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The Ritchie Centre, Hudson Institute of Medical Research, Clayton, Australia
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Department of Biological and Medical Sciences, Oxford Brookes University, Oxford, UK
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) However, relatively little is known about the long-term effects of naturally occurring increments in fetal cortisol concentrations of the magnitude seen in response to prenatal environmental challenges known to programme adult metabolic and endocrine
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The Ritchie Centre, Hudson Institute of Medical Research, Clayton, Australia
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Institute for Women’s Health, University College London, London, UK
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Department of Biological and Medical Sciences, Oxford Brookes University, Oxford, UK
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study in fetal sheep has demonstrated that the natural prepartum cortisol surge closely parallels the increase in mitochondrial OXPHOS capacity of skeletal muscle towards term ( Davies et al. 2020 ). However, whether these changes are the direct
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Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom
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(RIAs) correlate well with measurements of its cortisol-binding capacity, except in samples containing CBG variants with abnormal steroid-binding properties ( Robinson & Hammond 1985 , Smith et al. 1992 , Emptoz-Bonneton et al. 2000 , Perogamvros
Department of Biological and Medical Sciences, Oxford Brookes University, Oxford, UK
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Department of Biological and Medical Sciences, Oxford Brookes University, Oxford, UK
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Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK
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Institute of Biomedicine, Research Centre for Integrative Physiology and Pharmacology, University of Turku, Turku, Finland
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described are 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) and the 5α-reductases type 1 and 2 (5αR1 and 2). 11β-HSD1 converts the inactive glucocorticoid cortisone to its active form cortisol, and 11β-Hsd1 –/– mice have a beneficial metabolic phenotype
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for a better assessment of the diurnal rhythm-mediated secretion of cortisol and sex steroids. The diurnal pattern of cortisol secretory activity is well characterized. Cortisol reaches a zenith around the time of awakening in the morning and a nadir
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Introduction Activation of the hypothalamic–pituitary–adrenal (HPA) axis is a vital component of the stress response, driving production of glucocorticoid hormones (cortisol in humans, corticosterone in rodents) that mediate essential adaptations of
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rate of 1. 0 ml/min. Under these experimental conditions, the retention time for cortisone and cortisol were 4.5 and 5.5 min respectively. The initial reaction velocities recorded were in the linear range and were determined by measuring the peak area
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-body cortisol to air stress. Although, theoretically, ethanol exposure could be a contributory factor in the current dexamethasone experiments, it should be noted that controls for these experiments were treated with similar concentrations of ethanol. Also
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Centre for Discovery Brain Science, University of Edinburgh, Hugh Robson Building, Edinburgh, UK
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Clinical & Translational Research Institute, Newcastle University, International Centre for Life, Central Parkway, Newcastle upon Tyne, UK
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Mass Spectrometry Core Laboratory, Edinburgh Clinical Research Facility, Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, UK
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Introduction 11β-Hydroxysteroid dehydrogenase 1 (11βHSD1) generates active 11-hydroxy glucocorticoids (cortisol (human), corticosterone (rodent and human)) from intrinsically inert 11-keto steroids (cortisone, 11-dehydrocorticosterone (11DHC
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, the Netherlands
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Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, the Netherlands
Corcept Therapeutics, Menlo Park, CA, USA
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Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, the Netherlands
Corcept Therapeutics, Menlo Park, CA, USA
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Introduction Glucocorticoid (GC) stress hormones are essential for physiology and exert numerous functions via binding to the glucocorticoid receptor (GR). The predominant active GC hormone is cortisol in humans, while rats and mice adrenals