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R Dobie, V E MacRae, C Huesa, R van't Hof, S F Ahmed and C Farquharson

insulin-like growth factor 1 (IGF1) production and autocrine/paracrine (local) actions via the osteoblast GH-receptor (GHR). In addition, local GH actions may be indirect (IGF1 dependent) or direct (IGF1 independent) ( Isgaard et al . 1986 , 1989 , Le

Open access

Jin-Ran Chen, Oxana P Lazarenko, Haijun Zhao, Alexander W Alund and Kartik Shankar

/mL) and glutamine (4 mM). α-MEM supplemented with 10% FBS, 1 mM ascorbyl-2-phosphate (Sigma-Aldrich) and 4 mM l -glutamine was used as osteoblast (OB) differentiation medium, while α-MEM supplemented with 10% FBS was used as control medium. Cell RNA from

Open access

Ryoko Yamamoto, Tomoko Minamizaki, Yuji Yoshiko, Hirotaka Yoshioka, Kazuo Tanne, Jane E Aubin and Norihiko Maeda

). FGF23 is expressed primarily in bones, most notably in osteoblasts and osteocytes ( Riminucci et al . 2003 , Kolek et al . 2005 , Yoshiko et al . 2007 b ). Indeed, analyses of Fgf23 -null ( Fgf23 −/− ) mice on a Hyp (a mouse model of X

Open access

David E Maridas, Victoria E DeMambro, Phuong T Le, Kenichi Nagano, Roland Baron, Subburaman Mohan and Clifford J Rosen

et al . 2013 ). IGFBP-4, which is highly expressed in adipocytes and osteoblasts, is the smallest IGF-binding protein and contains a cleavage site for pregnancy-associated plasma protein A (PAPPA). It also circulates in relatively substantial amounts

Open access

J Jeyabalan, M Shah, B Viollet, J P Roux, P Chavassieux, M Korbonits and C Chenu

metformin, are osteogenic in vitro . They stimulate proliferation, differentiation and mineralisation of MC3T3-E1 osteoblastic cells ( Kanazawa et al . 2008 , 2009 , Jang et al . 2011 a , b , Mai et al . 2011 ), primary osteoblasts ( Shah et al

Open access

Thomas Funck-Brentano, Karin H Nilsson, Robert Brommage, Petra Henning, Ulf H Lerner, Antti Koskela, Juha Tuukkanen, Martine Cohen-Solal, Sofia Movérare-Skrtic and Claes Ohlsson

. Osteoblast-specific deletion of Wls led to dramatic reductions of both trabecular and cortical bone mass and spontaneous fractures in mice ( Zhong et al. 2012 ). Based on these findings, we hypothesized that inhibiting Porcupine could also lead to adverse

Open access

Bernard Freudenthal, John Logan, Sanger Institute Mouse Pipelines, Peter I Croucher, Graham R Williams and J H Duncan Bassett

osteoblasts and osteoclasts. Both these pathways have subsequently been targeted by novel osteoporosis treatments. Table 1 Monogenic disorders that have identified key skeletal genes in bone remodelling. Disease Clinical features Gene

Open access

Claes Ohlsson, Petra Henning, Karin H Nilsson, Jianyao Wu, Karin L Gustafsson, Klara Sjögren, Anna Törnqvist, Antti Koskela, Fu-Ping Zhang, Marie K Lagerquist, Matti Poutanen, Juha Tuukkanen, Ulf H Lerner and Sofia Movérare-Skrtic

. 2012 , Zheng et al . 2012 , Garcia-Ibarbia et al . 2013 , Koller et al . 2013 , Hendrickx et al . 2014 ). Subsequent translational studies using global as well as cell-specific Wnt16 inactivation in mice demonstrated that osteoblast

Open access

Vikte Lionikaite, Karin L Gustafsson, Anna Westerlund, Sara H Windahl, Antti Koskela, Juha Tuukkanen, Helena Johansson, Claes Ohlsson, H Herschel Conaway, Petra Henning and Ulf H Lerner

decreased number of osteoblasts ( Yorgan et al. 2016 ). Although numerous investigations have shown either stimulatory or inhibitory effects of vitamin A on osteoblast differentiation and function in vitro (reviewed in Conaway et al. 2013 , Green

Open access

Louise Grahnemo, Caroline Jochems, Annica Andersson, Cecilia Engdahl, Claes Ohlsson, Ulrika Islander and Hans Carlsten

cells produce pro-inflammatory cytokines, which inhibit osteoblast maturation, induce osteoblast apoptosis, and increase osteoclast activity and maturation, thus favoring bone resorption ( Kurihara et al . 1990 , Jilka et al . 1992 , Jimi et al