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Geoffrey L Hammond

proteins regulate the non-protein-bound or ‘free’ fraction of steroid hormones in plasma, and control their ability to leave the blood vessels within tissues and to access their target cells ( Siiteri et al. 1982 ). Albumin binds all classes of steroids

Open access

Esther Nuñez-Durán, Belén Chanclón, Silva Sütt, Joana Real, Hanns-Ulrich Marschall, Ingrid Wernstedt Asterholm, Emmelie Cansby and Margit Mahlapuu

metabolism, we recently identified serine/threonine protein kinase 25 (STK25, also referred to as YSK1 or SOK1), a broadly expressed member of the sterile 20 (STE20) kinase superfamily ( Thompson & Sahai 2015 ), as a central regulator of whole-body glucose

Open access

L Nicol, M-O Faure, J R McNeilly, J Fontaine, C Taragnat and A S McNeilly

it acts as an autocrine and/or paracrine regulator of FSH synthesis. Recently, other members of the TGFβ superfamily, the bone morphogenetic proteins (BMPs), were shown to modulate preferentially FSH secretion. In ovine pituitary cells, BMP-4 (50 ng

Open access

Georgina G J Hazell, Song T Yao, James A Roper, Eric R Prossnitz, Anne-Marie O'Carroll and Stephen J Lolait

to their target DNA sequences in the nucleus or interact with other nuclear proteins to alter gene activation, and this genomic action occurs slowly (hours–days). However, it is well documented that E 2 can also provoke many fast ‘non

Open access

M E Cleasby, Q Lau, E Polkinghorne, S A Patel, S J Leslie, N Turner, G J Cooney, A Xu and E W Kraegen

energy sensing molecule AMP-activated protein kinase (AMPK; Tomas et al . 2002 , Yamauchi et al . 2002 , Yoon et al . 2006 ). AMPK activation is reported to occur after binding of adiponectin to a pair of adiponectin receptors (AdipoRs) located on

Open access

Karen Piper Hanley, Tom Hearn, Andrew Berry, Melanie J Carvell, Ann-Marie Patch, Louise J Williams, Sarah A Sugden, David I Wilson, Sian Ellard and Neil A Hanley

progenitors, leading to increased expression of the Ras-associated small molecular mass GTP-binding protein, RAB3B. RAB3 proteins regulate intracellular trafficking and exocytosis in a range of cell types ( Gonzalez & Scheller 1999 ) with RAB3B recently

Open access

J Jeyabalan, M Shah, B Viollet, J P Roux, P Chavassieux, M Korbonits and C Chenu

Introduction AMP-activated protein kinase (AMPK) is a sensor and regulator of energy homeostasis not only at the cellular level but also at the whole-body level where it mediates the central and peripheral effects of many hormones on the metabolisms

Open access

Young Hoon Son, Seok-Jin Lee, Ki-Baek Lee, Jin-Haeng Lee, Eui Man Jeong, Sun Gun Chung, Sang-Chul Park and In-Gyu Kim

Introduction Glucocorticoids have diverse and tissue-specific effects on cellular metabolism. During metabolic stress, such as starvation, glucocorticoids promote degradation and suppress synthesis of muscle proteins in the skeletal muscle, thereby

Open access

Nami Kim, Jung Ok Lee, Hye Jeong Lee, Yong Woo Lee, Hyung Ip Kim, Su Jin Kim, Sun Hwa Park, Chul Su Lee, Sun Woo Ryoo, Geum-Sook Hwang and Hyeon Soo Kim

-independent manner. AMP-activated protein kinase (AMPK) is activated during exercise and promotes glucose uptake in the absence of insulin ( Hayashi et al . 1997 ). Impairment of glucose uptake in the muscles is observed in pathological conditions such as obesity

Open access

Judith E Cartwright and Paula Juliet Williams

(KISS1R), an orphan G-protein-coupled receptor GPR54 ( Ohtaki et al . 2001 ). The KISS1 gene was originally identified as a human metastasis suppressor gene; however, additional roles have now been revealed including a fundamental role in reproductive