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Saadia Basharat, Jennifer A Parker, Kevin G Murphy, Stephen R Bloom, Julia C Buckingham and Christopher D John

( Shapiro et al . 2010 ). Human septic patients have elevated circulating levels of the soluble leptin receptor (Ob-Re), which correlate with disease severity indices ( Shapiro et al . 2010 ). Leptin has been reported to serve as an early biomarker of

Open access

Jeffrey Friedman

locomotor activity, are quite gentle and non-aggressive, and are not sexually active. Thus, the identification of leptin and later the localization of the leptin receptor ( Tartaglia et al . 1995 , Lee et al . 1996 ), encoded by the db gene, have

Open access

Dawn E W Livingstone, Sarah L Grassick, Gillian L Currie, Brian R Walker and Ruth Andrew

leptin resistant db/db mice ( Liu et al . 2005 ). These differences may reflect the distinctions between the defects in leptin signalling in these models. Leptin signals through several splice variants of the leptin receptor (Ob-R; Lee et al . 1996

Open access

F Wahab, M Shahab and R Behr

neurons ( Louis et al . 2011 ). Indeed, leptin receptors are located on many neuronal populations in the hypothalamus ( Wada et al . 2014 ) which cross-talk with KPergic neurons ( Backholer et al . 2010 , Fu & van den Pol 2010 , Kim et al . 2010

Open access

David O'Regan, Christopher J Kenyon, Jonathan R Seckl and Megan C Holmes

Maternal glucocorticoid treatment modulates placental leptin and leptin receptor expression and materno–fetal leptin physiology during late pregnancy, and elicits hypertension associated with hyperleptinaemia in the early-growth-retarded adult offspring

Open access

Gisela Helfer and Qing-Feng Wu

susceptible to diet-induced obesity than others. Plasma chemerin levels were raised in genetically obese (ob/ob) mice ( Ernst et al . 2010 ), whereas leptin receptor-deficient mice (db/db mice) had decreased levels of serum chemerin concentration and

Open access

Mark E Cleasby, Pauline M Jamieson and Philip J Atherton

components of the pathway were identified in leptin receptor-null (db/db) mice and obese Zucker rats. Treatment with the insulin-sensitising thiazolidinedione drug rosiglitazone also led to an improvement in muscle mass, leading to the suggestion that IR per