone (CORT), testosterone, and progesterone in endpoint plasma and BM from male and female mice, using a 13-point calibration curve and isotopically labelled internal standards, as described ( Lovdel et

Article Type:
Research Article
Collections:
Sex effects collection
DOI:
https://doi.org/10.1530/JOE-24-0072
Volume/Issue:
Volume 262: Issue 2
Open access
T V Novoselova Centre for Endocrinology, Queen Mary University of London, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Charterhouse Square, London, UK

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R Larder University of Cambridge Metabolic Research Laboratories, MRC Metabolic Disease Unit, Wellcome Trust-MRC Institute of Metabolic Science and NIHR Cambridge Biomedical Research Centre, Addenbrooke’s Hospital, Cambridge, UK

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D Rimmington University of Cambridge Metabolic Research Laboratories, MRC Metabolic Disease Unit, Wellcome Trust-MRC Institute of Metabolic Science and NIHR Cambridge Biomedical Research Centre, Addenbrooke’s Hospital, Cambridge, UK

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C Lelliott Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK

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E H Wynn Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK

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R J Gorrigan Centre for Endocrinology, Queen Mary University of London, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Charterhouse Square, London, UK

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P H Tate Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK

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L Guasti Centre for Endocrinology, Queen Mary University of London, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Charterhouse Square, London, UK

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The Sanger Mouse Genetics Project Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK

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S O’Rahilly University of Cambridge Metabolic Research Laboratories, MRC Metabolic Disease Unit, Wellcome Trust-MRC Institute of Metabolic Science and NIHR Cambridge Biomedical Research Centre, Addenbrooke’s Hospital, Cambridge, UK

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A J L Clark Centre for Endocrinology, Queen Mary University of London, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Charterhouse Square, London, UK

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D W Logan Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK

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A P Coll University of Cambridge Metabolic Research Laboratories, MRC Metabolic Disease Unit, Wellcome Trust-MRC Institute of Metabolic Science and NIHR Cambridge Biomedical Research Centre, Addenbrooke’s Hospital, Cambridge, UK

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L F Chan Centre for Endocrinology, Queen Mary University of London, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Charterhouse Square, London, UK

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hormone (ACTH) and α-MSH ( Cone 2005 , Chan et al . 2009 ). Of the five MCRs (MC1R–MC5R), only the function of the melanocortin 2 receptor (MC2R) is clearly recognized to be facilitated by MRAPs ( Metherell et al . 2005 , Chan et al . 2009 ), although

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-16-0057
Volume/Issue:
Volume 230: Issue 1
Open access
M J F Newson Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology (LINE), School of Clinical Sciences, University of Bristol, Dorothy Hodgkin Building, Whitson Street, Bristol BS1 3NY, UK

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G R Pope Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology (LINE), School of Clinical Sciences, University of Bristol, Dorothy Hodgkin Building, Whitson Street, Bristol BS1 3NY, UK

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E M Roberts Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology (LINE), School of Clinical Sciences, University of Bristol, Dorothy Hodgkin Building, Whitson Street, Bristol BS1 3NY, UK

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S J Lolait Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology (LINE), School of Clinical Sciences, University of Bristol, Dorothy Hodgkin Building, Whitson Street, Bristol BS1 3NY, UK

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A-M O'Carroll Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology (LINE), School of Clinical Sciences, University of Bristol, Dorothy Hodgkin Building, Whitson Street, Bristol BS1 3NY, UK

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the hypothalamic PVN. The presence of APJ transcripts and apelin-ir in the pPVN and in the pituitary suggested that the peptide may be involved in adenohypophyseal hormone release. A role for apelin as a neurohormone pivotal to the neuroendocrine

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-12-0375
Volume/Issue:
Volume 216: Issue 1
Open access
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