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Scott Haston Developmental Biology and Cancer Research Programme, Birth Defects Research Centre, UCL Great Ormond Street Institute of Child Health, London, UK

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Saba Manshaei Developmental Biology and Cancer Research Programme, Birth Defects Research Centre, UCL Great Ormond Street Institute of Child Health, London, UK

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Juan Pedro Martinez-Barbera Developmental Biology and Cancer Research Programme, Birth Defects Research Centre, UCL Great Ormond Street Institute of Child Health, London, UK

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Introduction The pituitary gland is known as the master regulator of the endocrine system, a title that is justified by the numerous critical physiological functions that it regulates including growth, metabolism, stress responses and

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-17-0258
Volume/Issue:
Volume 236: Issue 1
Open access
Dominik Simon Botermann Institute of Human Genetics, Molecular Developmental Genetics and Tumor Genetics Group, University Medical Center, Göttingen, Germany

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Nadine Brandes Institute of Human Genetics, Molecular Developmental Genetics and Tumor Genetics Group, University Medical Center, Göttingen, Germany

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Anke Frommhold Institute of Human Genetics, Molecular Developmental Genetics and Tumor Genetics Group, University Medical Center, Göttingen, Germany

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Ina Heß Institute of Human Genetics, Molecular Developmental Genetics and Tumor Genetics Group, University Medical Center, Göttingen, Germany

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Alexander Wolff Institute of Human Genetics, Molecular Developmental Genetics and Tumor Genetics Group, University Medical Center, Göttingen, Germany

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Arne Zibat Institute of Human Genetics, Molecular Developmental Genetics and Tumor Genetics Group, University Medical Center, Göttingen, Germany

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Heidi Hahn Institute of Human Genetics, Molecular Developmental Genetics and Tumor Genetics Group, University Medical Center, Göttingen, Germany

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Rolf Buslei Institute of Pathology, Sozialstiftung Bamberg, Klinikum am Bruderwald, Bamberg, Germany

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Anja Uhmann Institute of Human Genetics, Molecular Developmental Genetics and Tumor Genetics Group, University Medical Center, Göttingen, Germany

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Introduction The pituitary gland is a key regulator of body homeostasis and responsible for signal exchanges between the hypothalamus and peripheral organs. Besides of the six different endocrine cell types (e.g. corticotrophs

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-20-0388
Volume/Issue:
Volume 248: Issue 3
Open access
Eva M G Viho Department of Medicine, Division of Endocrinology, Leiden University Medical Center, Leiden, the Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, the Netherlands

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Jan Kroon Department of Medicine, Division of Endocrinology, Leiden University Medical Center, Leiden, the Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, the Netherlands
Corcept Therapeutics, Menlo Park, CA, USA

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Richard A Feelders Department of Internal Medicine, Division of Endocrinology, Erasmus Medical Center, Rotterdam, the Netherlands

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René Houtman Precision Medicine Lab, Oss, the Netherlands

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Elisabeth S R van den Dungen Department of Internal Medicine, Division of Endocrinology, Erasmus Medical Center, Rotterdam, the Netherlands

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Alberto M Pereira Department of Endocrinology and Metabolism, Amsterdam University Medical Center, Amsterdam, the Netherlands

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Hazel J Hunt Corcept Therapeutics, Menlo Park, CA, USA

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Leo J Hofland Department of Internal Medicine, Division of Endocrinology, Erasmus Medical Center, Rotterdam, the Netherlands

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Onno C Meijer Department of Medicine, Division of Endocrinology, Leiden University Medical Center, Leiden, the Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, the Netherlands
Corcept Therapeutics, Menlo Park, CA, USA

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( de Kloet et al. 2005 , Joëls 2018 ). The maintenance of homeostasis by GCs is tightly regulated by hypothalamus–pituitary–adrenal (HPA) axis activity ( Lightman et al. 2020 ). The hypothalamic neurons from the paraventricular nucleus release the

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-22-0263
Volume/Issue:
Volume 256: Issue 2
Open access
J Fahrenkrug Department of Clinical Biochemistry, Bispebjerg and Frederiksberg Hospital, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark

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B Georg Department of Clinical Biochemistry, Bispebjerg and Frederiksberg Hospital, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark

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J Hannibal Department of Clinical Biochemistry, Bispebjerg and Frederiksberg Hospital, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark

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H L Jørgensen Department of Clinical Biochemistry, Bispebjerg and Frederiksberg Hospital, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark

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Introduction There is growing evidence that endocrine body rhythms including the hypothalamic–pituitary–thyroid (HPT) axis are regulated by the circadian timing system, which consists of the master pacemaker located in the hypothalamic

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-17-0111
Volume/Issue:
Volume 233: Issue 3
Open access
L A Nolan Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, University of Bristol, Dorothy Hodgkin Building, Whitson Street, Bristol BS1 3NY, UK

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A Levy Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, University of Bristol, Dorothy Hodgkin Building, Whitson Street, Bristol BS1 3NY, UK

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Introduction The anterior pituitary, like many other endocrine tissues, retains considerable plasticity throughout adult life. The precise quantitative and qualitative nature of any pituitary mitotic and/or apoptotic response is influenced by the

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-08-0474
Volume/Issue:
Volume 200: Issue 3
Open access
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K E Lines Academic Endocrine Unit, Radcliffe Department of Medicine, University of Oxford, Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), Churchill Hospital, Headington, Oxford, UK

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P J Newey Academic Endocrine Unit, Radcliffe Department of Medicine, University of Oxford, Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), Churchill Hospital, Headington, Oxford, UK
Division of Molecular & Clinical Medicine, University of Dundee, Ninewells Hospital & Medical School, Dundee, UK

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C J Yates Academic Endocrine Unit, Radcliffe Department of Medicine, University of Oxford, Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), Churchill Hospital, Headington, Oxford, UK

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M Stevenson Academic Endocrine Unit, Radcliffe Department of Medicine, University of Oxford, Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), Churchill Hospital, Headington, Oxford, UK

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R Dyar Academic Endocrine Unit, Radcliffe Department of Medicine, University of Oxford, Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), Churchill Hospital, Headington, Oxford, UK

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G V Walls Academic Endocrine Unit, Radcliffe Department of Medicine, University of Oxford, Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), Churchill Hospital, Headington, Oxford, UK

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M R Bowl Academic Endocrine Unit, Radcliffe Department of Medicine, University of Oxford, Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), Churchill Hospital, Headington, Oxford, UK

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R V Thakker Academic Endocrine Unit, Radcliffe Department of Medicine, University of Oxford, Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), Churchill Hospital, Headington, Oxford, UK

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Introduction Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant disorder characterised by the combined occurrence of parathyroid, pituitary and pancreatic islet tumours ( Pieterman et al. 2009 , Goudet et al. 2010

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-18-0278
Volume/Issue:
Volume 240: Issue 1
Open access
Saadia Basharat
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Jennifer A Parker Division of Diabetes, University College London, Brunel University, Endocrinology and Metabolism, Department of Investigative Medicine, Imperial College London, Hammersmith Hospital Campus, 6th Floor, Commonwealth Building, Du Cane Road, London W12 0NN, UK

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Kevin G Murphy
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Stephen R Bloom
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Julia C Buckingham Division of Diabetes, University College London, Brunel University, Endocrinology and Metabolism, Department of Investigative Medicine, Imperial College London, Hammersmith Hospital Campus, 6th Floor, Commonwealth Building, Du Cane Road, London W12 0NN, UK

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Christopher D John
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sepsis in patients, allowing differentiation between patients with systemic inflammatory response syndrome and patients with sepsis ( Yousef et al . 2010 ). The hypothalamic–pituitary–adrenal (HPA) axis plays an important protective role in the body

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-13-0249
Volume/Issue:
Volume 221: Issue 2
Open access
Shona Wood Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, UK

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Andrew Loudon Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, UK

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-out of the seasonal response is seen in the expression of a seasonal pituitary prolactin rhythm, which is activated by long photoperiods, driving moult cycles in birds and mammals ( Fig. 1 ). In small short-lived mammals such as Siberian hamsters, LD

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-14-0141
Volume/Issue:
Volume 222: Issue 2
Open access
Nerine T Joseph Royal (Dick) School of Veterinary Studies, MRC Human Reproductive Sciences Unit, MRC/UCT, The Roslin Institute, University of Edinburgh, Roslin, Midlothian, Edinburgh EH25 9PS, UK
Royal (Dick) School of Veterinary Studies, MRC Human Reproductive Sciences Unit, MRC/UCT, The Roslin Institute, University of Edinburgh, Roslin, Midlothian, Edinburgh EH25 9PS, UK

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Kevin Morgan Royal (Dick) School of Veterinary Studies, MRC Human Reproductive Sciences Unit, MRC/UCT, The Roslin Institute, University of Edinburgh, Roslin, Midlothian, Edinburgh EH25 9PS, UK

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Robin Sellar Royal (Dick) School of Veterinary Studies, MRC Human Reproductive Sciences Unit, MRC/UCT, The Roslin Institute, University of Edinburgh, Roslin, Midlothian, Edinburgh EH25 9PS, UK

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Derek McBride Royal (Dick) School of Veterinary Studies, MRC Human Reproductive Sciences Unit, MRC/UCT, The Roslin Institute, University of Edinburgh, Roslin, Midlothian, Edinburgh EH25 9PS, UK

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Robert P Millar Royal (Dick) School of Veterinary Studies, MRC Human Reproductive Sciences Unit, MRC/UCT, The Roslin Institute, University of Edinburgh, Roslin, Midlothian, Edinburgh EH25 9PS, UK
Royal (Dick) School of Veterinary Studies, MRC Human Reproductive Sciences Unit, MRC/UCT, The Roslin Institute, University of Edinburgh, Roslin, Midlothian, Edinburgh EH25 9PS, UK

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Ian C Dunn Royal (Dick) School of Veterinary Studies, MRC Human Reproductive Sciences Unit, MRC/UCT, The Roslin Institute, University of Edinburgh, Roslin, Midlothian, Edinburgh EH25 9PS, UK

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evidence for a third GnRH ligand in the chicken to date. Both cGnRH-I and GnRH-II stimulate LH release from chicken pituitary in vitro ( Hattori et al . 1986 , Millar et al . 1986 ) and in vivo ( Chou et al . 1985 , Hattori et al . 1986 , Sharp

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-08-0544
Volume/Issue:
Volume 202: Issue 1
Open access
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Michael J F Newson Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, University of Bristol, Dorothy Hodgkin Building, Whitson Street, Bristol BS1 3NY, UK

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Emma M Roberts Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, University of Bristol, Dorothy Hodgkin Building, Whitson Street, Bristol BS1 3NY, UK

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George R Pope Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, University of Bristol, Dorothy Hodgkin Building, Whitson Street, Bristol BS1 3NY, UK

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Stephen J Lolait Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, University of Bristol, Dorothy Hodgkin Building, Whitson Street, Bristol BS1 3NY, UK

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Anne-Marie O'Carroll Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, University of Bristol, Dorothy Hodgkin Building, Whitson Street, Bristol BS1 3NY, UK

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cell bodies have been detected in the PVN, supraoptic nucleus (SON), the median eminence ( Reaux et al . 2002 ) and in the posterior pituitary ( Brailoiu et al . 2002 ). Outside the CNS, apelin immunoreactivity and mRNA are present in vascular

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-09-0093
Volume/Issue:
Volume 202: Issue 1
Open access
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