Filter

Refine by date

—

Refine by collections

Refine by access

  • Print
  • Save

Search Results

You are looking at 1 - 10 of 30 items for :

  • "lipogenesis" x
  • Refine by access: Open Access content only x
Clear All
Tina Seidu Department of Physiology and Biophysics, Howard University College of Medicine, Washington, DC, USA

Search for other papers by Tina Seidu in
Google Scholar
PubMed Close
,
Patrick McWhorter Department of Chemistry, Youngstown State University, Youngstown, Ohio, USA

Search for other papers by Patrick McWhorter in
Google Scholar
PubMed Close
,
Jessie Myer Department of Biology, University of Missouri, Columbia, Missouri, USA

Search for other papers by Jessie Myer in
Google Scholar
PubMed Close
,
Rabita Alamgir Department of Physiology and Biophysics, Howard University College of Medicine, Washington, DC, USA

Search for other papers by Rabita Alamgir in
Google Scholar
PubMed Close
,
Nicole Eregha Department of Physiology and Biophysics, Howard University College of Medicine, Washington, DC, USA

Search for other papers by Nicole Eregha in
Google Scholar
PubMed Close
,
Dilip Bogle Department of Physiology and Biophysics, Howard University College of Medicine, Washington, DC, USA

Search for other papers by Dilip Bogle in
Google Scholar
PubMed Close
,
Taylor Lofton Department of Physiology and Biophysics, Howard University College of Medicine, Washington, DC, USA

Search for other papers by Taylor Lofton in
Google Scholar
PubMed Close
,
Carolyn Ecelbarger Department of Medicine, Georgetown University Medical Center, Washington, DC, USA

Search for other papers by Carolyn Ecelbarger in
Google Scholar
PubMed Close
, and
Stanley Andrisse Department of Physiology and Biophysics, Howard University College of Medicine, Washington, DC, USA
Department of Pediatrics, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA

Search for other papers by Stanley Andrisse in
Google Scholar
PubMed Close

FFA uptake, de novo lipogenesis (DNL), and/or reduced lipid removal. ( Dowman et al. 2010 , Pettinelli et al. 2011 , Berlanga et al. 2014 ). The development of hepatic steatosis in PCOS is unique due to the influence of HA and is multi

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-21-0040
Volume/Issue:
Volume 250: Issue 2
Open access
Bettina Geidl-Flueck Department of Endocrinology, Diabetology and Clinical Nutrition, University Hospital Zurich (USZ) and University of Zurich (UZH), Switzerland

Search for other papers by Bettina Geidl-Flueck in
Google Scholar
PubMed Close
and
Philipp A Gerber Department of Endocrinology, Diabetology and Clinical Nutrition, University Hospital Zurich (USZ) and University of Zurich (UZH), Switzerland

Search for other papers by Philipp A Gerber in
Google Scholar
PubMed Close

hypothesized that an increased de novo lipogenesis after fructose intake in parallel with a decreased fatty acid oxidation leads to hepatic fat deposition. ACC, acetyl-CoA-carboxylase; ATP, adenosine triphosphate; CPT1a, carnitine palmitoyltransferase 1A; FA

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-22-0270
Volume/Issue:
Volume 257: Issue 2
Open access
Hyo Youl Moon
Search for other papers by Hyo Youl Moon in
Google Scholar
PubMed Close
,
Parkyong Song BioSignal Network Laboratory, Division of Molecular and Life Sciences, Lee Gil Ya Cancer and Diabetes Institute, School of Nano-Biotechnology and Chemical Engineering, Ulsan National Institute of Science and Technology, Engineering Building 104, 689-805 Ulsan, Republic of Korea

Search for other papers by Parkyong Song in
Google Scholar
PubMed Close
,
Cheol Soo Choi BioSignal Network Laboratory, Division of Molecular and Life Sciences, Lee Gil Ya Cancer and Diabetes Institute, School of Nano-Biotechnology and Chemical Engineering, Ulsan National Institute of Science and Technology, Engineering Building 104, 689-805 Ulsan, Republic of Korea

Search for other papers by Cheol Soo Choi in
Google Scholar
PubMed Close
,
Sung Ho Ryu BioSignal Network Laboratory, Division of Molecular and Life Sciences, Lee Gil Ya Cancer and Diabetes Institute, School of Nano-Biotechnology and Chemical Engineering, Ulsan National Institute of Science and Technology, Engineering Building 104, 689-805 Ulsan, Republic of Korea

Search for other papers by Sung Ho Ryu in
Google Scholar
PubMed Close
, and
Pann-Ghill Suh
Search for other papers by Pann-Ghill Suh in
Google Scholar
PubMed Close

suggested to be critical features ( Browning & Horton 2004 ). Indeed, in HFD-induced hepatic steatosis, both elevated hepatic lipogenesis and impaired lipid oxidation contribute to hepatic TG accumulation ( Postic & Girard 2008 ). Hepatic lipid homeostasis

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-13-0135
Volume/Issue:
Volume 218: Issue 3
Open access
Gencer Sancar German Center for Diabetes Research, Neuherberg, Germany
Department of Internal Medicine IV, Division of Diabetology, Endocrinology and Nephrology, Eberhard-Karls University of Tübingen, Tübingen, Germany
Institute for Diabetes Research and Metabolic Diseases, Helmholtz Center Munich, Eberhard-Karls University of Tübingen, Tübingen, Germany

Search for other papers by Gencer Sancar in
Google Scholar
PubMed Close
and
Andreas L Birkenfeld German Center for Diabetes Research, Neuherberg, Germany
Department of Internal Medicine IV, Division of Diabetology, Endocrinology and Nephrology, Eberhard-Karls University of Tübingen, Tübingen, Germany
Institute for Diabetes Research and Metabolic Diseases, Helmholtz Center Munich, Eberhard-Karls University of Tübingen, Tübingen, Germany

Search for other papers by Andreas L Birkenfeld in
Google Scholar
PubMed Close

novo lipogenesis. Moreover, enhanced lipolysis and decreased lipid storage capacity of the dysfunctional adipose tissue provide FFAs and glycerol that increase re-esterification of TAG, exacerbating hepatosteatosis and liver insulin resistance. DAG

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-24-0115
Volume/Issue:
Volume 262: Issue 3
Open access
T V Novoselova Centre for Endocrinology, Queen Mary University of London, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Charterhouse Square, London, UK

Search for other papers by T V Novoselova in
Google Scholar
PubMed Close
,
R Larder University of Cambridge Metabolic Research Laboratories, MRC Metabolic Disease Unit, Wellcome Trust-MRC Institute of Metabolic Science and NIHR Cambridge Biomedical Research Centre, Addenbrooke’s Hospital, Cambridge, UK

Search for other papers by R Larder in
Google Scholar
PubMed Close
,
D Rimmington University of Cambridge Metabolic Research Laboratories, MRC Metabolic Disease Unit, Wellcome Trust-MRC Institute of Metabolic Science and NIHR Cambridge Biomedical Research Centre, Addenbrooke’s Hospital, Cambridge, UK

Search for other papers by D Rimmington in
Google Scholar
PubMed Close
,
C Lelliott Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK

Search for other papers by C Lelliott in
Google Scholar
PubMed Close
,
E H Wynn Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK

Search for other papers by E H Wynn in
Google Scholar
PubMed Close
,
R J Gorrigan Centre for Endocrinology, Queen Mary University of London, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Charterhouse Square, London, UK

Search for other papers by R J Gorrigan in
Google Scholar
PubMed Close
,
P H Tate Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK

Search for other papers by P H Tate in
Google Scholar
PubMed Close
,
L Guasti Centre for Endocrinology, Queen Mary University of London, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Charterhouse Square, London, UK

Search for other papers by L Guasti in
Google Scholar
PubMed Close
,
The Sanger Mouse Genetics Project Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK

Search for other papers by The Sanger Mouse Genetics Project in
Google Scholar
PubMed Close
,
S O’Rahilly University of Cambridge Metabolic Research Laboratories, MRC Metabolic Disease Unit, Wellcome Trust-MRC Institute of Metabolic Science and NIHR Cambridge Biomedical Research Centre, Addenbrooke’s Hospital, Cambridge, UK

Search for other papers by S O’Rahilly in
Google Scholar
PubMed Close
,
A J L Clark Centre for Endocrinology, Queen Mary University of London, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Charterhouse Square, London, UK

Search for other papers by A J L Clark in
Google Scholar
PubMed Close
,
D W Logan Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK

Search for other papers by D W Logan in
Google Scholar
PubMed Close
,
A P Coll University of Cambridge Metabolic Research Laboratories, MRC Metabolic Disease Unit, Wellcome Trust-MRC Institute of Metabolic Science and NIHR Cambridge Biomedical Research Centre, Addenbrooke’s Hospital, Cambridge, UK

Search for other papers by A P Coll in
Google Scholar
PubMed Close
, and
L F Chan Centre for Endocrinology, Queen Mary University of London, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Charterhouse Square, London, UK

Search for other papers by L F Chan in
Google Scholar
PubMed Close

state of enzymes involved in lipogenesis and fatty acid synthesis as well as phosphorylation of the rate-limiting enzyme for lipolysis of hormone sensitive lipase (HSL). Phosphorylation of ATP-citrate lyase (ACL), an enzyme responsible for the synthesis

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-16-0057
Volume/Issue:
Volume 230: Issue 1
Open access
Yanli Miao Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

Search for other papers by Yanli Miao in
Google Scholar
PubMed Close
,
Haojie Qin Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

Search for other papers by Haojie Qin in
Google Scholar
PubMed Close
,
Yi Zhong Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

Search for other papers by Yi Zhong in
Google Scholar
PubMed Close
,
Kai Huang Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

Search for other papers by Kai Huang in
Google Scholar
PubMed Close
, and
Caijun Rao Department of Geriatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

Search for other papers by Caijun Rao in
Google Scholar
PubMed Close

) Relative mRNA expression of lipogenesis-related genes in mice scWAT ( n  = 4–8). (B and C) Lipogenesis was rescued by oltipraz treatment in Ad-Asprosin cells ( n  = 3). (B) Western blot analysis of ACC1 and FASN in the scWAT of experimental mice ( n  = 5

Article Type:
Research Article
Collections:
Top-cited articles of 2023
DOI:
https://doi.org/10.1530/JOE-20-0503
Volume/Issue:
Volume 249: Issue 2
Open access
Xuefeng Yang Department of Nutrition, Department of Nutrition and Food Hygiene, Department of Preventive Medicine, Department of Nutrition and Food Hygiene, Department of Medicine, Department of Medicine (Endocrinology), Department of Medicine (Endocrinology and Metabolism), Gillings School of Global Public Health, Nutrition Research Institute (NRI) at Kannapolis, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27559, USA
Department of Nutrition, Department of Nutrition and Food Hygiene, Department of Preventive Medicine, Department of Nutrition and Food Hygiene, Department of Medicine, Department of Medicine (Endocrinology), Department of Medicine (Endocrinology and Metabolism), Gillings School of Global Public Health, Nutrition Research Institute (NRI) at Kannapolis, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27559, USA

Search for other papers by Xuefeng Yang in
Google Scholar
PubMed Close
,
Shuang Mei Department of Nutrition, Department of Nutrition and Food Hygiene, Department of Preventive Medicine, Department of Nutrition and Food Hygiene, Department of Medicine, Department of Medicine (Endocrinology), Department of Medicine (Endocrinology and Metabolism), Gillings School of Global Public Health, Nutrition Research Institute (NRI) at Kannapolis, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27559, USA

Search for other papers by Shuang Mei in
Google Scholar
PubMed Close
,
Haihua Gu Department of Nutrition, Department of Nutrition and Food Hygiene, Department of Preventive Medicine, Department of Nutrition and Food Hygiene, Department of Medicine, Department of Medicine (Endocrinology), Department of Medicine (Endocrinology and Metabolism), Gillings School of Global Public Health, Nutrition Research Institute (NRI) at Kannapolis, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27559, USA

Search for other papers by Haihua Gu in
Google Scholar
PubMed Close
,
Huailan Guo Department of Nutrition, Department of Nutrition and Food Hygiene, Department of Preventive Medicine, Department of Nutrition and Food Hygiene, Department of Medicine, Department of Medicine (Endocrinology), Department of Medicine (Endocrinology and Metabolism), Gillings School of Global Public Health, Nutrition Research Institute (NRI) at Kannapolis, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27559, USA
Department of Nutrition, Department of Nutrition and Food Hygiene, Department of Preventive Medicine, Department of Nutrition and Food Hygiene, Department of Medicine, Department of Medicine (Endocrinology), Department of Medicine (Endocrinology and Metabolism), Gillings School of Global Public Health, Nutrition Research Institute (NRI) at Kannapolis, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27559, USA

Search for other papers by Huailan Guo in
Google Scholar
PubMed Close
,
Longying Zha Department of Nutrition, Department of Nutrition and Food Hygiene, Department of Preventive Medicine, Department of Nutrition and Food Hygiene, Department of Medicine, Department of Medicine (Endocrinology), Department of Medicine (Endocrinology and Metabolism), Gillings School of Global Public Health, Nutrition Research Institute (NRI) at Kannapolis, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27559, USA
Department of Nutrition, Department of Nutrition and Food Hygiene, Department of Preventive Medicine, Department of Nutrition and Food Hygiene, Department of Medicine, Department of Medicine (Endocrinology), Department of Medicine (Endocrinology and Metabolism), Gillings School of Global Public Health, Nutrition Research Institute (NRI) at Kannapolis, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27559, USA

Search for other papers by Longying Zha in
Google Scholar
PubMed Close
,
Junwei Cai Department of Nutrition, Department of Nutrition and Food Hygiene, Department of Preventive Medicine, Department of Nutrition and Food Hygiene, Department of Medicine, Department of Medicine (Endocrinology), Department of Medicine (Endocrinology and Metabolism), Gillings School of Global Public Health, Nutrition Research Institute (NRI) at Kannapolis, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27559, USA
Department of Nutrition, Department of Nutrition and Food Hygiene, Department of Preventive Medicine, Department of Nutrition and Food Hygiene, Department of Medicine, Department of Medicine (Endocrinology), Department of Medicine (Endocrinology and Metabolism), Gillings School of Global Public Health, Nutrition Research Institute (NRI) at Kannapolis, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27559, USA

Search for other papers by Junwei Cai in
Google Scholar
PubMed Close
,
Xuefeng Li Department of Nutrition, Department of Nutrition and Food Hygiene, Department of Preventive Medicine, Department of Nutrition and Food Hygiene, Department of Medicine, Department of Medicine (Endocrinology), Department of Medicine (Endocrinology and Metabolism), Gillings School of Global Public Health, Nutrition Research Institute (NRI) at Kannapolis, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27559, USA

Search for other papers by Xuefeng Li in
Google Scholar
PubMed Close
,
Zhenqi Liu Department of Nutrition, Department of Nutrition and Food Hygiene, Department of Preventive Medicine, Department of Nutrition and Food Hygiene, Department of Medicine, Department of Medicine (Endocrinology), Department of Medicine (Endocrinology and Metabolism), Gillings School of Global Public Health, Nutrition Research Institute (NRI) at Kannapolis, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27559, USA

Search for other papers by Zhenqi Liu in
Google Scholar
PubMed Close
, and
Wenhong Cao Department of Nutrition, Department of Nutrition and Food Hygiene, Department of Preventive Medicine, Department of Nutrition and Food Hygiene, Department of Medicine, Department of Medicine (Endocrinology), Department of Medicine (Endocrinology and Metabolism), Gillings School of Global Public Health, Nutrition Research Institute (NRI) at Kannapolis, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27559, USA
Department of Nutrition, Department of Nutrition and Food Hygiene, Department of Preventive Medicine, Department of Nutrition and Food Hygiene, Department of Medicine, Department of Medicine (Endocrinology), Department of Medicine (Endocrinology and Metabolism), Gillings School of Global Public Health, Nutrition Research Institute (NRI) at Kannapolis, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27559, USA
Department of Nutrition, Department of Nutrition and Food Hygiene, Department of Preventive Medicine, Department of Nutrition and Food Hygiene, Department of Medicine, Department of Medicine (Endocrinology), Department of Medicine (Endocrinology and Metabolism), Gillings School of Global Public Health, Nutrition Research Institute (NRI) at Kannapolis, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27559, USA

Search for other papers by Wenhong Cao in
Google Scholar
PubMed Close

. Table 2 The mRNA levels of genes involved in lipogenesis and fat oxidation. Results represent mean± s.d. of six to eight mice Glargine vs control (fold) Liver P value Muscle P value Cpt1 α (Cpt1 β ) ( Chpt1 ) 0.824±0.581 0.580 1.131±0.893 0

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-14-0117
Volume/Issue:
Volume 221: Issue 3
Open access
Ashley Patton Department of Specialty Medicine, Heritage College of Osteopathic Medicine, Ohio University, Athens, Ohio, USA
Diabetes Institute, Ohio University, Athens, Ohio, USA
Department of Biological Sciences, Ohio University, Athens, Ohio, USA
Molecular & Cellular Biology Program, College of Arts and Sciences, Ohio University, Athens, Ohio, USA

Search for other papers by Ashley Patton in
Google Scholar
PubMed Close
,
Tyler Church Department of Specialty Medicine, Heritage College of Osteopathic Medicine, Ohio University, Athens, Ohio, USA
Diabetes Institute, Ohio University, Athens, Ohio, USA

Search for other papers by Tyler Church in
Google Scholar
PubMed Close
,
Caroline Wilson Department of Chemical and Biomolecular Engineering, Russ College of Engineering and Technology, Ohio University, Athens, Ohio, USA

Search for other papers by Caroline Wilson in
Google Scholar
PubMed Close
,
Jean Thuma Department of Specialty Medicine, Heritage College of Osteopathic Medicine, Ohio University, Athens, Ohio, USA
Diabetes Institute, Ohio University, Athens, Ohio, USA

Search for other papers by Jean Thuma in
Google Scholar
PubMed Close
,
Douglas J Goetz Department of Chemical and Biomolecular Engineering, Russ College of Engineering and Technology, Ohio University, Athens, Ohio, USA
Molecular & Cellular Biology Program, College of Arts and Sciences, Ohio University, Athens, Ohio, USA
Biomedical Engineering Program, Ohio University, Athens, Ohio, USA

Search for other papers by Douglas J Goetz in
Google Scholar
PubMed Close
,
Darlene E Berryman Diabetes Institute, Ohio University, Athens, Ohio, USA
Department of Biomedical Sciences, Ohio University, Athens, Ohio, USA
The Edison Biotechnology Institute, Ohio University, Athens, Ohio, USA

Search for other papers by Darlene E Berryman in
Google Scholar
PubMed Close
,
Edward O List Department of Specialty Medicine, Heritage College of Osteopathic Medicine, Ohio University, Athens, Ohio, USA
Diabetes Institute, Ohio University, Athens, Ohio, USA
The Edison Biotechnology Institute, Ohio University, Athens, Ohio, USA

Search for other papers by Edward O List in
Google Scholar
PubMed Close
,
Frank Schwartz Department of Specialty Medicine, Heritage College of Osteopathic Medicine, Ohio University, Athens, Ohio, USA
Diabetes Institute, Ohio University, Athens, Ohio, USA

Search for other papers by Frank Schwartz in
Google Scholar
PubMed Close
, and
Kelly D McCall Department of Specialty Medicine, Heritage College of Osteopathic Medicine, Ohio University, Athens, Ohio, USA
Diabetes Institute, Ohio University, Athens, Ohio, USA
Department of Biological Sciences, Ohio University, Athens, Ohio, USA
Molecular & Cellular Biology Program, College of Arts and Sciences, Ohio University, Athens, Ohio, USA
Biomedical Engineering Program, Ohio University, Athens, Ohio, USA
Department of Biomedical Sciences, Ohio University, Athens, Ohio, USA

Search for other papers by Kelly D McCall in
Google Scholar
PubMed Close

lipogenesis and TG accumulation ( Feingold & Grunfeld 1987 , Grunfeld et al . 1988 , 1991 , Feingold et al . 1990 , 1992 ). Exogenous Tnfa in mice and rats has caused increased TG production and storage in the liver ( Feingold & Grunfeld 1987

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-18-0078
Volume/Issue:
Volume 237: Issue 3
Open access
I J Bujalska
Search for other papers by I J Bujalska in
Google Scholar
PubMed Close
,
L L Gathercole
Search for other papers by L L Gathercole in
Google Scholar
PubMed Close
,
J W Tomlinson
Search for other papers by J W Tomlinson in
Google Scholar
PubMed Close
,
C Darimont Division of Medical Sciences, Nestle Research Center, Pfizer Global Research and Development, The Medical School, Institute of Biomedical Research, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK

Search for other papers by C Darimont in
Google Scholar
PubMed Close
,
J Ermolieff Division of Medical Sciences, Nestle Research Center, Pfizer Global Research and Development, The Medical School, Institute of Biomedical Research, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK

Search for other papers by J Ermolieff in
Google Scholar
PubMed Close
,
A N Fanjul Division of Medical Sciences, Nestle Research Center, Pfizer Global Research and Development, The Medical School, Institute of Biomedical Research, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK

Search for other papers by A N Fanjul in
Google Scholar
PubMed Close
,
P A Rejto Division of Medical Sciences, Nestle Research Center, Pfizer Global Research and Development, The Medical School, Institute of Biomedical Research, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK

Search for other papers by P A Rejto in
Google Scholar
PubMed Close
, and
P M Stewart
Search for other papers by P M Stewart in
Google Scholar
PubMed Close

was assessed. Measuring lipid content in human subcutaneous s–v cells Lipogenesis in human subcutaneous s–v cells was measured as triglyceride accumulation. Cells were carefully washed with PBS and lysed in situ by adding 50 μl/well of Hecameg (10

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-08-0050
Volume/Issue:
Volume 197: Issue 2
Open access
View license
Nikolaos Nikolaou Oxford Centre for Diabetes, Endocrinology and Metabolism, NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford, UK

Search for other papers by Nikolaos Nikolaou in
Google Scholar
PubMed Close
,
Anastasia Arvaniti Oxford Centre for Diabetes, Endocrinology and Metabolism, NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford, UK
Department of Biological and Medical Sciences, Oxford Brookes University, Oxford, UK

Search for other papers by Anastasia Arvaniti in
Google Scholar
PubMed Close
,
Nathan Appanna Oxford Centre for Diabetes, Endocrinology and Metabolism, NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford, UK

Search for other papers by Nathan Appanna in
Google Scholar
PubMed Close
,
Anna Sharp Oxford Centre for Diabetes, Endocrinology and Metabolism, NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford, UK

Search for other papers by Anna Sharp in
Google Scholar
PubMed Close
,
Beverly A Hughes Institute of Metabolism and Systems Research, University of Birmingham, Edgbaston, Birmingham, UK

Search for other papers by Beverly A Hughes in
Google Scholar
PubMed Close
,
Dena Digweed Diurnal Ltd, Cardiff, UK

Search for other papers by Dena Digweed in
Google Scholar
PubMed Close
,
Martin J Whitaker Diurnal Ltd, Cardiff, UK

Search for other papers by Martin J Whitaker in
Google Scholar
PubMed Close
,
Richard Ross Department of Oncology and Metabolism, Faculty of Medicine, Dentistry and Health, University of Sheffield, Sheffield, UK

Search for other papers by Richard Ross in
Google Scholar
PubMed Close
,
Wiebke Arlt Institute of Metabolism and Systems Research, University of Birmingham, Edgbaston, Birmingham, UK
NIHR Birmingham Biomedical Research Centre, University Hospitals Birmingham NHS Foundation Trust and University of Birmingham, Birmingham, UK

Search for other papers by Wiebke Arlt in
Google Scholar
PubMed Close
,
Trevor M Penning Department of Systems Pharmacology & Translational Therapeutics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA

Search for other papers by Trevor M Penning in
Google Scholar
PubMed Close
,
Karen Morris Biochemistry Department, Manchester University NHS Trust, Manchester, UK

Search for other papers by Karen Morris in
Google Scholar
PubMed Close
,
Sherly George Biochemistry Department, Manchester University NHS Trust, Manchester, UK

Search for other papers by Sherly George in
Google Scholar
PubMed Close
,
Brian G Keevil Biochemistry Department, Manchester University NHS Trust, Manchester, UK

Search for other papers by Brian G Keevil in
Google Scholar
PubMed Close
,
Leanne Hodson Oxford Centre for Diabetes, Endocrinology and Metabolism, NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford, UK

Search for other papers by Leanne Hodson in
Google Scholar
PubMed Close
,
Laura L Gathercole Oxford Centre for Diabetes, Endocrinology and Metabolism, NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford, UK
Department of Biological and Medical Sciences, Oxford Brookes University, Oxford, UK

Search for other papers by Laura L Gathercole in
Google Scholar
PubMed Close
, and
Jeremy W Tomlinson Oxford Centre for Diabetes, Endocrinology and Metabolism, NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford, UK

Search for other papers by Jeremy W Tomlinson in
Google Scholar
PubMed Close

decrease in expression with advancing severity of non-alcoholic fatty liver disease (NAFLD) ( Valanejad et al. 2018 , Nikolaou et al. 2019 b ). In this context, AKR1D1 knockdown increased the expression of key enzymes involved in lipogenesis as

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-19-0473
Volume/Issue:
Volume 245: Issue 2
Open access