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Kevin J P Ryan Division of Nutritional Sciences, School of Biosciences, University of Nottingham, Loughborough, Leics LE12 5RD, UK

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Zoe C T R Daniel Division of Nutritional Sciences, School of Biosciences, University of Nottingham, Loughborough, Leics LE12 5RD, UK

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Lucinda J L Craggs Division of Nutritional Sciences, School of Biosciences, University of Nottingham, Loughborough, Leics LE12 5RD, UK

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Tim Parr Division of Nutritional Sciences, School of Biosciences, University of Nottingham, Loughborough, Leics LE12 5RD, UK

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John M Brameld Division of Nutritional Sciences, School of Biosciences, University of Nottingham, Loughborough, Leics LE12 5RD, UK

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adipogenic media, suggesting that this concentration (10 −5  M) may have a different effect to the other concentrations, possibly involving anti-differentiation, pro-apoptotic and/or toxic effects. Expression of gene markers of brown adipocytes As 1,25(OH) 2

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-12-0234
Volume/Issue:
Volume 217: Issue 1
Open access
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T’ng Choong Kwok University/BHF Centre for Cardiovascular Science, University of Edinburgh, Queen’s Medical Research Institute, Edinburgh, United Kingdom

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Roland H Stimson University/BHF Centre for Cardiovascular Science, University of Edinburgh, Queen’s Medical Research Institute, Edinburgh, United Kingdom

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. 2009 , Sharp et al. 2012 , Jespersen et al. 2013 , Porter et al. 2016 ). Human BAT biopsies and brown adipocyte cultures have been used to identify regulators of BAT function such as bile acids, glucocorticoids and the β2-adrenergic receptor

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-23-0017
Volume/Issue:
Volume 259: Issue 1
Open access
Noelia Martínez-Sánchez Department of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, Spain
CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela, Spain

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José M Moreno-Navarrete CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela, Spain
Department of Diabetes, Endocrinology and Nutrition, Hospital de Girona ‘Dr Josep Trueta’, Institut D’investigació Biomèdica de Girona (IdIBGi) and University of Girona, Girona, Spain

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Cristina Contreras Department of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, Spain
CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela, Spain

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Eva Rial-Pensado Department of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, Spain
CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela, Spain

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Johan Fernø Department of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, Spain
Department of Clinical Science, KG Jebsen Center for Diabetes Research, University of Bergen, Bergen, Norway

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Rubén Nogueiras Department of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, Spain
CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela, Spain

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Carlos Diéguez Department of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, Spain
CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela, Spain

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José-Manuel Fernández-Real CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela, Spain
Department of Diabetes, Endocrinology and Nutrition, Hospital de Girona ‘Dr Josep Trueta’, Institut D’investigació Biomèdica de Girona (IdIBGi) and University of Girona, Girona, Spain

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Miguel López Department of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, Spain
CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela, Spain

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, thermogenesis occurs mainly in the brown adipose tissue (BAT) ( Cannon & Nedergaard 2004 , Silva 2006 , von Ballmoos et al . 2009 ). THs act on brown adipocyte thermogenesis by increasing the stimulatory action of norepinephrine (NE), as well as enhancing the

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-16-0425
Volume/Issue:
Volume 232: Issue 2
Open access
Koichiro Taguchi Department of General Internal Medicine, Gifu University Graduate School of Medicine, Gifu, Japan

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Kazuo Kajita Department of General Internal Medicine, Gifu University Graduate School of Medicine, Gifu, Japan

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Yoshihiko Kitada Department of General Internal Medicine, Gifu University Graduate School of Medicine, Gifu, Japan

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Masayuki Fuwa Department of General Internal Medicine, Gifu University Graduate School of Medicine, Gifu, Japan

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Motochika Asano Department of General Internal Medicine, Gifu University Graduate School of Medicine, Gifu, Japan

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Takahide Ikeda Department of General Internal Medicine, Gifu University Graduate School of Medicine, Gifu, Japan

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Toshiko Kajita Department of General Internal Medicine, Gifu University Graduate School of Medicine, Gifu, Japan

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Tatsuo Ishizuka Department of General Internal Medicine and Rheumatology, Gifu Municipal Hospital, Gifu, Japan

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Itaru Kojima Laboratory of Cell Physiology, Institute for Molecular and Cellular Regulation, Gunma University, Gunma, Japan

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Hiroyuki Morita Department of General Internal Medicine, Gifu University Graduate School of Medicine, Gifu, Japan

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visceral adipocytes differ from those of s.c. adipocytes. Recent studies have demonstrated that cold exposure or chronic stimulation with β-adrenergic agonist leads to the appearance of morphologically and functionally brown adipocyte-like cells, namely

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-19-0503
Volume/Issue:
Volume 245: Issue 1
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M A Hyatt Early Life Nutrition Research Unit, Respiratory Biomedical Research Unit, Department of Animal Sciences, Division of Human Development, Academic Child Health

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D H Keisler Early Life Nutrition Research Unit, Respiratory Biomedical Research Unit, Department of Animal Sciences, Division of Human Development, Academic Child Health

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H Budge Early Life Nutrition Research Unit, Respiratory Biomedical Research Unit, Department of Animal Sciences, Division of Human Development, Academic Child Health
Early Life Nutrition Research Unit, Respiratory Biomedical Research Unit, Department of Animal Sciences, Division of Human Development, Academic Child Health

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M E Symonds Early Life Nutrition Research Unit, Respiratory Biomedical Research Unit, Department of Animal Sciences, Division of Human Development, Academic Child Health
Early Life Nutrition Research Unit, Respiratory Biomedical Research Unit, Department of Animal Sciences, Division of Human Development, Academic Child Health

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health . Proceedings of the Nutrition Society 68 416 – 421 . Teruel T Valverde AM Benito M Lorenzo M 1996 Insulin-like growth factor I and insulin induce adipogenic-related gene expression in fetal brown adipocyte primary cultures

Article Type:
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DOI:
https://doi.org/10.1677/JOE-09-0358
Volume/Issue:
Volume 204: Issue 2
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David M Golding School of Biosciences, Cardiff University, Cardiff, UK

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Daniel J Rees Institute of Life Sciences, College of Medicine, Swansea University, Swansea, UK

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Jennifer R Davies Behavioural Genetics Group, MRC Centre for Neuropsychiatric Genetics and Genomics, Neuroscience and Mental Health Research Institute, Schools of Medicine & Psychology, Cardiff University, Cardiff, UK

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Dinko Relkovic Behavioural Genetics Group, MRC Centre for Neuropsychiatric Genetics and Genomics, Neuroscience and Mental Health Research Institute, Schools of Medicine & Psychology, Cardiff University, Cardiff, UK

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Hannah V Furby Behavioural Genetics Group, MRC Centre for Neuropsychiatric Genetics and Genomics, Neuroscience and Mental Health Research Institute, Schools of Medicine & Psychology, Cardiff University, Cardiff, UK

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Irina A Guschina School of Biosciences, Cardiff University, Cardiff, UK

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Anna L Hopkins School of Biosciences, Cardiff University, Cardiff, UK

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Jeffrey S Davies Institute of Life Sciences, College of Medicine, Swansea University, Swansea, UK

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James L Resnick Center for Mammalian Genetics, University of Florida, College of Medicine, Gainesville, Florida, USA

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Anthony R Isles Behavioural Genetics Group, MRC Centre for Neuropsychiatric Genetics and Genomics, Neuroscience and Mental Health Research Institute, Schools of Medicine & Psychology, Cardiff University, Cardiff, UK

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Timothy Wells School of Biosciences, Cardiff University, Cardiff, UK

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De Matteis R Cinti S 2010 The emergence of cold-induced brown adipocytes in mouse white fat depots is determined predominantly by brown adipocyte transdifferentiation . American Journal of Physiology: Endocrinology and Metabolism 298 E

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-16-0367
Volume/Issue:
Volume 232: Issue 1
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Yanli Miao Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

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Haojie Qin Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

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Yi Zhong Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

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Kai Huang Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

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Caijun Rao Department of Geriatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

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al. 2018 ) was applied to the subsequent cell experiments, cAMP is a ubiquitous second messenger that plays an important role in a wide range of cells and multiple signaling pathways. The cAMP signaling pathway is very important for early brown

Article Type:
Research Article
Collections:
Top-cited articles of 2023
DOI:
https://doi.org/10.1530/JOE-20-0503
Volume/Issue:
Volume 249: Issue 2
Open access
Mark E Cleasby Department of Comparative Biomedical Sciences, Royal Veterinary College, University of London, London, UK

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Pauline M Jamieson Centre for Cardiovascular Science, Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, UK

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Philip J Atherton Division of Medical Sciences and Graduate Entry Medicine, University of Nottingham, Medical School, Royal Derby Hospital, Derby, UK

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lipolysis and fatty acid oxidation in peripheral tissues, and also increases the expression of brown adipocyte markers in white adipose tissue ( Zhang et al. 2012 ), providing a number of potential mechanisms for its metabolic activity. Importantly, we

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-15-0533
Volume/Issue:
Volume 229: Issue 2
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Samrin Kagdi Department of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada

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Sulayman A Lyons Department of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada

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Jacqueline L Beaudry Department of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada

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expenditure and had no effect on oxygen consumption in individual brown adipocytes ( Zhang et al. 2021 ). However, acute administration of acyl-GIP (30 nmol/kg) decreased RER and increased FA oxidation, suggesting a preferential increase in whole-body lipid

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-23-0361
Volume/Issue:
Volume 261: Issue 3
Open access
Gencer Sancar German Center for Diabetes Research, Neuherberg, Germany
Department of Internal Medicine IV, Division of Diabetology, Endocrinology and Nephrology, Eberhard-Karls University of Tübingen, Tübingen, Germany
Institute for Diabetes Research and Metabolic Diseases, Helmholtz Center Munich, Eberhard-Karls University of Tübingen, Tübingen, Germany

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Andreas L Birkenfeld German Center for Diabetes Research, Neuherberg, Germany
Department of Internal Medicine IV, Division of Diabetology, Endocrinology and Nephrology, Eberhard-Karls University of Tübingen, Tübingen, Germany
Institute for Diabetes Research and Metabolic Diseases, Helmholtz Center Munich, Eberhard-Karls University of Tübingen, Tübingen, Germany

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– 1868.e11 . ( https://doi.org/10.1016/j.cmet.2021.08.002 ) Czech MP 2020 Mechanisms of insulin resistance related to white, beige, and brown adipocytes . Molecular Metabolism 34 27 – 42 . ( https://doi.org/10.1016/j.molmet.2019.12.014 ) Deng ZB

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-24-0115
Volume/Issue:
Volume 262: Issue 3
Open access