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K L Gustafsson
K L Gustafsson
Center for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
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K H Nilsson
K H Nilsson
Center for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
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H H Farman
H H Farman
Center for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
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A Andersson
A Andersson
Center for Bone and Arthritis Research, Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
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V Lionikaite
V Lionikaite
Center for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
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P Henning
P Henning
Center for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
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J Wu
J Wu
Center for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
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S H Windahl
S H Windahl
Center for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
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U Islander
U Islander
Center for Bone and Arthritis Research, Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
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S Movérare-Skrtic
S Movérare-Skrtic
Center for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
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K Sjögren
K Sjögren
Center for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
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H Carlsten
H Carlsten
Center for Bone and Arthritis Research, Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
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J-Å Gustafsson
J-Å Gustafsson
Center for Nuclear Receptors and Cell Signaling, Department of Biology and Biochemistry, University of Houston, Houston, Texas, USA
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C Ohlsson
C Ohlsson
Center for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
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M K Lagerquist
M K Lagerquist
Center for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
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Estrogen treatment has positive effects on the skeleton, and we have shown that estrogen receptor alpha (ERα) expression in cells of hematopoietic origin contributes to a normal estrogen treatment response in bone tissue. T lymphocytes are implicated in the estrogenic regulation of bone mass, but it is not known whether T lymphocytes are direct estrogen target cells. Therefore, the aim of this study was to determine the importance of ERα expression in T lymphocytes for the estrogenic regulation of the skeleton using female mice lacking ERα expression specifically in T lymphocytes (Lck-ERα−/−) and ERαflox/flox littermate (control) mice. Deletion of ERα expression in T lymphocytes did not affect bone mineral density (BMD) in sham-operated Lck-ERα−/− compared to control mice, and ovariectomy (ovx) resulted in a similar decrease in BMD in control and Lck-ERα−/− mice compared to sham-operated mice. Furthermore, estrogen treatment of ovx Lck-ERα−/− led to an increased BMD that was indistinguishable from the increase seen after estrogen treatment of ovx control mice. Detailed analysis of both the appendicular (femur) and axial (vertebrae) skeleton showed that both trabecular and cortical bone parameters responded to a similar extent regardless of the presence of ERα in T lymphocytes. In conclusion, ERα expression in T lymphocytes is dispensable for normal estrogenic regulation of bone mass in female mice.
Lisa Rice
Lisa Rice
Faculty of Medical and Human Sciences, Faculty of Life Sciences, Faculty of Medical and Human Sciences, School of Medicine
Faculty of Medical and Human Sciences, Faculty of Life Sciences, Faculty of Medical and Human Sciences, School of Medicine
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Faculty of Medical and Human Sciences, Faculty of Life Sciences, Faculty of Medical and Human Sciences, School of Medicine
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Charlotte E Waters
Charlotte E Waters
Faculty of Medical and Human Sciences, Faculty of Life Sciences, Faculty of Medical and Human Sciences, School of Medicine
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Jennifer Eccles
Jennifer Eccles
Faculty of Medical and Human Sciences, Faculty of Life Sciences, Faculty of Medical and Human Sciences, School of Medicine
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Helen Garside
Helen Garside
Faculty of Medical and Human Sciences, Faculty of Life Sciences, Faculty of Medical and Human Sciences, School of Medicine
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Paula Sommer
Paula Sommer
Faculty of Medical and Human Sciences, Faculty of Life Sciences, Faculty of Medical and Human Sciences, School of Medicine
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Paul Kay
Paul Kay
Faculty of Medical and Human Sciences, Faculty of Life Sciences, Faculty of Medical and Human Sciences, School of Medicine
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Fiona H Blackhall
Fiona H Blackhall
Faculty of Medical and Human Sciences, Faculty of Life Sciences, Faculty of Medical and Human Sciences, School of Medicine
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Leo Zeef
Leo Zeef
Faculty of Medical and Human Sciences, Faculty of Life Sciences, Faculty of Medical and Human Sciences, School of Medicine
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Brian Telfer
Brian Telfer
Faculty of Medical and Human Sciences, Faculty of Life Sciences, Faculty of Medical and Human Sciences, School of Medicine
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Ian Stratford
Ian Stratford
Faculty of Medical and Human Sciences, Faculty of Life Sciences, Faculty of Medical and Human Sciences, School of Medicine
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Rob Clarke
Rob Clarke
Faculty of Medical and Human Sciences, Faculty of Life Sciences, Faculty of Medical and Human Sciences, School of Medicine
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Dave Singh
Dave Singh
Faculty of Medical and Human Sciences, Faculty of Life Sciences, Faculty of Medical and Human Sciences, School of Medicine
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Adam Stevens
Adam Stevens
Faculty of Medical and Human Sciences, Faculty of Life Sciences, Faculty of Medical and Human Sciences, School of Medicine
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Anne White
Anne White
Faculty of Medical and Human Sciences, Faculty of Life Sciences, Faculty of Medical and Human Sciences, School of Medicine
Faculty of Medical and Human Sciences, Faculty of Life Sciences, Faculty of Medical and Human Sciences, School of Medicine
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Faculty of Medical and Human Sciences, Faculty of Life Sciences, Faculty of Medical and Human Sciences, School of Medicine
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David W Ray
David W Ray
Faculty of Medical and Human Sciences, Faculty of Life Sciences, Faculty of Medical and Human Sciences, School of Medicine
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Introduction Glucocorticoids (GC) act through the GC receptor (GR), a member of the nuclear receptor superfamily of ligand-regulated transcription factors ( Hollenberg et al . 1985 , Weinberger et al . 1985 , 1987 , Perlmann & Evans 1997
Eva M G Viho
Eva M G Viho
Department of Medicine, Division of Endocrinology, Leiden University Medical Center, Leiden, the Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, the Netherlands
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Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, the Netherlands
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Jan Kroon
Jan Kroon
Department of Medicine, Division of Endocrinology, Leiden University Medical Center, Leiden, the Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, the Netherlands
Corcept Therapeutics, Menlo Park, CA, USA
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Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, the Netherlands
Corcept Therapeutics, Menlo Park, CA, USA
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Richard A Feelders
Richard A Feelders
Department of Internal Medicine, Division of Endocrinology, Erasmus Medical Center, Rotterdam, the Netherlands
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René Houtman
René Houtman
Precision Medicine Lab, Oss, the Netherlands
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Elisabeth S R van den Dungen
Elisabeth S R van den Dungen
Department of Internal Medicine, Division of Endocrinology, Erasmus Medical Center, Rotterdam, the Netherlands
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Alberto M Pereira
Alberto M Pereira
Department of Endocrinology and Metabolism, Amsterdam University Medical Center, Amsterdam, the Netherlands
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Hazel J Hunt
Hazel J Hunt
Corcept Therapeutics, Menlo Park, CA, USA
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Leo J Hofland
Leo J Hofland
Department of Internal Medicine, Division of Endocrinology, Erasmus Medical Center, Rotterdam, the Netherlands
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Onno C Meijer
Onno C Meijer
Department of Medicine, Division of Endocrinology, Leiden University Medical Center, Leiden, the Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, the Netherlands
Corcept Therapeutics, Menlo Park, CA, USA
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Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, the Netherlands
Corcept Therapeutics, Menlo Park, CA, USA
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reference genes (RG) Hprt , GusB and Gapdh , as previously described ( Blažević et al. 2022 ). Microarray assay for real-time coregulator-nuclear receptor interaction GR-coregulator interactions were assessed in the presence of 1 µM cortisol
Lisa L Koorneef
Lisa L Koorneef
Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, The Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands
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Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands
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Jan Kroon
Jan Kroon
Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, The Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands
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Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands
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Eva M G Viho
Eva M G Viho
Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, The Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands
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Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands
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Lucas F Wahl
Lucas F Wahl
Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, The Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands
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Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands
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Kim M L Heckmans
Kim M L Heckmans
Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, The Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands
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Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands
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Marloes M A R van Dorst
Marloes M A R van Dorst
Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, The Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands
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Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands
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Menno Hoekstra
Menno Hoekstra
Division of BioTherapeutics, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands
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René Houtman
René Houtman
Pamgene International, Den Bosch, The Netherlands
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Hazel Hunt
Hazel Hunt
Corcept Therapeutics, Menlo Park, California, USA
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Onno C Meijer
Onno C Meijer
Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, The Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands
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Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands
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nuclear receptors ( Kroon et al. 2018 ). CORT125281 has beneficial effects in metabolic disease models, which is likely, in part, mediated via activation of brown adipose tissue (BAT) ( Kroon et al. 2018 ). In this study, we characterized the
Laura L Gathercole
Laura L Gathercole
Oxford Centre for Diabetes, Endocrinology and Metabolism, NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford, UK
Department of Biological and Medical Sciences, Oxford Brookes University, Oxford, UK
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Department of Biological and Medical Sciences, Oxford Brookes University, Oxford, UK
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Nikolaos Nikolaou
Nikolaos Nikolaou
Oxford Centre for Diabetes, Endocrinology and Metabolism, NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford, UK
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Shelley E Harris
Shelley E Harris
Oxford Centre for Diabetes, Endocrinology and Metabolism, NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford, UK
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Anastasia Arvaniti
Anastasia Arvaniti
Oxford Centre for Diabetes, Endocrinology and Metabolism, NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford, UK
Department of Biological and Medical Sciences, Oxford Brookes University, Oxford, UK
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Department of Biological and Medical Sciences, Oxford Brookes University, Oxford, UK
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Toryn M Poolman
Toryn M Poolman
Oxford Centre for Diabetes, Endocrinology and Metabolism, NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford, UK
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Jonathan M Hazlehurst
Jonathan M Hazlehurst
Oxford Centre for Diabetes, Endocrinology and Metabolism, NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford, UK
Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK
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Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK
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Denise V Kratschmar
Denise V Kratschmar
Swiss Centre for Applied Human Toxicology and Division of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland
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Marijana Todorčević
Marijana Todorčević
Oxford Centre for Diabetes, Endocrinology and Metabolism, NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford, UK
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Ahmad Moolla
Ahmad Moolla
Oxford Centre for Diabetes, Endocrinology and Metabolism, NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford, UK
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Niall Dempster
Niall Dempster
Oxford Centre for Diabetes, Endocrinology and Metabolism, NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford, UK
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Ryan C Pink
Ryan C Pink
Department of Biological and Medical Sciences, Oxford Brookes University, Oxford, UK
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Michael F Saikali
Michael F Saikali
Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada
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Liz Bentley
Liz Bentley
Mammalian Genetics Unit, Medical Research Council Harwell, Oxford, UK
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Trevor M Penning
Trevor M Penning
Center of Excellence in Environmental Toxicology, Department of Systems Pharmacology & Translational Therapeutics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA
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Claes Ohlsson
Claes Ohlsson
Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
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Carolyn L Cummins
Carolyn L Cummins
Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada
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Matti Poutanen
Matti Poutanen
Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
Institute of Biomedicine, Research Centre for Integrative Physiology and Pharmacology, University of Turku, Turku, Finland
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Institute of Biomedicine, Research Centre for Integrative Physiology and Pharmacology, University of Turku, Turku, Finland
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Alex Odermatt
Alex Odermatt
Swiss Centre for Applied Human Toxicology and Division of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland
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Roger D Cox
Roger D Cox
Mammalian Genetics Unit, Medical Research Council Harwell, Oxford, UK
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Jeremy W Tomlinson
Jeremy W Tomlinson
Oxford Centre for Diabetes, Endocrinology and Metabolism, NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford, UK
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others) Ces2c, CYP2C18, Cyp3a25 (includes others), CYP3A5, CYP8B1 POR Enzyme 3.68E-11 Hsd3b4 (includes others) Aldh1a7, Ces2a, Ces2c, CYP2C18, CYP8B1, MSMO1, UGDH NR1I3 Ligand-dependent nuclear receptor 1.955 1.29 2.08E
Sara Della Torre
Sara Della Torre
Center of Excellence on Neurodegenerative Diseases, University of Milan, Milan, Italy
Department of Pharmacological and Biomolecular Sciences, University of Milan, Milan, Italy
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Department of Pharmacological and Biomolecular Sciences, University of Milan, Milan, Italy
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Gianpaolo Rando
Gianpaolo Rando
Center of Excellence on Neurodegenerative Diseases, University of Milan, Milan, Italy
Department of Pharmacological and Biomolecular Sciences, University of Milan, Milan, Italy
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Department of Pharmacological and Biomolecular Sciences, University of Milan, Milan, Italy
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Clara Meda
Clara Meda
Center of Excellence on Neurodegenerative Diseases, University of Milan, Milan, Italy
Department of Pharmacological and Biomolecular Sciences, University of Milan, Milan, Italy
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Department of Pharmacological and Biomolecular Sciences, University of Milan, Milan, Italy
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Paolo Ciana
Paolo Ciana
Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy
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Luisa Ottobrini
Luisa Ottobrini
Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy
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Adriana Maggi
Adriana Maggi
Center of Excellence on Neurodegenerative Diseases, University of Milan, Milan, Italy
Department of Pharmacological and Biomolecular Sciences, University of Milan, Milan, Italy
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Department of Pharmacological and Biomolecular Sciences, University of Milan, Milan, Italy
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the nuclear receptor (NR) family ( Tsai & O’Malley 1994 , Kininis & Kraus 2008 ). In addition, ERs may interfere with the signalling of other membrane receptors as well as intracellular receptors, and ERα, may associate with the plasma membrane and
Nikolaos Nikolaou
Nikolaos Nikolaou
Oxford Centre for Diabetes, Endocrinology and Metabolism, NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford, UK
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Anastasia Arvaniti
Anastasia Arvaniti
Oxford Centre for Diabetes, Endocrinology and Metabolism, NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford, UK
Department of Biological and Medical Sciences, Oxford Brookes University, Oxford, UK
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Department of Biological and Medical Sciences, Oxford Brookes University, Oxford, UK
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Nathan Appanna
Nathan Appanna
Oxford Centre for Diabetes, Endocrinology and Metabolism, NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford, UK
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Anna Sharp
Anna Sharp
Oxford Centre for Diabetes, Endocrinology and Metabolism, NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford, UK
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Beverly A Hughes
Beverly A Hughes
Institute of Metabolism and Systems Research, University of Birmingham, Edgbaston, Birmingham, UK
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Dena Digweed
Dena Digweed
Diurnal Ltd, Cardiff, UK
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Martin J Whitaker
Martin J Whitaker
Diurnal Ltd, Cardiff, UK
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Richard Ross
Richard Ross
Department of Oncology and Metabolism, Faculty of Medicine, Dentistry and Health, University of Sheffield, Sheffield, UK
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Wiebke Arlt
Wiebke Arlt
Institute of Metabolism and Systems Research, University of Birmingham, Edgbaston, Birmingham, UK
NIHR Birmingham Biomedical Research Centre, University Hospitals Birmingham NHS Foundation Trust and University of Birmingham, Birmingham, UK
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NIHR Birmingham Biomedical Research Centre, University Hospitals Birmingham NHS Foundation Trust and University of Birmingham, Birmingham, UK
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Trevor M Penning
Trevor M Penning
Department of Systems Pharmacology & Translational Therapeutics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA
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Karen Morris
Karen Morris
Biochemistry Department, Manchester University NHS Trust, Manchester, UK
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Sherly George
Sherly George
Biochemistry Department, Manchester University NHS Trust, Manchester, UK
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Brian G Keevil
Brian G Keevil
Biochemistry Department, Manchester University NHS Trust, Manchester, UK
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Leanne Hodson
Leanne Hodson
Oxford Centre for Diabetes, Endocrinology and Metabolism, NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford, UK
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Laura L Gathercole
Laura L Gathercole
Oxford Centre for Diabetes, Endocrinology and Metabolism, NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford, UK
Department of Biological and Medical Sciences, Oxford Brookes University, Oxford, UK
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Department of Biological and Medical Sciences, Oxford Brookes University, Oxford, UK
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Jeremy W Tomlinson
Jeremy W Tomlinson
Oxford Centre for Diabetes, Endocrinology and Metabolism, NIHR Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford, UK
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nuclear receptors including the LXRs, GR, PXR and the retinoic acid receptor-related orphan receptors (RORs) ( Ma & Nelson 2019 ). In this regard, there is compelling evidence on the role of oxysterols as important mediators of metabolic syndrome
Jin-Ran Chen
Jin-Ran Chen
Arkansas Children’s Nutrition Center, Little Rock, Arkansas, USA
Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
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Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
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Oxana P Lazarenko
Oxana P Lazarenko
Arkansas Children’s Nutrition Center, Little Rock, Arkansas, USA
Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
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Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
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Haijun Zhao
Haijun Zhao
Arkansas Children’s Nutrition Center, Little Rock, Arkansas, USA
Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
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Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
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Alexander W Alund
Alexander W Alund
Interdisciplinary Biomedical Sciences , University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
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Kartik Shankar
Kartik Shankar
Arkansas Children’s Nutrition Center, Little Rock, Arkansas, USA
Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
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Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
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with activation of hundreds of transcription factors including nuclear receptors such as PPARγ. We found that PPARγ expression was increased in embryonic calvarial osteo-progenitor cells from HFD-induced obese dams ( Fig. 2A ). To determine whether HFD
A McMaster
A McMaster
Medicine, Faculty of Life Sciences, Centre for Molecular
Medicine, Faculty of Life Sciences, Centre for Molecular
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Medicine, Faculty of Life Sciences, Centre for Molecular
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T Chambers
T Chambers
Medicine, Faculty of Life Sciences, Centre for Molecular
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Q-J Meng
Q-J Meng
Medicine, Faculty of Life Sciences, Centre for Molecular
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S Grundy
S Grundy
Medicine, Faculty of Life Sciences, Centre for Molecular
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A S I Loudon
A S I Loudon
Medicine, Faculty of Life Sciences, Centre for Molecular
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R Donn
R Donn
Medicine, Faculty of Life Sciences, Centre for Molecular
Medicine, Faculty of Life Sciences, Centre for Molecular
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Medicine, Faculty of Life Sciences, Centre for Molecular
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D W Ray
D W Ray
Medicine, Faculty of Life Sciences, Centre for Molecular
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point, reporter gene assays, and provides additional reassurance that our real-time reporter gene approach authentically reports the underlying biological effect ( De Bosscher et al . 2005 ). Different molecular structures act on nuclear receptors to
Jin Yu
Jin Yu
Department of Gynecology of Traditional Chinese Medicine, Changhai Hospital, Naval Medical University, Shanghai, China
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Yuhuan Liu
Yuhuan Liu
Department of Gynecology and Obstetrics, Changhai Hospital, Naval Medical University, Shanghai, China
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Danying Zhang
Danying Zhang
Department of Gynecology of Traditional Chinese Medicine, Changhai Hospital, Naval Medical University, Shanghai, China
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Dongxia Zhai
Dongxia Zhai
Department of Gynecology of Traditional Chinese Medicine, Changhai Hospital, Naval Medical University, Shanghai, China
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Linyi Song
Linyi Song
Department of Gynecology of Traditional Chinese Medicine, Changhai Hospital, Naval Medical University, Shanghai, China
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Zailong Cai
Zailong Cai
Department of Biochemistry and Molecular Biology, Naval Medical University, Shanghai, China
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Chaoqin Yu
Chaoqin Yu
Department of Gynecology of Traditional Chinese Medicine, Changhai Hospital, Naval Medical University, Shanghai, China
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. The human HSD3B2 promoter can be activated by GATA4 and GATA6 and acts in concert with the nuclear receptor SF1 and liver receptor homolog 1 (LRH1) ( Martin et al. 2005 ). This suggests that GATA factors are key regulators of HSD3B2 and that
