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Open access

Young Hoon Son, Seok-Jin Lee, Ki-Baek Lee, Jin-Haeng Lee, Eui Man Jeong, Sun Gun Chung, Sang-Chul Park and In-Gyu Kim

hypertriglyceridemia ( Gazzerro et al . 2010 ). Moreover, we have demonstrated that the level of CAV1 in skeletal muscle is related to insulin sensitivity in vitro and in vivo ( Oh et al . 2008 ), indicating that CAV1 may regulate insulin signaling. Notably, Cav

Open access

A Tsuchiya, T Kanno and T Nishizaki

kinase 1 (Pak1; Mao et al . 2008 ), in a PI3K-independent manner. This study was conducted to gain further insight into PI3K-induced Akt activation in the insulin signal transduction pathway. To address this, we monitored GLUT4 mobilizations, measured

Open access

Thomas Nicholson, Chris Church, Kostas Tsintzas, Robert Jones, Leigh Breen, Edward T Davis, David J Baker and Simon W Jones

effect of recombinant human vaspin on insulin signalling and glucose uptake in human skeletal muscle tissue. Materials and methods Human samples Gluteus maximus skeletal muscle, SAT and blood samples were obtained from 21 lean (BMI 22.8 ± 0

Open access

Corinne Caillaud, Mie Mechta, Heidi Ainge, Andreas N Madsen, Patricia Ruell, Emilie Mas, Catherine Bisbal, Jacques Mercier, Stephen Twigg, Trevor A Mori, David Simar and Romain Barrès

al . 2013 ). In this study, we investigated the effect of both acute and chronic EPO treatment on whole-body glucose metabolism and activation of the insulin signaling pathway in skeletal muscle. We found that EPO ameliorates diet-induced glucose

Open access

Xuefeng Yang, Shuang Mei, Haihua Gu, Huailan Guo, Longying Zha, Junwei Cai, Xuefeng Li, Zhenqi Liu and Wenhong Cao

insulin resistance without insulin. In other words, insulin plays an essential role in converting nutrients into insulin resistance and then T2DM. We have previously shown that blunting insulin signaling can actually prevent the HFD-induced insulin

Open access

M E Cleasby, Q Lau, E Polkinghorne, S A Patel, S J Leslie, N Turner, G J Cooney, A Xu and E W Kraegen

was abolished by APPL1 down-regulation in these cells ( Mao et al . 2006 ). These data suggest that APPL1 may provide a means for crosstalk between adiponectin and insulin signalling pathways and thus a potential mechanism for the insulin

Open access

Manon M Roustit, Joan M Vaughan, Pauline M Jamieson and Mark E Cleasby

disposal occurred after administration of a glucose load and may have been mediated by the activation of the insulin signalling pathway, the concurrent AMPK activation and/or the increased GLUT1/4 protein expression observed. The 1 week time point was

Open access

Maayan Vatarescu, Sapir Bechor, Yulia Haim, Tal Pecht, Tanya Tarnovscki, Noa Slutsky, Ori Nov, Hagit Shapiro, Avishai Shemesh, Angel Porgador, Nava Bashan and Assaf Rudich

weighed weekly at the same hour. For insulin signaling, in vivo insulin was injected after overnight fast 12 min before the mice were killed with CO 2 or isoflurane. Tissue lysates were prepared in RIPA lysis buffer from 15 mg liver or 100 mg epididymal

Open access

Sandra Pereira, Wen Qin Yu, María E Frigolet, Jacqueline L Beaudry, Yaniv Shpilberg, Edward Park, Cristina Dirlea, B L Grégoire Nyomba, Michael C Riddell, I George Fantus and Adria Giacca

through which IKKB induces insulin resistance are twofold: i) direct phosphorylation of insulin receptor substrate (IRS)-1 at serine 307 ( Gao et al . 2002 ), which impairs tyrosine phosphorylation of IRS-1 and therefore dampens the insulin signal

Open access

Gulizar Issa Ameen and Silvia Mora

molecular mechanisms that may be involved in the upregulation of RBP4 expression in adipose tissue, we examined the insulin signalling pathways in the adipose tissue of c-Cbl-null mice and WT animals. Expression of the insulin-responsive substrate 1 (IRS1