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J Jeyabalan, M Shah, B Viollet, J P Roux, P Chavassieux, M Korbonits and C Chenu

level, we examined bone formation and resorption in the tibia of those mice, using bone histomorphometry. Analysis of BFR using double fluorescence labelling showed that the Ampkα1 −/− mice had a higher BFR than Ampkα1 + / + mice ( Fig. 2 A), but

Open access

Thomas Funck-Brentano, Karin H Nilsson, Robert Brommage, Petra Henning, Ulf H Lerner, Antti Koskela, Juha Tuukkanen, Martine Cohen-Solal, Sofia Movérare-Skrtic and Claes Ohlsson

mRNA levels in trabecular bone. (G) Summary diagram of the effects of Porcupine inhibition on cortical or trabecular bone formation and resorption. For each graph, n  = 10 animals per group. Bars represent the mean and error bars represent the 95% CI

Open access

Louise Grahnemo, Caroline Jochems, Annica Andersson, Cecilia Engdahl, Claes Ohlsson, Ulrika Islander and Hans Carlsten

measured by μCT was decreased in dex-treated compared with vehicle-treated ovx mice ( Fig. 2 F). In these mice, bone formation and resorption were assessed by serum analysis of osteocalcin and CTX1, and dex clearly decreased levels of the two markers in ovx