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Open access

Alessandro Pocai

insulin. Recent work on understanding the physiological function of proglucagon-derived peptides has renewed interest in glucagon-based therapeutics. One of these peptides is glucagon-like peptide-1 (GLP1), which is secreted from the L cells of the

Open access

Eun Young Lee, Shuji Kaneko, Promsuk Jutabha, Xilin Zhang, Susumu Seino, Takahito Jomori, Naohiko Anzai, and Takashi Miki

Introduction Oral ingestion of nutrients triggers the secretion of gut hormones from various enteroendocrine cells ( Ezcurra et al . 2013 , Cho et al . 2014 ). Among these, glucagon-like peptide 1 (GLP1) and glucose-dependent insulinotropic

Open access

Alyce M Martin, Emily W Sun, and Damien J Keating

-like peptide 1 (GLP-1), peptide YY (PYY) and oxyntomodulin (OXM), and glucose-dependent insulinotropic peptide (GIP) secreting K cells. It is now clear that such a classification system is not accurate given the accumulation of evidence that cross-over in

Open access

Sami Ayari, Eva Gil-Iturbe, Léa le Gléau, Céline Osinski, Nathalie Kapel, Hedi Antoine Soula, Armelle Leturque, Fabrizio Andreelli, Karine Clément, Patricia Serradas, and Agnès Ribeiro

Changes in dietary habits have occurred concomitantly with a rise of type 2 diabetes (T2D) and obesity. Intestine is the first organ facing nutrient ingestion and has to adapt its metabolism with these dietary changes. HNF-4γ, a transcription factor member of the nuclear receptor superfamily and mainly expressed in intestine has been suggested involved in susceptibility to T2D. Our aim was to investigate the role of HNF-4γ in metabolic disorders and related mechanisms. Hnf4g-/- mice were fed high-fat/high-fructose (HF-HF) diet for 6 weeks to induce obesity and T2D. Glucose homeostasis, energy homeostasis in metabolic cages, body composition and stool energy composition, as well as gene expression analysis in jejunum were analyzed. Despite an absence of decrease in calorie intake, of increase in locomotor activity or energy expenditure, Hnf4g-/- mice fed HF-HF are protected against weight gain after 6 weeks of HF-HF diet. We showed that Hnf4g-/- mice fed HF-HF display an increase in fecal calorie loss, mainly due to intestinal lipid malabsorption. Gene expression of lipid transporters, Fatp4 and Scarb1 and of triglyceride-rich lipoprotein secretion proteins, Mttp and ApoB are decreased in gut epithelium of Hnf4g-/- mice fed HF-HF, showing the HNF-4γ role in intestine lipid absorption. Furthermore, plasma GLP-1 and jejunal GLP-1 content are increased in Hnf4g-/- mice fed HF-HF, which could contribute to the glucose intolerance protection. The loss of HNF-4γ leads to a protection against a diet-induced weight gain and to a deregulated glucose homeostasis, associated with lipid malabsorption.

Open access

S J Brandt, M Kleinert, M H Tschöp, and T D Müller

). For example, following Roux-en-Y gastric bypass, gastric banding or sleeve gastronomy, there is an increase in the secretion of glucagon-like peptide 1 (GLP-1) ( Laferrere 2016 , Meek et al. 2016 , Clemmensen et al. 2017 ), which is known not

Open access

Yoshinori Kanemaru, Norio Harada, Satoko Shimazu-Kuwahara, Shunsuke Yamane, Eri Ikeguchi, Yuki Murata, Sakura Kiyobayashi, Tomonobu Hatoko, and Nobuya Inagaki

test (ITT), and measurement of GIP and GLP-1 content in intestine were evaluated in the second cohort. Energy expenditure, food intake, and gene expression were evaluated in the third cohort. The mice were housed in an air-controlled 25°C room with a

Open access

Md Nurul Islam, Yuichiro Mita, Keisuke Maruyama, Ryota Tanida, Weidong Zhang, Hideyuki Sakoda, and Masamitsu Nakazato

placed in individual cages and allowed to recover for at least 7 days, during which they were handled daily for acclimation. Ghrelin (human), LEAP2 (human), des-acyl ghrelin (rat), NPY, and GLP-1 were purchased from Peptide Institute (Osaka, Japan). [D

Open access

Karen Piper Hanley, Tom Hearn, Andrew Berry, Melanie J Carvell, Ann-Marie Patch, Louise J Williams, Sarah A Sugden, David I Wilson, Sian Ellard, and Neil A Hanley

al . 2003 ). Rab3a and Rab27a knockout mice show defects in glucose-stimulated insulin secretion (GSIS) similar to those observed in patients with type 2 diabetes and in mice lacking the glucagon-like peptide-1 (GLP-1) receptor ( Scrocchi et al

Open access

Noelia Martínez-Sánchez, José M Moreno-Navarrete, Cristina Contreras, Eva Rial-Pensado, Johan Fernø, Rubén Nogueiras, Carlos Diéguez, José-Manuel Fernández-Real, and Miguel López

glucagon-like peptide 1 (GLP-1) agonism ( Beiroa et al . 2014 ). To elucidate the contribution of hypothalamic AMPK activity on the browning of WAT by THs, we genetically activated AMPK in the VMH of rats centrally treated with T 3 . Our data showed that

Open access

Kunihisa Hamano, Yuko Nakagawa, Yoshiaki Ohtsu, Longfei Li, Johan Medina, Yuji Tanaka, Katsuyoshi Masuda, Mitsuhisa Komatsu, and Itaru Kojima

-sensing receptor in human GLP-1-secreting cells . Molecular and Cellular Endocrinology 394 70 – 79 . ( doi:10.1016/j.mce.2014.07.004 ) Oya M Suzuki H Watanabe Y Sato M Tsuboi T 2011 Amino acid taste receptor regulates insulin secretion in