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Yizhou Zhang Department of Human Anatomy, Hebei Medical University, Shijiazhuang, Hebei, China
Neuroscience Research Center, Hebei Medical University, Shijiazhuang, Hebei, China
Hebei Key Laboratory of Neurodegenerative Disease Mechanism, Hebei Medical University, Shijiazhuang, Hebei, China

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Meiqin Chen Department of Human Anatomy, Hebei Medical University, Shijiazhuang, Hebei, China

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Huan Chen Department of Human Anatomy, Hebei Medical University, Shijiazhuang, Hebei, China
Neuroscience Research Center, Hebei Medical University, Shijiazhuang, Hebei, China
Hebei Key Laboratory of Neurodegenerative Disease Mechanism, Hebei Medical University, Shijiazhuang, Hebei, China

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Shixiong Mi Department of Human Anatomy, Hebei Medical University, Shijiazhuang, Hebei, China

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Chang Wang Department of Human Anatomy, Hebei Medical University, Shijiazhuang, Hebei, China
Neuroscience Research Center, Hebei Medical University, Shijiazhuang, Hebei, China
Hebei Key Laboratory of Neurodegenerative Disease Mechanism, Hebei Medical University, Shijiazhuang, Hebei, China

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Hongchun Zuo Department of Human Anatomy, Hebei Medical University, Shijiazhuang, Hebei, China

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Leigang Song Department of Human Anatomy, Hebei Medical University, Shijiazhuang, Hebei, China

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Juan Du Department of Human Anatomy, Hebei Medical University, Shijiazhuang, Hebei, China
Neuroscience Research Center, Hebei Medical University, Shijiazhuang, Hebei, China
Hebei Key Laboratory of Neurodegenerative Disease Mechanism, Hebei Medical University, Shijiazhuang, Hebei, China

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Huixian Cui Department of Human Anatomy, Hebei Medical University, Shijiazhuang, Hebei, China
Neuroscience Research Center, Hebei Medical University, Shijiazhuang, Hebei, China
Hebei Key Laboratory of Neurodegenerative Disease Mechanism, Hebei Medical University, Shijiazhuang, Hebei, China

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Sha Li Department of Human Anatomy, Hebei Medical University, Shijiazhuang, Hebei, China
Neuroscience Research Center, Hebei Medical University, Shijiazhuang, Hebei, China
Hebei Key Laboratory of Neurodegenerative Disease Mechanism, Hebei Medical University, Shijiazhuang, Hebei, China

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role by activating the transcription factor activity of the ARs. However, numerous studies have reported that many cellular responses to androgens are not diminished by transcription inhibitors, indicating that these actions may be independent of the

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-23-0114
Volume/Issue:
Volume 260: Issue 2
Open access
Seokwon Jo Department of Integrative Biology & Physiology, University of Minnesota Medical School, Minneapolis, Minnesota, USA

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Emilyn U Alejandro Department of Integrative Biology & Physiology, University of Minnesota Medical School, Minneapolis, Minnesota, USA

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steadily increasing. Its origins are complex, involving a mix of genetic factors and exposure to environmental elements over a person’s lifetime ( Lango et al . 2008, Bruce & Byrne 2009 ). T2D is a multifaceted condition that primarily arises due to the

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-23-0069
Volume/Issue:
Volume 259: Issue 3
Open access
Margaret K Hahn Centre for Addiction and Mental Health, Toronto, Ontario, Canada
Institute of Medical Sciences, University of Toronto, Toronto, Ontario, Canada
Department of Pharmacology, University of Toronto, Toronto, Ontario, Canada
Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
Banting & Best Diabetes Centre, Toronto, Ontario, Canada

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Adria Giacca Institute of Medical Sciences, University of Toronto, Toronto, Ontario, Canada
Banting & Best Diabetes Centre, Toronto, Ontario, Canada
Department of Physiology, University of Toronto, Toronto, Ontario, Canada

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Sandra Pereira Centre for Addiction and Mental Health, Toronto, Ontario, Canada
Department of Physiology, University of Toronto, Toronto, Ontario, Canada

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sensitivity and suppresses gluconeogenesis via the transcription factor FoxO1 . Diabetes 68 291 – 304 . ( https://doi.org/10.2337/db18-0638 ) Yook JS Taxin ZH Yuan B Oikawa S Auger C Mutlu B Puigserver P Hui S & Kajimura S 2023 The SLC25

Article Type:
Review Article
Collections:
Insulin resistance and type 2 diabetes mellitus
DOI:
https://doi.org/10.1530/JOE-23-0308
Volume/Issue:
Volume 260: Issue 3
Open access
Elisa Villalobos University/British Heart Foundation Centre for Cardiovascular Science, The Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom
Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, United Kingdom

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Allende Miguelez-Crespo University/British Heart Foundation Centre for Cardiovascular Science, The Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom

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Ruth A Morgan University/British Heart Foundation Centre for Cardiovascular Science, The Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom
Scotland’s Rural College, The Roslin Institute, Easter Bush Campus, United Kingdom

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Lisa Ivatt University/British Heart Foundation Centre for Cardiovascular Science, The Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom

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Mhairi Paul University/British Heart Foundation Centre for Cardiovascular Science, The Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom

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Joanna P Simpson University/British Heart Foundation Centre for Cardiovascular Science, The Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom

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Natalie Z M Homer University/British Heart Foundation Centre for Cardiovascular Science, The Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom

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Dominic Kurian The Roslin Institute, Royal (Dick) School of Veterinary Studies, College of Medicine and Veterinary Medicine, University of Edinburgh, Easter Bush Campus, Edinburgh, United Kingdom

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Judit Aguilar The Roslin Institute, Royal (Dick) School of Veterinary Studies, College of Medicine and Veterinary Medicine, University of Edinburgh, Easter Bush Campus, Edinburgh, United Kingdom

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Rachel A Kline The Roslin Institute, Royal (Dick) School of Veterinary Studies, College of Medicine and Veterinary Medicine, University of Edinburgh, Easter Bush Campus, Edinburgh, United Kingdom

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Thomas M Wishart The Roslin Institute, Royal (Dick) School of Veterinary Studies, College of Medicine and Veterinary Medicine, University of Edinburgh, Easter Bush Campus, Edinburgh, United Kingdom

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Nicholas M Morton University/British Heart Foundation Centre for Cardiovascular Science, The Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom
Centre for Systems Health and Integrated Metabolic Research, Nottingham Trent University, Nottingham, United Kingdom

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Roland H Stimson University/British Heart Foundation Centre for Cardiovascular Science, The Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom

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Ruth Andrew University/British Heart Foundation Centre for Cardiovascular Science, The Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom

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Brian R Walker University/British Heart Foundation Centre for Cardiovascular Science, The Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom
Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, United Kingdom

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Mark Nixon University/British Heart Foundation Centre for Cardiovascular Science, The Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom

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-responsive gene transcription. Moreover, analysis of ABCC1 expression revealed an increase in mRNA levels in subcutaneous and visceral adipose tissue from obese patients compared with lean controls ( Nixon et al. 2016 ), suggesting a compensatory mechanism to

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-24-0024
Volume/Issue:
Volume 262: Issue 2
Open access
A Tsuchiya Division of Bioinformation, Department of Physiology, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya 663-8501, Japan

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T Kanno Division of Bioinformation, Department of Physiology, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya 663-8501, Japan

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T Nishizaki Division of Bioinformation, Department of Physiology, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya 663-8501, Japan

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.x ) Tontonoz P Hu E Spiegelman BM 1994 Stimulation of adipogenesis in fibroblasts by PPARγ2, a lipid-activated transcription factor . Cell 79 1147 – 1156 . ( doi:10.1016/0092-8674(94)90006-X ) Vanhaesebroeck B Alessi DR 2000

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-13-0172
Volume/Issue:
Volume 220: Issue 1
Open access
Laura L Hernandez Department of Animal Sciences, Department of Molecular and Cellular Physiology, University of Arizona, Tucson, Arizona 85721, USA
Department of Animal Sciences, Department of Molecular and Cellular Physiology, University of Arizona, Tucson, Arizona 85721, USA

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Sean W Limesand Department of Animal Sciences, Department of Molecular and Cellular Physiology, University of Arizona, Tucson, Arizona 85721, USA

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Jayne L Collier Department of Animal Sciences, Department of Molecular and Cellular Physiology, University of Arizona, Tucson, Arizona 85721, USA

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Nelson D Horseman Department of Animal Sciences, Department of Molecular and Cellular Physiology, University of Arizona, Tucson, Arizona 85721, USA

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Robert J Collier Department of Animal Sciences, Department of Molecular and Cellular Physiology, University of Arizona, Tucson, Arizona 85721, USA

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epithelial cell mass ( Peaker 1995 ). Acting in concert, systemic and local hormonal factors adjust mammary gland physiology not only to meet the demands of the offspring, but also to compensate for circumstances such as local mastitis, nutrient supply, and

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-09-0187
Volume/Issue:
Volume 203: Issue 1
Open access
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Gisela Helfer School of Chemistry and Biosciences, University of Bradford, Bradford, UK

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Qing-Feng Wu State Key Laboratory of Molecular Development Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China

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tolerance tests ( Takahashi et al . 2011 , Ernst et al . 2012 ). Mechanistically, loss of chemerin in mice downregulates the expression of transcription factor MAFA and its downstream target gene GLUT2, which serves as a sensor and transporter for glucose

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-18-0174
Volume/Issue:
Volume 238: Issue 2
Open access
Sian J S Simpson Department of Diabetes, School of Life Course Sciences, Faculty of Life Science and Medicine, King’s College London, London, UK

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Lorna I F Smith Department of Diabetes, School of Life Course Sciences, Faculty of Life Science and Medicine, King’s College London, London, UK

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Peter M Jones Department of Diabetes, School of Life Course Sciences, Faculty of Life Science and Medicine, King’s College London, London, UK

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James E Bowe Department of Diabetes, School of Life Course Sciences, Faculty of Life Science and Medicine, King’s College London, London, UK

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following purification from the exocrine pancreas for subsequent RNA extraction using RNeasy Mini Kit (Qiagen) and High-Capacity cDNA Reverse Transcription Kit (Applied Biosystems) for cDNA synthesis, as described previously ( Drynda et al . 2018

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-19-0568
Volume/Issue:
Volume 245: Issue 2
Open access
Antonia Hufnagel University of Cambridge Metabolic Research Laboratories and MRC Metabolic Diseases Unit, Wellcome Trust-MRC Institute of Metabolic Science, Level 4, Addenbrooke’s Hospital, Cambridge, Cambridgeshire, UK

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Laura Dearden University of Cambridge Metabolic Research Laboratories and MRC Metabolic Diseases Unit, Wellcome Trust-MRC Institute of Metabolic Science, Level 4, Addenbrooke’s Hospital, Cambridge, Cambridgeshire, UK

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Denise S Fernandez-Twinn University of Cambridge Metabolic Research Laboratories and MRC Metabolic Diseases Unit, Wellcome Trust-MRC Institute of Metabolic Science, Level 4, Addenbrooke’s Hospital, Cambridge, Cambridgeshire, UK

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Susan E Ozanne University of Cambridge Metabolic Research Laboratories and MRC Metabolic Diseases Unit, Wellcome Trust-MRC Institute of Metabolic Science, Level 4, Addenbrooke’s Hospital, Cambridge, Cambridgeshire, UK

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Introduction Around 50% of women worldwide enter pregnancy overweight or obese ( Hill et al. 2019 ). Maternal obesity is the main risk factor for the development of gestational diabetes mellitus (GDM) in pregnancy, which affects

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-21-0332
Volume/Issue:
Volume 253: Issue 2
Open access
Sushil K Mahata VA San Diego Healthcare System Metabolic Physiology & Ultrastructural Biology Lab., Department of Medicine, University of California at San Diego, La Jolla, CA, USA

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Hong Zheng Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, NE, USA

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Sumana Mahata Caltech Division of Biology, California Institute of Technology, Pasadena, CA, USA

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Xuefei Liu Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, NE, USA

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Kaushik P Patel Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, NE, USA

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Introduction Enhanced neurohumoral drive is a major risk factor that influences the progression of chronic heart failure (HF) and mortality in patients and the experimental models ( Packer 1988 , Zucker et al . 1995 , Patel 1997 ). During

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-16-0146
Volume/Issue:
Volume 230: Issue 3
Open access