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Programming of cardiometabolic health: the role of maternal and fetal hyperinsulinaemia

Antonia Hufnagel

Antonia Hufnagel University of Cambridge Metabolic Research Laboratories and MRC Metabolic Diseases Unit, Wellcome Trust-MRC Institute of Metabolic Science, Level 4, Addenbrooke’s Hospital, Cambridge, Cambridgeshire, UK

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Laura Dearden

Laura Dearden University of Cambridge Metabolic Research Laboratories and MRC Metabolic Diseases Unit, Wellcome Trust-MRC Institute of Metabolic Science, Level 4, Addenbrooke’s Hospital, Cambridge, Cambridgeshire, UK

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Denise S Fernandez-Twinn

Denise S Fernandez-Twinn University of Cambridge Metabolic Research Laboratories and MRC Metabolic Diseases Unit, Wellcome Trust-MRC Institute of Metabolic Science, Level 4, Addenbrooke’s Hospital, Cambridge, Cambridgeshire, UK

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Susan E Ozanne

Susan E Ozanne University of Cambridge Metabolic Research Laboratories and MRC Metabolic Diseases Unit, Wellcome Trust-MRC Institute of Metabolic Science, Level 4, Addenbrooke’s Hospital, Cambridge, Cambridgeshire, UK

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cardiometabolic health ( Dashe et al. 2009 , HAPO Study Cooperative Research Group 2010 ). The observation that an adverse in utero environment programmes the long-term health of the offspring, called developmental programming, is now well-evidenced with a

Article Type:: Review Article

DOI:: https://doi.org/10.1530/JOE-21-0332

Volume/Issue:: Volume 253: Issue 2

Open access

Resveratrol and curcumin enhance pancreatic β-cell function by inhibiting phosphodiesterase activity

Michael Rouse

Michael Rouse Laboratory of Clinical Investigation, Laboratory of Cardiovascular Science, National Institute on Aging, Intramural Research Program, National Institutes of Health, 251 Bayview Blvd, Baltimore, Maryland 21224, USA

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Antoine Younès

Antoine Younès Laboratory of Clinical Investigation, Laboratory of Cardiovascular Science, National Institute on Aging, Intramural Research Program, National Institutes of Health, 251 Bayview Blvd, Baltimore, Maryland 21224, USA

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Josephine M Egan

Josephine M Egan Laboratory of Clinical Investigation, Laboratory of Cardiovascular Science, National Institute on Aging, Intramural Research Program, National Institutes of Health, 251 Bayview Blvd, Baltimore, Maryland 21224, USA

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% confluency was reached in a fresh culture medium. Human islets were provided by the National Institute of Diabetes and Digestive and Kidney Diseases-funded Integrated Islet Distribution Program at the City of Hope. For primary cultures, human islets were

Article Type:: Research Article

DOI:: https://doi.org/10.1530/JOE-14-0335

Volume/Issue:: Volume 223: Issue 2

Open access

RISING STARS: Mechanistic insights into maternal–fetal cross talk and islet beta-cell development

Seokwon Jo

Seokwon Jo Department of Integrative Biology & Physiology, University of Minnesota Medical School, Minneapolis, Minnesota, USA

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Emilyn U Alejandro

Emilyn U Alejandro Department of Integrative Biology & Physiology, University of Minnesota Medical School, Minneapolis, Minnesota, USA

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Washington, where she conducted type 1 diabetes research as an undergraduate McNair Scholar at Dr Ake Lernmark’s lab. She furthered her scientific passion by participating in a postbaccalaureate program at the National Cancer Institute at NIH under Dr Elise

Article Type:: Review Article

DOI:: https://doi.org/10.1530/JOE-23-0069

Volume/Issue:: Volume 259: Issue 3

Open access

Early-life glucocorticoids programme behaviour and metabolism in adulthood in zebrafish

K S Wilson

K S Wilson The University/BHF Centre for Cardiovascular Science, University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh, UK

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C S Tucker

C S Tucker The University/BHF Centre for Cardiovascular Science, University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh, UK

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E A S Al-Dujaili

E A S Al-Dujaili The University/BHF Centre for Cardiovascular Science, University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh, UK

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M C Holmes

M C Holmes The University/BHF Centre for Cardiovascular Science, University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh, UK

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P W F Hadoke

P W F Hadoke The University/BHF Centre for Cardiovascular Science, University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh, UK

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C J Kenyon

C J Kenyon The University/BHF Centre for Cardiovascular Science, University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh, UK

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M A Denvir

M A Denvir The University/BHF Centre for Cardiovascular Science, University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh, UK

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al . 2009 , Braun et al . 2013 , Reynolds 2013 ). This is commonly referred to as early-life programming and has been widely studied in rodents where maternal GC treatment has been shown to increase blood pressure ( Levitt et al . 1996 , Tang et

Article Type:: Research Article

DOI:: https://doi.org/10.1530/JOE-15-0376

Volume/Issue:: Volume 230: Issue 1

Open access

Maternal glucocorticoids do not directly mediate the effects of maternal social stress on the fetus

Ying Sze

Ying Sze Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, UK
The Roslin Institute, University of Edinburgh, Easter Bush Campus, Midlothian, UK

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Joana Fernandes

Joana Fernandes The Roslin Institute, University of Edinburgh, Easter Bush Campus, Midlothian, UK

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Zofia M Kołodziejczyk

Zofia M Kołodziejczyk Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, UK

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Paula J Brunton

Paula J Brunton Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, UK
The Roslin Institute, University of Edinburgh, Easter Bush Campus, Midlothian, UK
Zhejiang University-University of Edinburgh Institute, International Campus, Haining, Zhejiang, P.R. China

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phenomenon is known as fetal programming, where changes during fetal development bring about long-lasting effects ( Barker 1990 ). In women, maternal anxiety or distress during pregnancy is associated with a greater risk of psychiatric or affective disorders

Article Type:: Research Article

DOI:: https://doi.org/10.1530/JOE-22-0226

Volume/Issue:: Volume 255: Issue 3

Open access

Prenatal dexamethasone ‘programmes’ hypotension, but stress-induced hypertension in adult offspring

David O'Regan

David O'Regan Endocrinology Unit, Queen's Medical Research Institute, Centre for Cardiovascular Science, 47 Little France Crescent, Edinburgh EH16 4TJ, UK

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Christopher J Kenyon

Christopher J Kenyon Endocrinology Unit, Queen's Medical Research Institute, Centre for Cardiovascular Science, 47 Little France Crescent, Edinburgh EH16 4TJ, UK

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Jonathan R Seckl

Jonathan R Seckl Endocrinology Unit, Queen's Medical Research Institute, Centre for Cardiovascular Science, 47 Little France Crescent, Edinburgh EH16 4TJ, UK

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Megan C Holmes

Megan C Holmes Endocrinology Unit, Queen's Medical Research Institute, Centre for Cardiovascular Science, 47 Little France Crescent, Edinburgh EH16 4TJ, UK

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metabolic syndrome and deaths from ischemic heart disease in later life ( Curhan et al . 1996 a , Barker 1999 ). To explain these links, the concept of developmental ‘programming’ has been advanced, whereby a factor acting during a critical developmental

Article Type:: Research Article

DOI:: https://doi.org/10.1677/JOE-07-0327

Volume/Issue:: Volume 196: Issue 2

Open access

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Prenatal cortisol exposure impairs adrenal function but not glucose metabolism in adult sheep

K L Davies

K L Davies Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge, UK

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J Miles

J Miles Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge, UK

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E J Camm

E J Camm Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge, UK
The Ritchie Centre, Hudson Institute of Medical Research, Clayton, Australia

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D J Smith

D J Smith Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge, UK

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P Barker

P Barker MRC Metabolic Diseases Unit, Mouse Biochemistry Laboratory, Cambridge Biomedical Campus, Cambridge, UK

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K Taylor

K Taylor Endocrine Laboratory, Blood Sciences, Cambridge University Hospitals NHS Foundation Trust, Hills Road, Cambridge, UK

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A J Forhead

A J Forhead Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge, UK
Department of Biological and Medical Sciences, Oxford Brookes University, Oxford, UK

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A L Fowden

A L Fowden Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge, UK

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). Collectively, these studies have led to the concept that adult metabolic and endocrine function can be programmed developmentally in utero . With many of the prenatal environmental challenges known to programme postnatal phenotype, concentrations of the

Article Type:: Research Article

DOI:: https://doi.org/10.1530/JOE-23-0326

Volume/Issue:: Volume 260: Issue 3

Open access

RISING STARS: Evidence for established and emerging forms of β-cell death

Kaitlyn A Colglazier

Kaitlyn A Colglazier Lilly Diabetes Center of Excellence, Indiana Biosciences Research Institute, Indianapolis, Indiana, USA

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Noyonika Mukherjee

Noyonika Mukherjee Department of Biochemistry & Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana, USA

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Christopher J Contreras

Christopher J Contreras Division of Endocrinology, Department of Medicine, Roudebush VA Medical Center and Indiana University School of Medicine, Indianapolis, Indiana, USA

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Andrew T Templin

Andrew T Templin Lilly Diabetes Center of Excellence, Indiana Biosciences Research Institute, Indianapolis, Indiana, USA
Department of Biochemistry & Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana, USA
Division of Endocrinology, Department of Medicine, Roudebush VA Medical Center and Indiana University School of Medicine, Indianapolis, Indiana, USA
Center for Diabetes and Metabolic Diseases, Indiana University School of Medicine, Indianapolis, Indiana, USA

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. 2003 , 2007 ) and necrosis ( Hoorens et al. 2001 , Scarim et al. 2001 , Fehsel et al. 2003 ). Apoptosis is triggered by intrinsic or extrinsic signals and has classically been considered the lone form of programmed cell death (PCD) ( Alberts

Article Type:: Review Article

DOI:: https://doi.org/10.1530/JOE-23-0378

Volume/Issue:: Volume 262: Issue 2

Open access

30 YEARS OF THE MINERALOCORTICOID RECEPTOR: Mineralocorticoid receptor antagonists: 60 years of research and development

Peter Kolkhof

Peter Kolkhof Drug Discovery, Cardiology Research, Bayer AG, Wuppertal, Germany

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Lars Bärfacker

Lars Bärfacker Drug Discovery, Medicinal Chemistry, Bayer AG, Wuppertal, Germany

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2004 ). One chemistry program at Searle was originally focused on ‘cardioregulatory agents specifically for treating cardiac arrhythmias’ ( Fitzgerald & Fitzgerald 2009 ), probably based on the attempt to combine parts of the steroidal structures of

Article Type:: Review Article

DOI:: https://doi.org/10.1530/JOE-16-0600

Volume/Issue:: Volume 234: Issue 1

Open access

Estrogen stimulates fetal vascular endothelial growth factor expression and microvascularization

Graham W Aberdeen

Graham W Aberdeen Departments of Obstetrics, Gynecology, Reproductive Sciences and Physiology, University of Maryland School of Medicine, Baltimore, Maryland, USA

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Jeffery S Babischkin

Jeffery S Babischkin Departments of Obstetrics, Gynecology, Reproductive Sciences and Physiology, University of Maryland School of Medicine, Baltimore, Maryland, USA

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Gerald J Pepe

Gerald J Pepe Department of Physiological Sciences, Eastern Virginia Medical School, Norfolk, Virginia, USA

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Eugene D Albrecht

Eugene D Albrecht Departments of Obstetrics, Gynecology, Reproductive Sciences and Physiology, University of Maryland School of Medicine, Baltimore, Maryland, USA

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disturbing trend. The hormonal milieu of pregnancy has an extremely important role in programming the developmental events in the fetus that control metabolic function after birth in the offspring ( Hoffman et al. 2021 ). Thus, circumstances in which the