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Gisela Helfer and Qing-Feng Wu

amplify local chemerin concentration for CMKLR1 interaction ( Zabel et al . 2008 , De Henau et al . 2016 ). The role of chemerin in energy balance regulation and obesity Effect on whole body metabolism After the discovery of leptin

Open access

Ismael González-García, Pablo B Martínez de Morentin, Ánxela Estévez-Salguero, Cristina Contreras, Amparo Romero-Picó, Johan Fernø, Rubén Nogueiras, Carlos Diéguez, Manuel Tena-Sempere, Sulay Tovar, and Miguel López

level, estrogen receptor alpha and beta (ERα and ERβ) are expressed in several hypothalamic nuclei with key roles in the regulation of energy balance, such as the arcuate (ARC), paraventricular (PVH) and ventromedial (VMH) ( Simerly et al. 1990

Open access

Jeffrey Friedman

Fidahusein N Denton D Friedman JM 1997 Physiological response to long-term peripheral and central leptin infusion in lean and obese mice . PNAS 94 8878 – 8883 . ( doi:10.1073/pnas.94.16.8878 ) Hervey GR 1969 Regulation of energy balance

Open access

Noelia Martínez-Sánchez, José M Moreno-Navarrete, Cristina Contreras, Eva Rial-Pensado, Johan Fernø, Rubén Nogueiras, Carlos Diéguez, José-Manuel Fernández-Real, and Miguel López

Introduction Thyroid hormones (THs; 3,3′,5,5′ tetraiodothyroxyne or T 4 and 3,3′,5-triiodothyronine or T 3 ) exert important biological actions, not only modulating the development and growth but also regulating metabolism and energy balance

Open access

Alyce M Martin, Emily W Sun, and Damien J Keating

in the regulation in glucose homeostasis through their differential actions on the liver and endocrine pancreas. They also play important roles in maintaining energy balance by modulating nutrient absorption, mobilization of fat stores from adipose

Open access

T V Novoselova, R Larder, D Rimmington, C Lelliott, E H Wynn, R J Gorrigan, P H Tate, L Guasti, The Sanger Mouse Genetics Project, S O’Rahilly, A J L Clark, D W Logan, A P Coll, and L F Chan

particular, the paradoxical observation that the mutant mice become obese without detectable changes in food intake or energy balance ( Asai et al . 2013 ) requires exploration, as does the potential role of MRAP2 in peripheral cholesterol and lipid

Open access

F Wahab, M Shahab, and R Behr

) from the hypothalamus, thus causing reproductive quiescence ( Bergendahl et al . 1991 , Cameron et al . 1991 , Wahab et al . 2013 a , b ). Initiation of reproductive function is delayed by conditions of negative energy balance while, in adults

Open access

Christina Antza, Georgios Kostopoulos, Samiul Mostafa, Krishnarajah Nirantharakumar, and Abd Tahrani

linking sleep duration to obesity and T2DM. There are multiple plausible mechanisms that lead to changes to energy balance, beta cell function and insulin resistance ( Fig. 1 ). Figure 1 The mechanisms between short sleep duration and type 2

Open access

M A Hyatt, D H Keisler, H Budge, and M E Symonds

secretes a number of cytokines and peptides, termed adipokines, which are involved in regulating insulin sensitivity, appetite, energy balance, inflammation and lipid metabolism (see Trayhurn & Wood 2004 ). Excess fat mass that accompanies obesity appears

Open access

J Jeyabalan, M Shah, B Viollet, J P Roux, P Chavassieux, M Korbonits, and C Chenu

. doi:10.1007/s00125-005-1913-1 . Hardie DG 2008 AMPK: a key regulator of energy balance in the single cell and the whole organism . International Journal of Obesity 32 ( Suppl 4 ) S7 – S12 . doi:10.1038/ijo.2008.116 . Hardie DG Hawley SA